Reference SummaryVan Der Kraak L, Mamm Genome 2016 Jun;27(5-6):213-24

Title

Mapping hyper-susceptibility to colitis-associated colorectal cancer in FVB/NJ mice.

Authors

Van Der Kraak L; Langlais D; Jothy S; Beauchemin N; Gros P

Journal

Mamm Genome

Volume

27

Issue

5-6

Year

2016

Pages

213-24

Abstract

Inbred strains of mice differ in susceptibility to colitis-associated colorectal cancer (CA-CRC). We tested 10 inbred strains of mice for their response to azoxymethane/dextran sulfate sodium-induced CA-CRC and identified a bimodal inter-strain distribution pattern when tumor multiplicity was used as a phenotypic marker of susceptibility. The FVB/NJ strain was particularly susceptible showing a higher tumor burden than any other susceptible strains (12.5-week post-treatment initiation). FVB/NJ hyper-susceptibility was detected as early as 8-week post-treatment initiation with FVB/NJ mice developing 5.5-fold more tumors than susceptible A/J or resistant B6 control mice. Linkage analysis by whole genome scan in informative (FVB/NJxC3H/HeJ)F2 mice identified a novel susceptibility locus designated as C olon c ancer s usceptibility 6 (Ccs6) on proximal mouse chromosome 6. When gender was used as a covariate, a LOD score of 5.4 was computed with the peak marker being positioned at rs13478727, 43.8 Mbp. Mice homozygous for FVB/NJ alleles at this locus had increased tumor multiplicity compared to homozygous C3H/HeJ mice. Positional candidates in this region of chromosome 6 were analyzed with respect to a possible role in carcinogenesis and a role in inflammatory response using a new epigenetic gene scoring tool (Myeloid Inflammation Score).

Links

26979842 – National Library of Medicine/PubMed

Models

Strain Model Name Treatment Agent(s) Organ Affected Frequency Model Details
FVB/NJ Intestine - Large Intestine - Colon adenocarcinoma
  • dextran sulfate sodium (DSS)
  • azoxymethane (AOM)
Intestine - Large Intestine - Colon

0

C3H/HeJ Intestine - Large Intestine - Colon adenocarcinoma
  • dextran sulfate sodium (DSS)
  • azoxymethane (AOM)
Intestine - Large Intestine - Colon

0

FVB/NJ Intestine - Large Intestine - Colon adenoma
  • dextran sulfate sodium (DSS)
  • azoxymethane (AOM)
Intestine - Large Intestine - Colon

observed

C3H/HeJ Intestine - Large Intestine - Colon adenoma
  • dextran sulfate sodium (DSS)
  • azoxymethane (AOM)
Intestine - Large Intestine - Colon

observed

FVB/NJ Intestine - Large Intestine - Colon carcinoma - adenosquamous
  • dextran sulfate sodium (DSS)
  • azoxymethane (AOM)
Intestine - Large Intestine - Colon

observed

FVB/NJ Intestine - Large Intestine - Colon dysplasia - high grade
  • dextran sulfate sodium (DSS)
  • azoxymethane (AOM)
Intestine - Large Intestine - Colon

observed

C3H/HeJ Intestine - Large Intestine - Colon dysplasia - high grade
  • dextran sulfate sodium (DSS)
  • azoxymethane (AOM)
Intestine - Large Intestine - Colon

0

FVB/NJ Intestine - Large Intestine - Colon dysplasia - low grade
  • dextran sulfate sodium (DSS)
  • azoxymethane (AOM)
Intestine - Large Intestine - Colon

observed

C3H/HeJ Intestine - Large Intestine - Colon dysplasia - low grade
  • dextran sulfate sodium (DSS)
  • azoxymethane (AOM)
Intestine - Large Intestine - Colon

observed

FVB/NJ Intestine - Large Intestine - Colon lesion
  • dextran sulfate sodium (DSS)
  • azoxymethane (AOM)
Intestine - Large Intestine - Colon

observed

C3H/HeJ Intestine - Large Intestine - Colon lesion
  • dextran sulfate sodium (DSS)
  • azoxymethane (AOM)
Intestine - Large Intestine - Colon

observed

(FVB/NJ x C3H/HeJ)F1 Intestine - Large Intestine - Colon lesion
  • dextran sulfate sodium (DSS)
  • azoxymethane (AOM)
Intestine - Large Intestine - Colon

observed

(FVB/NJ x C3H/HeJ)F2 Intestine - Large Intestine - Colon lesion
  • dextran sulfate sodium (DSS)
  • azoxymethane (AOM)
Intestine - Large Intestine - Colon

observed

NOD/ShiLtJ Intestine - Large Intestine - Colon tumor
  • dextran sulfate sodium (DSS)
  • azoxymethane (AOM)
Intestine - Large Intestine - Colon

0 - 100

FVB/NJ Intestine - Large Intestine - Colon tumor
  • dextran sulfate sodium (DSS)
  • azoxymethane (AOM)
Intestine - Large Intestine - Colon

observed - 100

AKR/J Intestine - Large Intestine - Colon tumor
  • dextran sulfate sodium (DSS)
  • azoxymethane (AOM)
Intestine - Large Intestine - Colon

100

C3H/HeJ Intestine - Large Intestine - Colon tumor
  • dextran sulfate sodium (DSS)
  • azoxymethane (AOM)
Intestine - Large Intestine - Colon

observed - 100

129S1/SvImJ Intestine - Large Intestine - Colon tumor
  • dextran sulfate sodium (DSS)
  • azoxymethane (AOM)
Intestine - Large Intestine - Colon

100

C57BL/6J Intestine - Large Intestine - Colon tumor
  • dextran sulfate sodium (DSS)
  • azoxymethane (AOM)
Intestine - Large Intestine - Colon

100

DBA/2J Intestine - Large Intestine - Colon tumor
  • dextran sulfate sodium (DSS)
  • azoxymethane (AOM)
Intestine - Large Intestine - Colon

100

CBA/J Intestine - Large Intestine - Colon tumor
  • dextran sulfate sodium (DSS)
  • azoxymethane (AOM)
Intestine - Large Intestine - Colon

100

A/J Intestine - Large Intestine - Colon tumor
  • dextran sulfate sodium (DSS)
  • azoxymethane (AOM)
Intestine - Large Intestine - Colon

100

BALB/cByJ Intestine - Large Intestine - Colon tumor
  • dextran sulfate sodium (DSS)
  • azoxymethane (AOM)
Intestine - Large Intestine - Colon

100

FVB/NJ Intestine - Large Intestine - Colon tumor Intestine - Large Intestine - Colon

0

(FVB/NJ x C3H/HeJ)F1 Intestine - Large Intestine - Colon tumor
  • dextran sulfate sodium (DSS)
  • azoxymethane (AOM)
Intestine - Large Intestine - Colon

observed

(FVB/NJ x C3H/HeJ)F2 Intestine - Large Intestine - Colon tumor
  • dextran sulfate sodium (DSS)
  • azoxymethane (AOM)
Intestine - Large Intestine - Colon

observed

AKR/J Intestine - Large Intestine tumor
  • dextran sulfate sodium (DSS)
  • azoxymethane (AOM)
Intestine - Large Intestine

100

C3H/HeJ Intestine - Large Intestine tumor
  • dextran sulfate sodium (DSS)
  • azoxymethane (AOM)
Intestine - Large Intestine

100

129S1/SvImJ Intestine - Large Intestine tumor
  • dextran sulfate sodium (DSS)
  • azoxymethane (AOM)
Intestine - Large Intestine

100

C57BL/6J Intestine - Large Intestine tumor
  • dextran sulfate sodium (DSS)
  • azoxymethane (AOM)
Intestine - Large Intestine

100

DBA/2J Intestine - Large Intestine tumor
  • dextran sulfate sodium (DSS)
  • azoxymethane (AOM)
Intestine - Large Intestine

100

CBA/J Intestine - Large Intestine tumor
  • dextran sulfate sodium (DSS)
  • azoxymethane (AOM)
Intestine - Large Intestine

100

A/J Intestine - Large Intestine tumor
  • dextran sulfate sodium (DSS)
  • azoxymethane (AOM)
Intestine - Large Intestine

100

BALB/cByJ Intestine - Large Intestine tumor
  • dextran sulfate sodium (DSS)
  • azoxymethane (AOM)
Intestine - Large Intestine

100

FVB/NJ Intestine - Large Intestine tumor
  • dextran sulfate sodium (DSS)
  • azoxymethane (AOM)
Intestine - Large Intestine

observed - 100

NOD/ShiLtJ Intestine - Large Intestine tumor
  • dextran sulfate sodium (DSS)
  • azoxymethane (AOM)
Intestine - Large Intestine

100

FVB/NJ Intestine - Large Intestine tumor Intestine - Large Intestine

0