Reference SummaryIgarashi I, J Vet Med Sci 2013 Feb;75(2):207-10
Title |
Background lesions during a 24-month observation period in connexin 32-deficient mice. | ||||||
Authors |
Igarashi I; Makino T; Suzuki Y; Kai K; Teranishi M; Takasaki W; Furuhama K | ||||||
Journal |
J Vet Med Sci | ||||||
Volume |
75 | ||||||
Issue |
2 | ||||||
Year |
2013 | ||||||
Pages |
207-10 | ||||||
Abstract |
Connexin 32 (Cx32) is a major gap junction protein in the liver. Neoplastic and non-neoplastic lesions were examined in Cx32-deficient (Cx32KO) mice maintained for 24-month, and compared with those in wild-type mice as a corresponding control. In neoplastic lesions, hepatocellular carcinoma increased significantly only in male Cx32KO mice, suggesting that Cx32 deficiency may be related to their pathogenesis. For females, the incidence of pituitary adenoma in the pars distalis of Cx32KO mice was lower than that of wild-type mice. No non-neoplastic lesions related to Cx32-deficiency were observed in the Cx32KO mice. In conclusion, these results demonstrate that the incidence of hepatocellular carcinoma increases only in male Cx32KO mice, presumably due to enhanced tumor promotion and progression signals associated with Cx32 deficiency. | ||||||
Links |
J:232380 – MGI References 23001129 – National Library of Medicine/PubMed |
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Strain Notes
|
Strain | Model Name | Treatment Agent(s) | Organ Affected | Frequency | Model Details |
---|---|---|---|---|---|
[not specified]-Gjb1tm1Kwi | Blood vessel hemangioma | Liver |
2 - 4 |
||
C57BL/6J | Blood vessel hemangioma | Liver |
2 - 6 |
||
[not specified]-Gjb1tm1Kwi | Blood vessel hemangiosarcoma | Liver |
2 - 4 |
||
C57BL/6J | Blood vessel hemangiosarcoma | Liver |
0 - 2 |
||
[not specified]-Gjb1tm1Kwi | Kidney cyst - macrocyst | Kidney |
0 - 2 |
||
C57BL/6J | Kidney cyst - macrocyst | Kidney |
2 - 4 |
||
[not specified]-Gjb1tm1Kwi | Kidney cyst - microcyst | Kidney |
4 - 6 |
||
C57BL/6J | Kidney cyst - microcyst | Kidney |
4 |
||
[not specified]-Gjb1tm1Kwi | Kidney metaplasia - osseous | Kidney |
0 |
||
C57BL/6J | Kidney metaplasia - osseous | Kidney |
0 - 2 |
||
[not specified]-Gjb1tm1Kwi | Kidney transitional cell hyperplasia | Kidney |
0 |
||
C57BL/6J | Kidney transitional cell hyperplasia | Kidney |
0 - 2 |
||
[not specified]-Gjb1tm1Kwi | Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma | Liver |
14 |
||
C57BL/6J | Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma | Liver |
6 - 12 |
||
[not specified]-Gjb1tm1Kwi | Leukocyte - Myelocyte (Granulocyte) - Basophil - Mast cell tumor | Liver |
0 - 2 |
||
C57BL/6J | Leukocyte - Myelocyte (Granulocyte) - Basophil - Mast cell tumor | Liver |
0 - 2 |
||
[not specified]-Gjb1tm1Kwi | Leukocyte lymphoma | Liver |
10 |
||
C57BL/6J | Leukocyte lymphoma | Liver |
6 - 8 |
||
[not specified]-Gjb1tm1Kwi | Liver - Bile duct cyst - macrocyst | Liver - Bile duct |
4 - 6 |
||
C57BL/6J | Liver - Bile duct cyst - macrocyst | Liver - Bile duct |
0 |
||
[not specified]-Gjb1tm1Kwi | Liver cyst - macrocyst | Liver |
4 - 8 |
||
C57BL/6J | Liver cyst - macrocyst | Liver |
0 - 2 |
||
[not specified]-Gjb1tm1Kwi | Liver foci - clear cell | Liver |
0 |
||
C57BL/6J | Liver foci - clear cell | Liver |
0 - 2 |
||
[not specified]-Gjb1tm1Kwi | Liver foci - eosinophilic | Liver |
2 - 6 |
||
C57BL/6J | Liver foci - eosinophilic | Liver |
0 - 2 |
||
[not specified]-Gjb1tm1Kwi | Liver foci - vacuolated cell | Liver |
0 - 2 |
||
C57BL/6J | Liver foci - vacuolated cell | Liver |
0 |
||
[not specified]-Gjb1tm1Kwi | Liver hepatocellular adenoma | Liver |
8 - 10 |
||
C57BL/6J | Liver hepatocellular adenoma | Liver |
0 - 2 |
||
[not specified]-Gjb1tm1Kwi | Liver hepatocellular carcinoma | Liver |
4 - 18 |
||
C57BL/6J | Liver hepatocellular carcinoma | Liver |
0 |
||
[not specified]-Gjb1tm1Kwi | Liver hepatocellular carcinoma - solid | Liver |
observed |
||
[not specified]-Gjb1tm1Kwi | Liver hepatocellular carcinoma - trabecular | Liver |
observed |
||
[not specified]-Gjb1tm1Kwi | Pituitary gland - Pars distalis adenoma | Pituitary gland - Pars distalis |
0 - 4 |
||
C57BL/6J | Pituitary gland - Pars distalis adenoma | Pituitary gland - Pars distalis |
0 - 20 |
||
[not specified]-Gjb1tm1Kwi | Pituitary gland - Pars distalis cyst - microcyst | Pituitary gland - Pars distalis |
0 |
||
C57BL/6J | Pituitary gland - Pars distalis cyst - microcyst | Pituitary gland - Pars distalis |
0 - 2 |
||
[not specified]-Gjb1tm1Kwi | Pituitary gland - Pars distalis hyperplasia - focal | Pituitary gland - Pars distalis |
0 - 14 |
||
C57BL/6J | Pituitary gland - Pars distalis hyperplasia - focal | Pituitary gland - Pars distalis |
0 - 12 |
||
[not specified]-Gjb1tm1Kwi | Pituitary gland - Pars intermedia adenoma | Pituitary gland - Pars intermedia |
0 - 2 |
||
C57BL/6J | Pituitary gland - Pars intermedia adenoma | Pituitary gland - Pars intermedia |
0 |
||
[not specified]-Gjb1tm1Kwi | Pituitary gland - Pars intermedia hyperplasia | Pituitary gland - Pars intermedia |
0 - 2 |
||
C57BL/6J | Pituitary gland - Pars intermedia hyperplasia | Pituitary gland - Pars intermedia |
0 - 4 |
||
[not specified]-Gjb1tm1Kwi | Pituitary gland carcinoma | Pituitary gland |
0 |
||
C57BL/6J | Pituitary gland carcinoma | Pituitary gland |
0 - 2 |
||
[not specified]-Gjb1tm1Kwi | Pituitary gland cyst - microcyst | Pituitary gland |
6 |
||
C57BL/6J | Pituitary gland cyst - microcyst | Pituitary gland |
2 |
||
[not specified]-Gjb1tm1Kwi | Pituitary gland hyperplasia - focal | Pituitary gland |
2 |
||
C57BL/6J | Pituitary gland hyperplasia - focal | Pituitary gland |
0 |