Reference SummaryMcLachlan JA, Cancer Res 1980 Nov;40(11):3988-99

Title

 Long-term effects on the female mouse genital tract associated with prenatal exposure to diethylstilbestrol.

Authors

 McLachlan JA; Newbold RR; Bullock BC

Journal

 Cancer Res

Volume

 40

Issue

 11

Year

 1980

Pages

 3988-99

Abstract

Links

 J:101635 – MGI References
7193511 – National Library of Medicine/PubMed

Strain Notes

Strain Note
CD-1 These mice were bought from Charles River Laboratories.

Models
Strain Model Name Treatment Agent(s) Organ Affected Frequency Model Details
CD-1 Genital tract tumor Genital tract

0
CD-1 Genital tract tumor
  • diethylstilbestrol (DES)
 Genital tract

4.8 - 35
CD-1 Genital tract tumor
  • 17beta-estradiol (E2)
 Genital tract

0
CD-1 Genital tract tumor
  • dimethylstilbestrol (DMS)
 Genital tract

0
CD-1 Lung adenocarcinoma
  • diethylstilbestrol (DES)
 Lung

observed
CD-1 Mammary gland adenocarcinoma Mammary gland

observed
CD-1 Mammary gland adenocarcinoma
  • diethylstilbestrol (DES)
 Mammary gland

observed
CD-1 Mammary gland tumor Mammary gland

3.8
CD-1 Mammary gland tumor
  • diethylstilbestrol (DES)
 Mammary gland

5.5
CD-1 Mesodermal cell/mesoblast sarcoma - stromal
  • diethylstilbestrol (DES)
 Uterus - Cervix

4.5 - 33
CD-1 Mesodermal cell/mesoblast sarcoma - stromal
  • diethylstilbestrol (DES)
 Uterus

4.5 - 9.1
CD-1 Muscle - Smooth leiomyoma
  • diethylstilbestrol (DES)
 Uterus - Cervix

4.8 - 50
CD-1 Muscle - Smooth leiomyoma
  • diethylstilbestrol (DES)
 Uterus

2.9 - 14
CD-1 Muscle - Smooth leiomyosarcoma
  • diethylstilbestrol (DES)
 Uterus - Cervix

5.0 - 10
CD-1 Ovary - Granulosa cell tumor
  • diethylstilbestrol (DES)
 Ovary - Granulosa cell

observed - 10
CD-1 Ovary cyst Ovary

observed - 16
CD-1 Ovary cyst
  • diethylstilbestrol (DES)
 Ovary

observed - 100
CD-1 Ovary cyst
  • 17beta-estradiol (E2)
 Ovary

58
CD-1 Ovary cyst
  • dimethylstilbestrol (DMS)
 Ovary

60
CD-1 Ovary cystadenoma - papillary
  • diethylstilbestrol (DES)
 Ovary

observed - 8.3
CD-1 Ovary tumor Ovary

0
CD-1 Ovary tumor
  • diethylstilbestrol (DES)
 Ovary

3.8
CD-1 Ovary tumor - gonadal stromal
  • diethylstilbestrol (DES)
 Ovary

observed
CD-1 Uterus - Cervix atypia
  • diethylstilbestrol (DES)
 Uterus - Cervix

2.9 - 8.3
CD-1 Uterus - Cervix cyst - keratinized
  • diethylstilbestrol (DES)
 Uterus - Cervix

4.5 - 9.1
CD-1 Uterus - Cervix hyperplasia - stromal
  • diethylstilbestrol (DES)
 Uterus - Cervix

2.9 - 8.3
CD-1 Uterus - Cervix metaplasia - squamous Uterus - Cervix

1.2 - 4.2
CD-1 Uterus - Cervix metaplasia - squamous
  • diethylstilbestrol (DES)
 Uterus - Cervix

observed - 33
CD-1 Uterus - Cervix papilloma
  • diethylstilbestrol (DES)
 Uterus - Cervix

5.3 - 25
CD-1 Uterus - Cervix tumor Uterus - Cervix

0
CD-1 Uterus - Cervix tumor
  • diethylstilbestrol (DES)
 Uterus - Cervix

0 - 50
CD-1 Uterus - Endometrium hyperplasia - atypical
  • diethylstilbestrol (DES)
 Uterus - Endometrium

observed
CD-1 Uterus - Endometrium hyperplasia - cystic Uterus - Endometrium

0 - 25
CD-1 Uterus - Endometrium hyperplasia - cystic
  • diethylstilbestrol (DES)
 Uterus - Endometrium

observed - 100
CD-1 Uterus - Endometrium hyperplasia - cystic
  • 17beta-estradiol (E2)
 Uterus - Endometrium

0
CD-1 Uterus - Endometrium hyperplasia - cystic
  • dimethylstilbestrol (DMS)
 Uterus - Endometrium

10
CD-1 Uterus adenocarcinoma
  • diethylstilbestrol (DES)
 Uterus

5.0 - 10
CD-1 Uterus metaplasia - squamous Uterus

0
CD-1 Uterus metaplasia - squamous
  • diethylstilbestrol (DES)
 Uterus

observed - 30
CD-1 Uterus metaplasia - squamous
  • 17beta-estradiol (E2)
 Uterus

0
CD-1 Uterus metaplasia - squamous
  • dimethylstilbestrol (DMS)
 Uterus

20
CD-1 Uterus tumor Uterus

0
CD-1 Uterus tumor
  • diethylstilbestrol (DES)
 Uterus

0 - 14
CD-1 Vagina - Basal cell hyperplasia
  • diethylstilbestrol (DES)
 Vagina - Basal cell

2.9 - 8.3
CD-1 Vagina adenocarcinoma
  • diethylstilbestrol (DES)
 Vagina

2.9 - 8.3
CD-1 Vagina tumor Vagina

0
CD-1 Vagina tumor
  • diethylstilbestrol (DES)
 Vagina

0 - 25
CD-1 Vagina tumor - epidermoid
  • diethylstilbestrol (DES)
 Vagina

observed - 25
CD-1 (Unspecified organ) lesion
  • diethylstilbestrol (DES)
 (Unspecified organ)

0
CD-1 (Unspecified organ) reticulum cell sarcoma Neck

14
CD-1 (Unspecified organ) reticulum cell sarcoma
  • diethylstilbestrol (DES)
 Uterus

8.3
CD-1 (Unspecified organ) tumor - mesenchymal
  • diethylstilbestrol (DES)
 Back

8.3