Reference SummaryChandra M, Toxicol Pathol 1991;19(2):164-7
Title |
Spontaneously occurring leiomyosarcomas of the mouse urinary bladder. |
Authors |
Chandra M; Frith CH |
Journal |
Toxicol Pathol |
Volume |
19 |
Issue |
2 |
Year |
1991 |
Pages |
164-7 |
Abstract |
Spontaneous leiomyosarcomas of the mouse urinary bladder have not been reported. Data from 8 chronic toxicity/oncogenicity studies that included 400 male and 400 female mice were reviewed and evaluated to gather information on spontaneously occurring urinary bladder leiomyosarcomas. Three control mice from 3 different studies had leiomyosarcomas in the submucosa of the trigone area of the urinary bladder. These tumors were not connected to the surface epithelium; however, they were connected to and destroyed the smooth muscle layer of the urinary bladder. This communication describes the incidence and histopathological features of these neoplasms. |
Links |
J:166043 – MGI References 1771368 – National Library of Medicine/PubMed |
| Strain | Model Name | Treatment Agent(s) | Organ Affected | Frequency | Model Details |
|---|---|---|---|---|---|
| CD-1 | Muscle - Smooth leiomyosarcoma | Urinary bladder |
0 - 0.75 |