PDX Model DetailsTM01125

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PDX Model Summary

Model Details
Model ID (Previous ID)
TM01125 (TM01125F)
Initial Diagnosis
Neuroendocrine carcinoma
Final Diagnosis
Neuroendocrine carcinoma
Stage/Grade
AJCC IV / Grade:1
Model Status
Active Available - PDX Resource Gold Standard
Primary Site
Pancreas
Sample Site
Pancreas
Tumor Type
Recurrent/Relapse

Patient
Sex
Male
Age (at time of tissue collection)
79
Race/Ethnicity
White / Not Hispanic or Latino
Treatment Naïve?
Yes
Current Smoker/Former Smoker
No / Yes

Engraftment
Host Strain
NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
(aka NSG or NOD Scid gamma)
Sample Type
Surgical resection (fragment)
Engraftment Site
no data

Molecular Data (Engrafted Tumor)

Variants

 Data Links:

Sample:TM01125F136P0 from passage:P0 Platform:Truseq_JAX Derived Data  Raw data 1  Raw data 2 


Gene Expression

 Data Links:

Sample:TM01125F136P0 from passage:P0 Platform:RNA_Seq Derived Data  Raw data 1  Raw data 2 


Platforms: RNA_Seq

Hatched bars indicate genes with expression levels determined to be mildly affected by alignment calculations. Details.

Gene CNV

 Data Links:

Sample:TM01125F136P0 from passage:P0 Platform:SNP Derived Data  Raw data 1 


CNV Plots

Tumor Mutation Burden

 no data

Microsatellite Instability

 no data

Gene Fusion
Fusion Genes
Sample TM01125F136P0 has fusion genes PDXDC1--NPIPB14P, PKD1--NPIPP1, AC021055.1--LINC01995, MRPS23--AC015845.2, ST6GALNAC5--AL035409.2, SYS1--DBNDD2, MBD1--CFAP53, BOLA2B--SMG1P2, TMED4--DDX56, SLC43A3--PRG2, SOGA3--KIAA0408, PACSIN2--ARFGAP3, SYN2--PPARG, COMMD3--BMI1, RLF--MYCL, SPATA5--LARP1B, AL033527.2--AL033527.3, KANSL1--ARL17A, PXMP2--PGAM5, PDXDC2P--NPIPB12, AC004967.1--AC079781.5, AC096711.2--RPL7AP28, SHISA9--U91319.1, CKLF--CMTM1, SCNN1A--TNFRSF1A, PCDHGB1--PCDHGA12, SLC29A1--HSP90AB3P, AC008443.2--AC008443.5, CPSF6--CHMP1A, ARPC4--TTLL3, KHDRBS1--NKAIN1, STX16--NPEPL1, AL355472.2--COA6, NAIP--OCLN, KSR1--LGALS9, PLCB1--PARAL1, SMURF2P1--LRRC37B, POLR2J2--AC004951.2, NDUFB8--SEC31B, RBM14--RBM4, TGIF2--RAB5IF, B3GALT5--AF064860.1, RBM14--RBM4B, B3GALT5--IGSF5, AP000347.1--ASLP1, ELAVL2--AL445623.2, PCDHA3--PCDHAC2, NHLH1--VANGL2, EEF1AKMT3--TSFM, UBE2Q2P2--GOLGA6L10, PTENP1-AS--TRBV26OR9-2, AC026191.1--SRGAP3, AC093895.1--SPARCL1, RNASEH1--AC108488.1, AC103810.8--SLC16A6, CACNA1C-AS1--CACNA1C-AS2, POLA2--CDC42EP2, AL391840.3--SH3BGRL2

Model Characterization

Histology

 Summary:
P1 pathology consistent with small cell (neuroendocrine) carcinoma. P3 pathology consistent with carcinoma.
Pathologist:
Dr. Regina Gandour-Edwards, University of California, Davis

Patient tumor for PDX model TM01125 stained for H&E.
P1 tumor F136 P0041 for PDX model TM01125 stained for H&E.

P1 tumor F136 P0041 for PDX model TM01125 stained for AE1AE3. Staining was positive.
P1 tumor F136 P0041 for PDX model TM01125 stained for CD45. Staining was negative.

P3 tumor F136 ID016 for PDX model TM01125 stained for H&E.
P3 tumor F136 ID020 for PDX model TM01125 stained for H&E.

P3 tumor F136 ID016 for PDX model TM01125 stained for AE1/AE3. Staining was positive.
P3 tumor F136 ID020 for PDX model TM01125 stained for AE1AE3. Staining was positive.

P3 tumor F136 ID016 for PDX model TM01125 stained for CD45. Staining was negative.
P3 tumor F136 ID020 for PDX model TM01125 stained for CD45. Staining was negative.

P3 tumor F136 ID016 for PDX model TM01125 stained for Ki67. Staining was positive.
P3 tumor F136 ID020 for PDX model TM01125 stained for Ki67. Staining was positive.

Dosing Studies

 no data

Circos Plots

 no data