Strain SummaryFVB/NTac-Tg(Hba-x-v-Ha-ras)TG.ACLed
Strain Name |
FVB/NTac-Tg(Hba-x-v-Ha-ras)TG.ACLed |
Strain Type(s) |
transgenic |
Strain Synonym(s) |
FVB/NTac-TgN(TG.AC)#Led • FVB/NTac-Tg(TG.AC)#Led • homozygous FVB/N Tg.AC • homozygous Tg.AC • homozygous v-HA-ras Tg.AC • Tg.AC • Tg.AC homozygous • Tg.AC Taconic Farms • TG • AC • v-HA-ras Tg.AC |
Description |
Homozygous mice. The transgene integrated on chromosome 11. |
Strain Genetics |
Tg(Hba-x-v-Ha-ras)TG.ACLed / Tg(Hba-x-v-Ha-ras)TG.ACLed |
| Frequency | ||||||||
|---|---|---|---|---|---|---|---|---|
| Model Name | Organ Affected | Tumor Inducing Agent(s) | Female | Male | Mixed Pop. | Unspecified | Additional Information | Model Details |
| Erythrocyte leukemia - erythroleukemia | Erythrocyte |
3.3 |
2.8 |
0 |
References: Eastin WC, Toxicol Pathol 2001;29 Suppl():60-80 |
|||
| Erythrocyte leukemia - erythroleukemia | Erythrocyte | cyclophosphamide (Cytoxan) |
0 - 26.7 |
References: Eastin WC, Toxicol Pathol 2001;29 Suppl():60-80 |
||||
| Forestomach lesion | Forestomach | dimethyl vinyl chloride (DMVC) |
100 |
100 |
References: Eastin WC, Toxicol Pathol 2001;29 Suppl():60-80 |
|||
| Forestomach lesion | Forestomach |
21.4 |
46.2 |
References: Eastin WC, Toxicol Pathol 2001;29 Suppl():60-80 |
||||
| Forestomach lesion | Forestomach | reserpine |
33.3 - 42.9 |
30.8 - 63.6 |
References: Eastin WC, Toxicol Pathol 2001;29 Suppl():60-80 |
|||
| Forestomach papilloma | Forestomach |
50 - 66.7 |
44.9 - 66.7 |
References: Eastin WC, Toxicol Pathol 2001;29 Suppl():60-80 |
||||
| Forestomach papilloma | Forestomach | diethylstilbestrol (DES) |
20 - 40 |
26.7 - 60 |
References: Eastin WC, Toxicol Pathol 2001;29 Suppl():60-80 |
|||
| Forestomach squamous cell papilloma | Forestomach |
80 |
57.1 |
References: Eastin WC, Toxicol Pathol 2001;29 Suppl():60-80 |
||||
| Forestomach squamous cell papilloma | Forestomach | melphalan (L-phenylalanine mustard) (L-sarcolysin) |
92.9 - 100 |
93.3 - 100 |
References: Eastin WC, Toxicol Pathol 2001;29 Suppl():60-80 |
|||
| Forestomach tumor | Forestomach |
6.7 - 80 |
0 - 75 |
References: Eastin WC, Toxicol Pathol 2001;29 Suppl():60-80 |
||||
| Forestomach tumor | Forestomach | dimethyl vinyl chloride (DMVC) |
90 - 93.3 |
77.8 - 86.7 |
References: Eastin WC, Toxicol Pathol 2001;29 Suppl():60-80 |
|||
| Forestomach tumor | Forestomach | Cyclosporin A |
27.3 - 40 |
11.1 - 33.3 |
References: Eastin WC, Toxicol Pathol 2001;29 Suppl():60-80 |
|||
| Forestomach tumor | Forestomach | ethinyl estradiol (EE) |
46.7 - 53.3 |
53.3 - 73.3 |
References: Eastin WC, Toxicol Pathol 2001;29 Suppl():60-80 |
|||
| Forestomach tumor | Forestomach | diethylhexylphthalate (DEHP) |
55.6 - 83.3 |
45.5 - 71.4 |
References: Eastin WC, Toxicol Pathol 2001;29 Suppl():60-80 |
|||
| Forestomach tumor | Forestomach | WY-14,643 |
41.7 - 54.5 |
45.5 - 60 |
References: Eastin WC, Toxicol Pathol 2001;29 Suppl():60-80 |
|||
| Forestomach tumor | Forestomach | reserpine |
0 - 50 |
26.7 - 62.5 |
References: Eastin WC, Toxicol Pathol 2001;29 Suppl():60-80 |
|||
| Forestomach tumor | Forestomach | cyclophosphamide (Cytoxan) |
30.8 - 60 |
40 - 57.1 |
References: Eastin WC, Toxicol Pathol 2001;29 Suppl():60-80 |
|||
| Leukocyte leukemia | Leukocyte |
observed |
References: Hansen LA, Carcinogenesis 1996 Sep;17(9):1825-33 |
|||||
| Leukocyte lymphoma | Leukocyte |
0.6 |
1.7 |
References: Eastin WC, Toxicol Pathol 2001;29 Suppl():60-80 |
||||
| Leukocyte tumor | Leukocyte |
0 |
0 |
References: Eastin WC, Toxicol Pathol 2001;29 Suppl():60-80 |
||||
| Leukocyte tumor | Leukocyte | dimethyl vinyl chloride (DMVC) |
0 |
0 |
References: Eastin WC, Toxicol Pathol 2001;29 Suppl():60-80 |
|||
| Leukocyte tumor | Leukocyte | Cyclosporin A |
0 - 23.1 |
0 |
References: Eastin WC, Toxicol Pathol 2001;29 Suppl():60-80 |
|||
| Liver hepatocellular adenoma | Liver | WY-14,643 |
13.3 |
References: Eastin WC, Toxicol Pathol 2001;29 Suppl():60-80 |
||||
| Liver hyperplasia - oval cell | Liver | WY-14,643 |
observed |
References: Eastin WC, Toxicol Pathol 2001;29 Suppl():60-80 |
||||
| Lung - Alveolus hyperplasia - focal | Lung - Alveolus | cyclophosphamide (Cytoxan) |
observed |
References: Eastin WC, Toxicol Pathol 2001;29 Suppl():60-80 |
||||
| Lung tumor | Lung |
2.2 |
1.1 |
References: Eastin WC, Toxicol Pathol 2001;29 Suppl():60-80 |
||||
| Ovary - Corpus luteum hyperplasia | Ovary - Corpus luteum | diethylstilbestrol (DES) |
observed |
References: Eastin WC, Toxicol Pathol 2001;29 Suppl():60-80 |
||||
| Salivary gland carcinoma | Salivary gland |
1.7 |
2.8 |
References: Eastin WC, Toxicol Pathol 2001;29 Suppl():60-80 |
||||
| Salivary gland squamous cell carcinoma | Salivary gland |
observed |
References: Hansen LA, Carcinogenesis 1996 Sep;17(9):1825-33 |
|||||
| Skin - Dermis papilloma | Vulva | melphalan (L-phenylalanine mustard) (L-sarcolysin) |
observed |
References: Eastin WC, Toxicol Pathol 2001;29 Suppl():60-80 |
||||
| Skin - Dorsal region papilloma | Skin - Dorsal region | 12-O-tetradecanoylphorbol-13-acetate (TPA) |
very high - 93.3 |
very high - 100 |
References: Eastin WC, Toxicol Pathol 2001;29 Suppl():60-80 |
|||
| Skin - Dorsal region papilloma | Skin - Dorsal region |
13.3 - 33.3 |
6.7 - 40 |
References: Eastin WC, Toxicol Pathol 2001;29 Suppl():60-80 |
||||
| Skin - Dorsal region papilloma | Skin - Dorsal region | Cyclosporin A |
40 - 73.3 |
33.3 - 46.7 |
References: Eastin WC, Toxicol Pathol 2001;29 Suppl():60-80 |
|||
| Skin - Dorsal region papilloma | Skin - Dorsal region | diethylstilbestrol (DES) |
26.7 - 80 |
0 - 53.3 |
References: Eastin WC, Toxicol Pathol 2001;29 Suppl():60-80 |
|||
| Skin - Dorsal region tumor | Skin - Dorsal region | 12-O-tetradecanoylphorbol-13-acetate (TPA) |
60 - 100 |
60 - 100 |
References: Eastin WC, Toxicol Pathol 2001;29 Suppl():60-80 |
|||
| Skin - Dorsal region tumor | Skin - Dorsal region |
0 - 20 |
0 - 20 |
References: Eastin WC, Toxicol Pathol 2001;29 Suppl():60-80 |
||||
| Skin - Dorsal region tumor | Skin - Dorsal region | ethinyl estradiol (EE) |
46.7 - 86.7 |
0 - 60 |
References: Eastin WC, Toxicol Pathol 2001;29 Suppl():60-80 |
|||
| Skin - Dorsal region tumor | Skin - Dorsal region | diethylhexylphthalate (DEHP) |
0 - 10 |
0 |
References: Eastin WC, Toxicol Pathol 2001;29 Suppl():60-80 |
|||
| Skin - Dorsal region tumor | Skin - Dorsal region | WY-14,643 |
0 - 27.3 |
0 |
References: Eastin WC, Toxicol Pathol 2001;29 Suppl():60-80 |
|||
| Skin - Dorsal region tumor | Skin - Dorsal region | benzene |
86.7 |
93.3 |
References: Eastin WC, Toxicol Pathol 2001;29 Suppl():60-80 |
|||
| Skin - Dorsal region tumor | Skin - Dorsal region | clofibrate |
0 - 100 |
66.7 - 80 |
References: Eastin WC, Toxicol Pathol 2001;29 Suppl():60-80 |
|||
| Skin - Dorsal region tumor | Skin - Dorsal region | methapyrilene |
0 |
0 - 6.7 |
References: Eastin WC, Toxicol Pathol 2001;29 Suppl():60-80 |
|||
| Skin - Dorsal region tumor | Skin - Dorsal region | reserpine |
6.7 - 20 |
6.7 - 26.7 |
References: Eastin WC, Toxicol Pathol 2001;29 Suppl():60-80 |
|||
| Skin - Dorsal region tumor | Skin - Dorsal region | phenacetin |
6.7 |
0 - 13.3 |
References: Eastin WC, Toxicol Pathol 2001;29 Suppl():60-80 |
|||
| Skin - Dorsal region tumor | Skin - Dorsal region | melphalan (L-phenylalanine mustard) (L-sarcolysin) |
6.7 - 20 |
0 - 40 |
References: Eastin WC, Toxicol Pathol 2001;29 Suppl():60-80 |
|||
| Skin - Dorsal region tumor | Skin - Dorsal region | cyclophosphamide (Cytoxan) |
0 - 13.3 |
0 - 20 |
References: Eastin WC, Toxicol Pathol 2001;29 Suppl():60-80 |
|||
| Skin carcinoma | Skin - Dorsal region | 12-O-tetradecanoylphorbol-13-acetate (TPA) |
observed |
References: Tober KL, Biochem Biophys Res Commun 1998 Jun 29;247(3):644-53 |
||||
| Skin carcinoma | Skin | wounding |
observed |
References: Tober KL, Biochem Biophys Res Commun 1998 Jun 29;247(3):644-53 |
||||
| Skin hyperplasia | Skin | wounding |
observed |
References: Cannon RE, Mol Carcinog 1997 Sep;20(1):108-14 |
||||
| Skin papilloma | Skin | wounding |
100 |
References: Cannon RE, Mol Carcinog 1997 Sep;20(1):108-14 |
||||
| Skin papilloma | Skin |
0 - 60 |
References: Spalding JW, Toxicol Sci 1999 Jun;49(2):241-54 ⋅ Tober KL, Biochem Biophys Res Commun 1998 Jun 29;247(3):644-53 |
|||||
| Skin papilloma | Skin - Dorsal region | 12-O-tetradecanoylphorbol-13-acetate (TPA) |
observed - very high |
References: Hansen LA, Carcinogenesis 1996 Sep;17(9):1825-33 ⋅ Tober KL, Biochem Biophys Res Commun 1998 Jun 29;247(3):644-53 |
||||
| Skin papilloma | Skin - Dorsal region | ultraviolet radiation (UV) |
0 - 100 |
References: Trempus CS, J Invest Dermatol 1998 Sep;111(3):445-51 |
||||
| Skin papilloma | Skin | benzene |
70 - 100 |
References: Spalding JW, Toxicol Sci 1999 Jun;49(2):241-54 |
||||
| Skin papilloma | Skin | 12-O-tetradecanoylphorbol-13-acetate (TPA) |
observed - 100 |
85 |
References: Eastin WC, Toxicol Pathol 2001;29 Suppl():60-80 ⋅ Spalding JW, Toxicol Sci 1999 Jun;49(2):241-54 |
|||
| Skin papilloma | Skin | benzethonium (BZTC) |
0 - 40 |
References: Spalding JW, Toxicol Sci 1999 Jun;49(2):241-54 |
||||
| Skin papilloma | Skin | 2-chloroethanol (2-CE) |
0 - 33.3 |
References: Spalding JW, Toxicol Sci 1999 Jun;49(2):241-54 |
||||
| Skin papilloma | Skin | o-benzyl-p-chlorophenol (BCP) |
7.7 - 84.2 |
References: Spalding JW, Toxicol Sci 1999 Jun;49(2):241-54 |
||||
| Skin papilloma | Skin | triethanolamine (TEA) |
21.1 - 38.5 |
References: Spalding JW, Toxicol Sci 1999 Jun;49(2):241-54 |
||||
| Skin papilloma | Skin | lauric acid diethanolamine (LDA) |
6.7 - 93.3 |
References: Spalding JW, Toxicol Sci 1999 Jun;49(2):241-54 |
||||
| Skin squamous cell carcinoma | Skin - Dorsal region | ultraviolet radiation (UV) |
observed - 60 |
References: Trempus CS, J Invest Dermatol 1998 Sep;111(3):445-51 |
||||
| Skin squamous cell carcinoma | Skin - Dorsal region | 12-O-tetradecanoylphorbol-13-acetate (TPA) |
observed |
References: Hansen LA, Carcinogenesis 1996 Sep;17(9):1825-33 |
||||
| Skin squamous cell papilloma | Scrotum |
6.7 |
References: Eastin WC, Toxicol Pathol 2001;29 Suppl():60-80 |
|||||
| Skin squamous cell papilloma | Scrotum | cyclophosphamide (Cytoxan) |
13.3 - 100 |
References: Eastin WC, Toxicol Pathol 2001;29 Suppl():60-80 |
||||
| Skin squamous cell papilloma | Vulva |
13.3 |
References: Eastin WC, Toxicol Pathol 2001;29 Suppl():60-80 |
|||||
| Skin squamous cell papilloma | Vulva | cyclophosphamide (Cytoxan) |
observed - 90.9 |
References: Eastin WC, Toxicol Pathol 2001;29 Suppl():60-80 |
||||
| Skin tumor | Skin |
13.3 - 40 |
0 - 33.3 |
References: Eastin WC, Toxicol Pathol 2001;29 Suppl():60-80 |
||||
| Skin tumor | Skin | diethylstilbestrol (DES) |
6.7 - 33.3 |
0 |
References: Eastin WC, Toxicol Pathol 2001;29 Suppl():60-80 |
|||
| Skin tumor | Skin | ethinyl estradiol (EE) |
13.3 - 20 |
6.7 - 13.3 |
References: Eastin WC, Toxicol Pathol 2001;29 Suppl():60-80 |
|||
| Skin tumor | (Unspecified organ) |
0 |
References: Eastin WC, Toxicol Pathol 2001;29 Suppl():60-80 |
|||||
| Skin tumor | (Unspecified organ) | melphalan (L-phenylalanine mustard) (L-sarcolysin) |
0 |
References: Eastin WC, Toxicol Pathol 2001;29 Suppl():60-80 |
||||
| Skin tumor | Vulva |
6.7 |
References: Eastin WC, Toxicol Pathol 2001;29 Suppl():60-80 |
|||||
| Skin tumor | Vulva | melphalan (L-phenylalanine mustard) (L-sarcolysin) |
20 - 80 |
References: Eastin WC, Toxicol Pathol 2001;29 Suppl():60-80 |
||||
| Skin tumor | Skin | melphalan (L-phenylalanine mustard) (L-sarcolysin) |
33.3 - 80 |
20 - 40 |
References: Eastin WC, Toxicol Pathol 2001;29 Suppl():60-80 |
|||
| Skin tumor | Skin | 12-O-tetradecanoylphorbol-13-acetate (TPA) |
93.3 |
93.3 |
References: Eastin WC, Toxicol Pathol 2001;29 Suppl():60-80 |
|||
| Skin tumor | Skin | cyclophosphamide (Cytoxan) |
20 - 100 |
13.3 - 100 |
References: Eastin WC, Toxicol Pathol 2001;29 Suppl():60-80 |
|||
| Skin tumor | Vagina | cyclophosphamide (Cytoxan) |
observed |
References: Eastin WC, Toxicol Pathol 2001;29 Suppl():60-80 |
||||
| Skin tumor - squamous | Skin |
26.7 |
28.6 |
References: Eastin WC, Toxicol Pathol 2001;29 Suppl():60-80 |
||||
| Skin tumor - squamous | Skin | ethinyl estradiol (EE) |
53.3 - 93.3 |
13.3 - 86.7 |
References: Eastin WC, Toxicol Pathol 2001;29 Suppl():60-80 |
|||
| Tooth odontoma | Tooth |
observed |
References: Hansen LA, Carcinogenesis 1996 Sep;17(9):1825-33 |
|||||
| Tooth odontoma | Bone - Jaw | benzene |
observed |
References: Spalding JW, Toxicol Sci 1999 Jun;49(2):241-54 |
||||
| Tooth odontoma | Bone - Jaw | benzethonium (BZTC) |
observed |
References: Spalding JW, Toxicol Sci 1999 Jun;49(2):241-54 |
||||
| Tooth odontoma | Bone - Jaw | 2-chloroethanol (2-CE) |
observed |
References: Spalding JW, Toxicol Sci 1999 Jun;49(2):241-54 |
||||
| Tooth odontoma | Bone - Jaw | o-benzyl-p-chlorophenol (BCP) |
observed |
References: Spalding JW, Toxicol Sci 1999 Jun;49(2):241-54 |
||||
| Tooth odontoma | Bone - Jaw | triethanolamine (TEA) |
observed |
References: Spalding JW, Toxicol Sci 1999 Jun;49(2):241-54 |
||||
| Tooth odontoma | Bone - Jaw | lauric acid diethanolamine (LDA) |
observed |
References: Spalding JW, Toxicol Sci 1999 Jun;49(2):241-54 |
||||
| Tooth odontoma | Bone - Jaw |
observed |
References: Spalding JW, Toxicol Sci 1999 Jun;49(2):241-54 |
|||||
| Tooth odontoma | Bone - Jaw | 12-O-tetradecanoylphorbol-13-acetate (TPA) |
observed |
References: Spalding JW, Toxicol Sci 1999 Jun;49(2):241-54 |
||||
| Tooth tumor | Bone - Jaw |
35 |
0 |
References: Wright JT, Arch Oral Biol 1995 Jul;40(7):631-8 |
||||
| Tooth tumor | Bone - Jaw - Mandible |
22 |
10 |
References: Wright JT, Arch Oral Biol 1995 Jul;40(7):631-8 |
||||
| Tooth tumor | Bone - Jaw - Maxilla |
8.6 |
References: Wright JT, Arch Oral Biol 1995 Jul;40(7):631-8 |
|||||
| Tooth tumor | Tooth |
13.0 - 30.0 |
7.0 - 25.8 |
References: Eastin WC, Toxicol Pathol 2001;29 Suppl():60-80 |
||||
| Tooth tumor | Tooth | Cyclosporin A |
13.0 - 30.0 |
7.0 - 20.0 |
References: Eastin WC, Toxicol Pathol 2001;29 Suppl():60-80 |
|||
| Uterus - Endometrium hyperplasia - cystic | Uterus - Endometrium | diethylstilbestrol (DES) |
observed |
References: Eastin WC, Toxicol Pathol 2001;29 Suppl():60-80 |
||||
| Yolk sac carcinoma | Yolk sac |
sporadic |
References: Hansen LA, Carcinogenesis 1996 Sep;17(9):1825-33 |
|||||
| (Unspecified organ) hyperplasia | (Unspecified organ) | diethylstilbestrol (DES) |
observed |
observed |
References: Eastin WC, Toxicol Pathol 2001;29 Suppl():60-80 |
|||
| (Unspecified organ) hyperplasia | (Unspecified organ) | ethinyl estradiol (EE) |
observed |
observed |
References: Eastin WC, Toxicol Pathol 2001;29 Suppl():60-80 |
|||
| (Unspecified organ) tumor | (Unspecified organ) |
2.2 |
0 |
References: Eastin WC, Toxicol Pathol 2001;29 Suppl():60-80 |
||||
| (Unspecified organ) tumor - spindle cell | Skin - Dorsal region | ultraviolet radiation (UV) |
observed - 20 |
References: Trempus CS, J Invest Dermatol 1998 Sep;111(3):445-51 |
||||
| (Unspecified organ) tumor - spindle cell | Skin - Dorsal region | 12-O-tetradecanoylphorbol-13-acetate (TPA) |
observed |
References: Hansen LA, Carcinogenesis 1996 Sep;17(9):1825-33 |
||||