Reference SummaryTrimble MS, Oncogene 1993 Nov;8(11):3037-42

Title

 PEA3 is overexpressed in mouse metastatic mammary adenocarcinomas.

Authors

 Trimble MS; Xin JH; Guy CT; Muller WJ; Hassell JA

Journal

 Oncogene

Volume

 8

Issue

 11

Year

 1993

Pages

 3037-42

Abstract

 Transgenic mice bearing the rat neu proto-oncogene under the transcriptional control of the mouse mammary tumor virus (MMTV) promoter develop focal mammary adenocarcinomas after long latency that are metastatic to the lung in a high percentage of the tumor-bearing animals. Because expression of the neu gene in the mammary epithelium precedes the occurrence of tumors, it appears that another genetic event in addition to neu transgene expression is required for tumorigenesis. We have investigated the expression of PEA3, a new member of the ets oncogene family of transcriptional regulatory factors, in neu-induced mammary tumors to learn whether PEA3 plays a role in tumor progression in this organ. We observed high levels of PEA3 RNA in neu-induced tumors, but little, if any, PEA3 RNA in the surrounding mammary epithelium. Moreover, mammary tumors that had metastasized to the lung also overexpressed the PEA3 gene, whereas normal lung tissue did not. Similar results were obtained after analyses of other transgenic mouse lines bearing metastatic mammary tumors induced by polyomavirus middle T antigen. These findings suggest that enhanced expression of PEA3 may be required to facilitate mammary tumor progression and metastasis.

Links

 J:72260 – MGI References
7692372 – National Library of Medicine/PubMed

Strain Notes

Strain Note
FVB/N-Tg(MMTVneu)169Mul No detectable amounts of Pea3 RNA were observed in normal mammary tissue.
Pea3 not expressed in normal lung tissue.
The transgene was expressed in normal mammary gland tissue.
FVB/N-Tg(MMTVneu)202Mul No detectable amounts of Pea3 RNA were observed in normal mammary tissue.
Pea3 not expressed in normal lung tissue.
The transgene was expressed in normal mammary gland tissue.
FVB/N-Tg(MMTVneu)721Mul No detectable amounts of Pea3 RNA were observed in normal mammary tissue.
Pea3 not expressed in normal lung tissue.
The transgene was expressed in normal mammary gland tissue.

Models
Strain Model Name Treatment Agent(s) Organ Affected Frequency Model Details
FVB/N-Tg(MMTV-PyVT)634Mul Mammary gland adenocarcinoma Mammary gland

high
FVB/N-Tg(MMTV-PyVT)668Mul Mammary gland adenocarcinoma Mammary gland

high
FVB/N-Tg(MMTV-PyVT)121Mul Mammary gland adenocarcinoma Mammary gland

high
FVB/N-Tg(MMTVneu)202Mul Mammary gland adenocarcinoma Mammary gland

50
FVB/N-Tg(MMTVneu)169Mul Mammary gland adenocarcinoma Mammary gland

observed
FVB/N-Tg(MMTVneu)721Mul Mammary gland adenocarcinoma Mammary gland

observed
FVB/N-Tg(MMTVneu)202Mul Mammary gland hyperplasia - cystic Mammary gland

observed