Reference SummaryPoutahidis T, Cancer Res 2015 Apr 1;75(7):1197-204
Title |
Dietary microbes modulate transgenerational cancer risk. |
Authors |
Poutahidis T; Varian BJ; Levkovich T; Lakritz JR; Mirabal S; Kwok C; Ibrahim YM; Kearney SM; Chatzigiagkos A; Alm EJ; Erdman SE |
Journal |
Cancer Res |
Volume |
75 |
Issue |
7 |
Year |
2015 |
Pages |
1197-204 |
Abstract |
Environmental factors are suspected in the increase of obesity and cancer in industrialized countries but are poorly understood. Here, we used animal models to test how future generations may be affected by Westernized diets. We discover long-term consequences of grandmothers' in utero dietary exposures, leading to high rates of obesity and frequent cancers of lung and liver in two subsequent generations of mice. Transgenerational effects were transplantable using diet-associated bacteria communities alone. Consequently, feeding of beneficial microbes was sufficient to lower transgenerational risk for cancer and obesity regardless of diet history. Targeting microbes may be a highly effective population-based approach to lower risk for cancer. Cancer Res; 75(7); 1197-204. (c)2015 AACR. |
Links |
J:220156 – MGI References 25716681 – National Library of Medicine/PubMed |
| Strain | Model Name | Treatment Agent(s) | Organ Affected | Frequency | Model Details |
|---|---|---|---|---|---|
| CD-1 | Blood vessel hemangiosarcoma |
|
Liver |
observed |
|
| CD-1 | Intestine - Small Intestine adenoma |
|
Intestine - Small Intestine |
observed |
|
| CD-1 | Intestine tumor |
|
Intestine |
0 |
|
| CD-1 | Intestine tumor |
|
Intestine |
0 - 10 |
|
| CD-1 | Intestine tumor |
|
Intestine |
0 |
|
| CD-1 | Leukocyte lymphoma |
|
Spleen |
observed |
|
| CD-1 | Leukocyte lymphoma |
|
Lymph node - Mesenteric |
observed |
|
| CD-1 | Leukocyte lymphoma |
|
Leukocyte |
55 |
|
| CD-1 | Leukocyte lymphoma |
|
Lymph node - Mesenteric |
observed |
|
| CD-1 | Leukocyte lymphoma - lymphoblastic |
|
Adipose tissue |
observed |
|
| CD-1 | Liver - Hepatocyte neoplasia |
|
Liver - Hepatocyte |
observed |
|
| CD-1 | Liver carcinoma |
|
Liver |
observed |
|
| CD-1 | Liver hepatocellular adenoma |
|
Liver |
0 - 10 |
|
| CD-1 | Liver hepatocellular adenoma |
|
Liver |
0 - 10 |
|
| CD-1 | Liver hepatocellular adenoma |
|
Liver |
0 |
|
| CD-1 | Liver hepatocellular carcinoma |
|
Liver |
0 - 70 |
|
| CD-1 | Liver hepatocellular carcinoma |
|
Liver |
0 |
|
| CD-1 | Liver hepatocellular carcinoma |
|
Liver |
0 - 10 |
|
| CD-1 | Liver hepatocellular carcinoma |
|
Liver |
0 |
|
| CD-1 | Liver neoplasm |
|
Liver |
observed |
|
| CD-1 | Liver tumor |
|
Liver |
0 - 10 |
|
| CD-1 | Liver tumor |
|
Liver |
60 - 80 |
|
| CD-1 | Liver tumor |
|
Liver |
0 - 5 |
|
| CD-1 | Liver tumor |
|
Liver |
10 |
|
| CD-1 | Lung adenocarcinoma |
|
Lung |
observed - 55 |
|
| CD-1 | Lung adenocarcinoma |
|
Lung |
observed |
|
| CD-1 | Lung adenocarcinoma - acinar |
|
Lung |
observed |
|
| CD-1 | Lung adenocarcinoma - papillary |
|
Lung |
observed |
|
| CD-1 | Lung adenocarcinoma - well-differentiated |
|
Lung |
observed |
|
| CD-1 | Lung adenoma |
|
Lung |
0 - 30 |
|
| CD-1 | Lung adenoma |
|
Lung |
0 - 10 |
|
| CD-1 | Lung adenoma |
|
Lung |
5 |
|
| CD-1 | Lung adenoma |
|
Lung |
0 - 10 |
|
| CD-1 | Lung carcinoma |
|
Lung |
40 - 80 |
|
| CD-1 | Lung carcinoma |
|
Lung |
0 |
|
| CD-1 | Lung carcinoma |
|
Lung |
0 |
|
| CD-1 | Lung carcinoma |
|
Lung |
0 |
|
| CD-1 | Lung neoplasm |
|
Lung |
observed |
|
| CD-1 | Lung tumor |
|
Lung |
0 - 10 |
|
| CD-1 | Lung tumor |
|
Lung |
0 - 80 |
|
| CD-1 | Lung tumor |
|
Lung |
5 |
|
| CD-1 | Lung tumor |
|
Lung |
10 |
|
| CD-1 | Lymph node tumor |
|
Lymph node |
0 - 30 |
|
| CD-1 | Lymph node tumor |
|
Lymph node |
30 - 80 |
|
| CD-1 | Lymph node tumor |
|
Lymph node |
10 - 20 |
|
| CD-1 | Lymph node tumor |
|
Lymph node |
30 |
|
| CD-1 | Mammary gland adenocarcinoma |
|
Mammary gland |
observed |
|
| CD-1 | Mammary gland carcinoma |
|
Mammary gland |
observed |
|
| CD-1 | Mammary gland neoplasia - epithelial |
|
Mammary gland |
observed |
|
| CD-1 | Mammary gland tumor |
|
Mammary gland |
0 |
|
| CD-1 | Mammary gland tumor |
|
Mammary gland |
20 |
|
| CD-1 | Mammary gland tumor |
|
Mammary gland |
0 |
|
| CD-1 | Ovary - Granulosa cell tumor |
|
Ovary - Granulosa cell |
observed - 40 |
|
| CD-1 | Ovary - Granulosa cell tumor |
|
Ovary - Granulosa cell |
0 |
|
| CD-1 | Ovary - Granulosa cell tumor |
|
Ovary - Granulosa cell |
0 |
|
| CD-1 | Ovary - Theca cell thecoma |
|
Ovary - Theca cell |
0 - 10 |
|
| CD-1 | Ovary - Theca cell thecoma |
|
Ovary - Theca cell |
0 |
|
| CD-1 | Ovary - Theca cell thecoma |
|
Ovary - Theca cell |
0 |
|
| CD-1 | Ovary - Theca cell tumor |
|
Ovary - Theca cell |
observed |
|
| CD-1 | Ovary adenoma - cystic |
|
Ovary |
10 - 20 |
|
| CD-1 | Ovary adenoma - cystic |
|
Ovary |
0 |
|
| CD-1 | Ovary adenoma - cystic |
|
Ovary |
0 |
|
| CD-1 | Ovary cyst |
|
Ovary |
observed |
|
| CD-1 | Ovary cystadenoma |
|
Ovary |
observed |
|
| CD-1 | Ovary tumor |
|
Ovary |
0 |
|
| CD-1 | Ovary tumor |
|
Ovary |
20 - 30 |
|
| CD-1 | Ovary tumor |
|
Ovary |
0 |
|
| CD-1 | Pancreas - Islet of Langerhans adenoma |
|
Pancreas - Islet of Langerhans |
observed |
|
| CD-1 | Pancreas tumor |
|
Pancreas |
0 |
|
| CD-1 | Pancreas tumor |
|
Pancreas |
0 - 10 |
|
| CD-1 | Pancreas tumor |
|
Pancreas |
0 |
|
| CD-1 | Reproductive system (sex not specified) tumor - malignant |
|
Reproductive system (sex not specified) |
observed |
|
| CD-1 | Uterus - Endometrium hyperplasia |
|
Uterus - Endometrium |
observed |
|
| CD-1 | (Unspecified organ) neoplasia |
|
(Unspecified organ) |
observed |