Reference SummaryChandra M, Toxicol Lett 1992 Jun;61(1):67-74
Title |
Spontaneous neoplasms in aged CD-1 mice. | ||||
Authors |
Chandra M; Frith CH | ||||
Journal |
Toxicol Lett | ||||
Volume |
61 | ||||
Issue |
1 | ||||
Year |
1992 | ||||
Pages |
67-74 | ||||
Abstract |
Spontaneous neoplasms in untreated control CD-1 mice (725 males and 725 females) used in carcinogenicity studies were evaluated and tabulated. The most common neoplasms in male mice were alveolar-bronchiolar adenomas (19.3%) followed by hepatocellular adenomas (11.0%), lymphoreticular neoplasms (6.8%), hepatocellular carcinomas (5.7%), Harderian gland adenomas (2.9%), alveolar-bronchiolar carcinomas (2.5%), and testicular interstitial cell tumors (1.9%). In the females, the most frequently occurring neoplasms were lymphoreticular neoplasms (16.4%) followed by alveolar-bronchiolar adenomas (12.3%), uterine endometrial polyps (4.3%), uterine leiomyomas (3.5%), mammary adenocarcinomas (2.5%), hepatocellular adenomas (1.8%), hemangiomas (1.7%), Harderian adenomas (1.7%), alveolar-bronchiolar carcinomas (1.5%), and pituitary adenomas (1.1%). Tumors in other various organs were found at a low incidence. | ||||
Links |
J:166041 – MGI References 1609440 – National Library of Medicine/PubMed |
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Strain Notes
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| Strain | Model Name | Treatment Agent(s) | Organ Affected | Frequency | Model Details |
|---|---|---|---|---|---|
| CD-1 | Adrenal gland - Cortex adenoma | Adrenal gland - Cortex |
0.1 - 0.4 |
||
| CD-1 | Adrenal gland - Medulla pheochromocytoma | Adrenal gland - Medulla |
0 - 0.1 |
||
| CD-1 | Blood vessel hemangioma | Blood vessel |
0.8 - 1.7 |
||
| CD-1 | Blood vessel hemangiosarcoma | Blood vessel |
0.6 - 0.8 |
||
| CD-1 | Bone osteoma | Bone |
0 |
||
| CD-1 | Bone osteoma | Bone - Rib |
0.1 |
||
| CD-1 | Bone osteosarcoma | Bone |
0 |
||
| CD-1 | Bone osteosarcoma | Bone - Rib |
0.3 |
||
| CD-1 | Connective tissue - Fibroblast fibrosarcoma | Spleen |
0 - 0.1 |
||
| CD-1 | Connective tissue - Fibroblast fibrosarcoma | Vagina |
0.1 |
||
| CD-1 | Eye - Harderian gland adenocarcinoma | Eye - Harderian gland |
0.1 |
||
| CD-1 | Eye - Harderian gland adenoma | Eye - Harderian gland |
1.5 - 2.8 |
||
| CD-1 | Intestine - Small Intestine adenocarcinoma | Intestine - Small Intestine |
0.1 |
||
| CD-1 | Kidney carcinoma | Kidney |
0.1 |
||
| CD-1 | Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma | Leukocyte - Monocyte - Macrophage - Histiocyte |
2.3 - 5.5 |
||
| CD-1 | Leukocyte lymphoma - lymphocytic | Leukocyte |
4.3 - 9.1 |
||
| CD-1 | Leukocyte lymphoma - mixed | Leukocyte |
0.1 - 1.8 |
||
| CD-1 | Leukocyte neoplasm | Leukocyte |
6.8 - 16.4 |
||
| CD-1 | Liver hepatocellular adenoma | Liver |
1.8 - 11.0 |
||
| CD-1 | Liver hepatocellular carcinoma | Liver |
0.7 - 5.7 |
||
| CD-1 | Liver hepatocellular tumor | Liver |
2.5 - 16.7 |
||
| CD-1 | Lung adenoma | Lung |
12.3 - 19.3 |
||
| CD-1 | Lung carcinoma | Lung |
1.5 - 2.5 |
||
| CD-1 | Mammary gland adenocarcinoma | Mammary gland |
0.1 - 2.5 |
||
| CD-1 | Mammary gland adenoma | Mammary gland |
0 - 0.3 |
||
| CD-1 | Mesodermal cell/mesoblast sarcoma - undifferentiated | Epididymis |
0.1 |
||
| CD-1 | Mesothelium mesothelioma | Lung |
0 - 0.1 |
||
| CD-1 | Muscle - Smooth leiomyoma | Uterus |
3.4 |
||
| CD-1 | Muscle - Smooth leiomyoma | Uterus - Cervix |
0.1 |
||
| CD-1 | Muscle - Smooth leiomyosarcoma | Uterus - Cervix |
0.1 |
||
| CD-1 | Ovary - Granulosa cell tumor | Ovary - Granulosa cell |
0.1 |
||
| CD-1 | Ovary - Theca cell tumor | Ovary - Theca cell |
0.3 |
||
| CD-1 | Ovary adenoma | Ovary |
0.4 |
||
| CD-1 | Ovary cystadenoma - papillary | Ovary |
0.7 |
||
| CD-1 | PNS - Schwann cell schwannoma | Heart |
0 - 0.1 |
||
| CD-1 | Pancreas - Islet of Langerhans adenoma | Pancreas - Islet of Langerhans |
0.1 |
||
| CD-1 | Parathyroid gland adenoma | Parathyroid gland |
0.1 - 0.3 |
||
| CD-1 | Pituitary gland - Anterior adenoma | Pituitary gland - Anterior |
0 - 1.1 |
||
| CD-1 | Prostate gland adenoma | Prostate gland |
0.1 |
||
| CD-1 | Seminal vesicle adenoma | Seminal vesicle |
0.1 |
||
| CD-1 | Skin - Epidermis - Basal cell tumor | Skin - Epidermis - Basal cell |
0 - 0.1 |
||
| CD-1 | Stomach - Glandular adenocarcinoma | Stomach - Glandular |
0 - 0.3 |
||
| CD-1 | Stomach - Glandular adenoma | Stomach - Glandular |
0.4 |
||
| CD-1 | Stomach - Glandular papilloma | Stomach - Glandular |
0 - 0.3 |
||
| CD-1 | Testis - Leydig cell (Interstitial cell) tumor | Testis - Leydig cell (Interstitial cell) |
2.1 |
||
| CD-1 | Testis - Leydig cell (Interstitial cell) tumor - benign | Testis - Leydig cell (Interstitial cell) |
1.9 |
||
| CD-1 | Testis - Leydig cell (Interstitial cell) tumor - malignant | Testis - Leydig cell (Interstitial cell) |
0.1 |
||
| CD-1 | Thyroid gland - Follicular cell adenoma | Thyroid gland - Follicular cell |
0.1 - 0.6 |
||
| CD-1 | Urinary bladder transitional cell carcinoma | Urinary bladder |
0 - 0.3 |
||
| CD-1 | Uterus - Endometrium polyp | Uterus - Endometrium |
4.3 |
||
| CD-1 | Uterus adenocarcinoma | Uterus |
0.3 |
||
| CD-1 | Uterus adenoma | Uterus |
0.1 |
||
| CD-1 | Uterus squamous cell carcinoma | Uterus |
0.1 |
||
| CD-1 | (Unspecified organ) tumor | (Unspecified organ) |
0 - 54.5 |
||
| CD-1 | (Unspecified organ) tumor - benign | (Unspecified organ) |
29.4 - 38.1 |
||
| CD-1 | (Unspecified organ) tumor - malignant | (Unspecified organ) |
16.4 - 24.1 |