PDX Model DetailsJ000106132

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This model is being distributed by The Jackson Laboratory on behalf of the Lymphoma Xenograft core at Dana-Farber Cancer Institute (DFCI).
Additional information can be found by registering at DFCI's PRoXe (https://www.proxe.org/) web site.
PRoXe model id: DFAM-22359-V1

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PDX Model Summary

Model Details

Model ID
J000106132
Initial Diagnosis
Acute myeloid leukemia
Final Diagnosis
Acute myeloid leukemia
Stage/Grade
no data
Primary Site
Bone marrow
Sample Site
Bone marrow
Tumor Type
Recurrent/Relapse

Publications citing this model

Procter, JL; et al. Single Doses of Antibody Drug Conjugates (ADCs) Targeted to CD117 or CD45 Have Potent In Vivo Anti-Leukemia Activity and Survival Benefit in Patient Derived AML Models. Blood 2018;132:3316. doi.org/10.1182/blood-2018-99-112726

Patient

Sex
Female
Age (at time of tissue collection)
44
Race/Ethnicity
White / Not Reported
Treatment Naïve?
No
Current Smoker/Former Smoker
no data

Engraftment

Host Strain
no data
Sample Type
Bone marrow aspirate
Engraftment Site
no data

Molecular Data (Engrafted Tumor)

Variants

Gene Expression

Platforms: RNA_Seq, stRNA_Seq

Hatched bars indicate genes with expression levels determined to be mildly affected by alignment calculations. Details.

Please Note: Expression data for this model is calculated as Log2(TPM+1)

Gene CNV

no CNV data

CNV Plots

no CNV plots

Tumor Mutation Burden

no data

Microsatellite Instability

no data

Gene Fusion

no data

Model Characterization

Histology

no data

Dosing Studies

no data

Circos Plots

no data