Reference SummaryWhite DE, Cancer Cell 2004 Aug;6(2):159-70
Title |
Targeted disruption of beta1-integrin in a transgenic mouse model of human breast cancer reveals an essential role in mammary tumor induction. |
Authors |
White DE; Kurpios NA; Zuo D; Hassell JA; Blaess S; Mueller U; Muller WJ |
Journal |
Cancer Cell |
Volume |
6 |
Issue |
2 |
Year |
2004 |
Pages |
159-70 |
Abstract |
Despite evidence demonstrating the role of beta1-integrin in the regulation of cancer cell proliferation in vitro, the importance of this cell adhesion receptor during the initiation and progression of epithelial tumors in vivo remains unclear. Here we have used the Cre/LoxP1 recombination system to disrupt beta1-integrin function in the mammary epithelium of a transgenic mouse model of human breast cancer. Using this approach, we show that beta1-integrin expression is critical for the initiation of mammary tumorigenesis in vivo, and for maintaining the proliferative capacity of late-stage tumor cells. These observations provide a direct demonstration that beta1-integrin plays a critical role in both the initiation and maintenance of mammary tumor growth in vivo. |
Links |
J:92547 – MGI References 15324699 – National Library of Medicine/PubMed |
| Strain | Model Name | Treatment Agent(s) | Organ Affected | Frequency | Model Details |
|---|---|---|---|---|---|
| FVB/N-Tg(MMTV-PyVT)634Mul | Mammary gland hyperplasia | Mammary gland |
observed |
||
| FVB-Itgb1tm1Mll/+ Tg(MMTV-cre)7Mul Tg(MMTV-PyVT)634Mul | Mammary gland hyperplasia | Mammary gland |
observed |
||
| FVB-Itgb1tm1Mll Tg(MMTV-cre)7Mul Tg(MMTV-PyVT)634Mul | Mammary gland hyperplasia | Mammary gland |
observed |
||
| FVB-Itgb1tm1Mll/+ Gt(ROSA)26Sortm1Sor Tg(MMTV-cre)7Mul Tg(MMTV-PyVT)634Mul | Mammary gland hyperplasia | Mammary gland |
observed |
||
| FVB-Itgb1tm1Mll Gt(ROSA)26Sortm1Sor Tg(MMTV-cre)7Mul Tg(MMTV-PyVT)634Mul | Mammary gland hyperplasia | Mammary gland |
observed |
||
| FVB-Itgb1tm1Mll/+ Tg(MMTV-cre)7Mul Tg(MMTV-PyVT)634Mul | Mammary gland tumor | Mammary gland |
observed |
||
| FVB-Itgb1tm1Mll Tg(MMTV-cre)7Mul Tg(MMTV-PyVT)634Mul | Mammary gland tumor | Mammary gland |
0 - observed |
||
| FVB/N-Tg(MMTV-PyVT)634Mul | Mammary gland tumor | Mammary gland |
observed |
||
| FVB-Itgb1tm1Mll Gt(ROSA)26Sortm1Sor Tg(MMTV-cre)7Mul Tg(MMTV-PyVT)634Mul | Mammary gland tumor | Mammary gland |
observed |
||
| FVB-Itgb1tm1Mll Gt(ROSA)26Sortm1Sor Tg(MMTV-PyVT)634Mul | Mammary gland tumor | Mammary gland |
observed |