Reference SummaryBerndt A, Vet Pathol 2014 Jul;51(4):846-57

Title

 Phenotypic characterization of the KK/HlJ inbred mouse strain.

Authors

 Berndt A; Sundberg BA; Silva KA; Kennedy VE; Richardson MA; Li Q; Bronson RT; Uitto J; Sundberg JP

Journal

 Vet Pathol

Volume

 51

Issue

 4

Year

 2014

Pages

 846-57

Abstract

 Detailed histopathological diagnoses of inbred mouse strains are important for interpreting research results and defining novel models of human diseases. The aim of this study was to histologically detect lesions affecting the KK/HlJ inbred strain. Mice were examined at 6, 12, and 20 months of age and near natural death (ie, moribund mice). Histopathological lesions were quantified by percentage of affected mice per age group and sex. Predominant lesions were mineralization, hyperplasia, and fibro-osseous lesions. Mineralization was most frequently found in the connective tissue dermal sheath of vibrissae, the heart, and the lung. Mineralization was also found in many other organs but to a lesser degree. Hyperplasia was found most commonly in the pancreatic islets, and fibro-osseous lesions were observed in several bones. The percentage of lesions increased with age until 20 months. This study shows that KK/HlJ mice demonstrate systemic aberrant mineralization, with greatest frequency in aged mice. The detailed information about histopathological lesions in the inbred strain KK/HlJ can help investigators to choose the right model and correctly interpret the experimental results.

Links

 J:227536 – MGI References
24009271 – National Library of Medicine/PubMed

Models
Strain Model Name Treatment Agent(s) Organ Affected Frequency Model Details
KK/HlJ Adipose tissue lipoma Abdominal cavity

0 - 50
KK/HlJ Adrenal gland adenoma Adrenal gland

0 - 14.29
KK/HlJ Adrenal gland hyperplasia Adrenal gland

0 - 28.57
KK/HlJ Bone lesion - fibro-osseous Bone

0 - 100
KK/HlJ Eye - Lacrimal gland hyperplasia Eye - Lacrimal gland

0 - 28.57
KK/HlJ Eye adenoma Eye

0 - 6.67
KK/HlJ Eye hyperplasia Eye

0 - 71.43
KK/HlJ Gallbladder cyst Gallbladder

0 - 11.11
KK/HlJ Intestine - Large Intestine - Cecum hyperplasia Intestine - Large Intestine - Cecum

0 - 14.29
KK/HlJ Intestine - Large Intestine - Colon hyperplasia Intestine - Large Intestine - Colon

0 - 14.29
KK/HlJ Intestine - Small Intestine - Jejunum polyp Intestine - Small Intestine - Jejunum

0 - 16.67
KK/HlJ Leukocyte - Lymphocyte - B-lymphocyte - Immature plasma cell plasmacytoma Lymph node

2.86
KK/HlJ Leukocyte - Lymphocyte - B-lymphocyte - Plasma cell plasmacytoma Lymph node - Cervical

0 - 14.29
KK/HlJ Leukocyte - Lymphocyte - B-lymphocyte - Plasma cell plasmacytoma Lymph node

0 - 14.29
KK/HlJ Leukocyte lymphoma Lymph node - Cervical

0 - 14.29
KK/HlJ Leukocyte lymphoma Leukocyte

0 - 33.33
KK/HlJ Liver tumor Liver

0 - 14.29
KK/HlJ Lung adenoma Lung

0 - 16.67
KK/HlJ Lymph node - Cervical cyst Lymph node - Cervical

0 - 42.86
KK/HlJ Lymph node cyst Lymph node

0 - 14.29
KK/HlJ Lymph node hyperplasia Lymph node

0 - 28.57
KK/HlJ Mesodermal cell/mesoblast myxosarcoma Muscle - Striated - Skeletal

0 - 14.29
KK/HlJ Mesodermal cell/mesoblast sarcoma Seminal vesicle

0 - 14.29
KK/HlJ Mesodermal cell/mesoblast sarcoma Muscle - Striated - Skeletal

0
KK/HlJ Muscle - Striated - Skeletal hyperplasia Muscle - Striated - Skeletal

0 - 14.29
KK/HlJ Muscle - Striated - Skeletal hyperplasia - acinar Muscle - Striated - Skeletal

0
KK/HlJ Ovary - Luteal cell tumor Ovary - Luteal cell

0 - 11.11
KK/HlJ Ovary cyst Ovary

0 - 71.43
KK/HlJ PNS - Nerve sheath tumor Skin

0 - 33.33
KK/HlJ Pancreas hyperplasia Pancreas

25 - 100
KK/HlJ Skin - Epidermis - Basal cell carcinoma Skin - Epidermis - Basal cell

0 - 14.29
KK/HlJ Skin dysplasia Skin

0 - 12.5
KK/HlJ Spleen hyperplasia Spleen

0 - 75
KK/HlJ Stomach adenoma Stomach

0 - 25
KK/HlJ Stomach hyperplasia Stomach

0 - 14.29
KK/HlJ Testis hyperplasia Testis

0 - 14.29
KK/HlJ Thyroid gland cyst Thyroid gland

0 - 14.29
KK/HlJ Thyroid gland hyperplasia Thyroid gland

0 - 28.57
KK/HlJ Tooth hyperplasia Tooth

0 - 33.33
KK/HlJ Uterus cyst Uterus

0 - 50