Reference SummaryBerndt A, Vet Pathol 2014 Jul;51(4):846-57
Title |
Phenotypic characterization of the KK/HlJ inbred mouse strain. |
Authors |
Berndt A; Sundberg BA; Silva KA; Kennedy VE; Richardson MA; Li Q; Bronson RT; Uitto J; Sundberg JP |
Journal |
Vet Pathol |
Volume |
51 |
Issue |
4 |
Year |
2014 |
Pages |
846-57 |
Abstract |
Detailed histopathological diagnoses of inbred mouse strains are important for interpreting research results and defining novel models of human diseases. The aim of this study was to histologically detect lesions affecting the KK/HlJ inbred strain. Mice were examined at 6, 12, and 20 months of age and near natural death (ie, moribund mice). Histopathological lesions were quantified by percentage of affected mice per age group and sex. Predominant lesions were mineralization, hyperplasia, and fibro-osseous lesions. Mineralization was most frequently found in the connective tissue dermal sheath of vibrissae, the heart, and the lung. Mineralization was also found in many other organs but to a lesser degree. Hyperplasia was found most commonly in the pancreatic islets, and fibro-osseous lesions were observed in several bones. The percentage of lesions increased with age until 20 months. This study shows that KK/HlJ mice demonstrate systemic aberrant mineralization, with greatest frequency in aged mice. The detailed information about histopathological lesions in the inbred strain KK/HlJ can help investigators to choose the right model and correctly interpret the experimental results. |
Links |
J:227536 – MGI References 24009271 – National Library of Medicine/PubMed |
Strain | Model Name | Treatment Agent(s) | Organ Affected | Frequency | Model Details |
---|---|---|---|---|---|
KK/HlJ | Adipose tissue lipoma | Abdominal cavity |
0 - 50 |
||
KK/HlJ | Adrenal gland adenoma | Adrenal gland |
0 - 14.29 |
||
KK/HlJ | Adrenal gland hyperplasia | Adrenal gland |
0 - 28.57 |
||
KK/HlJ | Bone lesion - fibro-osseous | Bone |
0 - 100 |
||
KK/HlJ | Eye - Lacrimal gland hyperplasia | Eye - Lacrimal gland |
0 - 28.57 |
||
KK/HlJ | Eye adenoma | Eye |
0 - 6.67 |
||
KK/HlJ | Eye hyperplasia | Eye |
0 - 71.43 |
||
KK/HlJ | Gallbladder cyst | Gallbladder |
0 - 11.11 |
||
KK/HlJ | Intestine - Large Intestine - Cecum hyperplasia | Intestine - Large Intestine - Cecum |
0 - 14.29 |
||
KK/HlJ | Intestine - Large Intestine - Colon hyperplasia | Intestine - Large Intestine - Colon |
0 - 14.29 |
||
KK/HlJ | Intestine - Small Intestine - Jejunum polyp | Intestine - Small Intestine - Jejunum |
0 - 16.67 |
||
KK/HlJ | Leukocyte - Lymphocyte - B-lymphocyte - Immature plasma cell plasmacytoma | Lymph node |
2.86 |
||
KK/HlJ | Leukocyte - Lymphocyte - B-lymphocyte - Plasma cell plasmacytoma | Lymph node - Cervical |
0 - 14.29 |
||
KK/HlJ | Leukocyte - Lymphocyte - B-lymphocyte - Plasma cell plasmacytoma | Lymph node |
0 - 14.29 |
||
KK/HlJ | Leukocyte lymphoma | Lymph node - Cervical |
0 - 14.29 |
||
KK/HlJ | Leukocyte lymphoma | Leukocyte |
0 - 33.33 |
||
KK/HlJ | Liver tumor | Liver |
0 - 14.29 |
||
KK/HlJ | Lung adenoma | Lung |
0 - 16.67 |
||
KK/HlJ | Lymph node - Cervical cyst | Lymph node - Cervical |
0 - 42.86 |
||
KK/HlJ | Lymph node cyst | Lymph node |
0 - 14.29 |
||
KK/HlJ | Lymph node hyperplasia | Lymph node |
0 - 28.57 |
||
KK/HlJ | Mesodermal cell/mesoblast myxosarcoma | Muscle - Striated - Skeletal |
0 - 14.29 |
||
KK/HlJ | Mesodermal cell/mesoblast sarcoma | Seminal vesicle |
0 - 14.29 |
||
KK/HlJ | Mesodermal cell/mesoblast sarcoma | Muscle - Striated - Skeletal |
0 |
||
KK/HlJ | Muscle - Striated - Skeletal hyperplasia | Muscle - Striated - Skeletal |
0 - 14.29 |
||
KK/HlJ | Muscle - Striated - Skeletal hyperplasia - acinar | Muscle - Striated - Skeletal |
0 |
||
KK/HlJ | Ovary - Luteal cell tumor | Ovary - Luteal cell |
0 - 11.11 |
||
KK/HlJ | Ovary cyst | Ovary |
0 - 71.43 |
||
KK/HlJ | PNS - Nerve sheath tumor | Skin |
0 - 33.33 |
||
KK/HlJ | Pancreas hyperplasia | Pancreas |
25 - 100 |
||
KK/HlJ | Skin - Epidermis - Basal cell carcinoma | Skin - Epidermis - Basal cell |
0 - 14.29 |
||
KK/HlJ | Skin dysplasia | Skin |
0 - 12.5 |
||
KK/HlJ | Spleen hyperplasia | Spleen |
0 - 75 |
||
KK/HlJ | Stomach adenoma | Stomach |
0 - 25 |
||
KK/HlJ | Stomach hyperplasia | Stomach |
0 - 14.29 |
||
KK/HlJ | Testis hyperplasia | Testis |
0 - 14.29 |
||
KK/HlJ | Thyroid gland cyst | Thyroid gland |
0 - 14.29 |
||
KK/HlJ | Thyroid gland hyperplasia | Thyroid gland |
0 - 28.57 |
||
KK/HlJ | Tooth hyperplasia | Tooth |
0 - 33.33 |
||
KK/HlJ | Uterus cyst | Uterus |
0 - 50 |