Strain SummaryB6129P2F1-Apctm1Rak/+

Strain Name

 B6129P2F1-Apctm1Rak/+

Strain Type(s)

 hybrid  •  targeted mutation (knockout)

Strain Synonym(s)

 Apc1638  •  B6,129-Apctm1Rak/+  •  Apc1638

Description

 Heterozygous mice carrying the Apctm1Rak mutation. The genetic background is 50% C57BL/6J, 50% 129P2/OlaHsd.

Strain Genetics

 Apctm1Rak / Apc+

Models

34 unique models displayed. A model is a set of tumors that share the same tumor name, organ(s) affected, and treatment type for a specific strain.
Frequency
Model Name Organ Affected Tumor Inducing Agent(s) Female Male Mixed Pop. Unspecified Additional Information Model Details
Gastrointestinal tract tumor Gastrointestinal tract

62.5

References: Yang K, J Exp Zool 1997 Feb 15;277(3):245-54

Intestine - Large Intestine - Cecum tumor Intestine - Large Intestine - Cecum

0

References: Fodde R, Proc Natl Acad Sci U S A 1994 Sep 13;91(19):8969-73

Intestine - Large Intestine - Colon - Distal adenocarcinoma Intestine - Large Intestine - Colon - Distal

0

References: Yang K, J Exp Zool 1997 Feb 15;277(3):245-54

Intestine - Large Intestine - Colon - Distal adenoma Intestine - Large Intestine - Colon - Distal

4.2 - 9.1

References: Fodde R, Proc Natl Acad Sci U S A 1994 Sep 13;91(19):8969-73   ⋅   Yang K, J Exp Zool 1997 Feb 15;277(3):245-54

Intestine - Large Intestine - Colon - Distal polyp Intestine - Large Intestine - Colon - Distal

55

References: Fodde R, Proc Natl Acad Sci U S A 1994 Sep 13;91(19):8969-73

Intestine - Large Intestine - Colon - Medial adenocarcinoma Intestine - Large Intestine - Colon - Medial

0

References: Yang K, J Exp Zool 1997 Feb 15;277(3):245-54

Intestine - Large Intestine - Colon - Medial adenoma Intestine - Large Intestine - Colon - Medial

0

References: Yang K, J Exp Zool 1997 Feb 15;277(3):245-54

Intestine - Large Intestine - Colon - Medial polyp Intestine - Large Intestine - Colon - Medial

9.1

References: Fodde R, Proc Natl Acad Sci U S A 1994 Sep 13;91(19):8969-73

Intestine - Large Intestine - Colon - Proximal adenocarcinoma Intestine - Large Intestine - Colon - Proximal

0

References: Yang K, J Exp Zool 1997 Feb 15;277(3):245-54

Intestine - Large Intestine - Colon - Proximal adenoma Intestine - Large Intestine - Colon - Proximal

4.2 - 9.1

References: Fodde R, Proc Natl Acad Sci U S A 1994 Sep 13;91(19):8969-73   ⋅   Yang K, J Exp Zool 1997 Feb 15;277(3):245-54

Intestine - Large Intestine - Colon - Proximal polyp Intestine - Large Intestine - Colon - Proximal

27

References: Fodde R, Proc Natl Acad Sci U S A 1994 Sep 13;91(19):8969-73

Intestine - Large Intestine - Colon dysplasia Intestine - Large Intestine - Colon

17

References: Yang K, J Exp Zool 1997 Feb 15;277(3):245-54

Intestine - Large Intestine - Colon polyp Intestine - Large Intestine - Colon

observed

References: Yang K, J Exp Zool 1997 Feb 15;277(3):245-54

Intestine - Large Intestine - Colon tumor Intestine - Large Intestine - Colon

8.3

References: Yang K, J Exp Zool 1997 Feb 15;277(3):245-54

Intestine - Small Intestine - Duodenum adenocarcinoma Intestine - Small Intestine - Duodenum

observed

References: Yang K, J Exp Zool 1997 Feb 15;277(3):245-54

Intestine - Small Intestine - Duodenum adenoma Intestine - Small Intestine - Duodenum

observed - 36

References: Fodde R, Proc Natl Acad Sci U S A 1994 Sep 13;91(19):8969-73   ⋅   Yang K, J Exp Zool 1997 Feb 15;277(3):245-54

Intestine - Small Intestine - Duodenum carcinoma Intestine - Small Intestine - Duodenum

27

References: Fodde R, Proc Natl Acad Sci U S A 1994 Sep 13;91(19):8969-73

Intestine - Small Intestine - Duodenum dysplasia Intestine - Small Intestine - Duodenum

17

References: Yang K, J Exp Zool 1997 Feb 15;277(3):245-54

Intestine - Small Intestine - Duodenum tumor Intestine - Small Intestine - Duodenum

42

References: Yang K, J Exp Zool 1997 Feb 15;277(3):245-54

Intestine - Small Intestine - Ileum adenocarcinoma Intestine - Small Intestine - Ileum

12.5

References: Yang K, J Exp Zool 1997 Feb 15;277(3):245-54

Intestine - Small Intestine - Ileum adenoma Intestine - Small Intestine - Ileum

4.2 - 9.1

References: Fodde R, Proc Natl Acad Sci U S A 1994 Sep 13;91(19):8969-73   ⋅   Yang K, J Exp Zool 1997 Feb 15;277(3):245-54

Intestine - Small Intestine - Ileum carcinoma Intestine - Small Intestine - Ileum

18

References: Fodde R, Proc Natl Acad Sci U S A 1994 Sep 13;91(19):8969-73

Sites of Metastasis: Liver
Intestine - Small Intestine - Ileum tumor Intestine - Small Intestine - Ileum

17

References: Yang K, J Exp Zool 1997 Feb 15;277(3):245-54

Intestine - Small Intestine - Jejunum adenocarcinoma Intestine - Small Intestine - Jejunum

observed

References: Yang K, J Exp Zool 1997 Feb 15;277(3):245-54

Intestine - Small Intestine - Jejunum adenoma Intestine - Small Intestine - Jejunum

observed - 18

References: Fodde R, Proc Natl Acad Sci U S A 1994 Sep 13;91(19):8969-73   ⋅   Yang K, J Exp Zool 1997 Feb 15;277(3):245-54

Intestine - Small Intestine - Jejunum carcinoma Intestine - Small Intestine - Jejunum

27

References: Fodde R, Proc Natl Acad Sci U S A 1994 Sep 13;91(19):8969-73

Intestine - Small Intestine - Jejunum tumor Intestine - Small Intestine - Jejunum

37.5

References: Yang K, J Exp Zool 1997 Feb 15;277(3):245-54

Intestine dysplasia Intestine

50

References: Yang K, J Exp Zool 1997 Feb 15;277(3):245-54

Stomach - Glandular adenoma Stomach - Glandular

13

References: Fodde R, Proc Natl Acad Sci U S A 1994 Sep 13;91(19):8969-73

Stomach - Glandular carcinoma Stomach - Glandular

13

References: Fodde R, Proc Natl Acad Sci U S A 1994 Sep 13;91(19):8969-73

Stomach adenocarcinoma Stomach

observed

References: Yang K, J Exp Zool 1997 Feb 15;277(3):245-54

Stomach adenoma Stomach

observed

References: Yang K, J Exp Zool 1997 Feb 15;277(3):245-54

Stomach dysplasia Stomach

17

References: Yang K, J Exp Zool 1997 Feb 15;277(3):245-54

Stomach tumor Stomach

25

References: Yang K, J Exp Zool 1997 Feb 15;277(3):245-54