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Last Database Update
2019-09-15
MTB 3.0
 
HelpHelp and Documentation PDX Model Details
Model Details
Model ID:TM00302 Previous ID:LG1306aF
Primary Site:Lung Initial Diagnosis:lung adenocarcinoma Final Diagnosis:lung adenocarcinoma
Tumor Site:Kidney Tumor Type:Metastatic Stage / Grade:AJCC IV /
Related Models: PDX models TM00222 and TM00302 originated from the same patient.
Patient
Sex:Female Age:53 Race / Ethnicity:White / Not Hispanic or Latino
Treatment Naive:No
Engraftment Host
Strain:NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
(aka NSG or NOD Scid gamma)
Implantation Site: Sample Type:Core needle biopsy
Tumor Mutation Burden
Sample from passage P1 has a TMB score of 8.08
TMB Range:0.81-305.22  (across all JAX PDX models)
TMB > 22 is considered high.
Variant Summary Help

Gene Expression Help Platforms:RNA_Seq, hu133
Hatched bars indicate genes with expression levels determined to be mildly affected by alignment calculations. Details.
Gene CNV Help
CNV Plots Help
Model Characterization
Histology: Summary:
High degree of concordance between morphologic features of patient tumor compared to P0 tumor. P3 is a carcinoma but has lost adenocarcinoma differentiation.
Pathologist:
Dr. Regina Gandour-Edwards, University of California, Davis

Patient tumor for PDX model TM00302. Sheets of pleomorphic carcinoma cells with vacuolated cytoplasm.

P0 tumor #130 for PDX model TM00302. Sheets of pleomorphic carcinoma cells with vacuolated cytoplasm.

P2 tumor F130 ID014 from model TM00302 stained for H&E. This is a 4x image.

P2 tumor F130 ID014 from model TM00302 stained for H&E. This is a 20x image.

P3 tumor F130 ID16 from model TM00302 stained for AE1AE3.
Dosing Studies: