Pathology Image Detail

Caption

Fig. 1G. The neoplasm is composed of bundles, streams and individual cells supported by a scant amount of fibrovascular stroma. Neoplastic cells are small to medium-sized, with ill-defined to indistinct cell borders, polygonal to spindloid, and with a small amount of basophilic cytoplasm. The nucleus is central, oval to elongated. Anisocytosis is moderate. The neoplasm invades the adjacent hepatic parenchyma (left upper portions of the photomicrograph).

Description

Hepatoblastoma, liver

Age at Necropsy

unknown

Contributor

Nakau M (J:78502)

Pathologist

Mikaelian I (J:94320)

Copyright

Reprinted by permission from the American Association for Cancer Research: Nakau M et al., "Hepatocellular carcinoma caused by loss of heterozygosity in lkb1 gene knockout mice." Cancer Res 2002 Aug 15;62(16):4549-53.

Method

H&E

Model

MMHC ID
MTB:24830
Tumor Name
Liver • hepatoblastoma
Treatment Type
None (spontaneous)
Tumor Synonyms
hepatoblastoma, liver
Organ Affected
Liver
Frequency
observed
Reference
J:78502

Strain

Strain
B6;129-Stk11tm1Mmt/+
Strain Types
targeted mutation (knockout)
General Note
Heterozygous mice. The genetic background was a mix of C57BL/6, 129X1/SvJ, and possibly some other unspecified "129/Sv" substrain.
Strain Synonyms
Lkb1 heterozygote
Lkb1 (+/-)
Lkb1 +/-
Strain Sex
Unspecified
Reproductive Status
reproductive status not specified