Patient-Derived Xenografts (PDX) are generated through the engraftment and passaging of tissue or cells from a patient's tumor into an immunodeficient or humanized mouse host. PDX models are an in vivo platform for cancer biology research and for pre-clinical testing of cancer drug efficacy.
The Mouse Models of Human Cancer Database provides access to information on hundreds of PDX models distributed by The Jackson Laboratory (JAX). Researchers can search for JAX PDXs by such criteria as primary cancer site, diagnosis, genomic characteristics of engrafted tumors, and PDX dosing study results.
- Try MMHCdb's PDX Like Me search tool to find models in the JAX repository that match multiple genomic criteria.
- MMHCdb has partnered with the European Bioinformatics Institute to develop PDCM Finder, which includes a global catalog of over 4,000 PDX models.
- Contact The Jackson Laboratory Mice, Research and Clinical Services group to request information on the JAX PDX program's capabilities and services.
- Learn more about how PDX models are generated at The Jackson Laboratory.
- See MMHCdb's Help Documentation for details on PDX search options and results.