PDX Model DetailsTM00016

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PDX Model Summary

Model Details

Model ID (Previous ID)
TM00016 (BL0293F)
Initial Diagnosis
Transitional cell carcinoma
Final Diagnosis
Sarcomatoid transitional cell carcinoma
Not Specified / Grade:high
Primary Site
Sample Site
Tumor Type
Primary Malignancy

Publications citing this model

Pan, C; et al. Development and Characterization of Bladder Cancer Patient-Derived Xenografts for Molecularly Guided Targeted Therapy. PLoS One 2015;10(8), p1-22. doi:10.1371/journal
Wang, M; et al. Humanized mice in studying efficacy and mechanisms of PD-1-targeted cancer immunotherapy. 2018 FASEB 2018 Mar;32(3):1537-1549.  10.1096/fj.201700740R


Age (at time of tissue collection)
White / Not Hispanic or Latino
Treatment Naïve?
Current Smoker/Former Smoker
No / Yes


Host Strain
NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
(aka NSG or NOD Scid gamma)
Sample Type
Surgical resection (fragment)
Engraftment Site
no data

Molecular Data (Engrafted Tumor)


Gene Expression

Platforms: RNA_Seq, hg10st

Hatched bars indicate genes with expression levels determined to be mildly affected by alignment calculations. Details.

Gene CNV

CNV Plots

Tumor Mutation Burden

no data

Microsatellite Instability

no data

Gene Fusion

no data

Model Characterization


P0 pathology consistent with sarcomatoid transitional cell carcinoma. P2 pathology consistent with poorly differentiated carcinoma.
Dr. Regina Gandour-Edwards, University of California, Davis

Patient tumor for PDX model TM000016. High grade urothelial carcinoma invading bladder wall.

P0 tumor #563 for PDX model TM00016. Sheets of high grade urothelial carcinoma cells.

P0 tumor #563 for PDX model TM00016. Positive staining for Ki67 indicating tumor cells of human origin.

P0 tumor #563 for PDX model TM00016. Diffuse positivity for vimentin staining in tumor cells.

P2 tumor F563 ID015 for PDX model TM00016 stained for H&E.

P2 tumor F563 ID015 for PDX model TM00016 stained for AE1/AE3. Staining was positive.

P2 tumor F563 ID015 for PDX model TM00016 stained for CD45. Staining was negative.

P2 tumor F563 ID015 for PDX model TM00016 stained for Ki67. Staining was positive.

Dosing Studies

no data

Circos Plots

Circos plot for P0 tumor #563 from PDX model TM00016