Reference SummaryIgarashi I, J Vet Med Sci 2013 Feb;75(2):207-10

Title

Background lesions during a 24-month observation period in connexin 32-deficient mice.

Authors

Igarashi I; Makino T; Suzuki Y; Kai K; Teranishi M; Takasaki W; Furuhama K

Journal

J Vet Med Sci

Volume

75

Issue

2

Year

2013

Pages

207-10

Abstract

Connexin 32 (Cx32) is a major gap junction protein in the liver. Neoplastic and non-neoplastic lesions were examined in Cx32-deficient (Cx32KO) mice maintained for 24-month, and compared with those in wild-type mice as a corresponding control. In neoplastic lesions, hepatocellular carcinoma increased significantly only in male Cx32KO mice, suggesting that Cx32 deficiency may be related to their pathogenesis. For females, the incidence of pituitary adenoma in the pars distalis of Cx32KO mice was lower than that of wild-type mice. No non-neoplastic lesions related to Cx32-deficiency were observed in the Cx32KO mice. In conclusion, these results demonstrate that the incidence of hepatocellular carcinoma increases only in male Cx32KO mice, presumably due to enhanced tumor promotion and progression signals associated with Cx32 deficiency.

Links

J:232380 – MGI References
23001129 – National Library of Medicine/PubMed

Strain Notes

Strain Note
C57BL/6J "Wild-type C57BL/6J mice were purchased from Charles River Laboratories (Yokohama, Japan)."
[not specified]-Gjb1tm1Kwi "Cx32KO mice were kindly provided by Willecke and colleagues [16], and then bred in our own facilities (Daiichi Sankyo Co., Ltd., Fukuroi, Japan)."
The choice of C57BL/6JCrj as a control strain implies that the background of these mice was predominantly C57BL/6.

Models

Strain Model Name Treatment Agent(s) Organ Affected Frequency Model Details
[not specified]-Gjb1tm1Kwi Blood vessel hemangioma Liver

2 - 4

C57BL/6J Blood vessel hemangioma Liver

2 - 6

[not specified]-Gjb1tm1Kwi Blood vessel hemangiosarcoma Liver

2 - 4

C57BL/6J Blood vessel hemangiosarcoma Liver

0 - 2

[not specified]-Gjb1tm1Kwi Kidney cyst - macrocyst Kidney

0 - 2

C57BL/6J Kidney cyst - macrocyst Kidney

2 - 4

[not specified]-Gjb1tm1Kwi Kidney cyst - microcyst Kidney

4 - 6

C57BL/6J Kidney cyst - microcyst Kidney

4

[not specified]-Gjb1tm1Kwi Kidney metaplasia - osseous Kidney

0

C57BL/6J Kidney metaplasia - osseous Kidney

0 - 2

[not specified]-Gjb1tm1Kwi Kidney transitional cell hyperplasia Kidney

0

C57BL/6J Kidney transitional cell hyperplasia Kidney

0 - 2

[not specified]-Gjb1tm1Kwi Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma Liver

14

C57BL/6J Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma Liver

6 - 12

[not specified]-Gjb1tm1Kwi Leukocyte - Myelocyte (Granulocyte) - Basophil - Mast cell tumor Liver

0 - 2

C57BL/6J Leukocyte - Myelocyte (Granulocyte) - Basophil - Mast cell tumor Liver

0 - 2

[not specified]-Gjb1tm1Kwi Leukocyte lymphoma Liver

10

C57BL/6J Leukocyte lymphoma Liver

6 - 8

[not specified]-Gjb1tm1Kwi Liver - Bile duct cyst - macrocyst Liver - Bile duct

4 - 6

C57BL/6J Liver - Bile duct cyst - macrocyst Liver - Bile duct

0

[not specified]-Gjb1tm1Kwi Liver cyst - macrocyst Liver

4 - 8

C57BL/6J Liver cyst - macrocyst Liver

0 - 2

[not specified]-Gjb1tm1Kwi Liver foci - clear cell Liver

0

C57BL/6J Liver foci - clear cell Liver

0 - 2

[not specified]-Gjb1tm1Kwi Liver foci - eosinophilic Liver

2 - 6

C57BL/6J Liver foci - eosinophilic Liver

0 - 2

[not specified]-Gjb1tm1Kwi Liver foci - vacuolated cell Liver

0 - 2

C57BL/6J Liver foci - vacuolated cell Liver

0

[not specified]-Gjb1tm1Kwi Liver hepatocellular adenoma Liver

8 - 10

C57BL/6J Liver hepatocellular adenoma Liver

0 - 2

[not specified]-Gjb1tm1Kwi Liver hepatocellular carcinoma Liver

4 - 18

C57BL/6J Liver hepatocellular carcinoma Liver

0

[not specified]-Gjb1tm1Kwi Liver hepatocellular carcinoma - solid Liver

observed

[not specified]-Gjb1tm1Kwi Liver hepatocellular carcinoma - trabecular Liver

observed

[not specified]-Gjb1tm1Kwi Pituitary gland - Pars distalis adenoma Pituitary gland - Pars distalis

0 - 4

C57BL/6J Pituitary gland - Pars distalis adenoma Pituitary gland - Pars distalis

0 - 20

[not specified]-Gjb1tm1Kwi Pituitary gland - Pars distalis cyst - microcyst Pituitary gland - Pars distalis

0

C57BL/6J Pituitary gland - Pars distalis cyst - microcyst Pituitary gland - Pars distalis

0 - 2

[not specified]-Gjb1tm1Kwi Pituitary gland - Pars distalis hyperplasia - focal Pituitary gland - Pars distalis

0 - 14

C57BL/6J Pituitary gland - Pars distalis hyperplasia - focal Pituitary gland - Pars distalis

0 - 12

[not specified]-Gjb1tm1Kwi Pituitary gland - Pars intermedia adenoma Pituitary gland - Pars intermedia

0 - 2

C57BL/6J Pituitary gland - Pars intermedia adenoma Pituitary gland - Pars intermedia

0

[not specified]-Gjb1tm1Kwi Pituitary gland - Pars intermedia hyperplasia Pituitary gland - Pars intermedia

0 - 2

C57BL/6J Pituitary gland - Pars intermedia hyperplasia Pituitary gland - Pars intermedia

0 - 4

[not specified]-Gjb1tm1Kwi Pituitary gland carcinoma Pituitary gland

0

C57BL/6J Pituitary gland carcinoma Pituitary gland

0 - 2

[not specified]-Gjb1tm1Kwi Pituitary gland cyst - microcyst Pituitary gland

6

C57BL/6J Pituitary gland cyst - microcyst Pituitary gland

2

[not specified]-Gjb1tm1Kwi Pituitary gland hyperplasia - focal Pituitary gland

2

C57BL/6J Pituitary gland hyperplasia - focal Pituitary gland

0