Reference SummaryLifsted T, Int J Cancer 1998 Aug 12;77(4):640-4

Title

 Identification of inbred mouse strains harboring genetic modifiers of mammary tumor age of onset and metastatic progression.

Authors

 Lifsted T; Le Voyer T; Williams M; Muller W; Klein-Szanto A; Buetow KH ; Hunter KW

Journal

 Int J Cancer

Volume

 77

Issue

 4

Year

 1998

Pages

 640-4

Abstract

 Metastasis is one of the most important and complex processes in human neoplastic disease. A large number of both positive and negative events must occur to permit a tumor cell to colonize a distant site successfully. To identify mouse strains that harbor dominant genetic modifiers of this process, a strain survey was initiated utilizing a transgenic mouse mammary tumor model that exhibits a high incidence of pulmonary metastases. The transgenic animal was bred to 27 different inbred strains of mice and scored for the metastatic organ tropism and metastatic density. Thirteen strains were identified that had a statistically significant reduction in the numbers of pulmonary metastases. In addition, 10 strains were identified that altered the kinetics of induction of the primary mammary tumor. These strains will likely provide useful model systems for the analysis of genetic interactions in the initiation and progression of mammary adenocarcinomas. Int. J. Cancer 77:640-644, 1998. (C) 1998 Wiley-Liss, Inc.

Links

 J:48854 – MGI References
9679770 – National Library of Medicine/PubMed

Models
Strain Model Name Treatment Agent(s) Organ Affected Frequency Model Details
FVB/N-Tg(MMTV-PyVT)634Mul Mammary gland tumor Mammary gland

observed
(I/LnJ x FVB/N)F1-Tg(MMTV-PyVT)634Mul Mammary gland tumor Mammary gland

observed
(C58/J x FVB/N)F1-Tg(MMTV-PyVT)634Mul Mammary gland tumor Mammary gland

observed
(LP/J x FVB/N)F1-Tg(MMTV-PyVT)634Mul Mammary gland tumor Mammary gland

observed
(129P3/J x FVB/N)F1-Tg(MMTV-PyVT)634Mul Mammary gland tumor Mammary gland

observed
(A/J x FVB/N)F1-Tg(MMTV-PyVT)634Mul Mammary gland tumor Mammary gland

observed
(BALB/cAnNIcr x FVB/N)F1-Tg(MMTV-PyVT)634Mul Mammary gland tumor Mammary gland

observed
(C3H/HeNIcr x FVB/N)F1-Tg(MMTV-PyVT)634Mul Mammary gland tumor Mammary gland

observed
(DBA/2J x FVB/N)F1-Tg(MMTV-PyVT)634Mul Mammary gland tumor Mammary gland

observed
(NZB/BlNJ x FVB/N)F1-Tg(MMTV-PyVT)634Mul Mammary gland tumor Mammary gland

observed
(C57BR/cdJ x FVB/N)F1-Tg(MMTV-PyVT)634Mul Mammary gland tumor Mammary gland

observed
(C57BL/10J x FVB/N)F1-Tg(MMTV-PyVT)634Mul Mammary gland tumor Mammary gland

observed
(CE/J x FVB/N)F1-Tg(MMTV-PyVT)634Mul Mammary gland tumor Mammary gland

observed
(RF/J x FVB/N)F1-Tg(MMTV-PyVT)634Mul Mammary gland tumor Mammary gland

observed
(SEA/GnJ x FVB/N)F1-Tg(MMTV-PyVT)634Mul Mammary gland tumor Mammary gland

observed
(P/J x FVB/N)F1-Tg(MMTV-PyVT)634Mul Mammary gland tumor Mammary gland

observed
(DBA/1J x FVB/N)F1-Tg(MMTV-PyVT)634Mul Mammary gland tumor Mammary gland

observed
(NZW/LacJ x FVB/N)F1-Tg(MMTV-PyVT)634Mul Mammary gland tumor Mammary gland

observed
(C57BL/6NIcr x FVB/N)F1-Tg(MMTV-PyVT)634Mul Mammary gland tumor Mammary gland

observed
(CAST/Ei x FVB/N)F1-Tg(MMTV-PyVT)634Mul Mammary gland tumor Mammary gland

observed
(NOD/ShiLtJ x FVB/N)F1-Tg(MMTV-PyVT)634Mul Mammary gland tumor Mammary gland

observed
(CBA/CaJ x FVB/N)F1-Tg(MMTV-PyVT)634Mul Mammary gland tumor Mammary gland

observed
(SWR/J x FVB/N)F1-Tg(MMTV-PyVT)634Mul Mammary gland tumor Mammary gland

observed
(AKR/J x FVB/N)F1-Tg(MMTV-PyVT)634Mul Mammary gland tumor Mammary gland

observed
(BUB/BnJ x FVB/N)F1-Tg(MMTV-PyVT)634Mul Mammary gland tumor Mammary gland

observed
(ST/bJ x FVB/N)F1-Tg(MMTV-PyVT)634Mul Mammary gland tumor Mammary gland

observed
(KK/HlJ x FVB/N)F1-Tg(MMTV-PyVT)634Mul Mammary gland tumor Mammary gland

observed
(MOLF/Ei x FVB/N)F1-Tg(MMTV-PyVT)634Mul Mammary gland tumor Mammary gland

observed