PDX Model DetailsTM00302

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Model Details

Model ID (Previous ID)
TM00302 (LG1306aF)
Primary Site
Lung
Tumor Site
Kidney
Tumor Type
Metastatic
Initial Diagnosis
lung adenocarcinoma
Final Diagnosis
lung adenocarcinoma
Stage/Grade
AJCC IV /
Related Models
PDX models TM00222 and TM00302 originated from the same patient.

Patient

Sex
Female
Age
53
Race/Ethnicity
White / Not Hispanic or Latino
Treatment Naïve
No

Engraftment Host

Strain
NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
(aka NSG or NOD Scid gamma)
Sample Type
Core needle biopsy

Tumor Mutation Burden

Sample
Sample from passage P1 has a TMB score of 8.08
TMB Range
0.0-291.5 (across all JAX PDX models; TMB > 22 is considered high)

Microsatellite Instability

Sample
Sample:LG1306F130P0078P1     Score:MSI-S

Variant Summary

Gene Expression

Platforms: RNA_Seq, hu133

Hatched bars indicate genes with expression levels determined to be mildly affected by alignment calculations. Details.

Gene CNV

CNV Plots

Model Characterization

Histology: Summary:
High degree of concordance between morphologic features of patient tumor compared to P0 tumor. P3 is a carcinoma but has lost adenocarcinoma differentiation.
Pathologist:
Dr. Regina Gandour-Edwards, University of California, Davis

Patient tumor for PDX model TM00302. Sheets of pleomorphic carcinoma cells with vacuolated cytoplasm.

P0 tumor #130 for PDX model TM00302. Sheets of pleomorphic carcinoma cells with vacuolated cytoplasm.

P2 tumor F130 ID014 from model TM00302 stained for H&E. This is a 4x image.

P2 tumor F130 ID014 from model TM00302 stained for H&E. This is a 20x image.

P3 tumor F130 ID16 from model TM00302 stained for AE1AE3.

Dosing Studies