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Last Database Update
2019-09-15
MTB 3.0
 
HelpHelp and Documentation PDX Model Details
Model Details
Model ID:TM00386 Previous ID:BR0555F
Primary Site:Breast Initial Diagnosis:invasive ductal carcinoma Final Diagnosis:invasive ductal carcinoma
Tumor Site:Breast Tumor Type:Primary Malignancy Stage / Grade:AJCC IV / Grade:2
Patient
Sex:Female Age:86 Race / Ethnicity:White / Not Reported
Treatment Naive:No
Engraftment Host
Strain:NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
(aka NSG or NOD Scid gamma)
Implantation Site: Sample Type:Surgical resection (fragment)
Tumor Mutation Burden
Sample from passage P0 has a TMB score of 5.66
TMB Range:0.81-305.22  (across all JAX PDX models)
TMB > 22 is considered high.
Variant Summary Help

Gene Expression Help Platforms:hg10st
Gene CNV Help
CNV Plots Help
Model Characterization
Histology: Tumor Markers:
Patient is ER positive; PR positive; HER2 (ERRB2) negative. P0 and P1 tumors reflect the marker status of the patient tumor. P4 pathology consistent with poorly differentiated carcinoma.
Pathologist:
Dr. Regina Gandour-Edwards, University of California, Davis

Patient tumor for PDX model TM00386.

Patient tumor for PDX model TM00386; PR marker (positive)

Patient tumor for PDX model TM00386; ER marker (positive)

P0 tumor #294 for PDX model TM00386.

P0 tumor #294 for PDX model TM00386; PR marker (positive)

P0 tumor #294 for PDX model TM00386; ER marker (positive)

P1 tumor #294 for PDX model TM00386.

P1 tumor #294 for PDX model TM00386.

P1 tumor #294 for PDX model TM00386; PR marker (positive)

P1 tumor #294 for PDX model TM00386; ER marker (positive)

P4 tumor F294 ID023 for PDX model TM00386 stained for H&E.

P4 tumor F294 ID023 for PDX model TM00386 stained for AE1/AE3. Staining was positive.

P4 tumor F294 ID023 for PDX model TM00386 stained for CD45. Staining was positive.

P4 tumor F294 ID023 for PDX model TM00386 stained for Ki67. Staining was positive.

P4 tumor F294 ID023 for PDX model TM00386 stained for AR. Staining was negative.

P4 tumor F294 ID023 for PDX model TM00386 stained for ER. Staining was positive.

P4 tumor F294 ID023 for PDX model TM00386 stained for ERBB2 (HER2). Staining was negative.

P4 tumor F294 ID023 for PDX model TM00386 stained for PR. Staining was negative.

P5 tumor F294 ID029 for PDX model TM00386 stained for H&E.

P5 tumor F294 ID029 for PDX model TM00386 stained for AE1/AE3.

P5 tumor F294 ID029 for PDX model TM00386 stained for CD45.

P5 tumor F294 ID029 for PDX model TM00386 stained for Ki67.

P5 tumor F294 ID029 for PDX model TM00386 stained for AR.

P5 tumor F294 ID029 for PDX model TM00386 stained for ER.

P5 tumor F294 ID029 for PDX model TM00386 stained for ERBB2 (HER2).

P5 tumor F294 ID029 for PDX model TM00386 stained for PR.
Circos Plots:

Circos plot for P0 tumor #294 from PDX model TM00386 (aka, BR0555F)
Dosing Studies: