Reference SummaryHard GC, Cancer Res 1985 Feb;45(2):703-8
Title |
Identification of a high-frequency model for renal carcinoma by the induction of renal tumors in the mouse with a single dose of streptozotocin. | ||||
Authors |
Hard GC | ||||
Journal |
Cancer Res | ||||
Volume |
45 | ||||
Issue |
2 | ||||
Year |
1985 | ||||
Pages |
703-8 | ||||
Abstract |
In order to develop a high-frequency, single-dose model of renal epithelial tumor induction in the mouse, streptozotocin (250 mg/kg) was administered i.v. to 6-week-old males and females of the CBA/H/T6J strain. In groups of 26 males and 30 females representing the effective number of survivors eligible for tumor estimates, renal cell tumors were found in 73% of males and 97% of females, including incidences of lesions diagnosed as renal carcinoma in 31 and 60%, respectively. The difference in renal tumor frequency between the sexes was not considered a real effect owing to the significantly decreased survival of the males. The neoplastic lesions ranged from small papillary or cystopapillary adenomas with a benign appearance to large, solid carcinomas with a low potential for metastasis. In the females, 22% of the larger tumors metastasized to distant sites, mainly the lungs. Intermediate lesions incorporating both papillary and solid adenomatous profiles suggested a sequential development of carcinomas along this pathway from the smaller papillary foci. The data establish the administration of a single dose of streptozotocin in the female CBA/H/T6J as a suitable high incidence model for the study of renal epithelial carcinogenesis in the mouse. | ||||
Links |
J:24857 – MGI References 3155646 – National Library of Medicine/PubMed |
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Strain Notes
|
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| Strain | Model Name | Treatment Agent(s) | Organ Affected | Frequency | Model Details |
|---|---|---|---|---|---|
| CBA/CaH-T(14;15)6Ca/J | Kidney - Cortex adenoma |
|
Kidney - Cortex |
69 - 93 |
|
| CBA/CaH-T(14;15)6Ca/J | Kidney - Cortex carcinoma |
|
Kidney - Cortex |
31 - 60 |
|
| CBA/CaH-T(14;15)6Ca/J | Kidney - Cortex tumor |
|
Kidney - Cortex |
73 - 97 |
|
| CBA/CaH-T(14;15)6Ca/J | Liver tumor |
|
Liver |
3.8 - 17 |
|
| CBA/CaH-T(14;15)6Ca/J | Lung - Alveolus tumor |
|
Lung - Alveolus |
35 - 87 |
|
| CBA/CaH-T(14;15)6Ca/J | Mesodermal cell/mesoblast sarcoma |
|
Uterus - Endometrium |
observed |
|
| CBA/CaH-T(14;15)6Ca/J | PNS - Schwann cell schwannoma |
|
Uterus |
observed |
|
| CBA/CaH-T(14;15)6Ca/J | Pancreas - Islet of Langerhans tumor |
|
Pancreas - Islet of Langerhans |
3.3 |
|
| CBA/CaH-T(14;15)6Ca/J | Uterus tumor |
|
Uterus |
50 |