PDX Model DetailsJ000077451

Request information on the availability of this model.

PDX Model Summary

Model Details
Model ID
J000077451
Initial Diagnosis
Adenocarcinoma
Final Diagnosis
Adenocarcinoma
Stage/Grade
AJCC IV /
Model Status
Active Available - PDX Resource Gold Standard
Primary Site
Prostate gland
Sample Site
Brain
Tumor Type
Metastatic

Patient
Sex
Male
Age (at time of tissue collection)
75
Race/Ethnicity
White / Not Hispanic or Latino
Treatment Naïve?
no data
Current Smoker/Former Smoker
no data

Engraftment
Host Strain
NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
(aka NSG or NOD Scid gamma)
Sample Type
Core needle biopsy
Engraftment Site
Right Flank

Molecular Data (Engrafted Tumor)

Variants

Gene Expression

 Data Links:

Sample:J000098320 from passage:P1 Platform:RNA_Seq Derived Data  Raw data 1  Raw data 2 


Platforms: RNA_Seq

Hatched bars indicate genes with expression levels determined to be mildly affected by alignment calculations. Details.

Gene CNV

CNV Plots

Tumor Mutation Burden
Sample J000077451PT from passage PT has a TMB score of 6.46
TMB Range
0.0-304.42 (across all JAX PDX models; TMB > 22 is considered high)

Microsatellite Instability
Sample:J000077451PT from passage PT     Score:MSI-S

Gene Fusion
Fusion Genes
Sample J000098320 has fusion genes PDXDC1--NPIPB14P, AC104819.3--SH3D19, ATPAF2--MPRIP, COPS3--MPRIP, SMURF2P1--LRRC37B, PLD3--LINC00457, POLR2J2--AC004951.2, BOLA2B--SMG1P2, OSBPL2--SS18L1, AC017074.1--ACRP1, AC025580.2--ETV1, GUSBP2--AL513548.1, PC--AP001885.3, ARHGEF7--WBP4, C11orf49--CREB3L1, AP2B1--HEATR9, PCDHGB2--PCDHGA8, HMGN2P46--ETV1, AC026412.1--SDHA, KIAA1109--LINC02511, SMBD1P--MUC20P1, MED11--COPS3, SCHLAP1--UBE2E3, AL390860.1--TRIM58, CAPN8--CAPN2, CRISPLD2--EYA2, LINC00437--WBP4, ARHGEF5--OR2A7, PLD3--AL161716.1, AC139493.2--AC106795.2, AC139493.2--AC106795.1, PDCD6--SDHAP3, LINC02050--LINC02027, SUCLG2--ATAD1, ACACA--AP2B1, UPK3B--PMS2P9, ARPC4--TTLL3, AL391840.3--SH3BGRL2

Model Characterization

Histology

 Summary:
Patient tumor is a brain carcinoma with a Gleason score of 10. The tumor is a metastasis of a prostate adenocarcinoma. The tumor diagnosis for the metastasis is different than the diagnosis for the parent tumor. P0 pathology consistent with carcinoma.
Pathologist:
Dr. Regina Gandour-Edwards, University of California, Davis.

Patient tumor for PDX model J000077451 stained for H&E.
P0 tumor F001 P0 for PDX model J000077451 stained for H&E.

P0 tumor F001 P0 for PDX model J000077451 immunostained for AE1/AE3. Staining was positive.
P0 tumor F001 P0 for PDX model J000077451 immunostained for CD45. Staining was negative.

P2 tumor ID018 for PDX model J000077451 stained for H&E.
P2 tumor ID018 for PDX model J000077451 stained for AE1AE3. Staining was positive.

P2 tumor ID018 for PDX model J000077451 stained for CD45. Staining was negative.

Dosing Studies

Circos Plots

 no data