PDX Model DetailsTM00360

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PDX Model Summary
Model Details	Model ID (Previous ID) TM00360 (SA0082F) Initial Diagnosis Embryonal rhabdomyosarcoma Final Diagnosis Embryonal rhabdomyosarcoma Stage/Grade Not Specified / Primary Site Brain Sample Site Brain Tumor Type Primary Malignancy
Publications citing this model	Hooper, JE; et al. A Patient-Derived Xenograft Model of Parameningeal Embryonal Rhabdomyosarcoma for Preclinical Studies. Sarcoma 2015;2015(2015), Article ID 826124, 7 pages. DOI:10.1155/2015/826124
Patient	Sex Female Age (at time of tissue collection) 14 Race/Ethnicity White / Not Reported Treatment Naïve? No Current Smoker/Former Smoker Unknown / Unknown
Engraftment	Host Strain NOD.Cg-Prkdc^scid Il2rg^tm1Wjl/SzJ (aka NSG or NOD Scid gamma) Sample Type Surgical resection (fragment) Engraftment Site no data

Molecular Data (Engrafted Tumor)
Variants	no variation plots
Gene Expression	Platforms: hg10st, stRNA_Seq Hatched bars indicate genes with expression levels determined to be mildly affected by alignment calculations. Details.
Gene CNV
CNV Plots
Tumor Mutation Burden	Sample SA0082F006P0000P1 from passage P1 has a TMB score of 7.27 TMB Range 0.0-304.42 (across all JAX PDX models; TMB > 22 is considered high)
Microsatellite Instability	Sample:SA0082F006P0000P1 from passage P1 Score:MSI-S
Gene Fusion	Fusion Genes Sample SA0082F006P0000P1015P2 has fusion genes LARP4--SPATS2, PDXDC1--NPIPB14P, NAIP--OCLN, TVP23C--CDRT4, AL121904.2--ANKRD30B, NF1--ATAD5, ANKRD13B--NF1, SRGAP3--LHFPL4, BOLA2B--SMG1P2, AKT1--AL512356.5, PRMT1--AP2A1, ZNF423--AC007610.1, AC092807.3--DDAH1, LBH--LINC01936, TTLL5--IFT43, AC011586.2--MSR1, FRMD8--PDE2A-AS1

Model Characterization

Histology

Summary:
P0 pathology consistent with rhabdomyosarcoma. P0 shows highly cellular spindle cell tumor with mitotic figures. P2 pathology consistent with embryonal rhabdomyosarcoma, high-grade malignancy.
Pathologist:
Dr. Regina Gandour-Edwards, University of California, Davis. P2 pathology done by Dr. Dorina Gui, University of California, Davis.

P0 tumor F001 for PDX model TM00360 stained for H&E.	P2 tumor F006 ID014 for PDX model TM00360 stained for H&E.
P2 tumor F006 ID014 for PDX model TM00360 stained for AE1AE3. Staining was negative.	P2 tumor F006 ID014 for PDX model TM00360 stained for CD45. Staining was negative.
P2 tumor F006 ID014 for PDX model TM00360 stained for Ki67. Staining was positive.