Mouse Models of Human Cancer Database (MMHCdb)

MMHCdb is a comprehensive, expertly curated resource of diverse mouse models of human cancer.

We focus on:

Top Mouse Models of Human Cancer

American Cancer Society Facts & Figures 2023 Mouse Models
Cancer Site Mortality Rank Estimated deaths USA Mutant Strains Other Strains All Strains PDX Models
Lung & other respiratory [1] 132,330 57 116 173 79
Lymphohematopoietic [2] 57,380 138 35 173 30
Colon & other intestine [3] 56,490 89 4 93 81
Pancreas [4] 50,550 38 2 40 15
Breast [5] 43,700 133 31 164 46
Prostate [6] 34,700 55 0 55 2
Liver & bile duct [7] 29,380 25 24 49 2
Brain & other nervous system [8] 18,990 42 0 42 25
Uterus & cervix [9] 17,340 7 3 10 6
Urinary bladder [10] 16,710 7 1 8 27
Esophagus [11] 16,120 0 8 8 0
Kidney & renal pelvis [12] 14,890 5 0 5 8
Ovary [13] 13,270 9 0 9 12
Skin [14] 12,470 24 13 37 20
Oral cavity & pharynx [15] 11,580 3 3 6 3
Stomach [16] 11,130 17 7 24 1
Soft tissue including heart [17] 5,140 27 20 47 28
Gallbladder & other biliary [18] 4,510 2 0 2 0
Endocrine system [19] 3,240 66 2 68 1
Bones & joints [20] 2,140 5 0 5 11

News & Events

  • MMHCdb has launched a YouTube page with tutorial videos covering multiple aspects of the database. Tutorials for the Advanced Search Page, the Tumor Frequency Grid and the Patient Derived Xenograft Search Page as well as a general overview of the entire database have been posted. More videos will be posted periodically.
  • Read our latest publication about MMHCdb: Begley DA, Disease Models & Mechanisms, 2023 Mar 27.
  • Stop by our poster at the AACR annual meeting 2023, 14-19 April, Orlando on Sunday April 16th.
  • PDXFinder has become PDCMFinder. It now includes organoids and cell lines and has a new URL www.cancermodels.org
  • New mini-grids have been added to MMHCdb on select Reference Summary pages for studies that emphasize the differences in tumor frequencies observed in mice with the same genotype on a variety of genetic backgrounds. Example. (November 2022)
  • MMHCdb now contains over 110,000 tumor frequency records! (April 2022)
  • MMHCdb will present a poster at the AACR annual meeting, April 8-13, 2022, New Orleans.
  • MMHCdb is featured as the primary repository for data from The Jackson Laboratory's lung cancer PDX resource published in bioRxiv (Woo, X.Y., et al.) A Genomically and Clinically Annotated Patient Derived Xenograft (PDX) Resource for Preclinical Research in Non-Small Cell Lung Cancer. Data about the models in this resource are also accessible from PDX Finder. (March 2022)
  • MMHCdb is highlighted in Chapter 2 of Pathology of genetically engineered mice and other mutants. Sundberg JP, Vogel P, and Ward JM, eds., Wiley. Begley D, Schofield PN, Sundberg JP. The Mouse Online: Open Mouse Biology and Pathology Data Resources for Biomedical Research. (2022) 6-21.
  • MMHCdb presented at the 19th Annual Workshop on the Pathology of Mouse Models for Human Disease, "Mouse Genome Informatics (MGI) and Mouse Models of Human Cancer Databases". (September 2021)
  • The MMHCdb web site has been updated to provide a new look, consolidate search forms, streamline searching, and introduce new functionality. A new advanced search form has been released which consolidates multiple search forms into a single interface and uses faceted searches to enable users to customize searches and iteratively increase search specificity. The web site layout has been redesigned to be more user friendly and improve data visibility. (September 2020)
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