Mouse Models of Human Cancer Database (MMHCdb)

MMHCdb is a comprehensive, expertly curated resource of diverse mouse models of human cancer.

We focus on:

Top Mouse Models of Human Cancer

American Cancer Society Facts & Figures 2024 Mouse Models
Cancer Site Mortality Rank Estimated deaths USA Mutant Strains Other Strains All Strains PDX Models
Lung & other respiratory [1] 130,450 58 116 174 79
Colon & other intestine [2] 57,290 112 4 116 81
Lymphohematopoietic [3] 57,260 142 43 185 46
Pancreas [4] 51,750 38 2 40 15
Breast [5] 42,780 183 33 216 46
Prostate [6] 35,250 55 0 55 2
Liver & bile duct [7] 29,840 25 24 49 2
Brain & other nervous system [8] 18,760 42 0 42 25
Uterus & cervix [9] 17,610 7 3 10 6
Urinary bladder [10] 16,840 7 1 8 27
Esophagus [11] 16,130 0 8 8 0
Kidney & renal pelvis [12] 14,390 5 0 5 8
Skin [13] 13,120 24 13 37 20
Ovary [14] 12,740 9 0 9 12
Oral cavity & pharynx [15] 12,230 3 3 6 3
Stomach [16] 10,880 17 7 24 1
Soft tissue including heart [17] 5,200 27 20 47 28
Gallbladder & other biliary [18] 4,530 2 0 2 0
Endocrine system [19] 3,300 66 2 68 1
Bones & joints [20] 2,050 5 0 5 11

News & Events

  • MMHCdb has launched a YouTube page with tutorial videos covering multiple aspects of the database. Tutorials for the Advanced Search Page, the Tumor Frequency Grid and the Patient Derived Xenograft Search Page as well as a general overview of the entire database have been posted. More videos will be posted periodically.
  • Read our latest publication about MMHCdb: Begley DA, Disease Models & Mechanisms, 2023 Mar 27.
  • Stop by our poster at the AACR annual meeting 2023, 14-19 April, Orlando on Sunday April 16th.
  • PDXFinder has become PDCMFinder. It now includes organoids and cell lines and has a new URL www.cancermodels.org
  • New mini-grids have been added to MMHCdb on select Reference Summary pages for studies that emphasize the differences in tumor frequencies observed in mice with the same genotype on a variety of genetic backgrounds. Example. (November 2022)
  • MMHCdb now contains over 110,000 tumor frequency records! (April 2022)
  • MMHCdb will present a poster at the AACR annual meeting, April 8-13, 2022, New Orleans.
  • MMHCdb is featured as the primary repository for data from The Jackson Laboratory's lung cancer PDX resource published in bioRxiv (Woo, X.Y., et al.) A Genomically and Clinically Annotated Patient Derived Xenograft (PDX) Resource for Preclinical Research in Non-Small Cell Lung Cancer. Data about the models in this resource are also accessible from PDX Finder. (March 2022)
  • MMHCdb is highlighted in Chapter 2 of Pathology of genetically engineered mice and other mutants. Sundberg JP, Vogel P, and Ward JM, eds., Wiley. Begley D, Schofield PN, Sundberg JP. The Mouse Online: Open Mouse Biology and Pathology Data Resources for Biomedical Research. (2022) 6-21.
  • MMHCdb presented at the 19th Annual Workshop on the Pathology of Mouse Models for Human Disease, "Mouse Genome Informatics (MGI) and Mouse Models of Human Cancer Databases". (September 2021)
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