Reference SummaryHashizume O, PLoS One 2015;10(3):e0118561
Title |
A specific nuclear DNA background is required for high frequency lymphoma development in transmitochondrial mice with G13997A mtDNA. |
Authors |
Hashizume O; Yamanashi H; Taketo MM; Nakada K; Hayashi J |
Journal |
PLoS One |
Volume |
10 |
Issue |
3 |
Year |
2015 |
Pages |
e0118561 |
Abstract |
We previously found that mouse mitochondrial DNA (mtDNA) with a G13997A mutation (G13997A mtDNA) controls not only the transformation of cultured lung carcinoma cells from poorly metastatic into highly metastatic cells, but also the transformation of lymphocytes into lymphomas in living C57BL/6 (B6) mice. Because the nuclear genetic background of the B6 strain makes the strain prone to develop lymphomas, here we examined whether G13997A mtDNA independently induces lymphoma development even in mice with the nuclear genetic background of the A/J strain, which is not prone to develop lymphomas. Our results showed that the B6 nuclear genetic background is required for frequent lymphoma development in mice with G13997A mtDNA. Moreover, G13997A mtDNA in mice did not enhance the malignant transformation of lung adenomas into adenocarcinomas or that of hepatocellular carcinomas from poorly metastatic into highly metastatic carcinomas. Therefore, G13997A mtDNA enhances the frequency of lymphoma development under the abnormalities in the B6 nuclear genome, and does not independently control tumor development and tumor progression. |
Links |
J:233444 – MGI References 25738506 – National Library of Medicine/PubMed |
| |
| Strain | Model Name | Treatment Agent(s) | Organ Affected | Frequency | Model Details |
|---|---|---|---|---|---|
| C57BL/6JJcl | Leukocyte lymphoma | Leukocyte |
8.57 |
||
| C57BL/6-mt-Nd6m2Jiha | Leukocyte lymphoma | Leukocyte |
45.71 |
||
| A;B6 | Leukocyte lymphoma | Leukocyte |
0 |
||
| A;B6-mt-Nd6m2Jiha | Leukocyte lymphoma | Leukocyte |
0 |
||
| C57BL/6JJcl | Leukocyte lymphoma |
|
Leukocyte |
0 |
|
| C57BL/6-mt-Nd6m2Jiha | Leukocyte lymphoma |
|
Leukocyte |
0 |
|
| B6;A | Leukocyte lymphoma |
|
Leukocyte |
0 |
|
| B6;A-mt-Nd6m2Jiha | Leukocyte lymphoma |
|
Leukocyte |
0 |
|
| C57BL/6-Stk11tm1Mmt/+ | Leukocyte lymphoma | Leukocyte |
0 |
||
| C57BL/6-mt-Nd6m2Jiha Stk11tm1Mmt/+ | Leukocyte lymphoma | Leukocyte |
0 |
||
| C57BL/6JJcl | Liver hepatocellular carcinoma | Liver |
0 |
||
| C57BL/6-mt-Nd6m2Jiha | Liver hepatocellular carcinoma | Liver |
0 |
||
| A;B6 | Liver hepatocellular carcinoma | Liver |
0 |
||
| A;B6-mt-Nd6m2Jiha | Liver hepatocellular carcinoma | Liver |
0 |
||
| C57BL/6JJcl | Liver hepatocellular carcinoma |
|
Liver |
0 |
|
| C57BL/6-mt-Nd6m2Jiha | Liver hepatocellular carcinoma |
|
Liver |
0 |
|
| B6;A | Liver hepatocellular carcinoma |
|
Liver |
0 |
|
| B6;A-mt-Nd6m2Jiha | Liver hepatocellular carcinoma |
|
Liver |
0 |
|
| C57BL/6-Stk11tm1Mmt/+ | Liver hepatocellular carcinoma | Liver |
73.68 |
||
| C57BL/6-mt-Nd6m2Jiha Stk11tm1Mmt/+ | Liver hepatocellular carcinoma | Liver |
81.25 |
||
| C57BL/6JJcl | Liver tumor | Liver |
0 |
||
| C57BL/6-mt-Nd6m2Jiha | Liver tumor | Liver |
0 |
||
| A;B6 | Liver tumor | Liver |
0 |
||
| A;B6-mt-Nd6m2Jiha | Liver tumor | Liver |
0 |
||
| C57BL/6JJcl | Liver tumor |
|
Liver |
0 |
|
| C57BL/6-mt-Nd6m2Jiha | Liver tumor |
|
Liver |
0 |
|
| B6;A | Liver tumor |
|
Liver |
0 |
|
| B6;A-mt-Nd6m2Jiha | Liver tumor |
|
Liver |
0 |
|
| C57BL/6-Stk11tm1Mmt/+ | Liver tumor | Liver |
73.68 |
||
| C57BL/6-mt-Nd6m2Jiha Stk11tm1Mmt/+ | Liver tumor | Liver |
81.25 |
||
| C57BL/6JJcl | Lung adenoma | Lung |
0 |
||
| C57BL/6-mt-Nd6m2Jiha | Lung adenoma | Lung |
0 |
||
| A;B6 | Lung adenoma | Lung |
80 |
||
| A;B6-mt-Nd6m2Jiha | Lung adenoma | Lung |
83.33 |
||
| C57BL/6JJcl | Lung adenoma |
|
Lung |
100 |
|
| C57BL/6-mt-Nd6m2Jiha | Lung adenoma |
|
Lung |
100 |
|
| B6;A | Lung adenoma |
|
Lung |
100 |
|
| B6;A-mt-Nd6m2Jiha | Lung adenoma |
|
Lung |
100 |
|
| C57BL/6-Stk11tm1Mmt/+ | Lung adenoma | Lung |
0 |
||
| C57BL/6-mt-Nd6m2Jiha Stk11tm1Mmt/+ | Lung adenoma | Lung |
0 |
||
| C57BL/6JJcl | Lung tumor | Lung |
0 |
||
| C57BL/6-mt-Nd6m2Jiha | Lung tumor | Lung |
0 |
||
| A;B6 | Lung tumor | Lung |
80 |
||
| A;B6-mt-Nd6m2Jiha | Lung tumor | Lung |
83.33 |
||
| C57BL/6JJcl | Lung tumor |
|
Lung |
100 |
|
| C57BL/6-mt-Nd6m2Jiha | Lung tumor |
|
Lung |
100 |
|
| B6;A | Lung tumor |
|
Lung |
100 |
|
| B6;A-mt-Nd6m2Jiha | Lung tumor |
|
Lung |
100 |
|
| C57BL/6-Stk11tm1Mmt/+ | Lung tumor | Lung |
0 |
||
| C57BL/6-mt-Nd6m2Jiha Stk11tm1Mmt/+ | Lung tumor | Lung |
0 |
||
| C57BL/6JJcl | (Unspecified organ) tumor | (Unspecified organ) |
0 |
||
| C57BL/6-mt-Nd6m2Jiha | (Unspecified organ) tumor | (Unspecified organ) |
0 |
||
| A;B6 | (Unspecified organ) tumor | (Unspecified organ) |
0 |
||
| A;B6-mt-Nd6m2Jiha | (Unspecified organ) tumor | (Unspecified organ) |
0 |
||
| C57BL/6JJcl | (Unspecified organ) tumor |
|
(Unspecified organ) |
0 |
|
| C57BL/6-mt-Nd6m2Jiha | (Unspecified organ) tumor |
|
(Unspecified organ) |
0 |
|
| B6;A | (Unspecified organ) tumor |
|
(Unspecified organ) |
0 |
|
| B6;A-mt-Nd6m2Jiha | (Unspecified organ) tumor |
|
(Unspecified organ) |
0 |
|
| C57BL/6-Stk11tm1Mmt/+ | (Unspecified organ) tumor | (Unspecified organ) |
0 |
||
| C57BL/6-mt-Nd6m2Jiha Stk11tm1Mmt/+ | (Unspecified organ) tumor | (Unspecified organ) |
0 |