Reference SummarySugino T, Int J Cancer 1993 Aug 19;55(1):141-7
Title |
Sequential process of blood-borne lung metastases of spontaneous mammary carcinoma in C3H mice. |
Authors |
Sugino T; Kawaguchi T; Suzuki T |
Journal |
Int J Cancer |
Volume |
55 |
Issue |
1 |
Year |
1993 |
Pages |
141-7 |
Abstract |
We examined the correlation between growth characteristics and the incidence of lung metastases of spontaneous mammary tumors in C3H mice. The growth pattern of the mammary tumors was composed of initial rapid growth, declining growth, and further exponential growth (re-growth). The re-growth was closely associated with loss of differentiation and progressive increase of the incidence of lung metastases. In addition, we observed the sequential process of blood-borne lung metastases. The findings involved (i) passive intravasation: carcinoma nests encased in newly formed endothelial cells are released into sinusoidal vessels within primary tumors; (ii) mechanical arrest and proliferation of multicellular tumor emboli in pulmonary arterioles; (iii) active extravasation: carcinoma cells rushed out to the lung parenchyma through the arteriolar walls ruptured by initial minimal penetration of carcinoma cells and intravascular pressure. The results indicate a stable progression in the natural history of C3H mouse mammary carcinomas characterized by growth characteristics, the incidence of lung metastases, and histological change generating a poorly differentiated clone which can successfully complete a sequential process of blood-borne lung metastasis. |
Links |
J:14583 – MGI References 7688351 – National Library of Medicine/PubMed |
| Strain | Model Name | Treatment Agent(s) | Organ Affected | Frequency | Model Details |
|---|---|---|---|---|---|
| C3H/He | Mammary gland adenocarcinoma | Mammary gland |
88 |