Reference SummaryLancaster M, Mamm Genome 2005 Feb;16(2):120-6
Title |
Modifiers of mammary tumor progression and metastasis on mouse chromosomes 7, 9, and 17. |
Authors |
Lancaster M; Rouse J; Hunter KW |
Journal |
Mamm Genome |
Volume |
16 |
Issue |
2 |
Year |
2005 |
Pages |
120-6 |
Abstract |
Tumor progression, the growth and dissemination of primary tumor to secondary sites, is of critical clinical importance since the vast majority of patients succumb to metastatic disease rather than to the primary tumor. Many factors are likely to influence this process, including the primary oncogenic events, environmental exposures and stress and progressive stochastic mutations. Previously, our laboratory demonstrated that an additional factor, the genetic background on which tumors arose, had a significant effect on metastatic efficiency. Using a highly metastatic transgene-induced mammary tumor model, a locus modulating metastatic efficiency, Mtes1, was localized on proximal mouse Chromosome 19. In addition, a number of additional suggestive loci were observed on several other chromosomes. To confirm the presence of these additional loci before initiating cloning strategies, chromosomal substitution strains have been constructed and assayed for modification of the cancer phenotypes. Using the chromosomal substitution strains, an additional modifier modulating tumor latency was confirmed, as well as three new modifier genes that alter the kinetics of tumor progression. Identification and analysis of these loci will likely present interesting and novel information about cancer heterogeneity in the human population. |
Links |
J:97671 – MGI References 15859357 – National Library of Medicine/PubMed |
| Strain | Model Name | Treatment Agent(s) | Organ Affected | Frequency | Model Details |
|---|---|---|---|---|---|
| FVB/N-Tg(MMTV-PyVT)634Mul | Mammary gland tumor | Mammary gland |
observed |
||
| FVB/N-Tg(MMTV-PyVT)634Mu Chr7I/LnJ | Mammary gland tumor | Mammary gland |
observed |
||
| FVB/N-Tg(MMTV-PyVT)634Mu Chr9NZB/B1nJ | Mammary gland tumor | Mammary gland |
observed |
||
| FVB/N-Tg(MMTV-PyVT)634Mu Chr17NZB/B1nJ | Mammary gland tumor | Mammary gland |
observed |
||
| FVB/N-Tg(MMTV-PyVT)634Mu Chr19NZB/B1nJ | Mammary gland tumor | Mammary gland |
observed |
||
| FVB/N-Tg(MMTV-PyVT)634Mu Chr9I/LnJ | Mammary gland tumor | Mammary gland |
observed |
||
| FVB/N-Tg(MMTV-PyVT)634Mul | (Unspecified organ) tumor | (Unspecified organ) |
observed |
||
| FVB/N-Tg(MMTV-PyVT)634Mu Chr7I/LnJ | (Unspecified organ) tumor | (Unspecified organ) |
observed |
||
| FVB/N-Tg(MMTV-PyVT)634Mu Chr9NZB/B1nJ | (Unspecified organ) tumor | (Unspecified organ) |
observed |
||
| FVB/N-Tg(MMTV-PyVT)634Mu Chr17NZB/B1nJ | (Unspecified organ) tumor | (Unspecified organ) |
observed |
||
| FVB/N-Tg(MMTV-PyVT)634Mu Chr19NZB/B1nJ | (Unspecified organ) tumor | (Unspecified organ) |
observed |
||
| FVB/N-Tg(MMTV-PyVT)634Mu Chr9I/LnJ | (Unspecified organ) tumor | (Unspecified organ) |
observed |