PDX Model DetailsTM00314

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PDX Model Summary

Model Details
Model ID (Previous ID)
TM00314 (PA0258F)
Initial Diagnosis
Pancreatic ductal adenocarcinoma
Final Diagnosis
Pancreatic ductal adenocarcinoma
Stage/Grade
AJCC IIIA / Grade:2
Primary Site
Pancreas
Sample Site
Pancreas
Tumor Type
Primary Malignancy

Patient
Sex
Female
Age (at time of tissue collection)
77
Race/Ethnicity
White / Not Hispanic or Latino
Treatment Naïve?
Yes
Current Smoker/Former Smoker
Unknown / Unknown

Engraftment
Host Strain
NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
(aka NSG or NOD Scid gamma)
Sample Type
Surgical resection (fragment)
Engraftment Site
no data

Molecular Data (Engrafted Tumor)

Variants

Gene Expression

Platforms: hu133, stRNA_Seq

Hatched bars indicate genes with expression levels determined to be mildly affected by alignment calculations. Details.

Gene CNV

no CNV data

CNV Plots

no CNV plots

Tumor Mutation Burden

 no data

Microsatellite Instability

 no data

Gene Fusion
Fusion Genes
Sample PA0258F006P0 has fusion genes PDXDC1--NPIPB14P, ZNF778--SPG7, SMURF2P1--LRRC37B, LEPROT--LEPR, AC004009.1--AC007130.1, BOLA2B--SMG1P2, LRRC8B--LRRC8C, MGC32805--AC008514.1, CTBS--GNG5, SAA4--SAA1, CRYZL2P--SEC16B, LY75--CD302, AL078587.2--AL390198.2, ZNF7--CFAP46, TVP23B--CDRT4, LAMC2--AL354953.1, MACC1--AC005062.1, AP003555.2--ANO1, KANSL1--ARL17A, SMC5-DT--MAMDC2-AS1, UBE2Q2P2--GOLGA6L10, ARHGEF5--OR2A7, PTK2B--EPHX2, PCDHA6--PCDHAC2, FAM117A--AGMO, EGFR--PSPHP1

Model Characterization

Histology

 Summary:
P1 pathology consistent with adenocarcinoma.
Pathologist:
Dr. Regina Gandour-Edwards, University of California, Davis

Patient tumor for PDX model TM00314 (AKA, PA258) stained for H&E. This is a 4x image.
Patient tumor for PDX model TM00314 (AKA, PA258) stained for H&E. This is a 20x image.

P1 tumor F006 P0063 P1 for PDX model TM00314 stained for H&E.
P1 tumor F006 P0063 P1 for PDX model TM00314 stained for AE1AE3. Staining was positive.

P1 tumor F006 P0063 P1 for PDX model TM00314 stained for CD45. Staining was negative
P1 tumor F006 P0063 P1 for PDX model TM00314 stained for KI67. Staining was positive.

Dosing Studies

 no data

Circos Plots

 no data