PDX Model DetailsTM00302

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PDX Model Summary

Model Details

Model ID (Previous ID)
TM00302 (LG1306aF)
Initial Diagnosis
lung adenocarcinoma
Final Diagnosis
lung adenocarcinoma
Stage/Grade
AJCC IV /
Primary Site
Lung
Sample Site
Kidney
Tumor Type
Metastatic

Related Models

PDX models TM00222 and TM00302 originated from the same patient.

Patient

Sex
Female
Age (at time of tissue collection)
53
Race/Ethnicity
White / Not Hispanic or Latino
Treatment Naïve?
No
Current Smoker/Former Smoker
No / Yes

Engraftment

Host Strain
NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
(aka NSG or NOD Scid gamma)
Sample Type
Core needle biopsy
Engraftment Site
no data

Molecular Data (Engrafted Tumor)

Variants

Gene Expression

Platforms: RNA_Seq, hu133

Hatched bars indicate genes with expression levels determined to be mildly affected by alignment calculations. Details.

Gene CNV

CNV Plots

Tumor Mutation Burden

Sample
Sample from passage P1 has a TMB score of 8.08
TMB Range
0.0-291.5 (across all JAX PDX models; TMB > 22 is considered high)

Microsatellite Instability

Sample
Sample:LG1306F130P0078P1     Score:MSI-S

Gene Fusion

no data

Model Characterization

Histology

Summary:
P0 pathology consistent with adenocarcinoma. P3 pathology consistent with carcinoma but has lost adenocarcinoma differentiation.
Pathologist:
Dr. Regina Gandour-Edwards, University of California, Davis

Patient tumor for PDX model TM00302. Sheets of pleomorphic carcinoma cells with vacuolated cytoplasm.

P0 tumor #130 for PDX model TM00302. Sheets of pleomorphic carcinoma cells with vacuolated cytoplasm.

P2 tumor F130 ID014 from model TM00302 stained for H&E. This is a 4x image.

P2 tumor F130 ID014 from model TM00302 stained for H&E. This is a 20x image.

P3 tumor F130 ID16 from model TM00302 stained for AE1AE3.

Dosing Studies

Circos Plots

no data