PDX Model DetailsJ000101328

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PDX Model Summary

Model Details

Model ID
J000101328
Initial Diagnosis
Adenocarcinoma
Final Diagnosis
Adenocarcinoma
Stage/Grade
IV /
Primary Site
Colon
Sample Site
Retroperitoneum
Tumor Type
Metastatic

Related Models

PDX models J000101328 and J000101329 originated from the same patient.

Patient

Sex
Male
Age (at time of tissue collection)
72
Race/Ethnicity
Not Reported / Not Reported
Treatment Naïve?
No
Current Smoker/Former Smoker
Unknown / Unknown

Engraftment

Host Strain
NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
(aka NSG or NOD Scid gamma)
Sample Type
Core needle biopsy
Engraftment Site
Right Flank

Molecular Data (Engrafted Tumor)

Variants

Gene Expression

Platforms: RNA_Seq

Hatched bars indicate genes with expression levels determined to be mildly affected by alignment calculations. Details.

Gene CNV

CNV Plots

Tumor Mutation Burden

Sample J000102289 from passage P0 has a TMB score of 44.42
Sample J000102291 from passage P0 has a TMB score of 44.42
Sample J000103053 from passage P1 has a TMB score of 47.64
TMB Range
0.0-304.42 (across all JAX PDX models; TMB > 22 is considered high)

Microsatellite Instability

Sample:J000102289 from passage P0     Score:MSI-H
Sample:J000102291 from passage P0     Score:MSI-H
Sample:J000103053 from passage P1     Score:MSI-H

Gene Fusion

no data

Model Characterization

Histology

no data

Dosing Studies

no data

Circos Plots

no data