Strain SummaryCD-1

Strain Name

CD-1

Strain Type(s)

outbred

Strain Synonym(s)

CD1  •  CD1 nontransgenic  •  CD-1 outbred  •  Charles River CD-1  •  Crj:CD-1(ICR)  •  Crl: CD-1 (ICR) BR  •  Crl:CD-1 (ICR) BR  •  Crl:CD-1(ICR)BR  •  Crl:CD-1®(ICR)  •  ICR  •  ICR(CD-1)  •  ICR Crj:CD-1  •  outbred CD1  •  outbred CD-1  •  random-bred Crl:CD-1(ICR)BR  •  (Swiss) CD-1  •  Swiss CD-1  •  Swiss CD-1®

Description

Outbred mice from Charles River.

Models

925 unique models displayed. A model is a set of tumors that share the same tumor name, organ(s) affected, and treatment type for a specific strain.
Frequency
Model Name Organ Affected Tumor Inducing Agent(s) Female Male Mixed Pop. Unspecified Additional Information Model Details
Abdominal cavity tumor - histiocytic Abdominal cavity

10 - 12.5

References: Baldrick P, Toxicol Pathol 2007;35(4):562-9

Adipose tissue lipoma Kidney

0

0.1

References: Maita K, Toxicol Pathol 1988;16(3):340-9

Adipose tissue lipoma Abdominal cavity

0.1

0.1

References: Maita K, Toxicol Pathol 1988;16(3):340-9

Adipose tissue lipoma Peritoneum - Mesentery 3'-azido-3'-deoxythymidine (AZT)

1.9

References: Diwan BA, Toxicol Appl Pharmacol 1999 Nov 15;161(1):82-99

Adipose tissue liposarcoma Subcutis

0.8

0

References: Maita K, Toxicol Pathol 1988;16(3):340-9

Adipose tissue liposarcoma Abdominal cavity

0.1

0

References: Maita K, Toxicol Pathol 1988;16(3):340-9

Adrenal gland - Cortex adenocarcinoma Adrenal gland - Cortex

0.3

0

References: Maita K, Toxicol Pathol 1988;16(3):340-9

Adrenal gland - Cortex adenoma Adrenal gland - Cortex

0 - 3.0

0.1 - 1.9

References: Baldrick P, Toxicol Pathol 2007;35(4):562-9   ⋅   Chandra M, Toxicol Lett 1992 Jun;61(1):67-74   ⋅   Diwan BA, Toxicol Appl Pharmacol 1999 Nov 15;161(1):82-99   ⋅   Maita K, Toxicol Pathol 1988;16(3):340-9   ⋅   Tannehill-Gregg SH, Toxicol Sci 2007 Jul;98(1):258-70   ⋅   Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Adrenal gland - Cortex adenoma Adrenal gland - Cortex sodium arsenite

26

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Adrenal gland - Cortex adenoma Adrenal gland - Cortex diethylstilbestrol (DES)

9.1

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Adrenal gland - Cortex adenoma Adrenal gland - Cortex tamoxifen (TAM)

5.7

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Adrenal gland - Cortex adenoma Adrenal gland - Cortex sodium arsenite   ⋅   diethylstilbestrol (DES)

24

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Adrenal gland - Cortex adenoma Adrenal gland - Cortex sodium arsenite   ⋅   tamoxifen (TAM)

20

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Adrenal gland - Cortex adenoma Adrenal gland - Cortex muraglitazar

0

0

References: Tannehill-Gregg SH, Toxicol Sci 2007 Jul;98(1):258-70

Adrenal gland - Medulla pheochromocytoma Adrenal gland - Medulla

0 - 1.7

0 - 1.7

References: Chandra M, Toxicol Lett 1992 Jun;61(1):67-74   ⋅   Maita K, Toxicol Pathol 1988;16(3):340-9   ⋅   Tannehill-Gregg SH, Toxicol Sci 2007 Jul;98(1):258-70

Sites of Metastasis: Lung

Adrenal gland - Medulla pheochromocytoma Adrenal gland - Medulla muraglitazar

0

0

References: Tannehill-Gregg SH, Toxicol Sci 2007 Jul;98(1):258-70

Adrenal gland - Medulla pheochromocytoma Adrenal gland - Medulla 3'-azido-3'-deoxythymidine (AZT)

2.0

References: Diwan BA, Toxicol Appl Pharmacol 1999 Nov 15;161(1):82-99

Adrenal gland - Medulla pheochromocytoma Adrenal gland - Medulla sodium barbital (BB)

2.9

References: Diwan BA, Toxicol Appl Pharmacol 1999 Nov 15;161(1):82-99

Adrenal gland - Medulla pheochromocytoma - benign Adrenal gland - Medulla

0.3 - 1.1

0.6

References: Baldrick P, Toxicol Pathol 2007;35(4):562-9

Adrenal gland - Medulla pheochromocytoma - malignant Adrenal gland - Medulla

0 - 1.7

0

References: Maita K, Toxicol Pathol 1988;16(3):340-9   ⋅   Tannehill-Gregg SH, Toxicol Sci 2007 Jul;98(1):258-70

Sites of Metastasis: Lung

Adrenal gland - Medulla pheochromocytoma - malignant Adrenal gland - Medulla muraglitazar

0

0 - 1.7

References: Tannehill-Gregg SH, Toxicol Sci 2007 Jul;98(1):258-70

Adrenal gland - Subcapsular cell adenoma Adrenal gland - Subcapsular cell

0 - 0.6

0 - 8.6

References: Baldrick P, Toxicol Pathol 2007;35(4):562-9   ⋅   Tannehill-Gregg SH, Toxicol Sci 2007 Jul;98(1):258-70

Adrenal gland - Subcapsular cell adenoma Adrenal gland - Subcapsular cell muraglitazar

0 - 1.7

0

References: Tannehill-Gregg SH, Toxicol Sci 2007 Jul;98(1):258-70

Adrenal gland - Subcapsular cell hyperplasia Adrenal gland - Subcapsular cell

observed

References: Baldrick P, Toxicol Pathol 2007;35(4):562-9

Adrenal gland adenoma Adrenal gland

2.0

References: Baldrick P, Toxicol Pathol 2007;35(4):562-9

Adrenal gland tumor Adrenal gland 3'-azido-3'-deoxythymidine (AZT)

0.9

References: Diwan BA, Toxicol Appl Pharmacol 1999 Nov 15;161(1):82-99

Ampullary gland hyperplasia Ampullary gland diethylstilbestrol (DES)

1.6

References: Newbold RR, Carcinogenesis 2000 Jul;21(7):1355-63

Blood vessel hemangioma Ovary tamoxifen (TAM)

0 - 18

References: Newbold RR, Carcinogenesis 1997 Dec;18(12):2293-8   ⋅   Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Blood vessel hemangioma Ovary

0 - 3.1

References: Maita K, Toxicol Pathol 1988;16(3):340-9   ⋅   Newbold RR, Carcinogenesis 1998 Sep;19(9):1655-63   ⋅   Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Blood vessel hemangioma Ovary diethylstilbestrol (DES)

0 - 6.3

References: Newbold RR, Carcinogenesis 1998 Sep;19(9):1655-63   ⋅   Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Blood vessel hemangioma Uterus diethylstilbestrol (DES)

2.9 - 8.3

References: Newbold RR, Carcinogenesis 1998 Sep;19(9):1655-63

Blood vessel hemangioma Testis diethylstilbestrol (DES)

1.6

References: Newbold RR, Carcinogenesis 2000 Jul;21(7):1355-63

Blood vessel hemangioma Liver

0 - 4.5

1.5 - 5.0

References: Baldrick P, Toxicol Pathol 2007;35(4):562-9   ⋅   Maita K, Toxicol Pathol 1988;16(3):340-9   ⋅   Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Blood vessel hemangioma Spleen

0.4 - 2.0

0.6 - 2.0

References: Baldrick P, Toxicol Pathol 2007;35(4):562-9   ⋅   Maita K, Toxicol Pathol 1988;16(3):340-9   ⋅   Tannehill-Gregg SH, Toxicol Sci 2007 Jul;98(1):258-70

Blood vessel hemangioma Uterus

0.9 - 3.9

References: Baldrick P, Toxicol Pathol 2007;35(4):562-9   ⋅   Maita K, Toxicol Pathol 1988;16(3):340-9   ⋅   Tannehill-Gregg SH, Toxicol Sci 2007 Jul;98(1):258-70

Blood vessel hemangioma Skin

0.4

References: Baldrick P, Toxicol Pathol 2007;35(4):562-9

Blood vessel hemangioma Testis

0.6

References: Baldrick P, Toxicol Pathol 2007;35(4):562-9

Blood vessel hemangioma Lymph node - Mesenteric

1.1

References: Baldrick P, Toxicol Pathol 2007;35(4):562-9

Blood vessel hemangioma Bone - Femur

0.5

References: Baldrick P, Toxicol Pathol 2007;35(4):562-9

Blood vessel hemangioma Bone - Sternum

0.8

0.8

References: Baldrick P, Toxicol Pathol 2007;35(4):562-9

Blood vessel hemangioma Tail

1.3

1.3

References: Baldrick P, Toxicol Pathol 2007;35(4):562-9

Blood vessel hemangioma Leg

14

References: Baldrick P, Toxicol Pathol 2007;35(4):562-9

Blood vessel hemangioma Stomach

1.5

References: Baldrick P, Toxicol Pathol 2007;35(4):562-9

Blood vessel hemangioma (Unspecified organ)

3.3 - 6.7

5.0

References: Baldrick P, Toxicol Pathol 2007;35(4):562-9

Blood vessel hemangioma Thymus

1.9

References: Baldrick P, Toxicol Pathol 2007;35(4):562-9

Blood vessel hemangioma Abdominal cavity

0.3 - 20

0

References: Baldrick P, Toxicol Pathol 2007;35(4):562-9   ⋅   Maita K, Toxicol Pathol 1988;16(3):340-9

Blood vessel hemangioma Ovary sodium arsenite

8.8

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Blood vessel hemangioma Liver sodium arsenite

0

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Blood vessel hemangioma Liver diethylstilbestrol (DES)

0

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Blood vessel hemangioma Liver tamoxifen (TAM)

0

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Blood vessel hemangioma Ovary sodium arsenite   ⋅   diethylstilbestrol (DES)

6.1

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Blood vessel hemangioma Liver sodium arsenite   ⋅   diethylstilbestrol (DES)

3.0

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Blood vessel hemangioma Ovary sodium arsenite   ⋅   tamoxifen (TAM)

5.7

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Blood vessel hemangioma Liver sodium arsenite   ⋅   tamoxifen (TAM)

0

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Blood vessel hemangioma Blood vessel

1.7 - 3.3

0 - 0.8

References: Chandra M, Toxicol Lett 1992 Jun;61(1):67-74   ⋅   Tannehill-Gregg SH, Toxicol Sci 2007 Jul;98(1):258-70

Blood vessel hemangioma Lymph node

0

0.1

References: Maita K, Toxicol Pathol 1988;16(3):340-9

Blood vessel hemangioma Lung

0.1

0

References: Maita K, Toxicol Pathol 1988;16(3):340-9

Blood vessel hemangioma Intestine - Small Intestine

0.1

0

References: Maita K, Toxicol Pathol 1988;16(3):340-9

Blood vessel hemangioma Epididymis

0.1

References: Maita K, Toxicol Pathol 1988;16(3):340-9

Blood vessel hemangioma Subcutis

0.9

0.4

References: Maita K, Toxicol Pathol 1988;16(3):340-9

Blood vessel hemangioma Muscle

0

0.1

References: Maita K, Toxicol Pathol 1988;16(3):340-9

Blood vessel hemangioma Blood vessel muraglitazar

0 - 3.3

0 - 1.7

References: Tannehill-Gregg SH, Toxicol Sci 2007 Jul;98(1):258-70

Blood vessel hemangiosarcoma Liver

0 - 0.4

0 - 5.0

References: Baldrick P, Toxicol Pathol 2007;35(4):562-9   ⋅   Maita K, Toxicol Pathol 1988;16(3):340-9   ⋅   Takahashi O, Toxicology 1997 Dec 26;124(2):95-103   ⋅   Tannehill-Gregg SH, Toxicol Sci 2007 Jul;98(1):258-70   ⋅   Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Blood vessel hemangiosarcoma Liver piperonyl butoxide (alpha-[2-(2-butoxyethoxy)ethoxy-4,5-methylenedioxy-2-propyltoluene)

0 - 80

0 - 44

References: Takahashi O, Toxicology 1997 Dec 26;124(2):95-103

Blood vessel hemangiosarcoma Skin

0.6

0.3

References: Baldrick P, Toxicol Pathol 2007;35(4):562-9

Blood vessel hemangiosarcoma Spleen

0.7

0.4 - 5.0

References: Baldrick P, Toxicol Pathol 2007;35(4):562-9   ⋅   Maita K, Toxicol Pathol 1988;16(3):340-9   ⋅   Tannehill-Gregg SH, Toxicol Sci 2007 Jul;98(1):258-70

Blood vessel hemangiosarcoma (Unspecified organ)

1.6

3.2

References: Baldrick P, Toxicol Pathol 2007;35(4):562-9

Blood vessel hemangiosarcoma Intestine - Large Intestine - Colon

2.0

References: Baldrick P, Toxicol Pathol 2007;35(4):562-9

Blood vessel hemangiosarcoma Bone

5.0

References: Baldrick P, Toxicol Pathol 2007;35(4):562-9

Blood vessel hemangiosarcoma Muscle

0 - 0.9

0.1

References: Baldrick P, Toxicol Pathol 2007;35(4):562-9   ⋅   Maita K, Toxicol Pathol 1988;16(3):340-9

Blood vessel hemangiosarcoma Thoracic cavity

12.5

References: Baldrick P, Toxicol Pathol 2007;35(4):562-9

Blood vessel hemangiosarcoma Uterus

0 - 4.3

References: Baldrick P, Toxicol Pathol 2007;35(4):562-9   ⋅   Diwan BA, Toxicol Appl Pharmacol 1999 Nov 15;161(1):82-99   ⋅   Maita K, Toxicol Pathol 1988;16(3):340-9   ⋅   Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Blood vessel hemangiosarcoma Blood vessel

0 - 3.3

0 - 6.7

References: Baldrick P, Toxicol Pathol 2007;35(4):562-9   ⋅   Chandra M, Toxicol Lett 1992 Jun;61(1):67-74   ⋅   Tannehill-Gregg SH, Toxicol Sci 2007 Jul;98(1):258-70

Blood vessel hemangiosarcoma Uterus sodium arsenite

2.9

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Blood vessel hemangiosarcoma Liver sodium arsenite

5.9

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Blood vessel hemangiosarcoma Uterus diethylstilbestrol (DES)

0

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Blood vessel hemangiosarcoma Liver diethylstilbestrol (DES)

0

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Blood vessel hemangiosarcoma Uterus tamoxifen (TAM)

0

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Blood vessel hemangiosarcoma Liver tamoxifen (TAM)

0

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Blood vessel hemangiosarcoma Uterus sodium arsenite   ⋅   diethylstilbestrol (DES)

0

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Blood vessel hemangiosarcoma Liver sodium arsenite   ⋅   diethylstilbestrol (DES)

0

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Blood vessel hemangiosarcoma Uterus sodium arsenite   ⋅   tamoxifen (TAM)

0

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Blood vessel hemangiosarcoma Liver sodium arsenite   ⋅   tamoxifen (TAM)

2.9

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Blood vessel hemangiosarcoma Lymph node

0.1

0

References: Maita K, Toxicol Pathol 1988;16(3):340-9

Blood vessel hemangiosarcoma Abdominal cavity

0.1

0.1

References: Maita K, Toxicol Pathol 1988;16(3):340-9

Blood vessel hemangiosarcoma Ovary

0.1

References: Maita K, Toxicol Pathol 1988;16(3):340-9

Blood vessel hemangiosarcoma Testis

1.7

References: Tannehill-Gregg SH, Toxicol Sci 2007 Jul;98(1):258-70

Blood vessel hemangiosarcoma Bone marrow

1.7

References: Tannehill-Gregg SH, Toxicol Sci 2007 Jul;98(1):258-70

Blood vessel hemangiosarcoma Subcutis

20 - 50

References: Tannehill-Gregg SH, Toxicol Sci 2007 Jul;98(1):258-70

Blood vessel hemangiosarcoma Gallbladder

2.5

References: Tannehill-Gregg SH, Toxicol Sci 2007 Jul;98(1):258-70

Blood vessel hemangiosarcoma Blood vessel muraglitazar

5.0 - 8.3

1.7 - 8.3

References: Tannehill-Gregg SH, Toxicol Sci 2007 Jul;98(1):258-70

Blood vessel hemangiosarcoma Spleen muraglitazar

1.7

5.0 - 6.7

References: Tannehill-Gregg SH, Toxicol Sci 2007 Jul;98(1):258-70

Blood vessel hemangiosarcoma Liver muraglitazar

3.3

6.7

References: Tannehill-Gregg SH, Toxicol Sci 2007 Jul;98(1):258-70

Blood vessel hemangiosarcoma Subcutis muraglitazar

14 - 100

References: Tannehill-Gregg SH, Toxicol Sci 2007 Jul;98(1):258-70

Blood vessel hemangiosarcoma Uterus 3'-azido-3'-deoxythymidine (AZT)

4.2

References: Diwan BA, Toxicol Appl Pharmacol 1999 Nov 15;161(1):82-99

Blood vessel hemangiosarcoma Blood vessel 3'-azido-3'-deoxythymidine (AZT)

observed

References: Diwan BA, Toxicol Appl Pharmacol 1999 Nov 15;161(1):82-99

Blood vessel hemangiosarcoma Liver New western diet (NWD) TD.96096   ⋅   AIN-76A

observed

References: Poutahidis T, Cancer Res 2015 Apr 1;75(7):1197-204

Blood vessel hemangiosarcoma Spleen N-methyl-N-nitrosourea (MNU)

25.93

References: Yamamoto M, Cancer Lett 2002 May 28;179(2):121-32

Blood vessel hemangiosarcoma Liver N-methyl-N-nitrosourea (MNU)

3.7

References: Yamamoto M, Cancer Lett 2002 May 28;179(2):121-32

Blood vessel hemangiosarcoma Intestine N-methyl-N-nitrosourea (MNU)

14.81

References: Yamamoto M, Cancer Lett 2002 May 28;179(2):121-32

Blood vessel tumor Subcutis

0.8

0.3

References: Maita K, Toxicol Pathol 1988;16(3):340-9

Blood vessel tumor Blood vessel

3.3 - 5.0

5.0 - 6.7

10.0 - 20.0

References: Diwan BA, Toxicol Appl Pharmacol 1999 Nov 15;161(1):82-99   ⋅   Tannehill-Gregg SH, Toxicol Sci 2007 Jul;98(1):258-70

Blood vessel tumor Blood vessel muraglitazar

5.0 - 8.3

1.7 - 8.3

References: Tannehill-Gregg SH, Toxicol Sci 2007 Jul;98(1):258-70

Blood vessel tumor Lung

1.7

References: Tannehill-Gregg SH, Toxicol Sci 2007 Jul;98(1):258-70

Blood vessel tumor Uterus

1.7

References: Tannehill-Gregg SH, Toxicol Sci 2007 Jul;98(1):258-70

Blood vessel tumor Spleen

1.7

References: Tannehill-Gregg SH, Toxicol Sci 2007 Jul;98(1):258-70

Blood vessel tumor Liver

1.7

References: Tannehill-Gregg SH, Toxicol Sci 2007 Jul;98(1):258-70

Blood vessel tumor Liver muraglitazar

1.7 - 8.3

References: Tannehill-Gregg SH, Toxicol Sci 2007 Jul;98(1):258-70

Blood vessel tumor Ovary muraglitazar

1.7 - 3.3

References: Tannehill-Gregg SH, Toxicol Sci 2007 Jul;98(1):258-70

Blood vessel tumor Uterus muraglitazar

3.3

References: Tannehill-Gregg SH, Toxicol Sci 2007 Jul;98(1):258-70

Blood vessel tumor Spleen muraglitazar

1.7 - 3.3

References: Tannehill-Gregg SH, Toxicol Sci 2007 Jul;98(1):258-70

Blood vessel tumor Bone marrow muraglitazar

1.7

References: Tannehill-Gregg SH, Toxicol Sci 2007 Jul;98(1):258-70

Blood vessel tumor Subcutis muraglitazar

1.7 - 5.9

33

References: Tannehill-Gregg SH, Toxicol Sci 2007 Jul;98(1):258-70

Blood vessel tumor Lung muraglitazar

1.7

References: Tannehill-Gregg SH, Toxicol Sci 2007 Jul;98(1):258-70

Blood vessel tumor Blood vessel 3'-azido-3'-deoxythymidine (AZT)

10.0 - 20.0

References: Diwan BA, Toxicol Appl Pharmacol 1999 Nov 15;161(1):82-99

Blood vessel tumor Blood vessel sodium barbital (BB)   ⋅   3'-azido-3'-deoxythymidine (AZT)

10.0 - 20.0

References: Diwan BA, Toxicol Appl Pharmacol 1999 Nov 15;161(1):82-99

Blood vessel tumor Blood vessel sodium barbital (BB)

10.0 - 20.0

References: Diwan BA, Toxicol Appl Pharmacol 1999 Nov 15;161(1):82-99

Bone marrow hyperplasia Bone marrow

observed

References: Baldrick P, Toxicol Pathol 2007;35(4):562-9

Bone osteoma Bone - Femur

0.3

0.3 - 0.7

References: Baldrick P, Toxicol Pathol 2007;35(4):562-9

Bone osteoma Bone

0.2 - 17

0 - 33

References: Baldrick P, Toxicol Pathol 2007;35(4):562-9   ⋅   Chandra M, Toxicol Lett 1992 Jun;61(1):67-74   ⋅   Maita K, Toxicol Pathol 1988;16(3):340-9

Bone osteoma Bone - Rib

0.1

References: Chandra M, Toxicol Lett 1992 Jun;61(1):67-74

Bone osteoma Spleen

0.1

0

References: Maita K, Toxicol Pathol 1988;16(3):340-9

Bone osteoma Bone - Skull

0

0.1

References: Maita K, Toxicol Pathol 1988;16(3):340-9

Bone osteosarcoma Bone

0 - 67

0 - 22

0.6

References: Baldrick P, Toxicol Pathol 2007;35(4):562-9   ⋅   Chandra M, Toxicol Lett 1992 Jun;61(1):67-74   ⋅   Lavigueur A, Mol Cell Biol 1989 Sep;9(9):3982-91   ⋅   Maita K, Toxicol Pathol 1988;16(3):340-9   ⋅   Son WC, Toxicol Lett 2003 Nov 1;145(1):88-98

Bone osteosarcoma Skin

0.2 - 0.5

0.2 - 0.3

References: Baldrick P, Toxicol Pathol 2007;35(4):562-9

Bone osteosarcoma Stomach

0.9

0.9

References: Baldrick P, Toxicol Pathol 2007;35(4):562-9

Bone osteosarcoma Uterus

1.7

References: Baldrick P, Toxicol Pathol 2007;35(4):562-9

Bone osteosarcoma Skin sodium arsenite   ⋅   tamoxifen (TAM)

2.9

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Bone osteosarcoma Bone - Rib

0.3

References: Chandra M, Toxicol Lett 1992 Jun;61(1):67-74

Bone osteosarcoma Abdominal cavity

0.1

0

References: Maita K, Toxicol Pathol 1988;16(3):340-9

Bone osteosarcoma Subcutis

0

0

References: Tannehill-Gregg SH, Toxicol Sci 2007 Jul;98(1):258-70

Bone osteosarcoma Subcutis muraglitazar

5.9

0

References: Tannehill-Gregg SH, Toxicol Sci 2007 Jul;98(1):258-70

Bone osteosarcoma Stomach - Glandular 3'-azido-3'-deoxythymidine (AZT)

2.0

References: Diwan BA, Toxicol Appl Pharmacol 1999 Nov 15;161(1):82-99

Bone osteosarcoma Subcutis 3'-azido-3'-deoxythymidine (AZT)

1.9

References: Diwan BA, Toxicol Appl Pharmacol 1999 Nov 15;161(1):82-99

Bulbourethral gland adenoma Bulbourethral gland

2.0

References: Takahashi O, Toxicology 1997 Dec 26;124(2):95-103

CNS - Meninges meningioma - malignant Bone - Skull

0

0.1

References: Maita K, Toxicol Pathol 1988;16(3):340-9

Clitoral gland adenocarcinoma Clitoral gland diethylstilbestrol (DES)

2.7

References: Newbold RR, Carcinogenesis 1998 Sep;19(9):1655-63

Connective tissue - Fibroblast fibroma Subcutis

0.3

0.1

References: Maita K, Toxicol Pathol 1988;16(3):340-9

Connective tissue - Fibroblast fibroma Uterus

0.1

References: Maita K, Toxicol Pathol 1988;16(3):340-9

Connective tissue - Fibroblast fibrosarcoma Mammary gland diethylstilbestrol (DES)

observed

References: Newbold RR, Carcinogenesis 2000 Jul;21(7):1355-63

Connective tissue - Fibroblast fibrosarcoma Skin

0 - 0.6

1.7 - 8.3

References: Baldrick P, Toxicol Pathol 2007;35(4):562-9

Connective tissue - Fibroblast fibrosarcoma Spleen

0

0.1

References: Chandra M, Toxicol Lett 1992 Jun;61(1):67-74

Connective tissue - Fibroblast fibrosarcoma Vagina

0.1

References: Chandra M, Toxicol Lett 1992 Jun;61(1):67-74

Connective tissue - Fibroblast fibrosarcoma Pancreas

0

0.1

References: Maita K, Toxicol Pathol 1988;16(3):340-9

Connective tissue - Fibroblast fibrosarcoma Subcutis

0 - 75

0 - 50

References: Maita K, Toxicol Pathol 1988;16(3):340-9   ⋅   Tannehill-Gregg SH, Toxicol Sci 2007 Jul;98(1):258-70

Sites of Metastasis: not Lung , not Lymph node

Connective tissue - Fibroblast fibrosarcoma Ear - Outer ear

0.1

0

References: Maita K, Toxicol Pathol 1988;16(3):340-9

Connective tissue - Fibroblast fibrosarcoma Connective tissue - Fibroblast

very low

References: Tannehill-Gregg SH, Toxicol Sci 2007 Jul;98(1):258-70

Sites of Metastasis: not Lung , Lymph node - Mesenteric , Pancreas

Connective tissue - Fibroblast fibrosarcoma Abdominal cavity

0

0 - 50

References: Tannehill-Gregg SH, Toxicol Sci 2007 Jul;98(1):258-70

Connective tissue - Fibroblast fibrosarcoma Subcutis muraglitazar

0 - 50

0 - 100

References: Tannehill-Gregg SH, Toxicol Sci 2007 Jul;98(1):258-70

Sites of Metastasis: not Lung , not Lymph node - Mesenteric , not Pancreas , Lung , Lymph node

Connective tissue - Fibroblast fibrosarcoma Abdominal cavity muraglitazar

0

0

References: Tannehill-Gregg SH, Toxicol Sci 2007 Jul;98(1):258-70

Connective tissue - Fibroblast fibrosarcoma Seminal vesicle 3'-azido-3'-deoxythymidine (AZT)

7.1

References: Diwan BA, Toxicol Appl Pharmacol 1999 Nov 15;161(1):82-99

Ear - Zymbal gland carcinoma Ear - Zymbal gland

1.7

References: Baldrick P, Toxicol Pathol 2007;35(4):562-9

Ear - Zymbal gland carcinoma - sebaceous Ear - Zymbal gland

1.7

References: Baldrick P, Toxicol Pathol 2007;35(4):562-9

Eye - Harderian gland adenocarcinoma Eye - Harderian gland

0.1 - 2.4

0.1 - 0.8

References: Baldrick P, Toxicol Pathol 2007;35(4):562-9   ⋅   Chandra M, Toxicol Lett 1992 Jun;61(1):67-74   ⋅   Maita K, Toxicol Pathol 1988;16(3):340-9

Sites of Metastasis: Lung

Eye - Harderian gland adenoma Eye - Harderian gland

1.5 - 11.8

1.9 - 19.4

References: Baldrick P, Toxicol Pathol 2007;35(4):562-9   ⋅   Chandra M, Toxicol Lett 1992 Jun;61(1):67-74   ⋅   Diwan BA, Toxicol Appl Pharmacol 1999 Nov 15;161(1):82-99   ⋅   Maita K, Toxicol Pathol 1988;16(3):340-9   ⋅   Tannehill-Gregg SH, Toxicol Sci 2007 Jul;98(1):258-70

Eye - Harderian gland adenoma Eye - Harderian gland muraglitazar

0 - 6.8

0 - 6.7

References: Tannehill-Gregg SH, Toxicol Sci 2007 Jul;98(1):258-70

Eye - Harderian gland carcinoma Eye - Harderian gland

0 - 3.3

0

References: Tannehill-Gregg SH, Toxicol Sci 2007 Jul;98(1):258-70

Sites of Metastasis: Adipose tissue - Brown , Blood vessel - Aorta , Lung , Thymus

Eye - Harderian gland carcinoma Eye - Harderian gland muraglitazar

0

0 - 1.7

References: Tannehill-Gregg SH, Toxicol Sci 2007 Jul;98(1):258-70

Sites of Metastasis: not Adipose tissue - Brown , not Blood vessel - Aorta , not Lung , not Thymus

Forestomach squamous cell carcinoma Forestomach

0 - 0.1

0 - 0.3

References: Maita K, Toxicol Pathol 1988;16(3):340-9   ⋅   Tannehill-Gregg SH, Toxicol Sci 2007 Jul;98(1):258-70

Forestomach squamous cell carcinoma Forestomach muraglitazar

0 - 1.7

0

References: Tannehill-Gregg SH, Toxicol Sci 2007 Jul;98(1):258-70

Forestomach squamous cell papilloma Forestomach

0 - 1.7

0

References: Tannehill-Gregg SH, Toxicol Sci 2007 Jul;98(1):258-70

Forestomach squamous cell papilloma Forestomach muraglitazar

0

0

References: Tannehill-Gregg SH, Toxicol Sci 2007 Jul;98(1):258-70

Forestomach tumor Forestomach

0

References: Diwan BA, Toxicol Appl Pharmacol 1999 Nov 15;161(1):82-99

Forestomach tumor Forestomach 3'-azido-3'-deoxythymidine (AZT)

observed - 3.7

References: Diwan BA, Toxicol Appl Pharmacol 1999 Nov 15;161(1):82-99

Gallbladder adenoma Gallbladder

0

0

References: Tannehill-Gregg SH, Toxicol Sci 2007 Jul;98(1):258-70

Gallbladder adenoma Gallbladder muraglitazar

0

0 - 3.3

References: Tannehill-Gregg SH, Toxicol Sci 2007 Jul;98(1):258-70

Gallbladder hyperplasia - focal Gallbladder

0 - observed

0 - observed

References: Tannehill-Gregg SH, Toxicol Sci 2007 Jul;98(1):258-70

Gallbladder hyperplasia - focal Gallbladder muraglitazar

0 - observed

observed

References: Tannehill-Gregg SH, Toxicol Sci 2007 Jul;98(1):258-70

Gallbladder papilloma Gallbladder

0.1 - 1.1

0.1 - 1.1

References: Baldrick P, Toxicol Pathol 2007;35(4):562-9   ⋅   Maita K, Toxicol Pathol 1988;16(3):340-9

Genital tract tumor Genital tract

0

References: McLachlan JA, Cancer Res 1980 Nov;40(11):3988-99

Genital tract tumor Genital tract diethylstilbestrol (DES)

4.8 - 35

References: McLachlan JA, Cancer Res 1980 Nov;40(11):3988-99

Genital tract tumor Genital tract 17beta-estradiol (E2)

0

References: McLachlan JA, Cancer Res 1980 Nov;40(11):3988-99

Genital tract tumor Genital tract dimethylstilbestrol (DMS)

0

References: McLachlan JA, Cancer Res 1980 Nov;40(11):3988-99

Head squamous cell carcinoma Head muraglitazar

50

References: Tannehill-Gregg SH, Toxicol Sci 2007 Jul;98(1):258-70

Head squamous cell carcinoma Head

0

References: Tannehill-Gregg SH, Toxicol Sci 2007 Jul;98(1):258-70

Head squamous cell papilloma Head muraglitazar

0

References: Tannehill-Gregg SH, Toxicol Sci 2007 Jul;98(1):258-70

Head squamous cell papilloma Head

100

References: Tannehill-Gregg SH, Toxicol Sci 2007 Jul;98(1):258-70

Intestine - Large Intestine - Anus adenoma Intestine - Large Intestine - Anus

0

0.1

References: Maita K, Toxicol Pathol 1988;16(3):340-9

Intestine - Large Intestine - Anus squamous cell carcinoma Intestine - Large Intestine - Anus

0

0.1

References: Maita K, Toxicol Pathol 1988;16(3):340-9

Intestine - Large Intestine - Cecum carcinoma Intestine - Large Intestine - Cecum

1.0

References: Baldrick P, Toxicol Pathol 2007;35(4):562-9

Intestine - Large Intestine squamous cell carcinoma Intestine - Large Intestine

0.1

0

References: Maita K, Toxicol Pathol 1988;16(3):340-9

Intestine - Small Intestine - Duodenum adenoma Intestine - Small Intestine - Duodenum

0 - 0.4

0

References: Baldrick P, Toxicol Pathol 2007;35(4):562-9   ⋅   Tannehill-Gregg SH, Toxicol Sci 2007 Jul;98(1):258-70

Intestine - Small Intestine - Duodenum adenoma Intestine - Small Intestine - Duodenum muraglitazar

0 - 1.7

0

References: Tannehill-Gregg SH, Toxicol Sci 2007 Jul;98(1):258-70

Intestine - Small Intestine - Duodenum hyperplasia - avillous Intestine - Small Intestine - Duodenum

observed

References: Baldrick P, Toxicol Pathol 2007;35(4):562-9

Intestine - Small Intestine - Jejunum adenoma Intestine - Small Intestine - Jejunum

2.1

References: Baldrick P, Toxicol Pathol 2007;35(4):562-9

Intestine - Small Intestine - Jejunum carcinoma Intestine - Small Intestine - Jejunum

0

0

References: Tannehill-Gregg SH, Toxicol Sci 2007 Jul;98(1):258-70

Intestine - Small Intestine - Jejunum carcinoma Intestine - Small Intestine - Jejunum muraglitazar

0 - 1.7

0

References: Tannehill-Gregg SH, Toxicol Sci 2007 Jul;98(1):258-70

Intestine - Small Intestine adenocarcinoma Intestine - Small Intestine

0.1 - 0.2

0 - 1.9

References: Chandra M, Toxicol Lett 1992 Jun;61(1):67-74   ⋅   Diwan BA, Toxicol Appl Pharmacol 1999 Nov 15;161(1):82-99   ⋅   Maita K, Toxicol Pathol 1988;16(3):340-9

Intestine - Small Intestine adenoma Intestine - Small Intestine sodium arsenite   ⋅   tamoxifen (TAM)

2.9

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Intestine - Small Intestine adenoma Intestine - Small Intestine

0.1 - 1.9

0.2 - 1.9

References: Diwan BA, Toxicol Appl Pharmacol 1999 Nov 15;161(1):82-99   ⋅   Maita K, Toxicol Pathol 1988;16(3):340-9

Intestine - Small Intestine adenoma Intestine - Small Intestine New western diet (NWD) TD.96096   ⋅   AIN-76A

observed

References: Poutahidis T, Cancer Res 2015 Apr 1;75(7):1197-204

Intestine adenocarcinoma Intestine N-methyl-N-nitrosourea (MNU)

0

References: Yamamoto M, Cancer Lett 2002 May 28;179(2):121-32

Intestine metaplasia Intestine N-methyl-N-nitrosourea (MNU)

0

References: Yamamoto M, Cancer Lett 2002 May 28;179(2):121-32

Intestine metaplasia Intestine

0

References: Yamamoto M, Cancer Lett 2002 May 28;179(2):121-32

Intestine tumor Intestine AIN-76A

0

0

0

References: Poutahidis T, Cancer Res 2015 Apr 1;75(7):1197-204

Intestine tumor Intestine New western diet (NWD) TD.96096   ⋅   AIN-76A

0 - 10

0 - 10

5 - 10

References: Poutahidis T, Cancer Res 2015 Apr 1;75(7):1197-204

Intestine tumor Intestine New western diet (NWD) TD.96096   ⋅   L. reuteri ATCC-PTA-6475   ⋅   AIN-76A

0

0

0

References: Poutahidis T, Cancer Res 2015 Apr 1;75(7):1197-204

Kidney - Renal tubule adenoma Kidney - Renal tubule

0

0.4 - 0.5

References: Baldrick P, Toxicol Pathol 2007;35(4):562-9

Kidney - Renal tubule carcinoma Kidney - Renal tubule

0 - 5.9

References: Baldrick P, Toxicol Pathol 2007;35(4):562-9

Kidney - Renal tubule hyperplasia - cystic Kidney - Renal tubule sodium arsenite

2.9

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Kidney - Renal tubule hyperplasia - cystic Kidney - Renal tubule sodium arsenite   ⋅   tamoxifen (TAM)

2.9

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Kidney adenocarcinoma Kidney

0.1

0.1

References: Maita K, Toxicol Pathol 1988;16(3):340-9

Kidney adenoma Kidney

0.1

0.3 - 1.9

References: Diwan BA, Toxicol Appl Pharmacol 1999 Nov 15;161(1):82-99   ⋅   Maita K, Toxicol Pathol 1988;16(3):340-9

Kidney adenoma - tubular Kidney

0

0

References: Tannehill-Gregg SH, Toxicol Sci 2007 Jul;98(1):258-70

Kidney adenoma - tubular Kidney muraglitazar

0

0 - 1.7

References: Tannehill-Gregg SH, Toxicol Sci 2007 Jul;98(1):258-70

Kidney carcinoma Kidney

0 - 0.1

0.1 - 0.2

References: Chandra M, Toxicol Lett 1992 Jun;61(1):67-74   ⋅   Maita K, Toxicol Pathol 1988;16(3):340-9   ⋅   Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Sites of Metastasis: Lung

Kidney carcinoma Kidney sodium arsenite

0

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Kidney carcinoma Kidney diethylstilbestrol (DES)

0

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Kidney carcinoma Kidney tamoxifen (TAM)

0

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Kidney carcinoma Kidney sodium arsenite   ⋅   diethylstilbestrol (DES)

0

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Kidney carcinoma Kidney sodium arsenite   ⋅   tamoxifen (TAM)

2.9

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Sites of Metastasis: Lung

Kidney cyst Kidney

observed

References: Baldrick P, Toxicol Pathol 2007;35(4):562-9

Kidney hyperplasia Kidney

0

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Kidney hyperplasia Kidney diethylstilbestrol (DES)

0

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Kidney hyperplasia Kidney tamoxifen (TAM)

0

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Kidney hyperplasia Kidney sodium arsenite   ⋅   diethylstilbestrol (DES)

0

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Leg squamous cell papilloma Leg

50

References: Baldrick P, Toxicol Pathol 2007;35(4):562-9

Leukocyte - Lymphocyte - B-lymphocyte - Follicular center cell lymphoma Leukocyte - Lymphocyte - B-lymphocyte - Follicular center cell

16.1 - 34.8

6.5 - 9.5

References: Diwan BA, Toxicol Appl Pharmacol 1999 Nov 15;161(1):82-99

Leukocyte - Lymphocyte - B-lymphocyte - Follicular center cell lymphoma Leukocyte - Lymphocyte - B-lymphocyte - Follicular center cell 3'-azido-3'-deoxythymidine (AZT)

0 - 21.4

0 - 7.1

References: Diwan BA, Toxicol Appl Pharmacol 1999 Nov 15;161(1):82-99

Leukocyte - Lymphocyte - B-lymphocyte - Follicular center cell lymphoma Leukocyte - Lymphocyte - B-lymphocyte - Follicular center cell sodium barbital (BB)   ⋅   3'-azido-3'-deoxythymidine (AZT)

0 - 30.4

0 - 4.3

References: Diwan BA, Toxicol Appl Pharmacol 1999 Nov 15;161(1):82-99

Leukocyte - Lymphocyte - B-lymphocyte - Follicular center cell lymphoma Leukocyte - Lymphocyte - B-lymphocyte - Follicular center cell sodium barbital (BB)

11.1 - 20

0 - 4.5

References: Diwan BA, Toxicol Appl Pharmacol 1999 Nov 15;161(1):82-99

Leukocyte - Lymphocyte - B-lymphocyte - Plasma cell lymphoma - plasmacytic Leukocyte - Lymphocyte - B-lymphocyte - Plasma cell

0.7

References: Baldrick P, Toxicol Pathol 2007;35(4):562-9

Leukocyte - Lymphocyte - T-lymphocyte lymphoma - lymphoblastic Leukocyte - Lymphocyte - T-lymphocyte

4.3 - 12.9

3.2 - 4.8

References: Diwan BA, Toxicol Appl Pharmacol 1999 Nov 15;161(1):82-99

Leukocyte - Lymphocyte - T-lymphocyte lymphoma - lymphoblastic Leukocyte - Lymphocyte - T-lymphocyte 3'-azido-3'-deoxythymidine (AZT)

0 - 25

0 - 7.1

References: Diwan BA, Toxicol Appl Pharmacol 1999 Nov 15;161(1):82-99

Leukocyte - Lymphocyte - T-lymphocyte lymphoma - lymphoblastic Leukocyte - Lymphocyte - T-lymphocyte sodium barbital (BB)   ⋅   3'-azido-3'-deoxythymidine (AZT)

7.7 - 13.0

8.7 - 14.3

References: Diwan BA, Toxicol Appl Pharmacol 1999 Nov 15;161(1):82-99

Leukocyte - Lymphocyte - T-lymphocyte lymphoma - lymphoblastic Leukocyte - Lymphocyte - T-lymphocyte sodium barbital (BB)

5.6 - 25

0

References: Diwan BA, Toxicol Appl Pharmacol 1999 Nov 15;161(1):82-99

Leukocyte - Lymphocyte - Thymocyte lymphoma Thymus 3'-azido-3'-deoxythymidine (AZT)

0 - 7.1

References: Diwan BA, Toxicol Appl Pharmacol 1999 Nov 15;161(1):82-99

Leukocyte - Lymphocyte hyperplasia Lymph node - Mandibular

observed

References: Baldrick P, Toxicol Pathol 2007;35(4):562-9

Leukocyte - Lymphocyte hyperplasia Lymph node - Mesenteric

observed

References: Baldrick P, Toxicol Pathol 2007;35(4):562-9

Leukocyte - Lymphocyte hyperplasia Spleen

observed

References: Baldrick P, Toxicol Pathol 2007;35(4):562-9

Leukocyte - Lymphocyte hyperplasia Thymus

observed

References: Baldrick P, Toxicol Pathol 2007;35(4):562-9

Leukocyte - Lymphocyte leukemia - lymphocytic Spleen

4.2 - 5.1

3.1

References: Baldrick P, Toxicol Pathol 2007;35(4):562-9

Leukocyte - Lymphocyte leukemia - lymphocytic Leukocyte - Lymphocyte

0

References: Diwan BA, Toxicol Appl Pharmacol 1999 Nov 15;161(1):82-99

Leukocyte - Lymphocyte leukemia - lymphocytic Leukocyte - Lymphocyte 3'-azido-3'-deoxythymidine (AZT)

0 - 3.7

References: Diwan BA, Toxicol Appl Pharmacol 1999 Nov 15;161(1):82-99

Leukocyte - Lymphocyte leukemia - lymphocytic Leukocyte - Lymphocyte sodium barbital (BB)   ⋅   3'-azido-3'-deoxythymidine (AZT)

0

References: Diwan BA, Toxicol Appl Pharmacol 1999 Nov 15;161(1):82-99

Leukocyte - Lymphocyte leukemia - lymphocytic Leukocyte - Lymphocyte sodium barbital (BB)

0

References: Diwan BA, Toxicol Appl Pharmacol 1999 Nov 15;161(1):82-99

Leukocyte - Lymphocyte lymphoma - lymphocytic Leukocyte - Lymphocyte

observed

References: Brayton CF, Vet Pathol 2012 Jan;49(1):85-105

Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma Liver

0.2 - 0.7

0 - 0.7

References: Baldrick P, Toxicol Pathol 2007;35(4):562-9

Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma Leukocyte - Monocyte - Macrophage - Histiocyte

0 - 15

0 - 5.1

References: Baldrick P, Toxicol Pathol 2007;35(4):562-9   ⋅   Chandra M, Toxicol Lett 1992 Jun;61(1):67-74   ⋅   Diwan BA, Toxicol Appl Pharmacol 1999 Nov 15;161(1):82-99   ⋅   Son WC, Toxicol Lett 2003 Nov 1;145(1):88-98   ⋅   Tannehill-Gregg SH, Toxicol Sci 2007 Jul;98(1):258-70

Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma Uterus

0 - 12.5

References: Baldrick P, Toxicol Pathol 2007;35(4):562-9

Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma Skin

0.4

0.4

References: Baldrick P, Toxicol Pathol 2007;35(4):562-9

Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma Epididymis

2.0

References: Baldrick P, Toxicol Pathol 2007;35(4):562-9

Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma Uterus - Cervix

1.7

References: Baldrick P, Toxicol Pathol 2007;35(4):562-9

Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma Connective tissue

20

References: Baldrick P, Toxicol Pathol 2007;35(4):562-9

Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma Vagina

1.7

References: Baldrick P, Toxicol Pathol 2007;35(4):562-9

Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma Lymph node - Mesenteric

2.0

References: Baldrick P, Toxicol Pathol 2007;35(4):562-9

Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma Leukocyte - Monocyte - Macrophage - Histiocyte muraglitazar

3.3 - 10

0 - 3.3

References: Tannehill-Gregg SH, Toxicol Sci 2007 Jul;98(1):258-70

Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma Uterus 3'-azido-3'-deoxythymidine (AZT)

4.2

References: Diwan BA, Toxicol Appl Pharmacol 1999 Nov 15;161(1):82-99

Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma Leukocyte - Monocyte - Macrophage - Histiocyte 3'-azido-3'-deoxythymidine (AZT)

0 - 11.1

0 - 4.3

References: Diwan BA, Toxicol Appl Pharmacol 1999 Nov 15;161(1):82-99

Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma Leukocyte - Monocyte - Macrophage - Histiocyte sodium barbital (BB)   ⋅   3'-azido-3'-deoxythymidine (AZT)

0 - 4.3

0 - 4.3

References: Diwan BA, Toxicol Appl Pharmacol 1999 Nov 15;161(1):82-99

Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma Leukocyte - Monocyte - Macrophage - Histiocyte sodium barbital (BB)

0

0

References: Diwan BA, Toxicol Appl Pharmacol 1999 Nov 15;161(1):82-99

Leukocyte - Monocyte - Macrophage - Histiocyte histiocytoma - benign Skin

1.1

References: Baldrick P, Toxicol Pathol 2007;35(4):562-9

Leukocyte - Monocyte - Macrophage - Histiocyte histiocytoma - benign Preputial gland (male)

3.1 - 5.9

References: Baldrick P, Toxicol Pathol 2007;35(4):562-9

Leukocyte - Monocyte - Macrophage - Histiocyte histiocytoma - benign Epididymis

0.6

References: Baldrick P, Toxicol Pathol 2007;35(4):562-9

Leukocyte - Monocyte - Macrophage - Histiocyte histiocytoma - benign Ear

12.5

References: Baldrick P, Toxicol Pathol 2007;35(4):562-9

Leukocyte - Monocyte - Macrophage - Histiocyte histiocytoma - benign Clitoral gland

1.7

References: Baldrick P, Toxicol Pathol 2007;35(4):562-9

Leukocyte - Monocyte - Macrophage - Histiocyte histiocytoma - benign Vagina

1.6

References: Baldrick P, Toxicol Pathol 2007;35(4):562-9

Leukocyte - Monocyte - Macrophage - Histiocyte histiocytoma - malignant Spleen

0.1

0.1

References: Maita K, Toxicol Pathol 1988;16(3):340-9

Leukocyte - Monocyte - Macrophage - Histiocyte histiocytoma - malignant Stomach

0.1

0

References: Maita K, Toxicol Pathol 1988;16(3):340-9

Leukocyte - Monocyte - Macrophage - Histiocyte histiocytoma - malignant Liver

0.3

0.1

References: Maita K, Toxicol Pathol 1988;16(3):340-9

Leukocyte - Monocyte - Macrophage - Histiocyte histiocytoma - malignant Subcutis

0.1

0

References: Maita K, Toxicol Pathol 1988;16(3):340-9

Leukocyte - Monocyte - Macrophage - Histiocyte histiocytoma - malignant Thoracic cavity

0

0.1

References: Maita K, Toxicol Pathol 1988;16(3):340-9

Leukocyte - Monocyte - Macrophage - Histiocyte histiocytoma - malignant Uterus

0.1

References: Maita K, Toxicol Pathol 1988;16(3):340-9

Leukocyte - Myelocyte (Granulocyte) - Basophil - Mast cell leukemia Leukocyte - Myelocyte (Granulocyte) - Basophil - Mast cell

0 - 1.7

0

References: Tannehill-Gregg SH, Toxicol Sci 2007 Jul;98(1):258-70

Leukocyte - Myelocyte (Granulocyte) - Basophil - Mast cell leukemia Leukocyte - Myelocyte (Granulocyte) - Basophil - Mast cell muraglitazar

0

0

References: Tannehill-Gregg SH, Toxicol Sci 2007 Jul;98(1):258-70

Leukocyte - Myelocyte (Granulocyte) - Basophil - Mast cell mastocytoma Leukocyte - Myelocyte (Granulocyte) - Basophil - Mast cell

0

0.2

References: Maita K, Toxicol Pathol 1988;16(3):340-9

Leukocyte - Myelocyte (Granulocyte) - Basophil - Mast cell mastocytoma - malignant Subcutis

0.1

0

References: Maita K, Toxicol Pathol 1988;16(3):340-9

Leukocyte - Myelocyte (Granulocyte) - Basophil - Mast cell tumor Leukocyte - Myelocyte (Granulocyte) - Basophil - Mast cell

0.8 - 1.0

References: Baldrick P, Toxicol Pathol 2007;35(4):562-9

Leukocyte - Myelocyte (Granulocyte) leukemia - myelocytic Leukocyte - Myelocyte (Granulocyte)

0 - 4.3

0 - 4.8

References: Baldrick P, Toxicol Pathol 2007;35(4):562-9   ⋅   Diwan BA, Toxicol Appl Pharmacol 1999 Nov 15;161(1):82-99   ⋅   Maita K, Toxicol Pathol 1988;16(3):340-9   ⋅   Son WC, Toxicol Lett 2003 Nov 1;145(1):88-98   ⋅   Tannehill-Gregg SH, Toxicol Sci 2007 Jul;98(1):258-70

Leukocyte - Myelocyte (Granulocyte) leukemia - myelocytic Leukocyte - Myelocyte (Granulocyte) muraglitazar

0

0

References: Tannehill-Gregg SH, Toxicol Sci 2007 Jul;98(1):258-70

Leukocyte - Myelocyte (Granulocyte) leukemia - myelocytic Leukocyte - Myelocyte (Granulocyte) 3'-azido-3'-deoxythymidine (AZT)

0 - 3.1

0 - 3.8

References: Diwan BA, Toxicol Appl Pharmacol 1999 Nov 15;161(1):82-99

Leukocyte - Myelocyte (Granulocyte) leukemia - myelocytic Leukocyte - Myelocyte (Granulocyte) sodium barbital (BB)   ⋅   3'-azido-3'-deoxythymidine (AZT)

0

0

References: Diwan BA, Toxicol Appl Pharmacol 1999 Nov 15;161(1):82-99

Leukocyte - Myelocyte (Granulocyte) leukemia - myelocytic Leukocyte - Myelocyte (Granulocyte) sodium barbital (BB)

0

0

References: Diwan BA, Toxicol Appl Pharmacol 1999 Nov 15;161(1):82-99

Leukocyte leukemia Leukocyte

3.0

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Leukocyte leukemia Leukocyte sodium arsenite   ⋅   diethylstilbestrol (DES)

3.0

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Leukocyte leukemia Leukocyte sodium arsenite   ⋅   tamoxifen (TAM)

2.9

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Leukocyte leukemia - unclassified Leukocyte

0.1 - 0.3

0.1 - 0.8

References: Baldrick P, Toxicol Pathol 2007;35(4):562-9   ⋅   Maita K, Toxicol Pathol 1988;16(3):340-9

Leukocyte leukemia - undifferentiated Leukocyte

20

References: Baldrick P, Toxicol Pathol 2007;35(4):562-9

Leukocyte lymphoma Leukocyte

0 - 30

0 - low

observed

1.5

References: Brayton CF, Vet Pathol 2012 Jan;49(1):85-105   ⋅   Diwan BA, Toxicol Appl Pharmacol 1999 Nov 15;161(1):82-99   ⋅   Lavigueur A, Mol Cell Biol 1989 Sep;9(9):3982-91   ⋅   Maita K, Toxicol Pathol 1988;16(3):340-9   ⋅   Son WC, Toxicol Lett 2003 Nov 1;145(1):88-98   ⋅   Takahashi O, Toxicology 1997 Dec 26;124(2):95-103   ⋅   Tannehill-Gregg SH, Toxicol Sci 2007 Jul;98(1):258-70   ⋅   Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Leukocyte lymphoma Leukocyte piperonyl butoxide (alpha-[2-(2-butoxyethoxy)ethoxy-4,5-methylenedioxy-2-propyltoluene)

low

low

References: Takahashi O, Toxicology 1997 Dec 26;124(2):95-103

Leukocyte lymphoma Leukocyte 1-methyl-1-nitrosourea (MNU)

10

References: Tamura T, Cancer Lett 1999 Aug 23;143(1):71-80

Leukocyte lymphoma Leukocyte sodium arsenite

5.9

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Leukocyte lymphoma Leukocyte diethylstilbestrol (DES)

9.1

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Leukocyte lymphoma Leukocyte tamoxifen (TAM)

17

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Leukocyte lymphoma Leukocyte sodium arsenite   ⋅   diethylstilbestrol (DES)

12

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Leukocyte lymphoma Leukocyte sodium arsenite   ⋅   tamoxifen (TAM)

29

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Leukocyte lymphoma Thymus

1.2

0.6

References: Maita K, Toxicol Pathol 1988;16(3):340-9

Leukocyte lymphoma Spleen

0.9

0.4

References: Maita K, Toxicol Pathol 1988;16(3):340-9

Leukocyte lymphoma Lymph node

0.6

0.6

References: Maita K, Toxicol Pathol 1988;16(3):340-9

Leukocyte lymphoma Intestine - Small Intestine

0.2

0

References: Maita K, Toxicol Pathol 1988;16(3):340-9

Leukocyte lymphoma Kidney

0

0.1

References: Maita K, Toxicol Pathol 1988;16(3):340-9

Leukocyte lymphoma Leukocyte muraglitazar

8.3 - 22

3.3 - 12

References: Tannehill-Gregg SH, Toxicol Sci 2007 Jul;98(1):258-70

Leukocyte lymphoma Leukocyte 3'-azido-3'-deoxythymidine (AZT)

0

0

References: Diwan BA, Toxicol Appl Pharmacol 1999 Nov 15;161(1):82-99

Leukocyte lymphoma Leukocyte sodium barbital (BB)   ⋅   3'-azido-3'-deoxythymidine (AZT)

0 - 4.3

0

References: Diwan BA, Toxicol Appl Pharmacol 1999 Nov 15;161(1):82-99

Leukocyte lymphoma Leukocyte sodium barbital (BB)

0

0

References: Diwan BA, Toxicol Appl Pharmacol 1999 Nov 15;161(1):82-99

Leukocyte lymphoma Spleen New western diet (NWD) TD.96096   ⋅   AIN-76A

observed

References: Poutahidis T, Cancer Res 2015 Apr 1;75(7):1197-204

Leukocyte lymphoma Lymph node - Mesenteric New western diet (NWD) TD.96096   ⋅   AIN-76A

observed

References: Poutahidis T, Cancer Res 2015 Apr 1;75(7):1197-204

Leukocyte lymphoma Leukocyte New western diet (NWD) TD.96096   ⋅   AIN-76A

55

References: Poutahidis T, Cancer Res 2015 Apr 1;75(7):1197-204

Leukocyte lymphoma Lymph node - Mesenteric New western diet (NWD) TD.96096   ⋅   L. reuteri ATCC-PTA-6475   ⋅   AIN-76A

observed

References: Poutahidis T, Cancer Res 2015 Apr 1;75(7):1197-204

Leukocyte lymphoma Spleen N-methyl-N-nitrosourea (MNU)

0

References: Yamamoto M, Cancer Lett 2002 May 28;179(2):121-32

Leukocyte lymphoma Thymus N-methyl-N-nitrosourea (MNU)

7.41

References: Yamamoto M, Cancer Lett 2002 May 28;179(2):121-32

Leukocyte lymphoma - immunoblastic Leukocyte

0

0 - 9.5

References: Diwan BA, Toxicol Appl Pharmacol 1999 Nov 15;161(1):82-99

Leukocyte lymphoma - immunoblastic Leukocyte 3'-azido-3'-deoxythymidine (AZT)

0 - 6.25

0

References: Diwan BA, Toxicol Appl Pharmacol 1999 Nov 15;161(1):82-99

Leukocyte lymphoma - immunoblastic Leukocyte sodium barbital (BB)   ⋅   3'-azido-3'-deoxythymidine (AZT)

0

0

References: Diwan BA, Toxicol Appl Pharmacol 1999 Nov 15;161(1):82-99

Leukocyte lymphoma - immunoblastic Leukocyte sodium barbital (BB)

0

0

References: Diwan BA, Toxicol Appl Pharmacol 1999 Nov 15;161(1):82-99

Leukocyte lymphoma - lymphoblastic Leukocyte

1.4 - 2.3

1.7 - 6.8

References: Baldrick P, Toxicol Pathol 2007;35(4):562-9

Leukocyte lymphoma - lymphoblastic Adipose tissue New western diet (NWD) TD.96096   ⋅   AIN-76A

observed

References: Poutahidis T, Cancer Res 2015 Apr 1;75(7):1197-204

Leukocyte lymphoma - lymphocytic Leukocyte

1.7 - 9.8

3.3 - 6.4

References: Baldrick P, Toxicol Pathol 2007;35(4):562-9   ⋅   Chandra M, Toxicol Lett 1992 Jun;61(1):67-74

Leukocyte lymphoma - mixed Leukocyte

1.8

0.1

References: Chandra M, Toxicol Lett 1992 Jun;61(1):67-74

Leukocyte lymphoma - pleomorphic Leukocyte

15 - 23.3

7.9 - 9.6

observed

References: Baldrick P, Toxicol Pathol 2007;35(4):562-9   ⋅   Brayton CF, Vet Pathol 2012 Jan;49(1):85-105

Leukocyte lymphoma - unclassified Leukocyte

7.8 - 8.4

3.6 - 18.6

References: Baldrick P, Toxicol Pathol 2007;35(4):562-9

Leukocyte neoplasm Leukocyte

observed - 16.4

observed - 6.8

References: Chandra M, Toxicol Lett 1992 Jun;61(1):67-74   ⋅   Tannehill-Gregg SH, Toxicol Sci 2007 Jul;98(1):258-70

Sites of Metastasis: (Unspecified organ)

Leukocyte neoplasm Leukocyte muraglitazar

observed

observed - 10

References: Tannehill-Gregg SH, Toxicol Sci 2007 Jul;98(1):258-70

Liver - Bile duct cholangiocarcinoma Liver - Bile duct

0 - 0.1

0

References: Maita K, Toxicol Pathol 1988;16(3):340-9   ⋅   Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Liver - Bile duct cholangiocarcinoma Liver - Bile duct sodium arsenite

2.9

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Liver - Bile duct cholangiocarcinoma Liver - Bile duct diethylstilbestrol (DES)

0

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Liver - Bile duct cholangiocarcinoma Liver - Bile duct tamoxifen (TAM)

0

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Liver - Bile duct cholangiocarcinoma Liver - Bile duct sodium arsenite   ⋅   diethylstilbestrol (DES)

0

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Liver - Bile duct cholangiocarcinoma Liver - Bile duct sodium arsenite   ⋅   tamoxifen (TAM)

0

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Liver - Bile duct cholangioma Liver - Bile duct

0.1 - 2.0

0

References: Maita K, Toxicol Pathol 1988;16(3):340-9   ⋅   Takahashi O, Toxicology 1997 Dec 26;124(2):95-103

Liver - Bile duct cholangioma Liver - Bile duct piperonyl butoxide (alpha-[2-(2-butoxyethoxy)ethoxy-4,5-methylenedioxy-2-propyltoluene)

0 - 1.6

0

References: Takahashi O, Toxicology 1997 Dec 26;124(2):95-103

Liver - Hepatocyte foci Liver - Hepatocyte ZnSO4

0

References: Tamano S, Carcinogenesis 1994 Sep;15(9):1791-8

Liver - Hepatocyte foci Liver - Hepatocyte ZnSO4   ⋅   N-diethylnitrosamine (N,N-diethylnitrosamine) (N-nitrosodiethylamine) (NDEA) (diethylnitrosamine) (DEN)

0 - observed

References: Tamano S, Carcinogenesis 1994 Sep;15(9):1791-8

Liver - Hepatocyte foci Liver - Hepatocyte ZnSO4   ⋅   phenobarbital (PB)   ⋅   N-diethylnitrosamine (N,N-diethylnitrosamine) (N-nitrosodiethylamine) (NDEA) (diethylnitrosamine) (DEN)

0 - observed

References: Tamano S, Carcinogenesis 1994 Sep;15(9):1791-8

Liver - Hepatocyte foci Liver - Hepatocyte ZnSO4   ⋅   phenobarbital (PB)

0

References: Tamano S, Carcinogenesis 1994 Sep;15(9):1791-8

Liver - Hepatocyte hyperplasia Liver - Hepatocyte

0

2.0

References: Takahashi O, Toxicology 1997 Dec 26;124(2):95-103

Liver - Hepatocyte hyperplasia Liver - Hepatocyte piperonyl butoxide (alpha-[2-(2-butoxyethoxy)ethoxy-4,5-methylenedioxy-2-propyltoluene)

14 - 32

9.9 - 38

References: Takahashi O, Toxicology 1997 Dec 26;124(2):95-103

Liver - Hepatocyte neoplasia Liver - Hepatocyte New western diet (NWD) TD.96096   ⋅   AIN-76A

observed

References: Poutahidis T, Cancer Res 2015 Apr 1;75(7):1197-204

Liver - Hepatocyte preneoplastic lesion Liver - Hepatocyte 1-methyl-1-nitrosourea (MNU)

0

40

References: Tamura T, Cancer Lett 1999 Aug 23;143(1):71-80

Liver - Hepatocyte preneoplastic lesion Liver - Hepatocyte 1-methyl-1-nitrosourea (MNU)   ⋅   hydroquinone (HQ)

13

91

References: Tamura T, Cancer Lett 1999 Aug 23;143(1):71-80

Liver - Hepatocyte preneoplastic lesion Liver - Hepatocyte 1-methyl-1-nitrosourea (MNU)   ⋅   1,1-dimethylhydrazine (UDMH)

0

40

References: Tamura T, Cancer Lett 1999 Aug 23;143(1):71-80

Liver - Hepatocyte preneoplastic lesion Liver - Hepatocyte hydroquinone (HQ)

0

0

References: Tamura T, Cancer Lett 1999 Aug 23;143(1):71-80

Liver - Hepatocyte preneoplastic lesion Liver - Hepatocyte 1,1-dimethylhydrazine (UDMH)

0

0

References: Tamura T, Cancer Lett 1999 Aug 23;143(1):71-80

Liver adenoma Liver

0

12.9 - 25

References: Diwan BA, Toxicol Appl Pharmacol 1999 Nov 15;161(1):82-99

Liver adenoma Liver 3'-azido-3'-deoxythymidine (AZT)

0 - 20

15.8 - 66.7

References: Diwan BA, Toxicol Appl Pharmacol 1999 Nov 15;161(1):82-99

Liver carcinoma Liver

0 - 9.1

0 - 40

References: Diwan BA, Toxicol Appl Pharmacol 1999 Nov 15;161(1):82-99

Sites of Metastasis: not Lung

Liver carcinoma Liver 3'-azido-3'-deoxythymidine (AZT)

0 - 10

4.2 - 37.5

References: Diwan BA, Toxicol Appl Pharmacol 1999 Nov 15;161(1):82-99

Sites of Metastasis: Lung

Liver carcinoma Liver New western diet (NWD) TD.96096   ⋅   AIN-76A

observed

References: Poutahidis T, Cancer Res 2015 Apr 1;75(7):1197-204

Liver carcinoma - histiocytic Liver

2.0

References: Baldrick P, Toxicol Pathol 2007;35(4):562-9

Liver hepatoblastoma Liver

0

0.4

References: Maita K, Toxicol Pathol 1988;16(3):340-9

Liver hepatoblastoma Liver 3'-azido-3'-deoxythymidine (AZT)

14.8

References: Diwan BA, Toxicol Appl Pharmacol 1999 Nov 15;161(1):82-99

Liver hepatocellular adenoma Liver

0 - 5.2

0 - 28.3

References: Baldrick P, Toxicol Pathol 2007;35(4):562-9   ⋅   Brayton CF, Vet Pathol 2012 Jan;49(1):85-105   ⋅   Chandra M, Toxicol Lett 1992 Jun;61(1):67-74   ⋅   Maita K, Toxicol Pathol 1988;16(3):340-9   ⋅   Son WC, Toxicol Lett 2003 Nov 1;145(1):88-98   ⋅   Takahashi O, Toxicology 1997 Dec 26;124(2):95-103   ⋅   Tannehill-Gregg SH, Toxicol Sci 2007 Jul;98(1):258-70   ⋅   Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Liver hepatocellular adenoma Liver piperonyl butoxide (alpha-[2-(2-butoxyethoxy)ethoxy-4,5-methylenedioxy-2-propyltoluene)

0 - 16

0 - 26

References: Takahashi O, Toxicology 1997 Dec 26;124(2):95-103

Liver hepatocellular adenoma Liver 1-methyl-1-nitrosourea (MNU)

0

10

References: Tamura T, Cancer Lett 1999 Aug 23;143(1):71-80

Liver hepatocellular adenoma Liver 1-methyl-1-nitrosourea (MNU)   ⋅   hydroquinone (HQ)

0

45

References: Tamura T, Cancer Lett 1999 Aug 23;143(1):71-80

Liver hepatocellular adenoma Liver 1-methyl-1-nitrosourea (MNU)   ⋅   1,1-dimethylhydrazine (UDMH)

0

13

References: Tamura T, Cancer Lett 1999 Aug 23;143(1):71-80

Liver hepatocellular adenoma Liver hydroquinone (HQ)

0

0

References: Tamura T, Cancer Lett 1999 Aug 23;143(1):71-80

Liver hepatocellular adenoma Liver 1,1-dimethylhydrazine (UDMH)

0

0

References: Tamura T, Cancer Lett 1999 Aug 23;143(1):71-80

Liver hepatocellular adenoma Liver ZnSO4

0

References: Tamano S, Carcinogenesis 1994 Sep;15(9):1791-8

Liver hepatocellular adenoma Liver ZnSO4   ⋅   N-diethylnitrosamine (N,N-diethylnitrosamine) (N-nitrosodiethylamine) (NDEA) (diethylnitrosamine) (DEN)

0 - observed

References: Tamano S, Carcinogenesis 1994 Sep;15(9):1791-8

Liver hepatocellular adenoma Liver ZnSO4   ⋅   phenobarbital (PB)   ⋅   N-diethylnitrosamine (N,N-diethylnitrosamine) (N-nitrosodiethylamine) (NDEA) (diethylnitrosamine) (DEN)

0 - observed

References: Tamano S, Carcinogenesis 1994 Sep;15(9):1791-8

Liver hepatocellular adenoma Liver ZnSO4   ⋅   phenobarbital (PB)

0

References: Tamano S, Carcinogenesis 1994 Sep;15(9):1791-8

Liver hepatocellular adenoma Liver sodium arsenite

2.9

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Liver hepatocellular adenoma Liver diethylstilbestrol (DES)

3.0

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Liver hepatocellular adenoma Liver tamoxifen (TAM)

0

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Liver hepatocellular adenoma Liver sodium arsenite   ⋅   diethylstilbestrol (DES)

9.1

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Liver hepatocellular adenoma Liver sodium arsenite   ⋅   tamoxifen (TAM)

8.6

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Liver hepatocellular adenoma Liver muraglitazar

0 - 3.3

0 - 5.0

References: Tannehill-Gregg SH, Toxicol Sci 2007 Jul;98(1):258-70

Liver hepatocellular adenoma Liver New western diet (NWD) TD.96096   ⋅   AIN-76A

0

0 - 10

0 - 5

References: Poutahidis T, Cancer Res 2015 Apr 1;75(7):1197-204

Liver hepatocellular adenoma Liver AIN-76A

0

10

5

References: Poutahidis T, Cancer Res 2015 Apr 1;75(7):1197-204

Liver hepatocellular adenoma Liver New western diet (NWD) TD.96096   ⋅   L. reuteri ATCC-PTA-6475   ⋅   AIN-76A

0

0

0

References: Poutahidis T, Cancer Res 2015 Apr 1;75(7):1197-204

Liver hepatocellular carcinoma Liver

0 - 8.6

0 - 12.9

References: Baldrick P, Toxicol Pathol 2007;35(4):562-9   ⋅   Brayton CF, Vet Pathol 2012 Jan;49(1):85-105   ⋅   Chandra M, Toxicol Lett 1992 Jun;61(1):67-74   ⋅   Maita K, Toxicol Pathol 1988;16(3):340-9   ⋅   Takahashi O, Toxicology 1997 Dec 26;124(2):95-103   ⋅   Tannehill-Gregg SH, Toxicol Sci 2007 Jul;98(1):258-70   ⋅   Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Sites of Metastasis: not Lung , Lung

Liver hepatocellular carcinoma Liver piperonyl butoxide (alpha-[2-(2-butoxyethoxy)ethoxy-4,5-methylenedioxy-2-propyltoluene)

0 - 80

0 - 53

References: Takahashi O, Toxicology 1997 Dec 26;124(2):95-103

Liver hepatocellular carcinoma Liver 1-methyl-1-nitrosourea (MNU)

0

0

References: Tamura T, Cancer Lett 1999 Aug 23;143(1):71-80

Liver hepatocellular carcinoma Liver 1-methyl-1-nitrosourea (MNU)   ⋅   hydroquinone (HQ)

0

9.1

References: Tamura T, Cancer Lett 1999 Aug 23;143(1):71-80

Liver hepatocellular carcinoma Liver 1-methyl-1-nitrosourea (MNU)   ⋅   1,1-dimethylhydrazine (UDMH)

0

6.7

References: Tamura T, Cancer Lett 1999 Aug 23;143(1):71-80

Liver hepatocellular carcinoma Liver hydroquinone (HQ)

0

0

References: Tamura T, Cancer Lett 1999 Aug 23;143(1):71-80

Liver hepatocellular carcinoma Liver 1,1-dimethylhydrazine (UDMH)

0

0

References: Tamura T, Cancer Lett 1999 Aug 23;143(1):71-80

Liver hepatocellular carcinoma Liver ZnSO4

0

References: Tamano S, Carcinogenesis 1994 Sep;15(9):1791-8

Liver hepatocellular carcinoma Liver ZnSO4   ⋅   N-diethylnitrosamine (N,N-diethylnitrosamine) (N-nitrosodiethylamine) (NDEA) (diethylnitrosamine) (DEN)

0

References: Tamano S, Carcinogenesis 1994 Sep;15(9):1791-8

Liver hepatocellular carcinoma Liver ZnSO4   ⋅   phenobarbital (PB)   ⋅   N-diethylnitrosamine (N,N-diethylnitrosamine) (N-nitrosodiethylamine) (NDEA) (diethylnitrosamine) (DEN)

0 - 40

References: Tamano S, Carcinogenesis 1994 Sep;15(9):1791-8

Liver hepatocellular carcinoma Liver ZnSO4   ⋅   phenobarbital (PB)

0

References: Tamano S, Carcinogenesis 1994 Sep;15(9):1791-8

Liver hepatocellular carcinoma Liver sodium arsenite

0

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Liver hepatocellular carcinoma Liver diethylstilbestrol (DES)

0

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Liver hepatocellular carcinoma Liver tamoxifen (TAM)

0

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Liver hepatocellular carcinoma Liver sodium arsenite   ⋅   diethylstilbestrol (DES)

6.1

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Liver hepatocellular carcinoma Liver sodium arsenite   ⋅   tamoxifen (TAM)

0

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Liver hepatocellular carcinoma Liver muraglitazar

0

1.7 - 6.7

References: Tannehill-Gregg SH, Toxicol Sci 2007 Jul;98(1):258-70

Sites of Metastasis: not Lung , Lung

Liver hepatocellular carcinoma Liver New western diet (NWD) TD.96096   ⋅   AIN-76A

10 - 60

0 - 70

5 - 65

observed

References: Poutahidis T, Cancer Res 2015 Apr 1;75(7):1197-204

Liver hepatocellular carcinoma Liver AIN-76A

0

0

0

References: Poutahidis T, Cancer Res 2015 Apr 1;75(7):1197-204

Liver hepatocellular carcinoma Liver New western diet (NWD) TD.96096   ⋅   L. reuteri ATCC-PTA-6475   ⋅   AIN-76A

0

0 - 10

0 - 5

References: Poutahidis T, Cancer Res 2015 Apr 1;75(7):1197-204

Liver hepatocellular carcinoma Liver N-methyl-N-nitrosourea (MNU)

0

References: Yamamoto M, Cancer Lett 2002 May 28;179(2):121-32

Liver hepatocellular tumor Liver

2.5

16.7

References: Chandra M, Toxicol Lett 1992 Jun;61(1):67-74

Liver neoplasm Liver New western diet (NWD) TD.96096   ⋅   AIN-76A

observed

References: Poutahidis T, Cancer Res 2015 Apr 1;75(7):1197-204

Liver tumor Liver

0 - 9.1

0 - 60

References: Diwan BA, Toxicol Appl Pharmacol 1999 Nov 15;161(1):82-99   ⋅   Jhappan C, Cell 1990 Jun 15;61(6):1137-46

Liver tumor Liver (see notes)

0

4.8

References: Takagi H, Cancer Res 1992 Oct 1;52(19):5171-7

Liver tumor Liver ZnSO4

0

0

References: Takagi H, Cancer Res 1992 Oct 1;52(19):5171-7   ⋅   Tamano S, Carcinogenesis 1994 Sep;15(9):1791-8

Liver tumor Liver ZnSO4   ⋅   castration

0

References: Takagi H, Cancer Res 1992 Oct 1;52(19):5171-7

Liver tumor Liver ZnSO4   ⋅   ovariectomy

0

References: Takagi H, Cancer Res 1992 Oct 1;52(19):5171-7

Liver tumor Liver ZnSO4   ⋅   testosterone   ⋅   ovariectomy

0

References: Takagi H, Cancer Res 1992 Oct 1;52(19):5171-7

Liver tumor Liver ZnSO4   ⋅   N-diethylnitrosamine (N,N-diethylnitrosamine) (N-nitrosodiethylamine) (NDEA) (diethylnitrosamine) (DEN)

observed

References: Tamano S, Carcinogenesis 1994 Sep;15(9):1791-8

Liver tumor Liver ZnSO4   ⋅   phenobarbital (PB)   ⋅   N-diethylnitrosamine (N,N-diethylnitrosamine) (N-nitrosodiethylamine) (NDEA) (diethylnitrosamine) (DEN)

observed

References: Tamano S, Carcinogenesis 1994 Sep;15(9):1791-8

Liver tumor Liver ZnSO4   ⋅   phenobarbital (PB)

0

References: Tamano S, Carcinogenesis 1994 Sep;15(9):1791-8

Liver tumor Liver 3'-azido-3'-deoxythymidine (AZT)

0 - 40

30.4 - 83.3

References: Diwan BA, Toxicol Appl Pharmacol 1999 Nov 15;161(1):82-99

Liver tumor Liver AIN-76A

0

0 - 10

0 - 10

References: Poutahidis T, Cancer Res 2015 Apr 1;75(7):1197-204

Liver tumor Liver New western diet (NWD) TD.96096   ⋅   AIN-76A

60 - 80

70 - 80

65 - 80

References: Poutahidis T, Cancer Res 2015 Apr 1;75(7):1197-204

Liver tumor Liver New western diet (NWD) TD.96096   ⋅   L. reuteri ATCC-PTA-6475   ⋅   AIN-76A

0

10

5

References: Poutahidis T, Cancer Res 2015 Apr 1;75(7):1197-204

Lung - Alveolus hyperplasia Lung - Alveolus 1-methyl-1-nitrosourea (MNU)

9.1

20

References: Tamura T, Cancer Lett 1999 Aug 23;143(1):71-80

Lung - Alveolus hyperplasia Lung - Alveolus 1-methyl-1-nitrosourea (MNU)   ⋅   hydroquinone (HQ)

13

9.1

References: Tamura T, Cancer Lett 1999 Aug 23;143(1):71-80

Lung - Alveolus hyperplasia Lung - Alveolus 1-methyl-1-nitrosourea (MNU)   ⋅   1,1-dimethylhydrazine (UDMH)

0

0

References: Tamura T, Cancer Lett 1999 Aug 23;143(1):71-80

Lung - Alveolus hyperplasia Lung - Alveolus hydroquinone (HQ)

0

0

References: Tamura T, Cancer Lett 1999 Aug 23;143(1):71-80

Lung - Alveolus hyperplasia Lung - Alveolus 1,1-dimethylhydrazine (UDMH)

0

0

References: Tamura T, Cancer Lett 1999 Aug 23;143(1):71-80

Lung adenocarcinoma Lung

2.9 - 17.2

4.3 - 20.0

observed

1.0

References: Brayton CF, Vet Pathol 2012 Jan;49(1):85-105   ⋅   Lavigueur A, Mol Cell Biol 1989 Sep;9(9):3982-91   ⋅   Maita K, Toxicol Pathol 1988;16(3):340-9   ⋅   Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Lung adenocarcinoma Lung sodium arsenite

15

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Lung adenocarcinoma Lung diethylstilbestrol (DES)

observed - 6.1

References: McLachlan JA, Cancer Res 1980 Nov;40(11):3988-99   ⋅   Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Lung adenocarcinoma Lung tamoxifen (TAM)

11

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Lung adenocarcinoma Lung sodium arsenite   ⋅   diethylstilbestrol (DES)

21

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Lung adenocarcinoma Lung sodium arsenite   ⋅   tamoxifen (TAM)

14

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Lung adenocarcinoma Lung New western diet (NWD) TD.96096   ⋅   AIN-76A

observed - 55

References: Poutahidis T, Cancer Res 2015 Apr 1;75(7):1197-204

Lung adenocarcinoma Lung New western diet (NWD) TD.96096   ⋅   L. reuteri ATCC-PTA-6475   ⋅   AIN-76A

observed

References: Poutahidis T, Cancer Res 2015 Apr 1;75(7):1197-204

Lung adenocarcinoma Lung N-methyl-N-nitrosourea (MNU)

44.44

References: Yamamoto M, Cancer Lett 2002 May 28;179(2):121-32

Lung adenocarcinoma - acinar Lung New western diet (NWD) TD.96096   ⋅   AIN-76A

observed

References: Poutahidis T, Cancer Res 2015 Apr 1;75(7):1197-204

Lung adenocarcinoma - papillary Lung New western diet (NWD) TD.96096   ⋅   AIN-76A

observed

References: Poutahidis T, Cancer Res 2015 Apr 1;75(7):1197-204

Lung adenocarcinoma - well-differentiated Lung New western diet (NWD) TD.96096   ⋅   AIN-76A

observed

References: Poutahidis T, Cancer Res 2015 Apr 1;75(7):1197-204

Lung adenoma Lung

0 - 18.2

0 - 40

observed

References: Baldrick P, Toxicol Pathol 2007;35(4):562-9   ⋅   Brayton CF, Vet Pathol 2012 Jan;49(1):85-105   ⋅   Chandra M, Toxicol Lett 1992 Jun;61(1):67-74   ⋅   Diwan BA, Toxicol Appl Pharmacol 1999 Nov 15;161(1):82-99   ⋅   Maita K, Toxicol Pathol 1988;16(3):340-9   ⋅   Son WC, Toxicol Lett 2003 Nov 1;145(1):88-98   ⋅   Takahashi O, Toxicology 1997 Dec 26;124(2):95-103   ⋅   Tannehill-Gregg SH, Toxicol Sci 2007 Jul;98(1):258-70   ⋅   Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Lung adenoma Lung piperonyl butoxide (alpha-[2-(2-butoxyethoxy)ethoxy-4,5-methylenedioxy-2-propyltoluene)

very low

References: Takahashi O, Toxicology 1997 Dec 26;124(2):95-103

Lung adenoma Lung 1-methyl-1-nitrosourea (MNU)

27

80

References: Tamura T, Cancer Lett 1999 Aug 23;143(1):71-80

Lung adenoma Lung 1-methyl-1-nitrosourea (MNU)   ⋅   hydroquinone (HQ)

87

55

References: Tamura T, Cancer Lett 1999 Aug 23;143(1):71-80

Lung adenoma Lung 1-methyl-1-nitrosourea (MNU)   ⋅   1,1-dimethylhydrazine (UDMH)

62.5

47

References: Tamura T, Cancer Lett 1999 Aug 23;143(1):71-80

Lung adenoma Lung hydroquinone (HQ)

6.7

0

References: Tamura T, Cancer Lett 1999 Aug 23;143(1):71-80

Lung adenoma Lung 1,1-dimethylhydrazine (UDMH)

0

0

References: Tamura T, Cancer Lett 1999 Aug 23;143(1):71-80

Lung adenoma Lung sodium arsenite

21

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Lung adenoma Lung diethylstilbestrol (DES)

9.1

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Lung adenoma Lung tamoxifen (TAM)

5.7

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Lung adenoma Lung sodium arsenite   ⋅   diethylstilbestrol (DES)

6.1

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Lung adenoma Lung sodium arsenite   ⋅   tamoxifen (TAM)

8.6

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Lung adenoma Lung muraglitazar

5.0 - 12

12 - 15

References: Tannehill-Gregg SH, Toxicol Sci 2007 Jul;98(1):258-70

Lung adenoma Lung 3'-azido-3'-deoxythymidine (AZT)

4.8 - 52.6

5.0 - 50

References: Diwan BA, Toxicol Appl Pharmacol 1999 Nov 15;161(1):82-99

Lung adenoma Lung New western diet (NWD) TD.96096   ⋅   AIN-76A

0 - 30

0 - 20

5 - 20

15

References: Poutahidis T, Cancer Res 2015 Apr 1;75(7):1197-204

Lung adenoma Lung AIN-76A

10

0

5

References: Poutahidis T, Cancer Res 2015 Apr 1;75(7):1197-204

Lung adenoma Lung New western diet (NWD) TD.96096   ⋅   L. reuteri ATCC-PTA-6475   ⋅   AIN-76A

10

0

5

References: Poutahidis T, Cancer Res 2015 Apr 1;75(7):1197-204

Lung carcinoma Lung 1-methyl-1-nitrosourea (MNU)

9.1

0

References: Tamura T, Cancer Lett 1999 Aug 23;143(1):71-80

Lung carcinoma Lung 1-methyl-1-nitrosourea (MNU)   ⋅   hydroquinone (HQ)

6.7

36

References: Tamura T, Cancer Lett 1999 Aug 23;143(1):71-80

Lung carcinoma Lung 1-methyl-1-nitrosourea (MNU)   ⋅   1,1-dimethylhydrazine (UDMH)

6.3

20

References: Tamura T, Cancer Lett 1999 Aug 23;143(1):71-80

Lung carcinoma Lung hydroquinone (HQ)

0

0

References: Tamura T, Cancer Lett 1999 Aug 23;143(1):71-80

Lung carcinoma Lung 1,1-dimethylhydrazine (UDMH)

0

0

References: Tamura T, Cancer Lett 1999 Aug 23;143(1):71-80

Lung carcinoma Lung

0 - 18.2

1.7 - 20

References: Baldrick P, Toxicol Pathol 2007;35(4):562-9   ⋅   Chandra M, Toxicol Lett 1992 Jun;61(1):67-74   ⋅   Diwan BA, Toxicol Appl Pharmacol 1999 Nov 15;161(1):82-99   ⋅   Tannehill-Gregg SH, Toxicol Sci 2007 Jul;98(1):258-70

Sites of Metastasis: not Blood vessel - Aorta , not Lymph node , not Thoracic cavity , Blood vessel - Aorta , Lymph node , Thoracic cavity

Lung carcinoma Lung muraglitazar

1.7 - 10

5.0 - 13

References: Tannehill-Gregg SH, Toxicol Sci 2007 Jul;98(1):258-70

Sites of Metastasis: not Blood vessel - Aorta , not Lymph node , not Thoracic cavity

Lung carcinoma Lung 3'-azido-3'-deoxythymidine (AZT)

9.5 - 40

4.3 - 40

References: Diwan BA, Toxicol Appl Pharmacol 1999 Nov 15;161(1):82-99

Lung carcinoma Lung New western diet (NWD) TD.96096   ⋅   AIN-76A

40 - 80

50 - 60

50 - 65

References: Poutahidis T, Cancer Res 2015 Apr 1;75(7):1197-204

Lung carcinoma Lung AIN-76A

0

0

0

References: Poutahidis T, Cancer Res 2015 Apr 1;75(7):1197-204

Lung carcinoma Lung New western diet (NWD) TD.96096   ⋅   L. reuteri ATCC-PTA-6475   ⋅   AIN-76A

0

0

0

References: Poutahidis T, Cancer Res 2015 Apr 1;75(7):1197-204

Lung neoplasm Lung New western diet (NWD) TD.96096   ⋅   AIN-76A

observed

References: Poutahidis T, Cancer Res 2015 Apr 1;75(7):1197-204

Lung tumor Lung

0 - 36.4

observed - 60

References: Brayton CF, Vet Pathol 2012 Jan;49(1):85-105   ⋅   Diwan BA, Toxicol Appl Pharmacol 1999 Nov 15;161(1):82-99   ⋅   Newbold RR, Carcinogenesis 2000 Jul;21(7):1355-63   ⋅   Tannehill-Gregg SH, Toxicol Sci 2007 Jul;98(1):258-70

Lung tumor Lung diethylstilbestrol (DES)

21 - 38

References: Newbold RR, Carcinogenesis 2000 Jul;21(7):1355-63

Lung tumor Lung muraglitazar

6.7 - 22

18 - 27

References: Tannehill-Gregg SH, Toxicol Sci 2007 Jul;98(1):258-70

Lung tumor Lung 3'-azido-3'-deoxythymidine (AZT)

14.3 - 73.7

13.0 - 87.5

References: Diwan BA, Toxicol Appl Pharmacol 1999 Nov 15;161(1):82-99

Lung tumor Lung AIN-76A

0 - 10

0

0 - 10

References: Poutahidis T, Cancer Res 2015 Apr 1;75(7):1197-204

Lung tumor Lung New western diet (NWD) TD.96096   ⋅   AIN-76A

70 - 80

0 - 70

70 - 75

References: Poutahidis T, Cancer Res 2015 Apr 1;75(7):1197-204

Lung tumor Lung New western diet (NWD) TD.96096   ⋅   L. reuteri ATCC-PTA-6475   ⋅   AIN-76A

10

5

References: Poutahidis T, Cancer Res 2015 Apr 1;75(7):1197-204

Lymph node tumor Lymph node AIN-76A

10 - 20

0 - 10

5 - 30

References: Poutahidis T, Cancer Res 2015 Apr 1;75(7):1197-204

Lymph node tumor Lymph node New western diet (NWD) TD.96096   ⋅   AIN-76A

60 - 80

30 - 50

50 - 65

References: Poutahidis T, Cancer Res 2015 Apr 1;75(7):1197-204

Lymph node tumor Lymph node New western diet (NWD) TD.96096   ⋅   L. reuteri ATCC-PTA-6475   ⋅   AIN-76A

30

10

20

References: Poutahidis T, Cancer Res 2015 Apr 1;75(7):1197-204

Mammary gland adenocarcinoma Mammary gland

0 - 6.3

0 - 0.1

References: Baldrick P, Toxicol Pathol 2007;35(4):562-9   ⋅   Brayton CF, Vet Pathol 2012 Jan;49(1):85-105   ⋅   Chandra M, Toxicol Lett 1992 Jun;61(1):67-74   ⋅   Diwan BA, Toxicol Appl Pharmacol 1999 Nov 15;161(1):82-99   ⋅   Maita K, Toxicol Pathol 1988;16(3):340-9   ⋅   McLachlan JA, Cancer Res 1980 Nov;40(11):3988-99   ⋅   Son WC, Toxicol Lett 2003 Nov 1;145(1):88-98

Sites of Metastasis: Liver , Lung

Mammary gland adenocarcinoma Mammary gland sodium arsenite

2.9

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Mammary gland adenocarcinoma Mammary gland diethylstilbestrol (DES)

observed

References: McLachlan JA, Cancer Res 1980 Nov;40(11):3988-99

Mammary gland adenocarcinoma Mammary gland 3'-azido-3'-deoxythymidine (AZT)

0 - 25

References: Diwan BA, Toxicol Appl Pharmacol 1999 Nov 15;161(1):82-99

Mammary gland adenocarcinoma Mammary gland sodium barbital (BB)   ⋅   3'-azido-3'-deoxythymidine (AZT)

0 - 13.0

References: Diwan BA, Toxicol Appl Pharmacol 1999 Nov 15;161(1):82-99

Mammary gland adenocarcinoma Mammary gland sodium barbital (BB)

0 - 5.0

References: Diwan BA, Toxicol Appl Pharmacol 1999 Nov 15;161(1):82-99

Mammary gland adenocarcinoma Mammary gland New western diet (NWD) TD.96096   ⋅   AIN-76A

observed

References: Poutahidis T, Cancer Res 2015 Apr 1;75(7):1197-204

Mammary gland adenoma Mammary gland

0.3 - 1.2

0 - 0.1

References: Baldrick P, Toxicol Pathol 2007;35(4):562-9   ⋅   Chandra M, Toxicol Lett 1992 Jun;61(1):67-74   ⋅   Maita K, Toxicol Pathol 1988;16(3):340-9

Mammary gland carcinoma Mammary gland

0 - 3.0

References: Tannehill-Gregg SH, Toxicol Sci 2007 Jul;98(1):258-70   ⋅   Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Mammary gland carcinoma Mammary gland muraglitazar

0 - 6.8

References: Tannehill-Gregg SH, Toxicol Sci 2007 Jul;98(1):258-70

Sites of Metastasis: Lung

Mammary gland carcinoma Mammary gland New western diet (NWD) TD.96096   ⋅   AIN-76A

observed

References: Poutahidis T, Cancer Res 2015 Apr 1;75(7):1197-204

Mammary gland carcinosarcoma Mammary gland

0 - 1.1

4.0

References: Baldrick P, Toxicol Pathol 2007;35(4):562-9   ⋅   Son WC, Toxicol Lett 2003 Nov 1;145(1):88-98

Mammary gland neoplasia - epithelial Mammary gland New western diet (NWD) TD.96096   ⋅   AIN-76A

observed

References: Poutahidis T, Cancer Res 2015 Apr 1;75(7):1197-204

Mammary gland tumor Mammary gland

3.8

References: McLachlan JA, Cancer Res 1980 Nov;40(11):3988-99

Mammary gland tumor Mammary gland diethylstilbestrol (DES)

5.5

References: McLachlan JA, Cancer Res 1980 Nov;40(11):3988-99

Mammary gland tumor Mammary gland 3'-azido-3'-deoxythymidine (AZT)

0 - 16.7

References: Diwan BA, Toxicol Appl Pharmacol 1999 Nov 15;161(1):82-99

Mammary gland tumor Mammary gland AIN-76A

0

References: Poutahidis T, Cancer Res 2015 Apr 1;75(7):1197-204

Mammary gland tumor Mammary gland New western diet (NWD) TD.96096   ⋅   AIN-76A

20

References: Poutahidis T, Cancer Res 2015 Apr 1;75(7):1197-204

Mammary gland tumor Mammary gland New western diet (NWD) TD.96096   ⋅   L. reuteri ATCC-PTA-6475   ⋅   AIN-76A

0

References: Poutahidis T, Cancer Res 2015 Apr 1;75(7):1197-204

Mesodermal cell/mesoblast myxosarcoma Mesodermal cell/mesoblast diethylstilbestrol (DES)

3.0

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Mesodermal cell/mesoblast myxosarcoma Subcutis

0

0

References: Tannehill-Gregg SH, Toxicol Sci 2007 Jul;98(1):258-70

Mesodermal cell/mesoblast myxosarcoma Subcutis muraglitazar

0 - 50

0

References: Tannehill-Gregg SH, Toxicol Sci 2007 Jul;98(1):258-70

Sites of Metastasis: not Blood vessel - Aorta , not Lung , not Ovary , not Pancreas , not Spleen , not Stomach - Glandular , not Thoracic cavity

Mesodermal cell/mesoblast myxosarcoma Abdominal cavity

17

0

References: Tannehill-Gregg SH, Toxicol Sci 2007 Jul;98(1):258-70

Sites of Metastasis: Blood vessel - Aorta , Lung , Ovary , Pancreas , Spleen , Stomach - Glandular , Thoracic cavity

Mesodermal cell/mesoblast myxosarcoma Abdominal cavity muraglitazar

0

0

References: Tannehill-Gregg SH, Toxicol Sci 2007 Jul;98(1):258-70

Mesodermal cell/mesoblast sarcoma Uterus diethylstilbestrol (DES)

2.8 - 3.4

References: Newbold RR, Carcinogenesis 1998 Sep;19(9):1655-63

Mesodermal cell/mesoblast sarcoma Seminal vesicle diethylstilbestrol (DES)

3.4

References: Newbold RR, Carcinogenesis 2000 Jul;21(7):1355-63

Mesodermal cell/mesoblast sarcoma Skin

0 - 6.7

1.9 - 2.2

References: Baldrick P, Toxicol Pathol 2007;35(4):562-9   ⋅   Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Mesodermal cell/mesoblast sarcoma Uterus - Endometrium - Stroma

1.0 - 1.6

References: Baldrick P, Toxicol Pathol 2007;35(4):562-9

Mesodermal cell/mesoblast sarcoma Abdominal cavity

10.5

17

References: Baldrick P, Toxicol Pathol 2007;35(4):562-9

Mesodermal cell/mesoblast sarcoma Ear

25

References: Baldrick P, Toxicol Pathol 2007;35(4):562-9

Mesodermal cell/mesoblast sarcoma Vagina

1.7

References: Baldrick P, Toxicol Pathol 2007;35(4):562-9

Mesodermal cell/mesoblast sarcoma Kidney

0.9

References: Baldrick P, Toxicol Pathol 2007;35(4):562-9

Mesodermal cell/mesoblast sarcoma Thoracic cavity

4.2 - 7.7

References: Baldrick P, Toxicol Pathol 2007;35(4):562-9

Mesodermal cell/mesoblast sarcoma Uterus

1.7

References: Baldrick P, Toxicol Pathol 2007;35(4):562-9

Mesodermal cell/mesoblast sarcoma Skin diethylstilbestrol (DES)

3.0

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Mesodermal cell/mesoblast sarcoma Uterus - Endometrium

0.2

References: Maita K, Toxicol Pathol 1988;16(3):340-9

Mesodermal cell/mesoblast sarcoma CNS - Meninges

0

0

References: Tannehill-Gregg SH, Toxicol Sci 2007 Jul;98(1):258-70

Mesodermal cell/mesoblast sarcoma CNS - Meninges muraglitazar

0 - 1.7

0

References: Tannehill-Gregg SH, Toxicol Sci 2007 Jul;98(1):258-70

Mesodermal cell/mesoblast sarcoma Skin 3'-azido-3'-deoxythymidine (AZT)

2.0

References: Diwan BA, Toxicol Appl Pharmacol 1999 Nov 15;161(1):82-99

Mesodermal cell/mesoblast sarcoma Intestine - Small Intestine 3'-azido-3'-deoxythymidine (AZT)

1.9

References: Diwan BA, Toxicol Appl Pharmacol 1999 Nov 15;161(1):82-99

Mesodermal cell/mesoblast sarcoma Abdominal cavity sodium barbital (BB)   ⋅   3'-azido-3'-deoxythymidine (AZT)

2.7

References: Diwan BA, Toxicol Appl Pharmacol 1999 Nov 15;161(1):82-99

Mesodermal cell/mesoblast sarcoma - stromal Uterus - Cervix diethylstilbestrol (DES)

4.5 - 33

References: McLachlan JA, Cancer Res 1980 Nov;40(11):3988-99

Sites of Metastasis: Liver , Ovary , Oviduct , Spleen , Uterus - Uterine horn

Mesodermal cell/mesoblast sarcoma - stromal Uterus diethylstilbestrol (DES)

4.5 - 9.1

References: McLachlan JA, Cancer Res 1980 Nov;40(11):3988-99

Mesodermal cell/mesoblast sarcoma - stromal Uterus - Endometrium - Stroma

0

References: Tannehill-Gregg SH, Toxicol Sci 2007 Jul;98(1):258-70

Mesodermal cell/mesoblast sarcoma - stromal Uterus - Cervix - Stroma

0

References: Tannehill-Gregg SH, Toxicol Sci 2007 Jul;98(1):258-70

Mesodermal cell/mesoblast sarcoma - stromal Uterus - Endometrium - Stroma muraglitazar

0 - 1.7

References: Tannehill-Gregg SH, Toxicol Sci 2007 Jul;98(1):258-70

Mesodermal cell/mesoblast sarcoma - stromal Uterus - Cervix - Stroma muraglitazar

0 - 1.8

References: Tannehill-Gregg SH, Toxicol Sci 2007 Jul;98(1):258-70

Mesodermal cell/mesoblast sarcoma - unclassified Intestine - Small Intestine

0

0.1

References: Maita K, Toxicol Pathol 1988;16(3):340-9

Mesodermal cell/mesoblast sarcoma - unclassified Intestine - Large Intestine

0

0.1

References: Maita K, Toxicol Pathol 1988;16(3):340-9

Mesodermal cell/mesoblast sarcoma - unclassified Subcutis

0.1

0

References: Maita K, Toxicol Pathol 1988;16(3):340-9

Mesodermal cell/mesoblast sarcoma - undifferentiated Epididymis

0.1

References: Chandra M, Toxicol Lett 1992 Jun;61(1):67-74

Mesodermal cell/mesoblast sarcoma - undifferentiated Adrenal gland

0.3

0.1

References: Maita K, Toxicol Pathol 1988;16(3):340-9

Mesothelium mesothelioma Lung

0.1

0

References: Chandra M, Toxicol Lett 1992 Jun;61(1):67-74

Mesothelium mesothelioma Heart

0

0.1

References: Maita K, Toxicol Pathol 1988;16(3):340-9

Mesothelium mesothelioma Thoracic cavity

0

0

References: Tannehill-Gregg SH, Toxicol Sci 2007 Jul;98(1):258-70

Mesothelium mesothelioma Thoracic cavity muraglitazar

0 - 12.5

0

References: Tannehill-Gregg SH, Toxicol Sci 2007 Jul;98(1):258-70

Sites of Metastasis: Abdominal cavity , Adrenal gland - Cortex , Gallbladder , Liver , Muscle - Striated - Skeletal , Pancreas , Skin , Spleen , Stomach - Glandular , Vagina

Mesothelium mesothelioma - malignant Abdominal cavity

0.1

0

References: Maita K, Toxicol Pathol 1988;16(3):340-9

Muscle - Smooth hyperplasia Uterus tamoxifen (TAM)

observed

References: Diwan BA, Carcinogenesis 1997 Oct;18(10):2009-14

Muscle - Smooth leiomyoma Uterus tamoxifen (TAM)

0 - 14

References: Diwan BA, Carcinogenesis 1997 Oct;18(10):2009-14

Muscle - Smooth leiomyoma Uterus

0 - 9.8

References: Baldrick P, Toxicol Pathol 2007;35(4):562-9   ⋅   Chandra M, Toxicol Lett 1992 Jun;61(1):67-74   ⋅   Diwan BA, Carcinogenesis 1997 Oct;18(10):2009-14   ⋅   Maita K, Toxicol Pathol 1988;16(3):340-9   ⋅   Tannehill-Gregg SH, Toxicol Sci 2007 Jul;98(1):258-70

Muscle - Smooth leiomyoma Ovary diethylstilbestrol (DES)

4.2

References: Newbold RR, Carcinogenesis 1998 Sep;19(9):1655-63

Muscle - Smooth leiomyoma Uterus diethylstilbestrol (DES)

2.9 - 14

References: McLachlan JA, Cancer Res 1980 Nov;40(11):3988-99   ⋅   Newbold RR, Carcinogenesis 1998 Sep;19(9):1655-63

Muscle - Smooth leiomyoma Uterus - Cervix diethylstilbestrol (DES)

2.8 - 50

References: McLachlan JA, Cancer Res 1980 Nov;40(11):3988-99   ⋅   Newbold RR, Carcinogenesis 1998 Sep;19(9):1655-63

Muscle - Smooth leiomyoma Stomach

2.0

References: Baldrick P, Toxicol Pathol 2007;35(4):562-9

Muscle - Smooth leiomyoma Ovary

0.6

References: Baldrick P, Toxicol Pathol 2007;35(4):562-9

Muscle - Smooth leiomyoma Uterus - Cervix

0 - 4.3

References: Baldrick P, Toxicol Pathol 2007;35(4):562-9   ⋅   Chandra M, Toxicol Lett 1992 Jun;61(1):67-74   ⋅   Diwan BA, Toxicol Appl Pharmacol 1999 Nov 15;161(1):82-99   ⋅   Tannehill-Gregg SH, Toxicol Sci 2007 Jul;98(1):258-70

Muscle - Smooth leiomyoma Oviduct

0.1

References: Maita K, Toxicol Pathol 1988;16(3):340-9

Muscle - Smooth leiomyoma Uterus muraglitazar

0 - 1.7

References: Tannehill-Gregg SH, Toxicol Sci 2007 Jul;98(1):258-70

Muscle - Smooth leiomyoma Uterus - Cervix muraglitazar

0 - 3.6

References: Tannehill-Gregg SH, Toxicol Sci 2007 Jul;98(1):258-70

Muscle - Smooth leiomyoma Urinary bladder

1.7

0

References: Tannehill-Gregg SH, Toxicol Sci 2007 Jul;98(1):258-70

Muscle - Smooth leiomyoma Urinary bladder muraglitazar

0

0

References: Tannehill-Gregg SH, Toxicol Sci 2007 Jul;98(1):258-70

Muscle - Smooth leiomyosarcoma Uterus tamoxifen (TAM)

0 - 4.5

References: Diwan BA, Carcinogenesis 1997 Oct;18(10):2009-14   ⋅   Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Muscle - Smooth leiomyosarcoma Uterus

0 - 4.3

References: Baldrick P, Toxicol Pathol 2007;35(4):562-9   ⋅   Diwan BA, Carcinogenesis 1997 Oct;18(10):2009-14   ⋅   Diwan BA, Toxicol Appl Pharmacol 1999 Nov 15;161(1):82-99   ⋅   Maita K, Toxicol Pathol 1988;16(3):340-9   ⋅   Tannehill-Gregg SH, Toxicol Sci 2007 Jul;98(1):258-70   ⋅   Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Muscle - Smooth leiomyosarcoma Esophagus

2.0

References: Baldrick P, Toxicol Pathol 2007;35(4):562-9

Muscle - Smooth leiomyosarcoma Uterus - Cervix

0 - 0.1

References: Chandra M, Toxicol Lett 1992 Jun;61(1):67-74   ⋅   Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Muscle - Smooth leiomyosarcoma Uterus sodium arsenite

2.9

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Muscle - Smooth leiomyosarcoma Uterus - Cervix sodium arsenite

0

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Muscle - Smooth leiomyosarcoma Uterus diethylstilbestrol (DES)

0

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Muscle - Smooth leiomyosarcoma Uterus - Cervix diethylstilbestrol (DES)

0 - 10

References: McLachlan JA, Cancer Res 1980 Nov;40(11):3988-99   ⋅   Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Muscle - Smooth leiomyosarcoma Uterus - Cervix tamoxifen (TAM)

0

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Muscle - Smooth leiomyosarcoma Uterus sodium arsenite   ⋅   diethylstilbestrol (DES)

0

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Muscle - Smooth leiomyosarcoma Uterus - Cervix sodium arsenite   ⋅   diethylstilbestrol (DES)

3.0

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Muscle - Smooth leiomyosarcoma Uterus sodium arsenite   ⋅   tamoxifen (TAM)

0

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Muscle - Smooth leiomyosarcoma Uterus - Cervix sodium arsenite   ⋅   tamoxifen (TAM)

0

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Muscle - Smooth leiomyosarcoma Urinary bladder

0.75

0

References: Chandra M, Toxicol Pathol 1991;19(2):164-7

Muscle - Smooth leiomyosarcoma Subcutis

0.1

0

References: Maita K, Toxicol Pathol 1988;16(3):340-9

Muscle - Smooth leiomyosarcoma Vagina

0.1

References: Maita K, Toxicol Pathol 1988;16(3):340-9

Muscle - Smooth leiomyosarcoma Uterus muraglitazar

0 - 1.7

References: Tannehill-Gregg SH, Toxicol Sci 2007 Jul;98(1):258-70

Muscle - Smooth leiomyosarcoma Vagina 3'-azido-3'-deoxythymidine (AZT)

4.5

References: Diwan BA, Toxicol Appl Pharmacol 1999 Nov 15;161(1):82-99

Muscle - Smooth leiomyosarcoma Uterus 3'-azido-3'-deoxythymidine (AZT)

3.7

References: Diwan BA, Toxicol Appl Pharmacol 1999 Nov 15;161(1):82-99

Muscle - Smooth leiomyosarcoma Intestine - Large Intestine - Colon 3'-azido-3'-deoxythymidine (AZT)

2.0

References: Diwan BA, Toxicol Appl Pharmacol 1999 Nov 15;161(1):82-99

Muscle - Striated - Skeletal rhabdomyosarcoma Skin

1.5

References: Baldrick P, Toxicol Pathol 2007;35(4):562-9

Muscle - Striated - Skeletal rhabdomyosarcoma Skin tamoxifen (TAM)

2.9

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Muscle - Striated - Skeletal rhabdomyosarcoma Skin sodium arsenite   ⋅   diethylstilbestrol (DES)

3.0

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Muscle - Striated - Skeletal rhabdomyosarcoma Subcutis

0.1

0.4

References: Maita K, Toxicol Pathol 1988;16(3):340-9

Muscle - Striated - Skeletal rhabdomyosarcoma Abdominal cavity

0

0.1

References: Maita K, Toxicol Pathol 1988;16(3):340-9

Myoepithelial cell myoepithelioma - malignant Salivary gland sodium arsenite   ⋅   diethylstilbestrol (DES)

3.0

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Nose - Nasal cavity adenoma Nose - Nasal cavity 1-methyl-1-nitrosourea (MNU)

10

References: Tamura T, Cancer Lett 1999 Aug 23;143(1):71-80

Nose - Nasal cavity adenoma Nose - Nasal cavity 1-methyl-1-nitrosourea (MNU)   ⋅   1,1-dimethylhydrazine (UDMH)

6.7

References: Tamura T, Cancer Lett 1999 Aug 23;143(1):71-80

Nose - Nasal cavity squamous cell carcinoma Nose - Nasal cavity

0.1

0

References: Maita K, Toxicol Pathol 1988;16(3):340-9

Oral cavity papilloma Oral cavity

0

0.1

References: Maita K, Toxicol Pathol 1988;16(3):340-9

Oral cavity squamous cell papilloma Oral cavity

100

100

References: Baldrick P, Toxicol Pathol 2007;35(4):562-9

Ovary - Granulosa cell tumor Ovary - Granulosa cell tamoxifen (TAM)

0 - 14

References: Diwan BA, Carcinogenesis 1997 Oct;18(10):2009-14

Ovary - Granulosa cell tumor Ovary - Granulosa cell diethylstilbestrol (DES)

observed - 10

References: McLachlan JA, Cancer Res 1980 Nov;40(11):3988-99   ⋅   Newbold RR, Carcinogenesis 1998 Sep;19(9):1655-63

Ovary - Granulosa cell tumor Ovary - Granulosa cell

0.1 - 0.2

References: Chandra M, Toxicol Lett 1992 Jun;61(1):67-74   ⋅   Maita K, Toxicol Pathol 1988;16(3):340-9

Ovary - Granulosa cell tumor Ovary - Granulosa cell 3'-azido-3'-deoxythymidine (AZT)

3.1

References: Diwan BA, Toxicol Appl Pharmacol 1999 Nov 15;161(1):82-99

Ovary - Granulosa cell tumor Ovary - Granulosa cell New western diet (NWD) TD.96096   ⋅   AIN-76A

observed - 40

References: Poutahidis T, Cancer Res 2015 Apr 1;75(7):1197-204

Ovary - Granulosa cell tumor Ovary - Granulosa cell AIN-76A

0

References: Poutahidis T, Cancer Res 2015 Apr 1;75(7):1197-204

Ovary - Granulosa cell tumor Ovary - Granulosa cell New western diet (NWD) TD.96096   ⋅   L. reuteri ATCC-PTA-6475   ⋅   AIN-76A

0

References: Poutahidis T, Cancer Res 2015 Apr 1;75(7):1197-204

Ovary - Granulosa cell tumor - benign Ovary - Granulosa cell

0.9 - 1.1

References: Baldrick P, Toxicol Pathol 2007;35(4):562-9

Ovary - Granulosa cell tumor - malignant Ovary - Granulosa cell

0.1

References: Maita K, Toxicol Pathol 1988;16(3):340-9

Ovary - Hilus cell cyst - epithelial Ovary - Hilus cell

observed

References: Long GG, Toxicol Pathol 2002 Sep-Oct;30(5):592-8

Ovary - Hilus cell hyperplasia - ductal Ovary - Hilus cell

observed

References: Long GG, Toxicol Pathol 2002 Sep-Oct;30(5):592-8

Ovary - Hilus cell lesion - papillary Ovary - Hilus cell

observed

References: Long GG, Toxicol Pathol 2002 Sep-Oct;30(5):592-8

Ovary - Sertoli cell tumor Ovary - Sertoli cell 3'-azido-3'-deoxythymidine (AZT)

4.2

References: Diwan BA, Toxicol Appl Pharmacol 1999 Nov 15;161(1):82-99

Ovary - Sertoli cell tumor - benign Ovary - Sertoli cell

1.6

References: Baldrick P, Toxicol Pathol 2007;35(4):562-9

Ovary - Sex cord stromal cell tumor - benign Ovary - Sex cord stromal cell

0.6

References: Baldrick P, Toxicol Pathol 2007;35(4):562-9

Ovary - Theca cell thecoma Ovary - Theca cell 3'-azido-3'-deoxythymidine (AZT)

3.7

References: Diwan BA, Toxicol Appl Pharmacol 1999 Nov 15;161(1):82-99

Ovary - Theca cell thecoma Ovary - Theca cell New western diet (NWD) TD.96096   ⋅   AIN-76A

0 - 10

References: Poutahidis T, Cancer Res 2015 Apr 1;75(7):1197-204

Ovary - Theca cell thecoma Ovary - Theca cell AIN-76A

0

References: Poutahidis T, Cancer Res 2015 Apr 1;75(7):1197-204

Ovary - Theca cell thecoma Ovary - Theca cell New western diet (NWD) TD.96096   ⋅   L. reuteri ATCC-PTA-6475   ⋅   AIN-76A

0

References: Poutahidis T, Cancer Res 2015 Apr 1;75(7):1197-204

Ovary - Theca cell tumor Ovary - Theca cell

0.3 - 0.4

References: Chandra M, Toxicol Lett 1992 Jun;61(1):67-74   ⋅   Maita K, Toxicol Pathol 1988;16(3):340-9

Ovary - Theca cell tumor Ovary - Theca cell sodium barbital (BB)

5.0

References: Diwan BA, Toxicol Appl Pharmacol 1999 Nov 15;161(1):82-99

Ovary - Theca cell tumor Ovary - Theca cell New western diet (NWD) TD.96096   ⋅   AIN-76A

observed

References: Poutahidis T, Cancer Res 2015 Apr 1;75(7):1197-204

Ovary adenoma Ovary

0 - 3.4

References: Chandra M, Toxicol Lett 1992 Jun;61(1):67-74   ⋅   Maita K, Toxicol Pathol 1988;16(3):340-9   ⋅   Tannehill-Gregg SH, Toxicol Sci 2007 Jul;98(1):258-70   ⋅   Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Ovary adenoma Ovary sodium arsenite

12

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Ovary adenoma Ovary diethylstilbestrol (DES)

6.1

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Ovary adenoma Ovary tamoxifen (TAM)

2.9

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Ovary adenoma Ovary sodium arsenite   ⋅   diethylstilbestrol (DES)

18

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Ovary adenoma Ovary sodium arsenite   ⋅   tamoxifen (TAM)

2.9

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Ovary adenoma Ovary muraglitazar

1.7 - 6.7

References: Tannehill-Gregg SH, Toxicol Sci 2007 Jul;98(1):258-70

Ovary adenoma - cystic Ovary New western diet (NWD) TD.96096   ⋅   AIN-76A

10 - 20

References: Poutahidis T, Cancer Res 2015 Apr 1;75(7):1197-204

Ovary adenoma - cystic Ovary AIN-76A

0

References: Poutahidis T, Cancer Res 2015 Apr 1;75(7):1197-204

Ovary adenoma - cystic Ovary New western diet (NWD) TD.96096   ⋅   L. reuteri ATCC-PTA-6475   ⋅   AIN-76A

0

References: Poutahidis T, Cancer Res 2015 Apr 1;75(7):1197-204

Ovary adenoma - tubulostromal Ovary

0 - 1.7

References: Baldrick P, Toxicol Pathol 2007;35(4):562-9   ⋅   Tannehill-Gregg SH, Toxicol Sci 2007 Jul;98(1):258-70

Ovary adenoma - tubulostromal Ovary muraglitazar

0

References: Tannehill-Gregg SH, Toxicol Sci 2007 Jul;98(1):258-70

Ovary carcinoma Ovary

0

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Ovary carcinoma Ovary sodium arsenite

0

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Ovary carcinoma Ovary diethylstilbestrol (DES)

0

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Ovary carcinoma Ovary tamoxifen (TAM)

0

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Ovary carcinoma Ovary sodium arsenite   ⋅   diethylstilbestrol (DES)

3.0

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Sites of Metastasis: Liver

Ovary carcinoma Ovary sodium arsenite   ⋅   tamoxifen (TAM)

5.7

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Ovary cyst Ovary tamoxifen (TAM)

0 - 86

References: Diwan BA, Carcinogenesis 1997 Oct;18(10):2009-14   ⋅   Newbold RR, Carcinogenesis 1997 Dec;18(12):2293-8

Ovary cyst Ovary

0 - 70

References: Baldrick P, Toxicol Pathol 2007;35(4):562-9   ⋅   Diwan BA, Carcinogenesis 1997 Oct;18(10):2009-14   ⋅   Long GG, Toxicol Pathol 2002 Sep-Oct;30(5):592-8   ⋅   McLachlan JA, Cancer Res 1980 Nov;40(11):3988-99   ⋅   Newbold RR, Carcinogenesis 1998 Sep;19(9):1655-63   ⋅   Son WC, Toxicol Lett 2003 Nov 1;145(1):88-98

Ovary cyst Ovary diethylstilbestrol (DES)

observed - 100

References: McLachlan JA, Cancer Res 1980 Nov;40(11):3988-99   ⋅   Newbold RR, Carcinogenesis 1998 Sep;19(9):1655-63

Ovary cyst Ovary 17beta-estradiol (E2)

58

References: McLachlan JA, Cancer Res 1980 Nov;40(11):3988-99

Ovary cyst Ovary dimethylstilbestrol (DMS)

60

References: McLachlan JA, Cancer Res 1980 Nov;40(11):3988-99

Ovary cyst Ovary New western diet (NWD) TD.96096   ⋅   AIN-76A

observed

observed

References: Poutahidis T, Cancer Res 2015 Apr 1;75(7):1197-204

Ovary cyst - epithelial Ovary

observed

References: Long GG, Toxicol Pathol 2002 Sep-Oct;30(5):592-8

Ovary cystadenoma Ovary tamoxifen (TAM)

5.3 - 8.3

References: Newbold RR, Carcinogenesis 1997 Dec;18(12):2293-8

Ovary cystadenoma Ovary

0.7 - 13

References: Baldrick P, Toxicol Pathol 2007;35(4):562-9   ⋅   Newbold RR, Carcinogenesis 1998 Sep;19(9):1655-63   ⋅   Tannehill-Gregg SH, Toxicol Sci 2007 Jul;98(1):258-70

Ovary cystadenoma Ovary diethylstilbestrol (DES)

2.9 - 18

References: Newbold RR, Carcinogenesis 1998 Sep;19(9):1655-63

Ovary cystadenoma Ovary muraglitazar

0

References: Tannehill-Gregg SH, Toxicol Sci 2007 Jul;98(1):258-70

Ovary cystadenoma Ovary 3'-azido-3'-deoxythymidine (AZT)

3.1 - 7.4

References: Diwan BA, Toxicol Appl Pharmacol 1999 Nov 15;161(1):82-99

Ovary cystadenoma Ovary New western diet (NWD) TD.96096   ⋅   AIN-76A

observed

References: Poutahidis T, Cancer Res 2015 Apr 1;75(7):1197-204

Ovary cystadenoma - papillary Ovary

0 - 0.7

References: Chandra M, Toxicol Lett 1992 Jun;61(1):67-74   ⋅   Long GG, Toxicol Pathol 2002 Sep-Oct;30(5):592-8

Ovary cystadenoma - papillary Ovary diethylstilbestrol (DES)

observed - 8.3

References: McLachlan JA, Cancer Res 1980 Nov;40(11):3988-99

Ovary hyperplasia - ductal Ovary

observed

References: Long GG, Toxicol Pathol 2002 Sep-Oct;30(5):592-8

Ovary hyperplasia - epithelial Ovary

5 - 37.5

References: Long GG, Toxicol Pathol 2002 Sep-Oct;30(5):592-8

Ovary lesion - epithelial Ovary

observed - 97.5

References: Long GG, Toxicol Pathol 2002 Sep-Oct;30(5):592-8

Ovary lesion - papillary Ovary

0 - 15

References: Long GG, Toxicol Pathol 2002 Sep-Oct;30(5):592-8

Ovary lesion - papillary Adipose tissue - Gonadal fat pad

observed

References: Long GG, Toxicol Pathol 2002 Sep-Oct;30(5):592-8

Ovary lesion - proliferative Ovary

observed - 37.5

References: Long GG, Toxicol Pathol 2002 Sep-Oct;30(5):592-8

Ovary luteoma Ovary

0 - 1.7

References: Baldrick P, Toxicol Pathol 2007;35(4):562-9   ⋅   Maita K, Toxicol Pathol 1988;16(3):340-9   ⋅   Tannehill-Gregg SH, Toxicol Sci 2007 Jul;98(1):258-70

Ovary luteoma Ovary muraglitazar

0

References: Tannehill-Gregg SH, Toxicol Sci 2007 Jul;98(1):258-70

Ovary papilloma Ovary

0.1

References: Maita K, Toxicol Pathol 1988;16(3):340-9

Ovary tumor Ovary

0

References: Diwan BA, Carcinogenesis 1997 Oct;18(10):2009-14   ⋅   Diwan BA, Toxicol Appl Pharmacol 1999 Nov 15;161(1):82-99   ⋅   McLachlan JA, Cancer Res 1980 Nov;40(11):3988-99   ⋅   Newbold RR, Carcinogenesis 1997 Dec;18(12):2293-8

Ovary tumor Ovary diethylstilbestrol (DES)

2.8 - 4.2

References: McLachlan JA, Cancer Res 1980 Nov;40(11):3988-99   ⋅   Newbold RR, Carcinogenesis 1998 Sep;19(9):1655-63

Ovary tumor Ovary 3'-azido-3'-deoxythymidine (AZT)

0 - 11.1

References: Diwan BA, Toxicol Appl Pharmacol 1999 Nov 15;161(1):82-99

Ovary tumor Ovary sodium barbital (BB)   ⋅   3'-azido-3'-deoxythymidine (AZT)

0

References: Diwan BA, Toxicol Appl Pharmacol 1999 Nov 15;161(1):82-99

Ovary tumor Ovary sodium barbital (BB)

0 - 5.0

References: Diwan BA, Toxicol Appl Pharmacol 1999 Nov 15;161(1):82-99

Ovary tumor Ovary AIN-76A

0

References: Poutahidis T, Cancer Res 2015 Apr 1;75(7):1197-204

Ovary tumor Ovary New western diet (NWD) TD.96096   ⋅   AIN-76A

20 - 30

References: Poutahidis T, Cancer Res 2015 Apr 1;75(7):1197-204

Ovary tumor Ovary New western diet (NWD) TD.96096   ⋅   L. reuteri ATCC-PTA-6475   ⋅   AIN-76A

0

References: Poutahidis T, Cancer Res 2015 Apr 1;75(7):1197-204

Ovary tumor - gonadal stromal Ovary

4.3

References: Newbold RR, Carcinogenesis 1998 Sep;19(9):1655-63

Ovary tumor - gonadal stromal Ovary diethylstilbestrol (DES)

observed

References: McLachlan JA, Cancer Res 1980 Nov;40(11):3988-99

Ovary tumor - granulosa-theca cell - benign Ovary

3.3

References: Tannehill-Gregg SH, Toxicol Sci 2007 Jul;98(1):258-70

Ovary tumor - granulosa-theca cell - benign Ovary muraglitazar

0

References: Tannehill-Gregg SH, Toxicol Sci 2007 Jul;98(1):258-70

Ovary tumor - granulosa-theca cell - malignant Ovary

3.3

References: Tannehill-Gregg SH, Toxicol Sci 2007 Jul;98(1):258-70

Ovary tumor - granulosa-theca cell - malignant Ovary muraglitazar

0

References: Tannehill-Gregg SH, Toxicol Sci 2007 Jul;98(1):258-70

Oviduct adenoma Oviduct

0

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Oviduct adenoma Oviduct sodium arsenite

0

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Oviduct adenoma Oviduct diethylstilbestrol (DES)

3.0

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Oviduct adenoma Oviduct tamoxifen (TAM)

2.9

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Oviduct adenoma Oviduct sodium arsenite   ⋅   diethylstilbestrol (DES)

6.1

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Oviduct adenoma Oviduct sodium arsenite   ⋅   tamoxifen (TAM)

8.6

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Oviduct carcinoma Oviduct

0

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Oviduct carcinoma Oviduct sodium arsenite

0

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Oviduct carcinoma Oviduct diethylstilbestrol (DES)

0

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Oviduct carcinoma Oviduct tamoxifen (TAM)

0

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Oviduct carcinoma Oviduct sodium arsenite   ⋅   diethylstilbestrol (DES)

0

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Oviduct carcinoma Oviduct sodium arsenite   ⋅   tamoxifen (TAM)

0

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Oviduct hyperplasia Oviduct tamoxifen (TAM)

30 - 100

References: Diwan BA, Carcinogenesis 1997 Oct;18(10):2009-14   ⋅   Newbold RR, Carcinogenesis 1997 Dec;18(12):2293-8   ⋅   Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Oviduct hyperplasia Oviduct

0 - 29

References: Diwan BA, Carcinogenesis 1997 Oct;18(10):2009-14   ⋅   Newbold RR, Carcinogenesis 1997 Dec;18(12):2293-8   ⋅   Newbold RR, Carcinogenesis 1998 Sep;19(9):1655-63   ⋅   Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Oviduct hyperplasia Oviduct diethylstilbestrol (DES)

14 - 73

References: Newbold RR, Carcinogenesis 1998 Sep;19(9):1655-63   ⋅   Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Oviduct hyperplasia Oviduct sodium arsenite

79

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Oviduct hyperplasia Oviduct sodium arsenite   ⋅   diethylstilbestrol (DES)

79

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Oviduct hyperplasia Oviduct sodium arsenite   ⋅   tamoxifen (TAM)

71

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Oviduct papilloma Oviduct

0.1

References: Maita K, Toxicol Pathol 1988;16(3):340-9

PNS - Schwann cell neurofibrosarcoma Skin

0

0

References: Tannehill-Gregg SH, Toxicol Sci 2007 Jul;98(1):258-70

PNS - Schwann cell neurofibrosarcoma Skin muraglitazar

0

0 - 8.3

References: Tannehill-Gregg SH, Toxicol Sci 2007 Jul;98(1):258-70

PNS - Schwann cell neurofibrosarcoma Leg 3'-azido-3'-deoxythymidine (AZT)

1.9

References: Diwan BA, Toxicol Appl Pharmacol 1999 Nov 15;161(1):82-99

PNS - Schwann cell schwannoma Heart

0

0.1

References: Chandra M, Toxicol Lett 1992 Jun;61(1):67-74

PNS - Schwann cell schwannoma - malignant Bone - Skull

0

0.1

References: Maita K, Toxicol Pathol 1988;16(3):340-9

Pancreas - Acinar cell adenoma Pancreas - Acinar cell

0

0.1

References: Maita K, Toxicol Pathol 1988;16(3):340-9

Pancreas - Islet of Langerhans adenoma Pancreas - Islet of Langerhans

0.1 - 0.9

0 - 7.8

References: Baldrick P, Toxicol Pathol 2007;35(4):562-9   ⋅   Chandra M, Toxicol Lett 1992 Jun;61(1):67-74   ⋅   Maita K, Toxicol Pathol 1988;16(3):340-9

Pancreas - Islet of Langerhans adenoma Pancreas - Islet of Langerhans 3'-azido-3'-deoxythymidine (AZT)

1.9

References: Diwan BA, Toxicol Appl Pharmacol 1999 Nov 15;161(1):82-99

Pancreas - Islet of Langerhans adenoma Pancreas - Islet of Langerhans New western diet (NWD) TD.96096   ⋅   AIN-76A

observed

References: Poutahidis T, Cancer Res 2015 Apr 1;75(7):1197-204

Pancreas tumor Pancreas 3'-azido-3'-deoxythymidine (AZT)

0.9

References: Diwan BA, Toxicol Appl Pharmacol 1999 Nov 15;161(1):82-99

Pancreas tumor Pancreas AIN-76A

0

0

0

References: Poutahidis T, Cancer Res 2015 Apr 1;75(7):1197-204

Pancreas tumor Pancreas New western diet (NWD) TD.96096   ⋅   AIN-76A

0 - 10

0 - 10

0 - 5

References: Poutahidis T, Cancer Res 2015 Apr 1;75(7):1197-204

Pancreas tumor Pancreas New western diet (NWD) TD.96096   ⋅   L. reuteri ATCC-PTA-6475   ⋅   AIN-76A

0

0

0

References: Poutahidis T, Cancer Res 2015 Apr 1;75(7):1197-204

Parathyroid gland adenoma Parathyroid gland

0 - 0.6

0 - 0.1

References: Baldrick P, Toxicol Pathol 2007;35(4):562-9   ⋅   Chandra M, Toxicol Lett 1992 Jun;61(1):67-74   ⋅   Maita K, Toxicol Pathol 1988;16(3):340-9   ⋅   Tannehill-Gregg SH, Toxicol Sci 2007 Jul;98(1):258-70

Parathyroid gland adenoma Parathyroid gland muraglitazar

0

0 - 2.4

References: Tannehill-Gregg SH, Toxicol Sci 2007 Jul;98(1):258-70

Pituitary gland - Anterior adenocarcinoma Pituitary gland - Anterior

0.2

0.2

References: Maita K, Toxicol Pathol 1988;16(3):340-9

Pituitary gland - Anterior adenoma Pituitary gland - Anterior

1.1 - 4.7

0 - 0.2

References: Chandra M, Toxicol Lett 1992 Jun;61(1):67-74   ⋅   Maita K, Toxicol Pathol 1988;16(3):340-9

Pituitary gland adenoma Pituitary gland

0 - 6.8

0 - 3.4

References: Baldrick P, Toxicol Pathol 2007;35(4):562-9   ⋅   Tannehill-Gregg SH, Toxicol Sci 2007 Jul;98(1):258-70

Pituitary gland adenoma Pituitary gland muraglitazar

0 - 5.1

0 - 1.8

References: Tannehill-Gregg SH, Toxicol Sci 2007 Jul;98(1):258-70

Pituitary gland adenoma Pituitary gland 3'-azido-3'-deoxythymidine (AZT)

2.0

References: Diwan BA, Toxicol Appl Pharmacol 1999 Nov 15;161(1):82-99

Pituitary gland adenoma Pituitary gland sodium barbital (BB)   ⋅   3'-azido-3'-deoxythymidine (AZT)

2.8

References: Diwan BA, Toxicol Appl Pharmacol 1999 Nov 15;161(1):82-99

Pituitary gland carcinoma Pituitary gland

1.6

References: Baldrick P, Toxicol Pathol 2007;35(4):562-9

Placenta - Decidua deciduoma Placenta - Decidua tamoxifen (TAM)

0 - 20

References: Diwan BA, Carcinogenesis 1997 Oct;18(10):2009-14

Placenta - Decidua deciduoma Placenta - Decidua

0 - 3.1

References: Diwan BA, Carcinogenesis 1997 Oct;18(10):2009-14   ⋅   Newbold RR, Carcinogenesis 1998 Sep;19(9):1655-63

Placenta - Decidua deciduoma Placenta - Decidua diethylstilbestrol (DES)

2.7 - 6.9

References: Newbold RR, Carcinogenesis 1998 Sep;19(9):1655-63

Preputial gland (male) adenoma Preputial gland (male)

0.1

References: Maita K, Toxicol Pathol 1988;16(3):340-9

Prostate gland - Anterior lobe adenoma Prostate gland - Anterior lobe

0.3

References: Maita K, Toxicol Pathol 1988;16(3):340-9

Prostate gland - Anterior lobe hyperplasia Prostate gland - Anterior lobe diethylstilbestrol (DES)

3.4

References: Newbold RR, Carcinogenesis 2000 Jul;21(7):1355-63

Prostate gland adenoma Prostate gland

0.1

References: Chandra M, Toxicol Lett 1992 Jun;61(1):67-74   ⋅   Maita K, Toxicol Pathol 1988;16(3):340-9

Prostate gland hyperplasia Prostate gland

2.9

References: Newbold RR, Carcinogenesis 2000 Jul;21(7):1355-63

Prostate gland hyperplasia Prostate gland diethylstilbestrol (DES)

3.4 - 9.0

References: Newbold RR, Carcinogenesis 2000 Jul;21(7):1355-63

Prostate gland tumor Prostate gland diethylstilbestrol (DES)

3.4

References: Newbold RR, Carcinogenesis 2000 Jul;21(7):1355-63

Reproductive system (sex not specified) tumor Reproductive system (sex not specified)

3

References: Diwan BA, Toxicol Appl Pharmacol 1999 Nov 15;161(1):82-99

Reproductive system (sex not specified) tumor Reproductive system (sex not specified) 3'-azido-3'-deoxythymidine (AZT)

7 - 12

References: Diwan BA, Toxicol Appl Pharmacol 1999 Nov 15;161(1):82-99

Reproductive system (sex not specified) tumor - malignant Reproductive system (sex not specified) New western diet (NWD) TD.96096   ⋅   AIN-76A

observed

References: Poutahidis T, Cancer Res 2015 Apr 1;75(7):1197-204

Salivary gland - Parotid adenoma Salivary gland - Parotid

0.2

0

References: Maita K, Toxicol Pathol 1988;16(3):340-9

Salivary gland - Submandibular adenoma Salivary gland - Submandibular

0

0.2

References: Maita K, Toxicol Pathol 1988;16(3):340-9

Salivary gland adenocarcinoma Salivary gland

1.6

References: Baldrick P, Toxicol Pathol 2007;35(4):562-9

Salivary gland carcinoma Salivary gland

1.7

References: Baldrick P, Toxicol Pathol 2007;35(4):562-9

Seminal vesicle adenocarcinoma Seminal vesicle

0.1

References: Maita K, Toxicol Pathol 1988;16(3):340-9

Seminal vesicle adenoma Seminal vesicle

0.1

References: Chandra M, Toxicol Lett 1992 Jun;61(1):67-74   ⋅   Maita K, Toxicol Pathol 1988;16(3):340-9

Seminal vesicle adenoma Seminal vesicle 3'-azido-3'-deoxythymidine (AZT)

3.6

References: Diwan BA, Toxicol Appl Pharmacol 1999 Nov 15;161(1):82-99

Seminal vesicle carcinosarcoma Seminal vesicle diethylstilbestrol (DES)

2.0

References: Newbold RR, Carcinogenesis 2000 Jul;21(7):1355-63

Seminal vesicle hyperplasia Seminal vesicle diethylstilbestrol (DES)

2.0 - 3.4

References: Newbold RR, Carcinogenesis 2000 Jul;21(7):1355-63

Seminal vesicle papilloma Seminal vesicle diethylstilbestrol (DES)

1.0

References: Newbold RR, Carcinogenesis 2000 Jul;21(7):1355-63

Seminal vesicle tumor Seminal vesicle

0

References: Diwan BA, Toxicol Appl Pharmacol 1999 Nov 15;161(1):82-99

Seminal vesicle tumor Seminal vesicle 3'-azido-3'-deoxythymidine (AZT)

0 - 10.7

References: Diwan BA, Toxicol Appl Pharmacol 1999 Nov 15;161(1):82-99

Seminal vesicle tumor Seminal vesicle sodium barbital (BB)   ⋅   3'-azido-3'-deoxythymidine (AZT)

0

References: Diwan BA, Toxicol Appl Pharmacol 1999 Nov 15;161(1):82-99

Seminal vesicle tumor Seminal vesicle sodium barbital (BB)

0

References: Diwan BA, Toxicol Appl Pharmacol 1999 Nov 15;161(1):82-99

Skin - Epidermis - Basal cell carcinoma Skin - Epidermis - Basal cell

0.1

0

References: Maita K, Toxicol Pathol 1988;16(3):340-9

Skin - Epidermis - Basal cell tumor Skin - Epidermis - Basal cell

0 - 1.9

0.1

References: Chandra M, Toxicol Lett 1992 Jun;61(1):67-74   ⋅   Diwan BA, Toxicol Appl Pharmacol 1999 Nov 15;161(1):82-99

Skin - Epidermis - Basal cell tumor - malignant Skin - Epidermis - Basal cell

0.6

References: Baldrick P, Toxicol Pathol 2007;35(4):562-9

Skin - Hair follicle - Basal cell trichoepithelioma Skin - Hair follicle - Basal cell

0 - 2.0

References: Baldrick P, Toxicol Pathol 2007;35(4):562-9   ⋅   Son WC, Toxicol Lett 2003 Nov 1;145(1):88-98

Skin - Hair follicle tumor Skin - Hair follicle

0.9

References: Baldrick P, Toxicol Pathol 2007;35(4):562-9

Skin - Melanocyte melanoma - benign Skin - Melanocyte

1.7

References: Baldrick P, Toxicol Pathol 2007;35(4):562-9

Skin adenoma - sebaceous Skin

0.9

1.8

References: Baldrick P, Toxicol Pathol 2007;35(4):562-9

Skin adenoma - sebaceous Skin 3'-azido-3'-deoxythymidine (AZT)

1.9

References: Diwan BA, Toxicol Appl Pharmacol 1999 Nov 15;161(1):82-99

Skin keratoacanthoma Skin

0.1 - 2.0

0.1

References: Baldrick P, Toxicol Pathol 2007;35(4):562-9   ⋅   Maita K, Toxicol Pathol 1988;16(3):340-9

Skin keratoacanthoma Skin sodium barbital (BB)   ⋅   3'-azido-3'-deoxythymidine (AZT)

2.7

References: Diwan BA, Toxicol Appl Pharmacol 1999 Nov 15;161(1):82-99

Skin papilloma Skin

0

0.2

References: Maita K, Toxicol Pathol 1988;16(3):340-9

Skin papilloma Skin 3'-azido-3'-deoxythymidine (AZT)

2.0

2.0

References: Diwan BA, Toxicol Appl Pharmacol 1999 Nov 15;161(1):82-99

Skin squamous cell carcinoma Skin

0.3 - 0.7

0.2 - 0.3

References: Baldrick P, Toxicol Pathol 2007;35(4):562-9   ⋅   Maita K, Toxicol Pathol 1988;16(3):340-9

Skin squamous cell papilloma Skin

0 - 20

0 - 0.2

References: Baldrick P, Toxicol Pathol 2007;35(4):562-9   ⋅   Tannehill-Gregg SH, Toxicol Sci 2007 Jul;98(1):258-70

Skin squamous cell papilloma Skin muraglitazar

0

0

References: Tannehill-Gregg SH, Toxicol Sci 2007 Jul;98(1):258-70

Stomach - Glandular - Pylorus hyperplasia Stomach - Glandular - Pylorus N-methyl-N-nitrosourea (MNU)

observed

References: Yamamoto M, Cancer Lett 2002 May 28;179(2):121-32

Stomach - Glandular - Pylorus hyperplasia Stomach - Glandular - Pylorus

0

References: Yamamoto M, Cancer Lett 2002 May 28;179(2):121-32

Stomach - Glandular - Pylorus lesion Stomach - Glandular - Pylorus N-methyl-N-nitrosourea (MNU)

100

References: Yamamoto M, Cancer Lett 2002 May 28;179(2):121-32

Stomach - Glandular - Pylorus lesion Stomach - Glandular - Pylorus

100

References: Yamamoto M, Cancer Lett 2002 May 28;179(2):121-32

Stomach - Glandular - Pylorus preneoplastic lesion Stomach - Glandular - Pylorus N-methyl-N-nitrosourea (MNU)

observed

References: Yamamoto M, Cancer Lett 2002 May 28;179(2):121-32

Stomach - Glandular - Pylorus preneoplastic lesion Stomach - Glandular - Pylorus

0

References: Yamamoto M, Cancer Lett 2002 May 28;179(2):121-32

Stomach - Glandular - Pylorus tumor Stomach - Glandular - Pylorus N-methyl-N-nitrosourea (MNU)

0

References: Yamamoto M, Cancer Lett 2002 May 28;179(2):121-32

Stomach - Glandular - Pylorus tumor Stomach - Glandular - Pylorus

0

References: Yamamoto M, Cancer Lett 2002 May 28;179(2):121-32

Stomach - Glandular adenocarcinoma Stomach - Glandular

0.3

0

References: Chandra M, Toxicol Lett 1992 Jun;61(1):67-74   ⋅   Yamamoto M, Cancer Lett 2002 May 28;179(2):121-32

Stomach - Glandular adenocarcinoma Stomach - Glandular N-methyl-N-nitrosourea (MNU)

18.52

References: Yamamoto M, Cancer Lett 2002 May 28;179(2):121-32

Stomach - Glandular adenocarcinoma - poorly differentiated Stomach - Glandular N-methyl-N-nitrosourea (MNU)

observed

References: Yamamoto M, Cancer Lett 2002 May 28;179(2):121-32

Stomach - Glandular adenocarcinoma - signet ring cell Stomach - Glandular N-methyl-N-nitrosourea (MNU)

0

References: Yamamoto M, Cancer Lett 2002 May 28;179(2):121-32

Stomach - Glandular adenocarcinoma - well-differentiated Stomach - Glandular N-methyl-N-nitrosourea (MNU)

observed

References: Yamamoto M, Cancer Lett 2002 May 28;179(2):121-32

Stomach - Glandular adenoma Stomach - Glandular

0 - 0.4

0 - 0.4

References: Chandra M, Toxicol Lett 1992 Jun;61(1):67-74   ⋅   Maita K, Toxicol Pathol 1988;16(3):340-9   ⋅   Yamamoto M, Cancer Lett 2002 May 28;179(2):121-32

Stomach - Glandular adenoma Stomach - Glandular N-methyl-N-nitrosourea (MNU)

48.15

References: Yamamoto M, Cancer Lett 2002 May 28;179(2):121-32

Stomach - Glandular carcinoma Stomach - Glandular

0

0 - 1.7

References: Tannehill-Gregg SH, Toxicol Sci 2007 Jul;98(1):258-70

Stomach - Glandular carcinoma Stomach - Glandular muraglitazar

0

0

References: Tannehill-Gregg SH, Toxicol Sci 2007 Jul;98(1):258-70

Stomach - Glandular papilloma Stomach - Glandular

0

0.3

References: Chandra M, Toxicol Lett 1992 Jun;61(1):67-74

Stomach - Glandular tumor Stomach - Glandular N-methyl-N-nitrosourea (MNU)

observed

References: Yamamoto M, Cancer Lett 2002 May 28;179(2):121-32

Stomach - Glandular tumor Stomach - Glandular

0

References: Yamamoto M, Cancer Lett 2002 May 28;179(2):121-32

Stomach adenocarcinoma Stomach N-methyl-N-nitrosourea (MNU)

17.86

References: Yamamoto M, Cancer Lett 2002 May 28;179(2):121-32

Stomach adenoma Stomach

1.0

References: Baldrick P, Toxicol Pathol 2007;35(4):562-9

Stomach squamous cell papilloma Stomach

0.3 - 0.6

0.6

References: Baldrick P, Toxicol Pathol 2007;35(4):562-9

Stomach tumor Stomach N-methyl-N-nitrosourea (MNU)

observed

References: Yamamoto M, Cancer Lett 2002 May 28;179(2):121-32

Testis - Leydig cell (Interstitial cell) hyperplasia Testis - Leydig cell (Interstitial cell) diethylstilbestrol (DES)

1.5 - 6.9

References: Newbold RR, Carcinogenesis 2000 Jul;21(7):1355-63

Testis - Leydig cell (Interstitial cell) hyperplasia Testis - Leydig cell (Interstitial cell)

observed

References: Baldrick P, Toxicol Pathol 2007;35(4):562-9

Testis - Leydig cell (Interstitial cell) tumor Testis - Leydig cell (Interstitial cell)

0 - 2.1

References: Chandra M, Toxicol Lett 1992 Jun;61(1):67-74   ⋅   Diwan BA, Toxicol Appl Pharmacol 1999 Nov 15;161(1):82-99   ⋅   Maita K, Toxicol Pathol 1988;16(3):340-9   ⋅   Newbold RR, Carcinogenesis 2000 Jul;21(7):1355-63

Testis - Leydig cell (Interstitial cell) tumor Testis - Leydig cell (Interstitial cell) diethylstilbestrol (DES)

1.5 - 3.2

References: Newbold RR, Carcinogenesis 2000 Jul;21(7):1355-63

Testis - Leydig cell (Interstitial cell) tumor Testis - Leydig cell (Interstitial cell) 3'-azido-3'-deoxythymidine (AZT)

0 - 15.4

References: Diwan BA, Toxicol Appl Pharmacol 1999 Nov 15;161(1):82-99

Testis - Leydig cell (Interstitial cell) tumor Testis - Leydig cell (Interstitial cell) sodium barbital (BB)   ⋅   3'-azido-3'-deoxythymidine (AZT)

0

References: Diwan BA, Toxicol Appl Pharmacol 1999 Nov 15;161(1):82-99

Testis - Leydig cell (Interstitial cell) tumor Testis - Leydig cell (Interstitial cell) sodium barbital (BB)

0 - 9.1

References: Diwan BA, Toxicol Appl Pharmacol 1999 Nov 15;161(1):82-99

Testis - Leydig cell (Interstitial cell) tumor - benign Testis - Leydig cell (Interstitial cell)

0 - 1.9

References: Baldrick P, Toxicol Pathol 2007;35(4):562-9   ⋅   Chandra M, Toxicol Lett 1992 Jun;61(1):67-74   ⋅   Tannehill-Gregg SH, Toxicol Sci 2007 Jul;98(1):258-70

Testis - Leydig cell (Interstitial cell) tumor - benign Testis - Leydig cell (Interstitial cell) muraglitazar

0 - 3.3

References: Tannehill-Gregg SH, Toxicol Sci 2007 Jul;98(1):258-70

Testis - Leydig cell (Interstitial cell) tumor - malignant Testis - Leydig cell (Interstitial cell)

0.1

References: Chandra M, Toxicol Lett 1992 Jun;61(1):67-74

Sites of Metastasis: Lung

Testis - Rete testis adenoma Testis - Rete testis

0 - 1.7

References: Baldrick P, Toxicol Pathol 2007;35(4):562-9   ⋅   Tannehill-Gregg SH, Toxicol Sci 2007 Jul;98(1):258-70

Testis - Rete testis adenoma Testis - Rete testis muraglitazar

0

References: Tannehill-Gregg SH, Toxicol Sci 2007 Jul;98(1):258-70

Testis - Rete testis hyperplasia Testis - Rete testis

5.7

References: Newbold RR, Carcinogenesis 2000 Jul;21(7):1355-63

Testis - Rete testis hyperplasia Testis - Rete testis diethylstilbestrol (DES)

7.7 - 35

References: Newbold RR, Carcinogenesis 2000 Jul;21(7):1355-63

Testis - Rete testis hyperplasia - lipoid Testis - Rete testis diethylstilbestrol (DES)

1.9

References: Newbold RR, Carcinogenesis 2000 Jul;21(7):1355-63

Testis - Rete testis tumor Testis - Rete testis diethylstilbestrol (DES)

1.2 - 1.9

References: Newbold RR, Carcinogenesis 2000 Jul;21(7):1355-63

Testis - Seminiferous tubules hyperplasia Testis - Seminiferous tubules diethylstilbestrol (DES)

1.4

References: Newbold RR, Carcinogenesis 2000 Jul;21(7):1355-63

Testis - Stroma tumor Testis - Stroma

0.1

References: Maita K, Toxicol Pathol 1988;16(3):340-9

Testis adenoma - papillary Testis

0.1

References: Maita K, Toxicol Pathol 1988;16(3):340-9

Thymus cyst Thymus

observed

References: Baldrick P, Toxicol Pathol 2007;35(4):562-9

Thymus thymoma Thymus

0 - 0.7

0.1

1.6

References: Baldrick P, Toxicol Pathol 2007;35(4):562-9   ⋅   Lavigueur A, Mol Cell Biol 1989 Sep;9(9):3982-91   ⋅   Maita K, Toxicol Pathol 1988;16(3):340-9

Thyroid gland - Follicular cell adenoma Thyroid gland - Follicular cell

0 - 1.7

0 - 3.3

References: Baldrick P, Toxicol Pathol 2007;35(4):562-9   ⋅   Chandra M, Toxicol Lett 1992 Jun;61(1):67-74   ⋅   Tannehill-Gregg SH, Toxicol Sci 2007 Jul;98(1):258-70

Thyroid gland - Follicular cell adenoma Thyroid gland - Follicular cell muraglitazar

0 - 1.7

0 - 1.7

References: Tannehill-Gregg SH, Toxicol Sci 2007 Jul;98(1):258-70

Thyroid gland - Follicular cell adenoma Thyroid gland - Follicular cell sodium barbital (BB)   ⋅   3'-azido-3'-deoxythymidine (AZT)

5.6

References: Diwan BA, Toxicol Appl Pharmacol 1999 Nov 15;161(1):82-99

Thyroid gland - Follicular cell adenoma Thyroid gland - Follicular cell sodium barbital (BB)

5.7

References: Diwan BA, Toxicol Appl Pharmacol 1999 Nov 15;161(1):82-99

Thyroid gland - Follicular cell cyst Thyroid gland - Follicular cell

observed

References: Baldrick P, Toxicol Pathol 2007;35(4):562-9

Thyroid gland - Medulla - C cell adenoma Thyroid gland - Medulla - C cell 3'-azido-3'-deoxythymidine (AZT)

1.9

References: Diwan BA, Toxicol Appl Pharmacol 1999 Nov 15;161(1):82-99

Thyroid gland adenocarcinoma Thyroid gland sodium arsenite   ⋅   diethylstilbestrol (DES)

3.0

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Thyroid gland adenoma Thyroid gland

0.7

0.9

References: Maita K, Toxicol Pathol 1988;16(3):340-9

Thyroid gland tumor Thyroid gland 3'-azido-3'-deoxythymidine (AZT)

0.9

References: Diwan BA, Toxicol Appl Pharmacol 1999 Nov 15;161(1):82-99

Tongue squamous cell papilloma Tongue

0.8 - 1.5

References: Baldrick P, Toxicol Pathol 2007;35(4):562-9

Tooth ameloblastoma Tooth

100

References: Tannehill-Gregg SH, Toxicol Sci 2007 Jul;98(1):258-70

Tooth tumor - benign Oral cavity

100

References: Baldrick P, Toxicol Pathol 2007;35(4):562-9

Urinary bladder - Transitional cell carcinoma - undifferentiated Urinary bladder - Transitional cell sodium arsenite   ⋅   diethylstilbestrol (DES)

observed

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Urinary bladder transitional cell carcinoma Urinary bladder

0 - 0.3

0 - 0.1

References: Chandra M, Toxicol Lett 1992 Jun;61(1):67-74   ⋅   Maita K, Toxicol Pathol 1988;16(3):340-9   ⋅   Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Urinary bladder transitional cell carcinoma Urinary bladder sodium arsenite

0

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Urinary bladder transitional cell carcinoma Urinary bladder diethylstilbestrol (DES)

0

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Urinary bladder transitional cell carcinoma Urinary bladder tamoxifen (TAM)

0

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Urinary bladder transitional cell carcinoma Urinary bladder sodium arsenite   ⋅   diethylstilbestrol (DES)

9.1

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Urinary bladder transitional cell carcinoma Urinary bladder sodium arsenite   ⋅   tamoxifen (TAM)

0

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Urinary bladder transitional cell hyperplasia Urinary bladder

3.0

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Urinary bladder transitional cell hyperplasia Urinary bladder sodium arsenite

15

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Urinary bladder transitional cell hyperplasia Urinary bladder diethylstilbestrol (DES)

3.0

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Urinary bladder transitional cell hyperplasia Urinary bladder tamoxifen (TAM)

0

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Urinary bladder transitional cell hyperplasia Urinary bladder sodium arsenite   ⋅   diethylstilbestrol (DES)

30

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Urinary bladder transitional cell hyperplasia Urinary bladder sodium arsenite   ⋅   tamoxifen (TAM)

26

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Urinary bladder transitional cell papilloma Urinary bladder

0

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Urinary bladder transitional cell papilloma Urinary bladder sodium arsenite

0

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Urinary bladder transitional cell papilloma Urinary bladder diethylstilbestrol (DES)

0

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Urinary bladder transitional cell papilloma Urinary bladder tamoxifen (TAM)

0

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Urinary bladder transitional cell papilloma Urinary bladder sodium arsenite   ⋅   diethylstilbestrol (DES)

0

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Urinary bladder transitional cell papilloma Urinary bladder sodium arsenite   ⋅   tamoxifen (TAM)

2.9

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Urinary bladder tumor Urinary bladder

2.0

References: Takahashi O, Toxicology 1997 Dec 26;124(2):95-103

Uterus - Cervix - Stroma polyp Uterus - Cervix - Stroma

0 - 1.7

References: Baldrick P, Toxicol Pathol 2007;35(4):562-9   ⋅   Tannehill-Gregg SH, Toxicol Sci 2007 Jul;98(1):258-70

Uterus - Cervix - Stroma polyp Uterus - Cervix - Stroma muraglitazar

0 - 3.6

References: Tannehill-Gregg SH, Toxicol Sci 2007 Jul;98(1):258-70

Uterus - Cervix adenoma Uterus - Cervix

0

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Uterus - Cervix adenoma Uterus - Cervix sodium arsenite

0

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Uterus - Cervix adenoma Uterus - Cervix diethylstilbestrol (DES)

0

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Uterus - Cervix adenoma Uterus - Cervix tamoxifen (TAM)

0

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Uterus - Cervix adenoma Uterus - Cervix sodium arsenite   ⋅   diethylstilbestrol (DES)

0

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Uterus - Cervix adenoma Uterus - Cervix sodium arsenite   ⋅   tamoxifen (TAM)

0

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Uterus - Cervix atypia Uterus - Cervix diethylstilbestrol (DES)

2.9 - 8.3

References: McLachlan JA, Cancer Res 1980 Nov;40(11):3988-99

Uterus - Cervix carcinoma Uterus - Cervix diethylstilbestrol (DES)

4.2 - 18

References: Newbold RR, Carcinogenesis 1998 Sep;19(9):1655-63   ⋅   Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Uterus - Cervix carcinoma Uterus - Cervix

0 - 1.7

References: Tannehill-Gregg SH, Toxicol Sci 2007 Jul;98(1):258-70   ⋅   Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Uterus - Cervix carcinoma Uterus - Cervix sodium arsenite

0

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Uterus - Cervix carcinoma Uterus - Cervix tamoxifen (TAM)

0

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Uterus - Cervix carcinoma Uterus - Cervix sodium arsenite   ⋅   diethylstilbestrol (DES)

24

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Uterus - Cervix carcinoma Uterus - Cervix sodium arsenite   ⋅   tamoxifen (TAM)

0

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Uterus - Cervix carcinoma Uterus - Cervix muraglitazar

0 - 1.8

References: Tannehill-Gregg SH, Toxicol Sci 2007 Jul;98(1):258-70

Uterus - Cervix cyst - keratinized Uterus - Cervix diethylstilbestrol (DES)

4.5 - 9.1

References: McLachlan JA, Cancer Res 1980 Nov;40(11):3988-99

Uterus - Cervix hyperplasia - stromal Uterus - Cervix diethylstilbestrol (DES)

2.9 - 8.3

References: McLachlan JA, Cancer Res 1980 Nov;40(11):3988-99

Uterus - Cervix metaplasia - squamous Uterus - Cervix

1.2 - 4.2

References: McLachlan JA, Cancer Res 1980 Nov;40(11):3988-99

Uterus - Cervix metaplasia - squamous Uterus - Cervix diethylstilbestrol (DES)

observed - 33

References: McLachlan JA, Cancer Res 1980 Nov;40(11):3988-99

Uterus - Cervix papilloma Uterus - Cervix diethylstilbestrol (DES)

5.3 - 25

References: McLachlan JA, Cancer Res 1980 Nov;40(11):3988-99

Uterus - Cervix squamous cell carcinoma Uterus - Cervix sodium arsenite   ⋅   diethylstilbestrol (DES)

observed

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Uterus - Cervix tumor Uterus - Cervix tamoxifen (TAM)

0

References: Diwan BA, Carcinogenesis 1997 Oct;18(10):2009-14

Uterus - Cervix tumor Uterus - Cervix

0

References: Diwan BA, Carcinogenesis 1997 Oct;18(10):2009-14   ⋅   McLachlan JA, Cancer Res 1980 Nov;40(11):3988-99

Uterus - Cervix tumor Uterus - Cervix diethylstilbestrol (DES)

0 - 50

References: McLachlan JA, Cancer Res 1980 Nov;40(11):3988-99

Uterus - Cervix tumor Uterus - Cervix 3'-azido-3'-deoxythymidine (AZT)

0 - 7.1

References: Diwan BA, Toxicol Appl Pharmacol 1999 Nov 15;161(1):82-99

Uterus - Endometrium - Stroma polyp Uterus - Endometrium - Stroma

0 - 17.6

References: Baldrick P, Toxicol Pathol 2007;35(4):562-9   ⋅   Tannehill-Gregg SH, Toxicol Sci 2007 Jul;98(1):258-70

Uterus - Endometrium - Stroma polyp Uterus - Endometrium - Stroma muraglitazar

0 - 6.7

References: Tannehill-Gregg SH, Toxicol Sci 2007 Jul;98(1):258-70

Uterus - Endometrium adenocarcinoma Uterus - Endometrium

0

References: Newbold RR, Carcinogenesis 1997 Dec;18(12):2293-8

Uterus - Endometrium adenocarcinoma Uterus - Endometrium tamoxifen (TAM)

0 - 50

References: Newbold RR, Carcinogenesis 1997 Dec;18(12):2293-8

Uterus - Endometrium carcinoma Uterus - Endometrium tamoxifen (TAM)

0

References: Diwan BA, Carcinogenesis 1997 Oct;18(10):2009-14

Uterus - Endometrium carcinoma Uterus - Endometrium

0

References: Diwan BA, Carcinogenesis 1997 Oct;18(10):2009-14

Uterus - Endometrium hyperplasia Uterus - Endometrium diethylstilbestrol (DES)

2.7 - 6.7

References: Newbold RR, Carcinogenesis 1998 Sep;19(9):1655-63

Uterus - Endometrium hyperplasia Uterus - Endometrium

observed

References: Baldrick P, Toxicol Pathol 2007;35(4):562-9

Uterus - Endometrium hyperplasia Uterus - Endometrium New western diet (NWD) TD.96096   ⋅   AIN-76A

observed

References: Poutahidis T, Cancer Res 2015 Apr 1;75(7):1197-204

Uterus - Endometrium hyperplasia - atypical Uterus - Endometrium

0

References: Newbold RR, Carcinogenesis 1997 Dec;18(12):2293-8

Uterus - Endometrium hyperplasia - atypical Uterus - Endometrium tamoxifen (TAM)

14 - 25

References: Newbold RR, Carcinogenesis 1997 Dec;18(12):2293-8

Uterus - Endometrium hyperplasia - atypical Uterus - Endometrium diethylstilbestrol (DES)

observed

References: McLachlan JA, Cancer Res 1980 Nov;40(11):3988-99

Uterus - Endometrium hyperplasia - cystic Uterus - Endometrium diethylstilbestrol (DES)

observed - 100

References: Li S, Cancer Res 1997 Oct 1;57(19):4356-9   ⋅   McLachlan JA, Cancer Res 1980 Nov;40(11):3988-99   ⋅   Newbold RR, Carcinogenesis 1998 Sep;19(9):1655-63

Uterus - Endometrium hyperplasia - cystic Uterus - Endometrium

0 - 83

References: McLachlan JA, Cancer Res 1980 Nov;40(11):3988-99   ⋅   Newbold RR, Carcinogenesis 1997 Dec;18(12):2293-8   ⋅   Newbold RR, Carcinogenesis 1998 Sep;19(9):1655-63

Uterus - Endometrium hyperplasia - cystic Uterus - Endometrium tamoxifen (TAM)

21 - 38

References: Newbold RR, Carcinogenesis 1997 Dec;18(12):2293-8

Uterus - Endometrium hyperplasia - cystic Uterus - Endometrium 17beta-estradiol (E2)

0

References: McLachlan JA, Cancer Res 1980 Nov;40(11):3988-99

Uterus - Endometrium hyperplasia - cystic Uterus - Endometrium dimethylstilbestrol (DMS)

10

References: McLachlan JA, Cancer Res 1980 Nov;40(11):3988-99

Uterus - Endometrium polyp Uterus - Endometrium

4.3 - 17

References: Chandra M, Toxicol Lett 1992 Jun;61(1):67-74   ⋅   Newbold RR, Carcinogenesis 1998 Sep;19(9):1655-63

Uterus - Endometrium polyp Uterus - Endometrium diethylstilbestrol (DES)

8.6 - 31

References: Newbold RR, Carcinogenesis 1998 Sep;19(9):1655-63

Uterus adenocarcinoma Uterus

0 - 0.4

References: Chandra M, Toxicol Lett 1992 Jun;61(1):67-74   ⋅   Maita K, Toxicol Pathol 1988;16(3):340-9   ⋅   Newbold RR, Carcinogenesis 1998 Sep;19(9):1655-63

Uterus adenocarcinoma Uterus diethylstilbestrol (DES)

0 - 16

References: McLachlan JA, Cancer Res 1980 Nov;40(11):3988-99   ⋅   Newbold RR, Carcinogenesis 1998 Sep;19(9):1655-63

Sites of Metastasis: Lymph node

Uterus adenocarcinoma Uterus sodium arsenite   ⋅   diethylstilbestrol (DES)

observed

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Uterus adenoma Uterus

0 - 0.6

References: Baldrick P, Toxicol Pathol 2007;35(4):562-9   ⋅   Chandra M, Toxicol Lett 1992 Jun;61(1):67-74   ⋅   Maita K, Toxicol Pathol 1988;16(3):340-9   ⋅   Tannehill-Gregg SH, Toxicol Sci 2007 Jul;98(1):258-70   ⋅   Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Uterus adenoma Uterus sodium arsenite

8.8

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Uterus adenoma Uterus diethylstilbestrol (DES)

0

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Uterus adenoma Uterus tamoxifen (TAM)

0

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Uterus adenoma Uterus sodium arsenite   ⋅   diethylstilbestrol (DES)

0

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Uterus adenoma Uterus sodium arsenite   ⋅   tamoxifen (TAM)

0

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Uterus adenoma Uterus muraglitazar

0 - 1.7

References: Tannehill-Gregg SH, Toxicol Sci 2007 Jul;98(1):258-70

Uterus carcinoma Uterus

0 - 1.7

References: Tannehill-Gregg SH, Toxicol Sci 2007 Jul;98(1):258-70   ⋅   Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Uterus carcinoma Uterus sodium arsenite

5.9

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Uterus carcinoma Uterus diethylstilbestrol (DES)

0

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Uterus carcinoma Uterus tamoxifen (TAM)

5.7

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Uterus carcinoma Uterus sodium arsenite   ⋅   diethylstilbestrol (DES)

21

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Uterus carcinoma Uterus sodium arsenite   ⋅   tamoxifen (TAM)

5.7

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Uterus carcinoma Uterus muraglitazar

0 - 3.3

References: Tannehill-Gregg SH, Toxicol Sci 2007 Jul;98(1):258-70

Uterus dysplasia Uterus tamoxifen (TAM)

observed

References: Diwan BA, Carcinogenesis 1997 Oct;18(10):2009-14

Uterus hyperplasia Uterus tamoxifen (TAM)

0 - 100

References: Diwan BA, Carcinogenesis 1997 Oct;18(10):2009-14

Uterus hyperplasia Uterus

0 - 75

References: Diwan BA, Carcinogenesis 1997 Oct;18(10):2009-14

Uterus hyperplasia - atypical Uterus diethylstilbestrol (DES)

2.9 - 17

References: Newbold RR, Carcinogenesis 1998 Sep;19(9):1655-63

Uterus hyperplasia - atypical - focal Uterus

4.3

References: Newbold RR, Carcinogenesis 1998 Sep;19(9):1655-63

Uterus metaplasia - papillary Uterus diethylstilbestrol (DES)

2.9

References: Newbold RR, Carcinogenesis 1998 Sep;19(9):1655-63

Uterus metaplasia - squamous Uterus tamoxifen (TAM)

0 - 57

References: Diwan BA, Carcinogenesis 1997 Oct;18(10):2009-14   ⋅   Newbold RR, Carcinogenesis 1997 Dec;18(12):2293-8

Uterus metaplasia - squamous Uterus

0 - observed

References: Baldrick P, Toxicol Pathol 2007;35(4):562-9   ⋅   Diwan BA, Carcinogenesis 1997 Oct;18(10):2009-14   ⋅   McLachlan JA, Cancer Res 1980 Nov;40(11):3988-99   ⋅   Newbold RR, Carcinogenesis 1997 Dec;18(12):2293-8

Uterus metaplasia - squamous Uterus diethylstilbestrol (DES)

observed - 30

References: McLachlan JA, Cancer Res 1980 Nov;40(11):3988-99   ⋅   Newbold RR, Carcinogenesis 1998 Sep;19(9):1655-63

Uterus metaplasia - squamous Uterus 17beta-estradiol (E2)

0

References: McLachlan JA, Cancer Res 1980 Nov;40(11):3988-99

Uterus metaplasia - squamous Uterus dimethylstilbestrol (DMS)

20

References: McLachlan JA, Cancer Res 1980 Nov;40(11):3988-99

Uterus papilloma Uterus

0.6

References: Maita K, Toxicol Pathol 1988;16(3):340-9

Uterus polyp Uterus tamoxifen (TAM)

observed

References: Newbold RR, Carcinogenesis 1997 Dec;18(12):2293-8

Uterus polyp Uterus 3'-azido-3'-deoxythymidine (AZT)

3.1 - 9.1

References: Diwan BA, Toxicol Appl Pharmacol 1999 Nov 15;161(1):82-99

Uterus polyp - adenomatous Uterus tamoxifen (TAM)

0 - 30

References: Diwan BA, Carcinogenesis 1997 Oct;18(10):2009-14

Uterus polyp - adenomatous Uterus

0 - 4.2

References: Diwan BA, Carcinogenesis 1997 Oct;18(10):2009-14

Uterus squamous cell carcinoma Uterus

0.1

References: Chandra M, Toxicol Lett 1992 Jun;61(1):67-74

Uterus tumor Uterus

0 - 13.0

References: Diwan BA, Toxicol Appl Pharmacol 1999 Nov 15;161(1):82-99   ⋅   McLachlan JA, Cancer Res 1980 Nov;40(11):3988-99   ⋅   Newbold RR, Carcinogenesis 1998 Sep;19(9):1655-63

Uterus tumor Uterus diethylstilbestrol (DES)

0 - 14

References: McLachlan JA, Cancer Res 1980 Nov;40(11):3988-99

Uterus tumor Uterus 3'-azido-3'-deoxythymidine (AZT)

0 - 21.4

References: Diwan BA, Toxicol Appl Pharmacol 1999 Nov 15;161(1):82-99

Uterus tumor Uterus sodium barbital (BB)   ⋅   3'-azido-3'-deoxythymidine (AZT)

0

References: Diwan BA, Toxicol Appl Pharmacol 1999 Nov 15;161(1):82-99

Uterus tumor Uterus sodium barbital (BB)

0

References: Diwan BA, Toxicol Appl Pharmacol 1999 Nov 15;161(1):82-99

Uterus tumor - granular cell - benign Uterus

0.8

References: Baldrick P, Toxicol Pathol 2007;35(4):562-9

Vagina - Basal cell hyperplasia Vagina - Basal cell diethylstilbestrol (DES)

2.9 - 8.3

References: McLachlan JA, Cancer Res 1980 Nov;40(11):3988-99

Vagina adenocarcinoma Vagina diethylstilbestrol (DES)

2.7 - 8.3

References: McLachlan JA, Cancer Res 1980 Nov;40(11):3988-99   ⋅   Newbold RR, Carcinogenesis 1998 Sep;19(9):1655-63

Vagina adenoma Vagina

0

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Vagina adenoma Vagina sodium arsenite

0

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Vagina adenoma Vagina diethylstilbestrol (DES)

0

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Vagina adenoma Vagina tamoxifen (TAM)

0

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Vagina adenoma Vagina sodium arsenite   ⋅   diethylstilbestrol (DES)

0

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Vagina adenoma Vagina sodium arsenite   ⋅   tamoxifen (TAM)

0

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Vagina carcinoma Vagina

0

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Vagina carcinoma Vagina sodium arsenite

0

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Vagina carcinoma Vagina diethylstilbestrol (DES)

3.0

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Vagina carcinoma Vagina tamoxifen (TAM)

0

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Vagina carcinoma Vagina sodium arsenite   ⋅   diethylstilbestrol (DES)

15

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Vagina carcinoma Vagina sodium arsenite   ⋅   tamoxifen (TAM)

0

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Vagina carcinoma in situ Vagina diethylstilbestrol (DES)

2.7 - 2.8

References: Newbold RR, Carcinogenesis 1998 Sep;19(9):1655-63

Vagina papilloma Vagina diethylstilbestrol (DES)

2.9

References: Newbold RR, Carcinogenesis 1998 Sep;19(9):1655-63

Vagina squamous cell carcinoma Vagina sodium arsenite   ⋅   diethylstilbestrol (DES)

observed

References: Waalkes MP, Cancer Res 2006 Feb 1;66(3):1337-45

Vagina squamous cell hyperplasia Vagina

observed

References: Baldrick P, Toxicol Pathol 2007;35(4):562-9

Vagina tumor Vagina tamoxifen (TAM)

0

References: Diwan BA, Carcinogenesis 1997 Oct;18(10):2009-14   ⋅   Newbold RR, Carcinogenesis 1997 Dec;18(12):2293-8

Vagina tumor Vagina

0

References: Diwan BA, Carcinogenesis 1997 Oct;18(10):2009-14   ⋅   McLachlan JA, Cancer Res 1980 Nov;40(11):3988-99   ⋅   Newbold RR, Carcinogenesis 1997 Dec;18(12):2293-8   ⋅   Newbold RR, Carcinogenesis 1998 Sep;19(9):1655-63

Vagina tumor Vagina diethylstilbestrol (DES)

0 - 25

References: McLachlan JA, Cancer Res 1980 Nov;40(11):3988-99

Vagina tumor - epidermoid Vagina diethylstilbestrol (DES)

observed - 25

References: McLachlan JA, Cancer Res 1980 Nov;40(11):3988-99

Vagina tumor - epithelial Vagina

0

References: Diwan BA, Toxicol Appl Pharmacol 1999 Nov 15;161(1):82-99

Vagina tumor - epithelial Vagina 3'-azido-3'-deoxythymidine (AZT)

0

References: Diwan BA, Toxicol Appl Pharmacol 1999 Nov 15;161(1):82-99

Vagina tumor - epithelial Vagina sodium barbital (BB)   ⋅   3'-azido-3'-deoxythymidine (AZT)

0

References: Diwan BA, Toxicol Appl Pharmacol 1999 Nov 15;161(1):82-99

Vagina tumor - epithelial Vagina sodium barbital (BB)

0

References: Diwan BA, Toxicol Appl Pharmacol 1999 Nov 15;161(1):82-99

(Unspecified organ) histiocytoma - fibrous - malignant Skin

3.2 - 10.9

0 - 1.5

References: Baldrick P, Toxicol Pathol 2007;35(4):562-9

(Unspecified organ) histiocytoma - fibrous - malignant Epididymis

0.1

References: Maita K, Toxicol Pathol 1988;16(3):340-9

(Unspecified organ) histiocytoma - fibrous - malignant Subcutis

0.4

0.3

References: Maita K, Toxicol Pathol 1988;16(3):340-9

(Unspecified organ) lesion (Unspecified organ) diethylstilbestrol (DES)

0

References: McLachlan JA, Cancer Res 1980 Nov;40(11):3988-99

(Unspecified organ) neoplasia (Unspecified organ) New western diet (NWD) TD.96096   ⋅   AIN-76A

observed

References: Poutahidis T, Cancer Res 2015 Apr 1;75(7):1197-204

(Unspecified organ) neoplasm (Unspecified organ)

0 - 86

0 - 83

References: Baldrick P, Toxicol Pathol 2007;35(4):562-9   ⋅   Diwan BA, Toxicol Appl Pharmacol 1999 Nov 15;161(1):82-99

(Unspecified organ) neoplasm (Unspecified organ) 3'-azido-3'-deoxythymidine (AZT)

0 - 22.2

0 - 32.1

References: Diwan BA, Toxicol Appl Pharmacol 1999 Nov 15;161(1):82-99

(Unspecified organ) neoplasm (Unspecified organ) sodium barbital (BB)   ⋅   3'-azido-3'-deoxythymidine (AZT)

0

0 - 8.7

References: Diwan BA, Toxicol Appl Pharmacol 1999 Nov 15;161(1):82-99

(Unspecified organ) neoplasm (Unspecified organ) sodium barbital (BB)

0

0

References: Diwan BA, Toxicol Appl Pharmacol 1999 Nov 15;161(1):82-99

(Unspecified organ) neoplasm - benign (Unspecified organ)

37 - 38

55 - 56

References: Baldrick P, Toxicol Pathol 2007;35(4):562-9

(Unspecified organ) neoplasm - malignant (Unspecified organ)

41 - 49

24 - 28

References: Baldrick P, Toxicol Pathol 2007;35(4):562-9

(Unspecified organ) reticulum cell sarcoma Neck

14

References: McLachlan JA, Cancer Res 1980 Nov;40(11):3988-99

(Unspecified organ) reticulum cell sarcoma Uterus diethylstilbestrol (DES)

8.3

References: McLachlan JA, Cancer Res 1980 Nov;40(11):3988-99

(Unspecified organ) tumor (Unspecified organ) tamoxifen (TAM)

0

References: Diwan BA, Carcinogenesis 1997 Oct;18(10):2009-14

(Unspecified organ) tumor (Unspecified organ)

0 - 53.5

0 - 54.5

References: Chandra M, Toxicol Lett 1992 Jun;61(1):67-74   ⋅   Diwan BA, Toxicol Appl Pharmacol 1999 Nov 15;161(1):82-99   ⋅   Son WC, Toxicol Lett 2003 Nov 1;145(1):88-98

(Unspecified organ) tumor (Unspecified organ) 3'-azido-3'-deoxythymidine (AZT)

0 - 50

0 - 21.4

References: Diwan BA, Toxicol Appl Pharmacol 1999 Nov 15;161(1):82-99

(Unspecified organ) tumor (Unspecified organ) sodium barbital (BB)   ⋅   3'-azido-3'-deoxythymidine (AZT)

7.7 - 52.2

14.3 - 17.4

References: Diwan BA, Toxicol Appl Pharmacol 1999 Nov 15;161(1):82-99

(Unspecified organ) tumor (Unspecified organ) sodium barbital (BB)

16.7 - 45

0 - 4.5

References: Diwan BA, Toxicol Appl Pharmacol 1999 Nov 15;161(1):82-99

(Unspecified organ) tumor - benign (Unspecified organ)

29.4

38.1

References: Chandra M, Toxicol Lett 1992 Jun;61(1):67-74

(Unspecified organ) tumor - malignant (Unspecified organ)

24.1

16.4

References: Chandra M, Toxicol Lett 1992 Jun;61(1):67-74

(Unspecified organ) tumor - mesenchymal Back diethylstilbestrol (DES)

8.3

References: McLachlan JA, Cancer Res 1980 Nov;40(11):3988-99