Reference SummaryGarcia-Cao I, EMBO J 2002 Nov 15;21(22):6225-35
Title |
'Super p53' mice exhibit enhanced DNA damage response, are tumor resistant and age normally. | ||||||
Authors |
Garcia-Cao I; Garcia-Cao M; Martin-Caballero J; Criado LM; Klatt P; Flores JM; Weill JC; Blasco MA; Serrano M | ||||||
Journal |
EMBO J | ||||||
Volume |
21 | ||||||
Issue |
22 | ||||||
Year |
2002 | ||||||
Pages |
6225-35 | ||||||
Abstract |
The tumor suppressor p53 is critical in preventing cancer due to its ability to trigger proliferation arrest and cell death upon the occurrence of a variety of stresses, most notably, DNA damage and oncogenic stress. Here, we report the generation and characterization of mice carrying supernumerary copies of the p53 gene in the form of large genomic transgenes. Prior to this, we demonstrate that the p53 transgenic allele (p53-tg), when present in a p53-null genetic background, behaves as a functional replica of the endogenous gene. 'Super p53' mice, carrying p53-tg alleles in addition to the two endogenous alleles, exhibit an enhanced response to DNA damage. Importantly, 'super p53' mice are significantly protected from cancer when compared with normal mice. Finally, in contrast to previously reported mice with constitutively active p53, 'super p53' mice do not show any indication of premature aging, probably reflecting the fact that p53 is under normal regulatory control. Together, our results prove that cancer resistance can be enhanced by a simple genetic modification and in the absence of undesirable effects. | ||||||
Links |
J:80311 – MGI References 12426394 – National Library of Medicine/PubMed |
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Strain Notes
|
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| Strain | Model Name | Treatment Agent(s) | Organ Affected | Frequency | Model Details |
|---|---|---|---|---|---|
| B6;CBA-Tg(Trp53)1Srn | CNS - Brain tumor | CNS - Brain |
0 |
||
| B6;CBA-Tg(Trp53)1Srn | Connective tissue - Fibroblast fibrosarcoma |
|
Connective tissue - Fibroblast |
33 |
|
| B6;CBA | Connective tissue - Fibroblast fibrosarcoma |
|
Connective tissue - Fibroblast |
92 |
|
| B6;CBA-Tg(Trp53)1Srn | Esophagus tumor | Esophagus |
0 |
||
| B6;CBA-Tg(Trp53)1Srn | Heart tumor | Heart |
0 |
||
| B6;CBA-Tg(Trp53)1Srn | Intestine - Large Intestine tumor | Intestine - Large Intestine |
0 |
||
| B6;CBA-Tg(Trp53)1Srn | Intestine - Small Intestine tumor | Intestine - Small Intestine |
0 |
||
| B6;CBA-Tg(Trp53)1Srn | Kidney tumor | Kidney |
0 |
||
| B6;CBA-Tg(Trp53)1Srn | Leukocyte lymphoma | Leukocyte |
17 |
||
| B6;CBA | Leukocyte lymphoma | Leukocyte |
19 |
||
| B6;CBA-Tg(Trp53)1Srn | Liver tumor | Liver |
0 |
||
| B6;CBA | Lung adenoma | Lung |
14 |
||
| B6;CBA-Tg(Trp53)1Srn | Lung tumor | Lung |
0 |
||
| B6;CBA-Tg(Trp53)1Srn | Ovary tumor | Ovary |
0 |
||
| B6;CBA-Tg(Trp53)1Srn | Pancreas tumor | Pancreas |
0 |
||
| B6;CBA-Tg(Trp53)1Srn | Pituitary gland tumor | Pituitary gland |
0 |
||
| B6;CBA-Tg(Trp53)1Srn | Prostate gland tumor | Prostate gland |
0 |
||
| B6;CBA-Tg(Trp53)1Srn | Salivary gland tumor | Salivary gland |
0 |
||
| B6;CBA-Tg(Trp53)1Srn | Skin tumor | Skin |
0 |
||
| B6;CBA-Tg(Trp53)1Srn | Spleen tumor | Spleen |
0 |
||
| B6;CBA-Tg(Trp53)1Srn | Stomach tumor | Stomach |
0 |
||
| B6;CBA-Tg(Trp53)1Srn | Testis tumor | Testis |
0 |
||
| B6;CBA-Tg(Trp53)1Srn | Thyroid gland tumor | Thyroid gland |
0 |
||
| B6;CBA-Tg(Trp53)1Srn | Urinary bladder transitional cell carcinoma |
|
Urinary bladder |
67 |
|
| B6;CBA | Urinary bladder transitional cell carcinoma |
|
Urinary bladder |
83 |
|
| B6;CBA-Tg(Trp53)1Srn | Urinary bladder tumor | Urinary bladder |
0 |
||
| B6;CBA-Tg(Trp53)1Srn | Uterus tumor | Uterus |
0 |
||
| B6;CBA-Tg(Trp53)1Srn | (Unspecified organ) tumor | (Unspecified organ) |
0 - 17 |
||
| B6;CBA | (Unspecified organ) tumor | (Unspecified organ) |
47 |