Reference SummaryHighman B, J Environ Pathol Toxicol 1980 Nov;4(5-6):81-95

Title

 Neoplastic and preneoplastic lesions induced in female C3H mice by diets containing diethylstilbestrol or 17 beta-estradiol.

Authors

 Highman B; Greenman DL; Norvell MJ; Farmer J; Shellenberger TE

Journal

 J Environ Pathol Toxicol

Volume

 4

Issue

 5-6

Year

 1980

Pages

 81-95

Abstract

 To study the long term effects of estrogenic diets, 2160 virgin female C3H/Hel mice, having a high titer to the mammary tumor virus factor (MMTV), were fed diets containing 0, 10, 100, 500, or 1000 ppb diethylstilbestrol (DES) or 100, 1000, or 5000 ppb 17 beta-estradiol (E2) from 6 to 110 weeks of age; 1368 virgin female C3HeB/FeJ mice, having a low titer to the MMTV, were fed diets containing 0, 10, 1000, or 500 ppb DES from 6 to 136 weeks. In estrogen-treated mice, the incidence of cervical adenosis and of mammary hyperplastic alveolar nodules was increased and the time to development of mammary adenocarcinomas was shortened. These changes tended to increase with dose and time and appeared earlier in the C3H/HeJ mice. Other tumors observed included 32 cervical and 20 endometrial adenocarcinomas, 16 cervical granular cell myoblastomas, 12 peritoneal mesotheliomas involving the uterus, 2 cervical and 4 vaginal squamous cell carcinomas, 2 ovarian teratomas, 6 osteosarcomas, 25 pheochromocytomas and 3 thyroid carcinomas. Of these tumors, 1 cervical and 2 endometrial adenocarcinomas, and 4 pheochromocytomas occurred in C3HeB/FeJ control mice at 104-130 weeks; none occurred in C3H/HeJ controls. This study indicates that the MMTV facilitates the development of mammary lesions in C3H mice, that estrogens predispose C3H mice to endometrial and cervical adenocarcinomas, and that cervical adenosis may be a precursor of cervical adenocarcinoma in C3H mice and serve as an early indicator of the potential uterine carcinogenicity of a test compound. It supports the view that the C3H mouse may serve as an animal model for uterine adenocarcinomas and adenosis in women exposed to estrogens.

Links

 J:237477 – MGI References
7217862 – National Library of Medicine/PubMed

Models
Strain Model Name Treatment Agent(s) Organ Affected Frequency Model Details
C3H/HeJ Adrenal gland - Medulla hyperplasia
  • MMTV - mouse mammary tumor virus
  • diethylstilbestrol (DES)
  • corn oil
 Adrenal gland - Medulla

observed
C3H/HeJ Adrenal gland - Medulla hyperplasia
  • MMTV - mouse mammary tumor virus
  • 17beta-estradiol (E2)
  • corn oil
 Adrenal gland - Medulla

observed
C3H/HeJ Adrenal gland - Medulla hyperplasia
  • MMTV - mouse mammary tumor virus
  • corn oil
 Adrenal gland - Medulla

observed
C3H/HeJ Adrenal gland - Medulla pheochromocytoma
  • MMTV - mouse mammary tumor virus
  • corn oil
 Adrenal gland - Medulla

0
C3H/HeJ Adrenal gland - Medulla pheochromocytoma
  • MMTV - mouse mammary tumor virus
  • diethylstilbestrol (DES)
  • corn oil
 Adrenal gland - Medulla

observed
C3H/HeJ Adrenal gland - Medulla pheochromocytoma
  • MMTV - mouse mammary tumor virus
  • diethylstilbestrol (DES)
  • corn oil
 Adrenal gland - Medulla

observed
C3H/HeJ Adrenal gland - Medulla pheochromocytoma
  • MMTV - mouse mammary tumor virus
  • diethylstilbestrol (DES)
  • corn oil
 Adrenal gland - Medulla

0
C3H/HeJ Adrenal gland - Medulla pheochromocytoma
  • MMTV - mouse mammary tumor virus
  • 17beta-estradiol (E2)
  • corn oil
 Adrenal gland - Medulla

observed
C3H/HeJ Adrenal gland - Medulla pheochromocytoma
  • 17beta-estradiol (E2)
  • MMTV - mouse mammary tumor virus
  • corn oil
 Adrenal gland - Medulla

0 - observed
C3HeB/FeJ Adrenal gland - Medulla pheochromocytoma
  • corn oil
 Adrenal gland - Medulla

observed
C3HeB/FeJ Adrenal gland - Medulla pheochromocytoma
  • diethylstilbestrol (DES)
  • corn oil
 Adrenal gland - Medulla

observed
C3HeB/FeJ Adrenal gland - Medulla pheochromocytoma
  • diethylstilbestrol (DES)
  • corn oil
 Adrenal gland - Medulla

observed
C3H/HeJ Bone osteosarcoma
  • MMTV - mouse mammary tumor virus
  • diethylstilbestrol (DES)
  • corn oil
 Bone

observed
C3H/HeJ Bone osteosarcoma
  • MMTV - mouse mammary tumor virus
  • diethylstilbestrol (DES)
  • corn oil
 Bone

0
C3H/HeJ Bone osteosarcoma
  • MMTV - mouse mammary tumor virus
  • diethylstilbestrol (DES)
  • corn oil
 Bone

observed
C3H/HeJ Bone osteosarcoma
  • MMTV - mouse mammary tumor virus
  • 17beta-estradiol (E2)
  • corn oil
 Bone

observed
C3H/HeJ Bone osteosarcoma
  • 17beta-estradiol (E2)
  • MMTV - mouse mammary tumor virus
  • corn oil
 Bone

0
C3H/HeJ Bone osteosarcoma
  • MMTV - mouse mammary tumor virus
  • 17beta-estradiol (E2)
  • corn oil
 Bone

0
C3HeB/FeJ Bone osteosarcoma
  • corn oil
 Bone

0
C3HeB/FeJ Bone osteosarcoma
  • diethylstilbestrol (DES)
  • corn oil
 Bone

observed
C3HeB/FeJ Bone osteosarcoma
  • diethylstilbestrol (DES)
  • corn oil
 Bone

observed
C3H/HeJ Liver hepatocellular adenoma
  • MMTV - mouse mammary tumor virus
  • corn oil
 Liver

1.24
C3H/HeJ Liver hepatocellular adenoma
  • MMTV - mouse mammary tumor virus
  • diethylstilbestrol (DES)
  • corn oil
 Liver

1.54
C3H/HeJ Liver hepatocellular adenoma
  • MMTV - mouse mammary tumor virus
  • 17beta-estradiol (E2)
  • corn oil
 Liver

1.4
C3HeB/FeJ Liver hepatocellular adenoma
  • MMTV - mouse mammary tumor virus
  • corn oil
 Liver

1.45
C3HeB/FeJ Liver hepatocellular adenoma
  • MMTV - mouse mammary tumor virus
  • diethylstilbestrol (DES)
  • corn oil
 Liver

2.13
C3H/HeJ Liver hepatocellular carcinoma
  • MMTV - mouse mammary tumor virus
  • corn oil
 Liver

1.65
C3H/HeJ Liver hepatocellular carcinoma
  • MMTV - mouse mammary tumor virus
  • diethylstilbestrol (DES)
  • corn oil
 Liver

0.92
C3H/HeJ Liver hepatocellular carcinoma
  • 17beta-estradiol (E2)
  • MMTV - mouse mammary tumor virus
  • corn oil
 Liver

1.4
C3HeB/FeJ Liver hepatocellular carcinoma
  • MMTV - mouse mammary tumor virus
  • corn oil
 Liver

10.14
C3HeB/FeJ Liver hepatocellular carcinoma
  • MMTV - mouse mammary tumor virus
  • diethylstilbestrol (DES)
  • corn oil
 Liver

5.33
C3H/HeJ Mammary gland adenocarcinoma
  • MMTV - mouse mammary tumor virus
  • corn oil
 Mammary gland

4.4 - 38
C3H/HeJ Mammary gland adenocarcinoma
  • MMTV - mouse mammary tumor virus
  • diethylstilbestrol (DES)
  • corn oil
 Mammary gland

4.3 - 100
C3H/HeJ Mammary gland adenocarcinoma
  • MMTV - mouse mammary tumor virus
  • diethylstilbestrol (DES)
  • corn oil
 Mammary gland

6.9 - 50
C3H/HeJ Mammary gland adenocarcinoma
  • MMTV - mouse mammary tumor virus
  • diethylstilbestrol (DES)
  • corn oil
 Mammary gland

45.31 - 53.85
C3H/HeJ Mammary gland adenocarcinoma
  • 17beta-estradiol (E2)
  • MMTV - mouse mammary tumor virus
  • corn oil
 Mammary gland

0 - 57.89
C3H/HeJ Mammary gland adenocarcinoma
  • MMTV - mouse mammary tumor virus
  • 17beta-estradiol (E2)
  • corn oil
 Mammary gland

4.26 - 47.06
C3H/HeJ Mammary gland adenocarcinoma
  • 17beta-estradiol (E2)
  • MMTV - mouse mammary tumor virus
  • corn oil
 Mammary gland

5.38 - 44.44
C3HeB/FeJ Mammary gland adenocarcinoma
  • corn oil
 Mammary gland

2.63 - 51.28
C3HeB/FeJ Mammary gland adenocarcinoma
  • diethylstilbestrol (DES)
  • corn oil
 Mammary gland

0 - 60
C3HeB/FeJ Mammary gland adenocarcinoma
  • diethylstilbestrol (DES)
  • corn oil
 Mammary gland

0 - 20.45
C3H/HeJ Mammary gland adenocarcinoma
  • MMTV - mouse mammary tumor virus
  • corn oil
 Mammary gland

26.32 - 44.83
C3H/HeJ Mammary gland adenocarcinoma
  • MMTV - mouse mammary tumor virus
  • diethylstilbestrol (DES)
  • corn oil
 Mammary gland

19.51 - 50
C3H/HeJ Mammary gland adenocarcinoma
  • MMTV - mouse mammary tumor virus
  • 17beta-estradiol (E2)
  • corn oil
 Mammary gland

37.5
C3H/HeJ Mammary gland adenocarcinoma
  • 17beta-estradiol (E2)
  • MMTV - mouse mammary tumor virus
  • corn oil
 Mammary gland

42.11 - 43.59
C3H/HeJ Mammary gland adenocarcinoma
  • MMTV - mouse mammary tumor virus
  • diethylstilbestrol (DES)
  • corn oil
 Mammary gland

50
C3H/HeJ Mammary gland adenocarcinoma
  • MMTV - mouse mammary tumor virus
  • 17beta-estradiol (E2)
  • corn oil
 Mammary gland

58.33
C3H/HeJ Mammary gland adenocarcinoma
  • MMTV - mouse mammary tumor virus
  • diethylstilbestrol (DES)
  • corn oil
 Mammary gland

27.27 - 38.1
C3H/HeJ Mammary gland adenocarcinoma - type A
  • MMTV - mouse mammary tumor virus
  • diethylstilbestrol (DES)
  • corn oil
 Mammary gland

observed
C3H/HeJ Mammary gland adenocarcinoma - type A
  • 17beta-estradiol (E2)
  • MMTV - mouse mammary tumor virus
  • corn oil
 Mammary gland

observed
C3H/HeJ Mammary gland adenocarcinoma - type A
  • MMTV - mouse mammary tumor virus
  • corn oil
 Mammary gland

observed
C3H/HeJ Mammary gland adenocarcinoma - type B
  • MMTV - mouse mammary tumor virus
  • diethylstilbestrol (DES)
  • corn oil
 Mammary gland

observed
C3H/HeJ Mammary gland adenocarcinoma - type B
  • 17beta-estradiol (E2)
  • MMTV - mouse mammary tumor virus
  • corn oil
 Mammary gland

observed
C3H/HeJ Mammary gland adenocarcinoma - type B
  • MMTV - mouse mammary tumor virus
  • corn oil
 Mammary gland

observed
C3H/HeJ Mammary gland adenocarcinoma - type C
  • MMTV - mouse mammary tumor virus
  • diethylstilbestrol (DES)
  • corn oil
 Mammary gland

observed
C3H/HeJ Mammary gland adenocarcinoma - type C
  • 17beta-estradiol (E2)
  • MMTV - mouse mammary tumor virus
  • corn oil
 Mammary gland

very low
C3H/HeJ Mammary gland adenocarcinoma - type C
  • MMTV - mouse mammary tumor virus
  • corn oil
 Mammary gland

very low
C3HeB/FeJ Mammary gland carcinoma
  • corn oil
 Mammary gland

8.11
C3H/HeJ Mammary gland foci
  • MMTV - mouse mammary tumor virus
  • diethylstilbestrol (DES)
  • corn oil
 Mammary gland

observed
C3H/HeJ Mammary gland foci
  • 17beta-estradiol (E2)
  • MMTV - mouse mammary tumor virus
  • corn oil
 Mammary gland

observed
C3H/HeJ Mammary gland hyperplasia - alveolar
  • MMTV - mouse mammary tumor virus
  • corn oil
 Mammary gland

0 - 12
C3H/HeJ Mammary gland hyperplasia - alveolar
  • MMTV - mouse mammary tumor virus
  • diethylstilbestrol (DES)
  • corn oil
 Mammary gland

0 - observed
C3H/HeJ Mammary gland hyperplasia - alveolar
  • MMTV - mouse mammary tumor virus
  • diethylstilbestrol (DES)
  • corn oil
 Mammary gland

0 - 3.23
C3H/HeJ Mammary gland hyperplasia - alveolar
  • MMTV - mouse mammary tumor virus
  • diethylstilbestrol (DES)
  • corn oil
 Mammary gland

0 - 75
C3H/HeJ Mammary gland hyperplasia - alveolar
  • MMTV - mouse mammary tumor virus
  • diethylstilbestrol (DES)
  • corn oil
 Mammary gland

5.13 - 61.54
C3H/HeJ Mammary gland hyperplasia - alveolar
  • MMTV - mouse mammary tumor virus
  • 17beta-estradiol (E2)
  • corn oil
 Mammary gland

0 - 35.29
C3H/HeJ Mammary gland hyperplasia - alveolar
  • MMTV - mouse mammary tumor virus
  • 17beta-estradiol (E2)
  • corn oil
 Mammary gland

0 - 27.59
C3H/HeJ Mammary gland hyperplasia - alveolar
  • 17beta-estradiol (E2)
  • MMTV - mouse mammary tumor virus
  • corn oil
 Mammary gland

0 - 33.33
C3HeB/FeJ Mammary gland hyperplasia - alveolar
  • corn oil
 Mammary gland

0 - 5.41
C3HeB/FeJ Mammary gland hyperplasia - alveolar
  • diethylstilbestrol (DES)
  • corn oil
 Mammary gland

0 - 40
C3HeB/FeJ Mammary gland hyperplasia - alveolar
  • diethylstilbestrol (DES)
  • corn oil
 Mammary gland

0 - 70
C3H/HeJ Mammary gland hyperplasia - alveolar
  • MMTV - mouse mammary tumor virus
  • corn oil
 Mammary gland

0 - 10.34
C3H/HeJ Mammary gland hyperplasia - alveolar
  • MMTV - mouse mammary tumor virus
  • diethylstilbestrol (DES)
  • corn oil
 Mammary gland

2.44 - 19.05
C3H/HeJ Mammary gland hyperplasia - alveolar
  • MMTV - mouse mammary tumor virus
  • diethylstilbestrol (DES)
  • corn oil
 Mammary gland

0 - 12.12
C3H/HeJ Mammary gland hyperplasia - alveolar
  • 17beta-estradiol (E2)
  • MMTV - mouse mammary tumor virus
  • corn oil
 Mammary gland

0 - 26.32
C3H/HeJ Mammary gland lesion
  • MMTV - mouse mammary tumor virus
  • diethylstilbestrol (DES)
  • corn oil
 Mammary gland

observed
C3H/HeJ Mammary gland lesion
  • 17beta-estradiol (E2)
  • MMTV - mouse mammary tumor virus
  • corn oil
 Mammary gland

observed
C3H/HeJ Mammary gland tumor
  • MMTV - mouse mammary tumor virus
  • diethylstilbestrol (DES)
  • corn oil
 Mammary gland

53.85
C3H/HeJ Mesothelium mesothelioma
  • MMTV - mouse mammary tumor virus
  • corn oil
 Uterus

0
C3H/HeJ Mesothelium mesothelioma
  • MMTV - mouse mammary tumor virus
  • diethylstilbestrol (DES)
  • corn oil
 Uterus

0
C3H/HeJ Mesothelium mesothelioma
  • MMTV - mouse mammary tumor virus
  • diethylstilbestrol (DES)
  • corn oil
 Uterus

0
C3H/HeJ Mesothelium mesothelioma
  • MMTV - mouse mammary tumor virus
  • diethylstilbestrol (DES)
  • corn oil
 Uterus

observed
C3H/HeJ Mesothelium mesothelioma
  • MMTV - mouse mammary tumor virus
  • diethylstilbestrol (DES)
  • corn oil
 Uterus

observed
C3H/HeJ Mesothelium mesothelioma
  • MMTV - mouse mammary tumor virus
  • 17beta-estradiol (E2)
  • corn oil
 Uterus

0
C3H/HeJ Mesothelium mesothelioma
  • 17beta-estradiol (E2)
  • MMTV - mouse mammary tumor virus
  • corn oil
 Uterus

0
C3H/HeJ Mesothelium mesothelioma
  • 17beta-estradiol (E2)
  • MMTV - mouse mammary tumor virus
  • corn oil
 Uterus

observed
C3HeB/FeJ Mesothelium mesothelioma
  • corn oil
 Uterus

0
C3HeB/FeJ Mesothelium mesothelioma
  • diethylstilbestrol (DES)
  • corn oil
 Uterus

0
C3HeB/FeJ Mesothelium mesothelioma
  • diethylstilbestrol (DES)
  • corn oil
 Uterus

observed
C3H/HeJ Ovary - Germ cell teratoma
  • MMTV - mouse mammary tumor virus
  • corn oil
 Ovary - Germ cell

0
C3H/HeJ Ovary - Germ cell teratoma
  • MMTV - mouse mammary tumor virus
  • diethylstilbestrol (DES)
  • corn oil
 Ovary - Germ cell

0
C3H/HeJ Ovary - Germ cell teratoma
  • MMTV - mouse mammary tumor virus
  • diethylstilbestrol (DES)
  • corn oil
 Ovary - Germ cell

0
C3H/HeJ Ovary - Germ cell teratoma
  • 17beta-estradiol (E2)
  • MMTV - mouse mammary tumor virus
  • corn oil
 Ovary - Germ cell

0
C3H/HeJ Ovary - Germ cell teratoma
  • 17beta-estradiol (E2)
  • MMTV - mouse mammary tumor virus
  • corn oil
 Ovary - Germ cell

observed
C3HeB/FeJ Ovary - Germ cell teratoma
  • corn oil
 Ovary - Germ cell

0
C3HeB/FeJ Ovary - Germ cell teratoma
  • diethylstilbestrol (DES)
  • corn oil
 Ovary - Germ cell

0
C3HeB/FeJ Ovary - Germ cell teratoma
  • diethylstilbestrol (DES)
  • corn oil
 Ovary - Germ cell

observed
C3H/HeJ Ovary - Granulosa cell tumor
  • corn oil
 Ovary - Granulosa cell

3.4
C3HeB/FeJ Ovary - Granulosa cell tumor
  • corn oil
 Ovary - Granulosa cell

5.3
C3H/HeJ Ovary adenoma - tubular
  • MMTV - mouse mammary tumor virus
  • corn oil
 Ovary

14.29 - 50
C3H/HeJ Ovary adenoma - tubular
  • MMTV - mouse mammary tumor virus
  • diethylstilbestrol (DES)
  • corn oil
 Ovary

20.83 - 63.64
C3H/HeJ Ovary adenoma - tubular
  • MMTV - mouse mammary tumor virus
  • diethylstilbestrol (DES)
  • corn oil
 Ovary

47.5
C3H/HeJ Ovary adenoma - tubular
  • MMTV - mouse mammary tumor virus
  • diethylstilbestrol (DES)
  • corn oil
 Ovary

33.33 - 100
C3H/HeJ Ovary adenoma - tubular
  • MMTV - mouse mammary tumor virus
  • diethylstilbestrol (DES)
  • corn oil
 Ovary

33.33
C3H/HeJ Ovary adenoma - tubular
  • MMTV - mouse mammary tumor virus
  • 17beta-estradiol (E2)
  • corn oil
 Ovary

0 - 60
C3H/HeJ Ovary adenoma - tubular
  • 17beta-estradiol (E2)
  • MMTV - mouse mammary tumor virus
  • corn oil
 Ovary

42.86 - 44
C3H/HeJ Ovary adenoma - tubular
  • MMTV - mouse mammary tumor virus
  • 17beta-estradiol (E2)
  • corn oil
 Ovary

12.5
C3HeB/FeJ Ovary adenoma - tubular
  • corn oil
 Ovary

0 - 36.36
C3HeB/FeJ Ovary adenoma - tubular
  • diethylstilbestrol (DES)
  • corn oil
 Ovary

8.82 - 11.9
C3HeB/FeJ Ovary adenoma - tubular
  • diethylstilbestrol (DES)
  • corn oil
 Ovary

0 - 50
C3H/HeJ Ovary luteoma
  • corn oil
 Ovary

3.0
C3HeB/FeJ Ovary luteoma
  • corn oil
 Ovary

2.1
C3H/HeJ Pancreas - Islet of Langerhans adenoma
  • MMTV - mouse mammary tumor virus
  • corn oil
 Pancreas - Islet of Langerhans

0
C3H/HeJ Pancreas - Islet of Langerhans adenoma
  • MMTV - mouse mammary tumor virus
  • diethylstilbestrol (DES)
  • corn oil
 Pancreas - Islet of Langerhans

observed
C3H/HeJ Pancreas - Islet of Langerhans adenoma
  • MMTV - mouse mammary tumor virus
  • diethylstilbestrol (DES)
  • corn oil
 Pancreas - Islet of Langerhans

0
C3H/HeJ Pancreas - Islet of Langerhans adenoma
  • 17beta-estradiol (E2)
  • MMTV - mouse mammary tumor virus
  • corn oil
 Pancreas - Islet of Langerhans

observed
C3H/HeJ Pancreas - Islet of Langerhans adenoma
  • MMTV - mouse mammary tumor virus
  • 17beta-estradiol (E2)
  • corn oil
 Pancreas - Islet of Langerhans

0 - observed
C3HeB/FeJ Pancreas - Islet of Langerhans adenoma
  • corn oil
 Pancreas - Islet of Langerhans

observed
C3HeB/FeJ Pancreas - Islet of Langerhans adenoma
  • diethylstilbestrol (DES)
  • corn oil
 Pancreas - Islet of Langerhans

0
C3HeB/FeJ Pancreas - Islet of Langerhans adenoma
  • diethylstilbestrol (DES)
  • corn oil
 Pancreas - Islet of Langerhans

0 - observed
C3H/HeJ Pituitary gland adenoma
  • MMTV - mouse mammary tumor virus
  • corn oil
 Pituitary gland

0
C3H/HeJ Pituitary gland adenoma
  • MMTV - mouse mammary tumor virus
  • diethylstilbestrol (DES)
  • corn oil
 Pituitary gland

observed
C3H/HeJ Pituitary gland adenoma
  • MMTV - mouse mammary tumor virus
  • diethylstilbestrol (DES)
  • corn oil
 Pituitary gland

0
C3H/HeJ Pituitary gland adenoma
  • MMTV - mouse mammary tumor virus
  • diethylstilbestrol (DES)
  • corn oil
 Pituitary gland

0
C3H/HeJ Pituitary gland adenoma
  • 17beta-estradiol (E2)
  • MMTV - mouse mammary tumor virus
  • corn oil
 Pituitary gland

observed
C3H/HeJ Pituitary gland adenoma
  • 17beta-estradiol (E2)
  • MMTV - mouse mammary tumor virus
  • corn oil
 Pituitary gland

0 - observed
C3HeB/FeJ Pituitary gland adenoma
  • corn oil
 Pituitary gland

observed
C3HeB/FeJ Pituitary gland adenoma
  • diethylstilbestrol (DES)
  • corn oil
 Pituitary gland

0
C3HeB/FeJ Pituitary gland adenoma
  • diethylstilbestrol (DES)
  • corn oil
 Pituitary gland

observed
C3H/HeJ Skin squamous cell carcinoma
  • MMTV - mouse mammary tumor virus
  • corn oil
 Skin

0
C3H/HeJ Skin squamous cell carcinoma
  • MMTV - mouse mammary tumor virus
  • diethylstilbestrol (DES)
  • corn oil
 Skin

observed
C3H/HeJ Skin squamous cell carcinoma
  • MMTV - mouse mammary tumor virus
  • diethylstilbestrol (DES)
  • corn oil
 Skin

0
C3H/HeJ Skin squamous cell carcinoma
  • MMTV - mouse mammary tumor virus
  • diethylstilbestrol (DES)
  • corn oil
 Skin

0
C3H/HeJ Skin squamous cell carcinoma
  • 17beta-estradiol (E2)
  • MMTV - mouse mammary tumor virus
  • corn oil
 Skin

0
C3H/HeJ Skin squamous cell carcinoma
  • MMTV - mouse mammary tumor virus
  • 17beta-estradiol (E2)
  • corn oil
 Skin

0
C3H/HeJ Skin squamous cell carcinoma
  • MMTV - mouse mammary tumor virus
  • 17beta-estradiol (E2)
  • corn oil
 Skin

0
C3HeB/FeJ Skin squamous cell carcinoma
  • corn oil
 Skin

0
C3HeB/FeJ Skin squamous cell carcinoma
  • diethylstilbestrol (DES)
  • corn oil
 Skin

observed
C3HeB/FeJ Skin squamous cell carcinoma
  • diethylstilbestrol (DES)
  • corn oil
 Skin

observed
C3H/HeJ Thyroid gland carcinoma
  • MMTV - mouse mammary tumor virus
  • corn oil
 Thyroid gland

0
C3H/HeJ Thyroid gland carcinoma
  • MMTV - mouse mammary tumor virus
  • diethylstilbestrol (DES)
  • corn oil
 Thyroid gland

0
C3H/HeJ Thyroid gland carcinoma
  • MMTV - mouse mammary tumor virus
  • diethylstilbestrol (DES)
  • corn oil
 Thyroid gland

0
C3H/HeJ Thyroid gland carcinoma
  • MMTV - mouse mammary tumor virus
  • diethylstilbestrol (DES)
  • corn oil
 Thyroid gland

observed
C3H/HeJ Thyroid gland carcinoma
  • 17beta-estradiol (E2)
  • MMTV - mouse mammary tumor virus
  • corn oil
 Thyroid gland

0
C3H/HeJ Thyroid gland carcinoma
  • 17beta-estradiol (E2)
  • MMTV - mouse mammary tumor virus
  • corn oil
 Thyroid gland

0
C3H/HeJ Thyroid gland carcinoma
  • MMTV - mouse mammary tumor virus
  • 17beta-estradiol (E2)
  • corn oil
 Thyroid gland

0
C3HeB/FeJ Thyroid gland carcinoma
  • corn oil
 Thyroid gland

0
C3HeB/FeJ Thyroid gland carcinoma
  • diethylstilbestrol (DES)
  • corn oil
 Thyroid gland

0 - observed
C3H/HeJ Uterus - Cervix adenocarcinoma
  • MMTV - mouse mammary tumor virus
  • corn oil
 Uterus - Cervix

0
C3H/HeJ Uterus - Cervix adenocarcinoma
  • MMTV - mouse mammary tumor virus
  • diethylstilbestrol (DES)
  • corn oil
 Uterus - Cervix

0
C3H/HeJ Uterus - Cervix adenocarcinoma
  • MMTV - mouse mammary tumor virus
  • diethylstilbestrol (DES)
  • corn oil
 Uterus - Cervix

observed
C3H/HeJ Uterus - Cervix adenocarcinoma
  • MMTV - mouse mammary tumor virus
  • diethylstilbestrol (DES)
  • corn oil
 Uterus - Cervix

observed
C3H/HeJ Uterus - Cervix adenocarcinoma
  • 17beta-estradiol (E2)
  • MMTV - mouse mammary tumor virus
  • corn oil
 Uterus - Cervix

observed
C3H/HeJ Uterus - Cervix adenocarcinoma
  • MMTV - mouse mammary tumor virus
  • 17beta-estradiol (E2)
  • corn oil
 Uterus - Cervix

0
C3H/HeJ Uterus - Cervix adenocarcinoma
  • 17beta-estradiol (E2)
  • MMTV - mouse mammary tumor virus
  • corn oil
 Uterus - Cervix

observed
C3HeB/FeJ Uterus - Cervix adenocarcinoma
  • corn oil
 Uterus - Cervix

observed
C3HeB/FeJ Uterus - Cervix adenocarcinoma
  • diethylstilbestrol (DES)
  • corn oil
 Uterus - Cervix

observed
C3HeB/FeJ Uterus - Cervix adenocarcinoma
  • diethylstilbestrol (DES)
  • corn oil
 Uterus - Cervix

observed
C3H/HeJ Uterus - Cervix adenocarcinoma
  • MMTV - mouse mammary tumor virus
  • 17beta-estradiol (E2)
  • diethylstilbestrol (DES)
  • corn oil
 Uterus - Cervix

observed
C3H/HeJ Uterus - Cervix adenocarcinoma
  • MMTV - mouse mammary tumor virus
  • 17beta-estradiol (E2)
  • diethylstilbestrol (DES)
  • corn oil
 Urethra

observed
C3H/HeJ Uterus - Cervix adenocarcinoma
  • MMTV - mouse mammary tumor virus
  • 17beta-estradiol (E2)
  • diethylstilbestrol (DES)
  • corn oil
 Ureter

observed
C3H/HeJ Uterus - Cervix adenocarcinoma
  • 17beta-estradiol (E2)
  • MMTV - mouse mammary tumor virus
  • diethylstilbestrol (DES)
  • corn oil
 Vagina

observed
C3H/HeJ Uterus - Cervix adenocarcinoma
  • 17beta-estradiol (E2)
  • MMTV - mouse mammary tumor virus
  • diethylstilbestrol (DES)
  • corn oil
 Intestine - Large Intestine - Rectum

observed
C3HeB/FeJ Uterus - Cervix adenocarcinoma
  • MMTV - mouse mammary tumor virus
  • 17beta-estradiol (E2)
  • diethylstilbestrol (DES)
  • corn oil
 Uterus - Cervix

observed
C3HeB/FeJ Uterus - Cervix adenocarcinoma
  • 17beta-estradiol (E2)
  • MMTV - mouse mammary tumor virus
  • diethylstilbestrol (DES)
  • corn oil
 Urinary bladder

observed
C3HeB/FeJ Uterus - Cervix adenocarcinoma
  • 17beta-estradiol (E2)
  • MMTV - mouse mammary tumor virus
  • diethylstilbestrol (DES)
  • corn oil
 Urethra

observed
C3HeB/FeJ Uterus - Cervix adenocarcinoma
  • MMTV - mouse mammary tumor virus
  • 17beta-estradiol (E2)
  • diethylstilbestrol (DES)
  • corn oil
 Ureter

observed
C3HeB/FeJ Uterus - Cervix adenocarcinoma
  • MMTV - mouse mammary tumor virus
  • 17beta-estradiol (E2)
  • diethylstilbestrol (DES)
  • corn oil
 Vagina

observed
C3HeB/FeJ Uterus - Cervix adenocarcinoma
  • MMTV - mouse mammary tumor virus
  • 17beta-estradiol (E2)
  • diethylstilbestrol (DES)
  • corn oil
 Intestine - Large Intestine - Rectum

observed
C3HeB/FeJ Uterus - Cervix adenocarcinoma
  • MMTV - mouse mammary tumor virus
  • 17beta-estradiol (E2)
  • diethylstilbestrol (DES)
  • corn oil
 Uterus

observed
C3H/HeJ Uterus - Cervix lesion
  • MMTV - mouse mammary tumor virus
  • corn oil
 Uterus - Cervix

5.41 - 15.79
C3H/HeJ Uterus - Cervix lesion
  • MMTV - mouse mammary tumor virus
  • corn oil
 Uterus - Cervix

7.14
C3H/HeJ Uterus - Cervix lesion
  • MMTV - mouse mammary tumor virus
  • diethylstilbestrol (DES)
  • corn oil
 Uterus - Cervix

6.82 - 27.91
C3H/HeJ Uterus - Cervix lesion
  • MMTV - mouse mammary tumor virus
  • diethylstilbestrol (DES)
  • corn oil
 Uterus - Cervix

14.29 - 83.33
C3H/HeJ Uterus - Cervix lesion
  • MMTV - mouse mammary tumor virus
  • diethylstilbestrol (DES)
  • corn oil
 Uterus - Cervix

0 - 41.18
C3H/HeJ Uterus - Cervix lesion
  • MMTV - mouse mammary tumor virus
  • diethylstilbestrol (DES)
  • corn oil
 Uterus - Cervix

41.67 - 97.78
C3H/HeJ Uterus - Cervix lesion
  • MMTV - mouse mammary tumor virus
  • diethylstilbestrol (DES)
  • corn oil
 Uterus - Cervix

64.29
C3H/HeJ Uterus - Cervix lesion
  • MMTV - mouse mammary tumor virus
  • 17beta-estradiol (E2)
  • corn oil
 Uterus - Cervix

2.7 - 59.52
C3H/HeJ Uterus - Cervix lesion
  • MMTV - mouse mammary tumor virus
  • 17beta-estradiol (E2)
  • corn oil
 Uterus - Cervix

11.11 - 57.14
C3H/HeJ Uterus - Cervix lesion
  • 17beta-estradiol (E2)
  • MMTV - mouse mammary tumor virus
  • corn oil
 Uterus - Cervix

21.43 - 50
C3H/HeJ Uterus - Cervix lesion
  • 17beta-estradiol (E2)
  • MMTV - mouse mammary tumor virus
  • corn oil
 Uterus - Cervix

73.33
C3HeB/FeJ Uterus - Cervix lesion
  • corn oil
 Uterus - Cervix

0 - 14.29
C3HeB/FeJ Uterus - Cervix lesion
  • diethylstilbestrol (DES)
  • corn oil
 Uterus - Cervix

6.9 - 91.67
C3HeB/FeJ Uterus - Cervix lesion
  • diethylstilbestrol (DES)
  • corn oil
 Uterus - Cervix

3.57 - 100
C3H/HeJ Uterus - Cervix myoblastoma - granular cell
  • MMTV - mouse mammary tumor virus
  • corn oil
 Uterus - Cervix

0
C3H/HeJ Uterus - Cervix myoblastoma - granular cell
  • MMTV - mouse mammary tumor virus
  • diethylstilbestrol (DES)
  • corn oil
 Uterus - Cervix

0
C3H/HeJ Uterus - Cervix myoblastoma - granular cell
  • MMTV - mouse mammary tumor virus
  • diethylstilbestrol (DES)
  • corn oil
 Uterus - Cervix

observed
C3H/HeJ Uterus - Cervix myoblastoma - granular cell
  • MMTV - mouse mammary tumor virus
  • diethylstilbestrol (DES)
  • corn oil
 Uterus - Cervix

0
C3H/HeJ Uterus - Cervix myoblastoma - granular cell
  • 17beta-estradiol (E2)
  • MMTV - mouse mammary tumor virus
  • corn oil
 Uterus - Cervix

0
C3H/HeJ Uterus - Cervix myoblastoma - granular cell
  • MMTV - mouse mammary tumor virus
  • 17beta-estradiol (E2)
  • corn oil
 Uterus - Cervix

observed
C3H/HeJ Uterus - Cervix myoblastoma - granular cell
  • 17beta-estradiol (E2)
  • MMTV - mouse mammary tumor virus
  • corn oil
 Uterus - Cervix

observed
C3HeB/FeJ Uterus - Cervix myoblastoma - granular cell
  • corn oil
 Uterus - Cervix

0
C3HeB/FeJ Uterus - Cervix myoblastoma - granular cell
  • diethylstilbestrol (DES)
  • corn oil
 Uterus - Cervix

observed
C3H/HeJ Uterus - Cervix squamous cell carcinoma
  • MMTV - mouse mammary tumor virus
  • corn oil
 Uterus - Cervix

0
C3H/HeJ Uterus - Cervix squamous cell carcinoma
  • MMTV - mouse mammary tumor virus
  • diethylstilbestrol (DES)
  • corn oil
 Uterus - Cervix

observed
C3H/HeJ Uterus - Cervix squamous cell carcinoma
  • MMTV - mouse mammary tumor virus
  • diethylstilbestrol (DES)
  • corn oil
 Uterus - Cervix

0
C3H/HeJ Uterus - Cervix squamous cell carcinoma
  • MMTV - mouse mammary tumor virus
  • diethylstilbestrol (DES)
  • corn oil
 Uterus - Cervix

0
C3H/HeJ Uterus - Cervix squamous cell carcinoma
  • 17beta-estradiol (E2)
  • MMTV - mouse mammary tumor virus
  • corn oil
 Uterus - Cervix

0
C3H/HeJ Uterus - Cervix squamous cell carcinoma
  • 17beta-estradiol (E2)
  • MMTV - mouse mammary tumor virus
  • corn oil
 Uterus - Cervix

0
C3HeB/FeJ Uterus - Cervix squamous cell carcinoma
  • corn oil
 Uterus - Cervix

0
C3HeB/FeJ Uterus - Cervix squamous cell carcinoma
  • diethylstilbestrol (DES)
  • corn oil
 Uterus - Cervix

0
C3HeB/FeJ Uterus - Cervix squamous cell carcinoma
  • diethylstilbestrol (DES)
  • corn oil
 Uterus - Cervix

0 - observed
C3H/HeJ Uterus - Endometrium carcinoma
  • MMTV - mouse mammary tumor virus
  • diethylstilbestrol (DES)
  • corn oil
 Uterus - Endometrium

observed
C3H/HeJ Uterus - Endometrium carcinoma
  • corn oil
 Uterus - Endometrium

0
C3H/HeJ Uterus - Endometrium carcinoma
  • MMTV - mouse mammary tumor virus
  • 17beta-estradiol (E2)
  • corn oil
 Uterus - Endometrium

observed
C3HeB/FeJ Uterus - Endometrium carcinoma
  • corn oil
 Uterus - Endometrium

0
C3HeB/FeJ Uterus - Endometrium carcinoma
  • MMTV - mouse mammary tumor virus
  • diethylstilbestrol (DES)
  • corn oil
 Uterus - Endometrium

observed
C3H/HeJ Uterus - Endometrium polyp
  • MMTV - mouse mammary tumor virus
  • diethylstilbestrol (DES)
  • corn oil
 Uterus - Endometrium

1.39
C3H/HeJ Uterus - Endometrium polyp
  • corn oil
 Uterus - Endometrium

3.85
C3H/HeJ Uterus - Endometrium polyp
  • 17beta-estradiol (E2)
  • MMTV - mouse mammary tumor virus
  • corn oil
 Uterus - Endometrium

1.59
C3HeB/FeJ Uterus - Endometrium polyp
  • corn oil
 Uterus - Endometrium

1.47
C3HeB/FeJ Uterus - Endometrium polyp
  • MMTV - mouse mammary tumor virus
  • diethylstilbestrol (DES)
  • corn oil
 Uterus - Endometrium

5.25
C3H/HeJ Uterus - Uterine horn adenoacanthoma
  • MMTV - mouse mammary tumor virus
  • corn oil
 Uterus - Uterine horn

0
C3H/HeJ Uterus - Uterine horn adenoacanthoma
  • MMTV - mouse mammary tumor virus
  • diethylstilbestrol (DES)
  • corn oil
 Uterus - Uterine horn

0
C3H/HeJ Uterus - Uterine horn adenoacanthoma
  • MMTV - mouse mammary tumor virus
  • diethylstilbestrol (DES)
  • corn oil
 Uterus - Uterine horn

0
C3H/HeJ Uterus - Uterine horn adenoacanthoma
  • MMTV - mouse mammary tumor virus
  • 17beta-estradiol (E2)
  • corn oil
 Uterus - Uterine horn

0 - observed
C3H/HeJ Uterus - Uterine horn adenoacanthoma
  • MMTV - mouse mammary tumor virus
  • 17beta-estradiol (E2)
  • corn oil
 Uterus - Uterine horn

0
C3HeB/FeJ Uterus - Uterine horn adenoacanthoma
  • corn oil
 Uterus - Uterine horn

0
C3HeB/FeJ Uterus - Uterine horn adenoacanthoma
  • diethylstilbestrol (DES)
  • corn oil
 Uterus - Uterine horn

0
C3HeB/FeJ Uterus - Uterine horn adenoacanthoma
  • diethylstilbestrol (DES)
  • corn oil
 Uterus - Uterine horn

0
C3H/HeJ Uterus - Uterine horn adenocarcinoma
  • MMTV - mouse mammary tumor virus
  • corn oil
 Uterus - Uterine horn

0
C3H/HeJ Uterus - Uterine horn adenocarcinoma
  • MMTV - mouse mammary tumor virus
  • diethylstilbestrol (DES)
  • corn oil
 Uterus - Uterine horn

observed
C3H/HeJ Uterus - Uterine horn adenocarcinoma
  • MMTV - mouse mammary tumor virus
  • diethylstilbestrol (DES)
  • corn oil
 Uterus - Uterine horn

observed
C3H/HeJ Uterus - Uterine horn adenocarcinoma
  • MMTV - mouse mammary tumor virus
  • diethylstilbestrol (DES)
  • corn oil
 Uterus - Uterine horn

observed
C3H/HeJ Uterus - Uterine horn adenocarcinoma
  • MMTV - mouse mammary tumor virus
  • diethylstilbestrol (DES)
  • corn oil
 Uterus - Uterine horn

0
C3H/HeJ Uterus - Uterine horn adenocarcinoma
  • 17beta-estradiol (E2)
  • MMTV - mouse mammary tumor virus
  • corn oil
 Uterus - Uterine horn

0
C3H/HeJ Uterus - Uterine horn adenocarcinoma
  • MMTV - mouse mammary tumor virus
  • 17beta-estradiol (E2)
  • corn oil
 Uterus - Uterine horn

observed
C3HeB/FeJ Uterus - Uterine horn adenocarcinoma
  • corn oil
 Uterus - Uterine horn

observed
C3HeB/FeJ Uterus - Uterine horn adenocarcinoma
  • diethylstilbestrol (DES)
  • corn oil
 Uterus - Uterine horn

observed
C3HeB/FeJ Uterus - Uterine horn adenocarcinoma
  • diethylstilbestrol (DES)
  • corn oil
 Uterus - Uterine horn

observed
C3H/HeJ Uterus adenocarcinoma
  • MMTV - mouse mammary tumor virus
  • corn oil
 Uterus

0
C3H/HeJ Uterus adenocarcinoma
  • MMTV - mouse mammary tumor virus
  • diethylstilbestrol (DES)
  • corn oil
 Uterus

0 - observed
C3H/HeJ Uterus adenocarcinoma
  • MMTV - mouse mammary tumor virus
  • diethylstilbestrol (DES)
  • corn oil
 Uterus

0
C3H/HeJ Uterus adenocarcinoma
  • MMTV - mouse mammary tumor virus
  • diethylstilbestrol (DES)
  • corn oil
 Uterus

observed
C3H/HeJ Uterus adenocarcinoma
  • 17beta-estradiol (E2)
  • MMTV - mouse mammary tumor virus
  • corn oil
 Uterus

0
C3H/HeJ Uterus adenocarcinoma
  • MMTV - mouse mammary tumor virus
  • 17beta-estradiol (E2)
  • corn oil
 Uterus

0
C3H/HeJ Uterus adenocarcinoma
  • 17beta-estradiol (E2)
  • MMTV - mouse mammary tumor virus
  • corn oil
 Uterus

observed
C3HeB/FeJ Uterus adenocarcinoma
  • corn oil
 Uterus

0
C3HeB/FeJ Uterus adenocarcinoma
  • diethylstilbestrol (DES)
  • corn oil
 Uterus

0
C3H/HeJ Uterus atypia
  • MMTV - mouse mammary tumor virus
  • 17beta-estradiol (E2)
  • diethylstilbestrol (DES)
  • corn oil
 Uterus

observed
C3HeB/FeJ Uterus atypia
  • 17beta-estradiol (E2)
  • diethylstilbestrol (DES)
  • corn oil
 Uterus

observed
C3H/HeJ Uterus preneoplastic lesion
  • 17beta-estradiol (E2)
  • MMTV - mouse mammary tumor virus
  • diethylstilbestrol (DES)
  • corn oil
 Uterus

observed
C3HeB/FeJ Uterus preneoplastic lesion
  • 17beta-estradiol (E2)
  • diethylstilbestrol (DES)
  • corn oil
 Uterus

observed
C3H/HeJ Vagina squamous cell carcinoma
  • MMTV - mouse mammary tumor virus
  • corn oil
 Vagina

0
C3H/HeJ Vagina squamous cell carcinoma
  • MMTV - mouse mammary tumor virus
  • diethylstilbestrol (DES)
  • corn oil
 Vagina

0
C3H/HeJ Vagina squamous cell carcinoma
  • MMTV - mouse mammary tumor virus
  • diethylstilbestrol (DES)
  • corn oil
 Vagina

0
C3H/HeJ Vagina squamous cell carcinoma
  • 17beta-estradiol (E2)
  • MMTV - mouse mammary tumor virus
  • corn oil
 Vagina

0
C3H/HeJ Vagina squamous cell carcinoma
  • 17beta-estradiol (E2)
  • MMTV - mouse mammary tumor virus
  • corn oil
 Vagina

0
C3HeB/FeJ Vagina squamous cell carcinoma
  • corn oil
 Vagina

0
C3HeB/FeJ Vagina squamous cell carcinoma
  • diethylstilbestrol (DES)
  • corn oil
 Vagina

observed
C3HeB/FeJ Vagina squamous cell carcinoma
  • diethylstilbestrol (DES)
  • corn oil
 Vagina

observed