Pathology Image Detail

Caption	Fig. 4C "p63 immunohistochemistry shows an increase in p63-expressing cells in HG PIN lesions in Brca2^F/F;Trp53^F/F;PBCre4 mutant prostates and normal expression in the basal cells of control (Brca2^F/F;Trp53^F/F) prostates. Arrows indicate a cluster of abnormal p63-expressing cells that are rounder and nearer the lumen. ... The anterior prostates of 16-month-old animals are shown."
Description	immunohistochemistry for Trp63 in HG PIN lesions from Brca2;Trp53 homozygous mutant mice compared to normal control prostate
Age at Necropsy	16 months
Notes	Fig. 4C
Contributor	Francis JC (J:161511)
Pathologist	Francis JC (J:161511)
Copyright	This image is from Francis JC, PLoS Genet 2010;6(6):e1000995, an open-access article distributed under the terms of the Creative Commons Attribution License.
Method	IHC for Trp63

Image Probes
Type: antibody	Name anti-p63 (4A4) (sc-8431) Target amino acids 1-205 at the N-terminus of human p63 Supplier Santa Cruz Biotechnology Notes mouse monoclonal IgG2a; "recommended for detection of p63 variants of m[ouse], r[at] and h[uman] origin"

Model

MMHC ID: MTB:46353

Tumor Name: Prostate gland • prostatic intraepithelial neoplasia - high grade (HGPIN)

Treatment Type: None (spontaneous)

Tumor Synonyms: prostate HG PIN; high-grade prostate intraepithelial neoplasia

Organ Affected: Prostate gland

Frequency: 84%

Reference: J:161511

Strain

Strain: [not specified]-Brca2^tm1Brn Tg(Pbsn-cre)4Prb Trp53^tm1Brn

Strain Types: targeted mutation (conditional); transgenic

General Note: Compound mutant mice. The genetic background of these mice was described as a "mixed genetic background" without the involved strains being specified. It included at least some 129P2/OlaHsd and some C57BL/6 and/or DBA/2.

Strain Synonyms: Brca2^F/F;Trp53^F/F;PBCre4; Brca2;Trp53 homozygous mutant

Strain Sex

Male

Reproductive Status

reproductive status not specified

Age of Onset

12 months

Age of Detection

15-19 months