PDX Model DetailsTM00024

PDX Model Summary
Model Details	Model ID (Previous ID) TM00024 (BL0440F) Initial Diagnosis Carcinoma: Urothelial carcinoma Final Diagnosis Bladder transitional cell carcinoma Stage/Grade AJCC IV / Grade:high Primary Site Bladder Sample Site Bladder Tumor Type Primary Malignancy
Publications citing this model	Pan, C; et al. Development and Characterization of Bladder Cancer Patient-Derived Xenografts for Molecularly Guided Targeted Therapy. PLoS One 2015;10(8), p1-22. doi:10.1371/journal
Patient	Sex Male Age (at time of tissue collection) 71 Race/Ethnicity Black / Not Hispanic or Latino Treatment Naïve? No Current Smoker/Former Smoker No / Yes
Engraftment	Host Strain NOD.Cg-Prkdc^scid Il2rg^tm1Wjl/SzJ (aka NSG or NOD Scid gamma) Sample Type Surgical resection (fragment) Engraftment Site no data

Molecular Data (Engrafted Tumor)
Variants	no variation plots
Gene Expression	Platforms: RNA_Seq, hu133 Hatched bars indicate genes with expression levels determined to be mildly affected by alignment calculations. Details.
Gene CNV
CNV Plots
Tumor Mutation Burden	no data
Microsatellite Instability	no data
Gene Fusion	Fusion Genes Sample BL0440F1664P0 has fusion genes GOLT1A--KISS1, PDXDC1--NPIPB14P, SPPL3--LUNAR1, NIPA1--CYFIP1, BOLA2B--SMG1P2, SEC11A--PLEKHG4B, POLR2J3--UPK3BL1, C6orf47--BAG6, LAMC2--AL354953.1, TVP23C--CDRT4, H2BC17--OR2B6, PPP2R1A--ZNF766, ARHGEF5--OR2A7, CCDC169--SOHLH2, CCL15--CCL14, FAM89A--RGS7, ARPIN--AP3S2, CYFIP1--NIPA1, SLC29A1--HSP90AB3P, SLC35A3--MFSD14A, TSTD1--F11R, ARPC4--TTLL3, ZNF8--AP006222.1, LINC00893--IDS, ADIRF--BMS1P3, STX16--NPEPL1, AC138866.1--AP000346.2, DET1--MRPL46, SENP5--PAK2, CAPN1--CAPN2, LINC01151--SMILR, MGST1--AC007529.2, SMURF2P1--LRRC37B, AC133041.1--ENPP7P2, ZNF431--RPSAP58, TOMM5--FBXO10, ANKHD1--EIF4EBP3, ERBB2--GRB7, AC004596.1--AC003102.1, TPTEP2--CSNK1E, NCKIPSD--CELSR3, IKZF2--SPAG16-DT, RBM14--RBM4B, AL079338.1--PSORS1C3, SEPTIN7P2--PSPH, RNASET2--RPS6KA2, UBE2Q2P2--GOLGA6L10, GFOD1--DAB1, GATAD1--AC007566.1, FPGT--TNNI3K, ZHX1--C8orf76, PPP1R12C--IFITM10, AL391840.3--SH3BGRL2, NRIP1--LINC02246, AC105339.6--ACTG1P17

Model Characterization

Patient tumor for PDX model TM00024.	Patient tumor for PDX model TM00024; Vimentin
P1 tumor #1666 for PDX model TM00024.	P1 tumor #1666 for PDX model TM00024; Vimentin