PDX Model DetailsTM00386

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Model Details

Model ID (Previous ID)
TM00386 (BR0555F)
Primary Site
Breast
Tumor Site
Breast
Tumor Type
Primary Malignancy
Initial Diagnosis
invasive ductal carcinoma
Final Diagnosis
invasive ductal carcinoma
Stage/Grade
AJCC IV / Grade:2

Patient

Sex
Female
Age
86
Race/Ethnicity
White / Not Reported
Treatment Naïve
No

Engraftment Host

Strain
NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
(aka NSG or NOD Scid gamma)
Sample Type
Surgical resection (fragment)

Tumor Mutation Burden

Sample
Sample from passage P0 has a TMB score of 5.66
TMB Range
0.0-291.5 (across all JAX PDX models; TMB > 22 is considered high)

Microsatellite Instability

Sample
Sample:BR0555F294P0     Score:MSI-S

Variant Summary

Gene Expression

Platforms: hg10st

Gene CNV

CNV Plots

Model Characterization

Histology: Tumor Markers:
Patient is ER positive; PR positive; HER2 (ERRB2) negative. P0 and P1 tumors reflect the marker status of the patient tumor. P4 pathology consistent with poorly differentiated carcinoma.
Pathologist:
Dr. Regina Gandour-Edwards, University of California, Davis

Patient tumor for PDX model TM00386.

Patient tumor for PDX model TM00386; PR marker (positive)

Patient tumor for PDX model TM00386; ER marker (positive)

P0 tumor #294 for PDX model TM00386.

P0 tumor #294 for PDX model TM00386; PR marker (positive)

P0 tumor #294 for PDX model TM00386; ER marker (positive)

P1 tumor #294 for PDX model TM00386.

P1 tumor #294 for PDX model TM00386.

P1 tumor #294 for PDX model TM00386; PR marker (positive)

P1 tumor #294 for PDX model TM00386; ER marker (positive)

P4 tumor F294 ID023 for PDX model TM00386 stained for H&E.

P4 tumor F294 ID023 for PDX model TM00386 stained for AE1/AE3. Staining was positive.

P4 tumor F294 ID023 for PDX model TM00386 stained for CD45. Staining was positive.

P4 tumor F294 ID023 for PDX model TM00386 stained for Ki67. Staining was positive.

P4 tumor F294 ID023 for PDX model TM00386 stained for AR. Staining was negative.

P4 tumor F294 ID023 for PDX model TM00386 stained for ER. Staining was positive.

P4 tumor F294 ID023 for PDX model TM00386 stained for ERBB2 (HER2). Staining was negative.

P4 tumor F294 ID023 for PDX model TM00386 stained for PR. Staining was negative.

P5 tumor F294 ID029 for PDX model TM00386 stained for H&E.

P5 tumor F294 ID029 for PDX model TM00386 stained for AE1/AE3.

P5 tumor F294 ID029 for PDX model TM00386 stained for CD45.

P5 tumor F294 ID029 for PDX model TM00386 stained for Ki67.

P5 tumor F294 ID029 for PDX model TM00386 stained for AR.

P5 tumor F294 ID029 for PDX model TM00386 stained for ER.

P5 tumor F294 ID029 for PDX model TM00386 stained for ERBB2 (HER2).

P5 tumor F294 ID029 for PDX model TM00386 stained for PR.
Circos Plots:

Circos plot for P0 tumor #294 from PDX model TM00386 (aka, BR0555F)

Dosing Studies