Reference SummaryAkamatsu Y, J Natl Cancer Inst 1975 Oct;55(4):893-7
Title |
Neoplasms in strains of splenectomized mice after a single 7,12-dimethylbenz[alpha]anthracene treatment. |
Authors |
Akamatsu Y |
Journal |
J Natl Cancer Inst |
Volume |
55 |
Issue |
4 |
Year |
1975 |
Pages |
893-7 |
Abstract |
The effects of splenectomy on carcinogenesis by a single 10-mg dose of 7,12-dimethylbenz[alpha]anthracene (DMBA) given in olive oil by gavage was tested on BTOs, C57BL/60s, C3H/HeOs, and BALB/cOs mice. The splenectomy, performed a week before the DMBA was given, did not affect physical status or the incidence of acute toxic death of animals. DMBA-treated animals developed neoplasms at a significantly higher rate than did untreated mice. Splenectomy did not influence the overall incidence of neoplasms. Observed tumors in DMBA-treated groups were those of skin, forestomach, colon, liver, lung, adrenal, ovary, breast, hematopoietic-lymphoreticular system, and vascular system, depending on the strain. Types of DMBA-treated neoplasms were affected by prior splenectomy, depending on the strain: Splenectomy inhibited lung adenomas in BALB/cOs females and hepatomas in C57BL/60s females; splenectomy enhanced skin neoplasms in C57BL/60s and squamous cell carcinoma of the forestomach in BTOs males. The most significant change was in the incidence of the group of lymphomas. Myelogenous leukemia was increased in DMBA-treated groups of all strains, but splenectomy inhibited the development of this type of lymphoma. |
Links |
J:24687 – MGI References 171427 – National Library of Medicine/PubMed |
| Strain | Model Name | Treatment Agent(s) | Organ Affected | Frequency | Model Details |
|---|---|---|---|---|---|
| C3H/HeOs | Adrenal gland - Medulla carcinoma |
|
Adrenal gland - Medulla |
3.8 |
|
| BT/Os | Adrenal gland tumor | Adrenal gland |
0 |
||
| BT/Os | Adrenal gland tumor |
|
Adrenal gland |
0 |
|
| BT/Os | Adrenal gland tumor |
|
Adrenal gland |
0 |
|
| C57BL/6Os | Adrenal gland tumor | Adrenal gland |
0 |
||
| C57BL/6Os | Adrenal gland tumor |
|
Adrenal gland |
0 |
|
| C57BL/6Os | Adrenal gland tumor |
|
Adrenal gland |
0 |
|
| C3H/HeOs | Adrenal gland tumor | Adrenal gland |
0 |
||
| C3H/HeOs | Adrenal gland tumor |
|
Adrenal gland |
0 |
|
| C3H/HeOs | Adrenal gland tumor |
|
Adrenal gland |
0 |
|
| BALB/cOs | Adrenal gland tumor | Adrenal gland |
0 |
||
| BALB/cOs | Adrenal gland tumor |
|
Adrenal gland |
0 |
|
| BALB/cOs | Adrenal gland tumor |
|
Adrenal gland |
0 |
|
| BT/Os | Blood vessel hemangioma | Blood vessel |
0 |
||
| BT/Os | Blood vessel hemangioma |
|
Blood vessel |
0 |
|
| BT/Os | Blood vessel hemangioma |
|
Blood vessel |
0 |
|
| C57BL/6Os | Blood vessel hemangioma | Blood vessel |
0 |
||
| C57BL/6Os | Blood vessel hemangioma |
|
Blood vessel |
13 - 22 |
|
| C57BL/6Os | Blood vessel hemangioma |
|
Blood vessel |
9.1 - 25 |
|
| C3H/HeOs | Blood vessel hemangioma | Blood vessel |
0 |
||
| C3H/HeOs | Blood vessel hemangioma |
|
Blood vessel |
0 - 15 |
|
| C3H/HeOs | Blood vessel hemangioma |
|
Blood vessel |
0 - 19 |
|
| BALB/cOs | Blood vessel hemangioma | Blood vessel |
0 |
||
| BALB/cOs | Blood vessel hemangioma |
|
Blood vessel |
23 |
|
| BALB/cOs | Blood vessel hemangioma |
|
Blood vessel |
18 |
|
| BT/Os | Forestomach keratoacanthoma |
|
Forestomach |
0 - 5.6 |
|
| BT/Os | Forestomach keratoacanthoma |
|
Forestomach |
4.5 - 8.7 |
|
| C57BL/6Os | Forestomach keratoacanthoma |
|
Forestomach |
7.4 - 9.7 |
|
| C57BL/6Os | Forestomach keratoacanthoma |
|
Forestomach |
12 - 12.5 |
|
| C3H/HeOs | Forestomach keratoacanthoma |
|
Forestomach |
0 - 5.1 |
|
| C3H/HeOs | Forestomach keratoacanthoma |
|
Forestomach |
0 - 7.7 |
|
| BALB/cOs | Forestomach keratoacanthoma |
|
Forestomach |
0 |
|
| BALB/cOs | Forestomach keratoacanthoma |
|
Forestomach |
5.9 |
|
| BT/Os | Forestomach squamous cell carcinoma |
|
Forestomach |
5.6 - 6.3 |
|
| BT/Os | Forestomach squamous cell carcinoma |
|
Forestomach |
4.5 - 22 |
|
| C57BL/6Os | Forestomach squamous cell carcinoma |
|
Forestomach |
0 - 7.4 |
|
| C57BL/6Os | Forestomach squamous cell carcinoma |
|
Forestomach |
0 - 3.0 |
|
| C3H/HeOs | Forestomach squamous cell carcinoma |
|
Forestomach |
0 - 15 |
|
| C3H/HeOs | Forestomach squamous cell carcinoma |
|
Forestomach |
0 |
|
| BALB/cOs | Forestomach squamous cell carcinoma |
|
Forestomach |
6.5 |
|
| BALB/cOs | Forestomach squamous cell carcinoma |
|
Forestomach |
0 |
|
| BT/Os | Forestomach squamous cell papilloma |
|
Forestomach |
6.3 - 22 |
|
| BT/Os | Forestomach squamous cell papilloma |
|
Forestomach |
9.1 - 22 |
|
| C57BL/6Os | Forestomach squamous cell papilloma |
|
Forestomach |
26 - 35 |
|
| C57BL/6Os | Forestomach squamous cell papilloma |
|
Forestomach |
45 - 62.5 |
|
| C3H/HeOs | Forestomach squamous cell papilloma |
|
Forestomach |
20 - 21 |
|
| C3H/HeOs | Forestomach squamous cell papilloma |
|
Forestomach |
6.3 - 19 |
|
| BALB/cOs | Forestomach squamous cell papilloma |
|
Forestomach |
35 |
|
| BALB/cOs | Forestomach squamous cell papilloma |
|
Forestomach |
5.9 |
|
| BT/Os | Forestomach tumor | Forestomach |
0 |
||
| C57BL/6Os | Forestomach tumor | Forestomach |
0 |
||
| C3H/HeOs | Forestomach tumor | Forestomach |
0 |
||
| BALB/cOs | Forestomach tumor | Forestomach |
0 |
||
| C57BL/6Os | Intestine - Large Intestine - Colon adenocarcinoma - well-differentiated |
|
Intestine - Large Intestine - Colon |
7.4 |
|
| C3H/HeOs | Intestine - Large Intestine - Colon adenocarcinoma - well-differentiated |
|
Intestine - Large Intestine - Colon |
2.6 |
|
| C3H/HeOs | Intestine - Large Intestine - Colon adenocarcinoma - well-differentiated |
|
Intestine - Large Intestine - Colon |
7.7 |
|
| BT/Os | Intestine - Large Intestine - Colon tumor | Intestine - Large Intestine - Colon |
0 |
||
| BT/Os | Intestine - Large Intestine - Colon tumor |
|
Intestine - Large Intestine - Colon |
0 |
|
| BT/Os | Intestine - Large Intestine - Colon tumor |
|
Intestine - Large Intestine - Colon |
0 |
|
| C57BL/6Os | Intestine - Large Intestine - Colon tumor | Intestine - Large Intestine - Colon |
0 |
||
| C57BL/6Os | Intestine - Large Intestine - Colon tumor |
|
Intestine - Large Intestine - Colon |
0 |
|
| C57BL/6Os | Intestine - Large Intestine - Colon tumor |
|
Intestine - Large Intestine - Colon |
0 |
|
| C3H/HeOs | Intestine - Large Intestine - Colon tumor | Intestine - Large Intestine - Colon |
0 |
||
| C3H/HeOs | Intestine - Large Intestine - Colon tumor |
|
Intestine - Large Intestine - Colon |
0 |
|
| C3H/HeOs | Intestine - Large Intestine - Colon tumor |
|
Intestine - Large Intestine - Colon |
0 |
|
| BALB/cOs | Intestine - Large Intestine - Colon tumor | Intestine - Large Intestine - Colon |
0 |
||
| BALB/cOs | Intestine - Large Intestine - Colon tumor |
|
Intestine - Large Intestine - Colon |
0 |
|
| BALB/cOs | Intestine - Large Intestine - Colon tumor |
|
Intestine - Large Intestine - Colon |
0 |
|
| BT/Os | Leukocyte - Lymphocyte leukemia - lymphocytic |
|
Leukocyte - Lymphocyte |
17 |
|
| BT/Os | Leukocyte - Lymphocyte leukemia - lymphocytic | Leukocyte - Lymphocyte |
2 |
||
| C57BL/6Os | Leukocyte - Lymphocyte leukemia - lymphocytic | Leukocyte - Lymphocyte |
2.3 - 6.3 |
||
| C57BL/6Os | Leukocyte - Lymphocyte leukemia - lymphocytic |
|
Leukocyte - Lymphocyte |
7.4 - 13 |
|
| C57BL/6Os | Leukocyte - Lymphocyte leukemia - lymphocytic |
|
Leukocyte - Lymphocyte |
0 - 3.0 |
|
| C3H/HeOs | Leukocyte - Lymphocyte leukemia - lymphocytic |
|
Leukocyte - Lymphocyte |
0 |
|
| BALB/cOs | Leukocyte - Lymphocyte leukemia - lymphocytic | Leukocyte - Lymphocyte |
3.3 |
||
| BALB/cOs | Leukocyte - Lymphocyte leukemia - lymphocytic |
|
Leukocyte - Lymphocyte |
16 |
|
| BALB/cOs | Leukocyte - Lymphocyte leukemia - lymphocytic |
|
Leukocyte - Lymphocyte |
18 |
|
| BT/Os | Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma |
|
Leukocyte - Monocyte - Macrophage - Histiocyte |
17 |
|
| BT/Os | Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma | Leukocyte - Monocyte - Macrophage - Histiocyte |
0 |
||
| C57BL/6Os | Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma | Leukocyte - Monocyte - Macrophage - Histiocyte |
0 |
||
| C57BL/6Os | Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma |
|
Leukocyte - Monocyte - Macrophage - Histiocyte |
3.2 - 11 |
|
| C57BL/6Os | Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma |
|
Leukocyte - Monocyte - Macrophage - Histiocyte |
12 - 37.5 |
|
| C3H/HeOs | Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma |
|
Leukocyte - Monocyte - Macrophage - Histiocyte |
0 - 10 |
|
| BALB/cOs | Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma | Leukocyte - Monocyte - Macrophage - Histiocyte |
0 |
||
| BALB/cOs | Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma |
|
Leukocyte - Monocyte - Macrophage - Histiocyte |
9.7 |
|
| BALB/cOs | Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma |
|
Leukocyte - Monocyte - Macrophage - Histiocyte |
0 |
|
| BT/Os | Leukocyte - Myelocyte (Granulocyte) leukemia - myelocytic |
|
Leukocyte - Myelocyte (Granulocyte) |
17 |
|
| BT/Os | Leukocyte - Myelocyte (Granulocyte) leukemia - myelocytic | Leukocyte - Myelocyte (Granulocyte) |
2 |
||
| C57BL/6Os | Leukocyte - Myelocyte (Granulocyte) leukemia - myelocytic | Leukocyte - Myelocyte (Granulocyte) |
0 |
||
| C57BL/6Os | Leukocyte - Myelocyte (Granulocyte) leukemia - myelocytic |
|
Leukocyte - Myelocyte (Granulocyte) |
0 - 26 |
|
| C57BL/6Os | Leukocyte - Myelocyte (Granulocyte) leukemia - myelocytic |
|
Leukocyte - Myelocyte (Granulocyte) |
0 |
|
| C3H/HeOs | Leukocyte - Myelocyte (Granulocyte) leukemia - myelocytic |
|
Leukocyte - Myelocyte (Granulocyte) |
0 - 5.1 |
|
| BALB/cOs | Leukocyte - Myelocyte (Granulocyte) leukemia - myelocytic | Leukocyte - Myelocyte (Granulocyte) |
0 |
||
| BALB/cOs | Leukocyte - Myelocyte (Granulocyte) leukemia - myelocytic |
|
Leukocyte - Myelocyte (Granulocyte) |
3.2 |
|
| BALB/cOs | Leukocyte - Myelocyte (Granulocyte) leukemia - myelocytic |
|
Leukocyte - Myelocyte (Granulocyte) |
0 |
|
| BT/Os | Leukocyte lymphoma | Leukocyte |
0 |
||
| BT/Os | Leukocyte lymphoma |
|
Leukocyte |
0 |
|
| BT/Os | Leukocyte lymphoma |
|
Leukocyte |
0 |
|
| C3H/HeOs | Leukocyte lymphoma | Leukocyte |
0 |
||
| C3H/HeOs | Leukocyte lymphoma |
|
Leukocyte |
0 |
|
| BT/Os | Liver hepatoma | Liver |
0 - 8 |
||
| BT/Os | Liver hepatoma |
|
Liver |
0 - 28 |
|
| BT/Os | Liver hepatoma |
|
Liver |
0 - 8.7 |
|
| C57BL/6Os | Liver hepatoma | Liver |
0 |
||
| C57BL/6Os | Liver hepatoma |
|
Liver |
0 - 15 |
|
| C57BL/6Os | Liver hepatoma |
|
Liver |
0 - 12.5 |
|
| C3H/HeOs | Liver hepatoma | Liver |
0 - 12.5 |
||
| C3H/HeOs | Liver hepatoma |
|
Liver |
0 - 36 |
|
| C3H/HeOs | Liver hepatoma |
|
Liver |
0 - 15 |
|
| BALB/cOs | Liver hepatoma | Liver |
0 |
||
| BALB/cOs | Liver hepatoma |
|
Liver |
13 |
|
| BALB/cOs | Liver hepatoma |
|
Liver |
0 |
|
| BT/Os | Lung adenoma | Lung |
0 |
||
| BT/Os | Lung adenoma |
|
Lung |
0 - 5.6 |
|
| BT/Os | Lung adenoma |
|
Lung |
4.3 - 4.5 |
|
| C57BL/6Os | Lung adenoma | Lung |
1.6 - 2.3 |
||
| C57BL/6Os | Lung adenoma |
|
Lung |
0 - 13 |
|
| C57BL/6Os | Lung adenoma |
|
Lung |
12 - 25 |
|
| C3H/HeOs | Lung adenoma | Lung |
0 |
||
| C3H/HeOs | Lung adenoma |
|
Lung |
0 - 7.7 |
|
| C3H/HeOs | Lung adenoma |
|
Lung |
0 - 3.8 |
|
| BALB/cOs | Lung adenoma | Lung |
1.6 |
||
| BALB/cOs | Lung adenoma |
|
Lung |
35 |
|
| BALB/cOs | Lung adenoma |
|
Lung |
0 |
|
| BT/Os | Mammary gland adenoacanthoma | Mammary gland |
0 |
||
| BT/Os | Mammary gland adenoacanthoma |
|
Mammary gland |
0 |
|
| BT/Os | Mammary gland adenoacanthoma |
|
Mammary gland |
0 |
|
| C57BL/6Os | Mammary gland adenoacanthoma |
|
Mammary gland |
0 |
|
| C3H/HeOs | Mammary gland adenoacanthoma | Mammary gland |
0 |
||
| C3H/HeOs | Mammary gland adenoacanthoma |
|
Mammary gland |
0 |
|
| C3H/HeOs | Mammary gland adenoacanthoma |
|
Mammary gland |
0 |
|
| BALB/cOs | Mammary gland adenoacanthoma | Mammary gland |
0 |
||
| BALB/cOs | Mammary gland adenoacanthoma |
|
Mammary gland |
19 |
|
| BALB/cOs | Mammary gland adenoacanthoma |
|
Mammary gland |
5.9 |
|
| BT/Os | Mammary gland adenocarcinoma | Mammary gland |
58 |
||
| BT/Os | Mammary gland adenocarcinoma |
|
Mammary gland |
69 |
|
| BT/Os | Mammary gland adenocarcinoma |
|
Mammary gland |
86 |
|
| C57BL/6Os | Mammary gland adenocarcinoma |
|
Mammary gland |
0 |
|
| C3H/HeOs | Mammary gland adenocarcinoma | Mammary gland |
74 |
||
| C3H/HeOs | Mammary gland adenocarcinoma |
|
Mammary gland |
90 |
|
| C3H/HeOs | Mammary gland adenocarcinoma |
|
Mammary gland |
81 |
|
| BALB/cOs | Mammary gland adenocarcinoma | Mammary gland |
3.3 |
||
| BALB/cOs | Mammary gland adenocarcinoma |
|
Mammary gland |
19 |
|
| BALB/cOs | Mammary gland adenocarcinoma |
|
Mammary gland |
41 |
|
| BT/Os | Mammary gland adenoma - fibroid | Mammary gland |
0 |
||
| BT/Os | Mammary gland adenoma - fibroid |
|
Mammary gland |
6.3 |
|
| BT/Os | Mammary gland adenoma - fibroid |
|
Mammary gland |
0 |
|
| C57BL/6Os | Mammary gland adenoma - fibroid |
|
Mammary gland |
3.0 |
|
| C3H/HeOs | Mammary gland adenoma - fibroid | Mammary gland |
0 |
||
| C3H/HeOs | Mammary gland adenoma - fibroid |
|
Mammary gland |
0 |
|
| C3H/HeOs | Mammary gland adenoma - fibroid |
|
Mammary gland |
0 |
|
| BALB/cOs | Mammary gland adenoma - fibroid | Mammary gland |
0 |
||
| BALB/cOs | Mammary gland adenoma - fibroid |
|
Mammary gland |
0 |
|
| BALB/cOs | Mammary gland adenoma - fibroid |
|
Mammary gland |
0 |
|
| C57BL/6Os | Mammary gland tumor | Mammary gland |
0 |
||
| C57BL/6Os | Mammary gland tumor |
|
Mammary gland |
0 |
|
| BT/Os | Mammary gland tumor | Mammary gland |
0 |
||
| BT/Os | Mammary gland tumor |
|
Mammary gland |
0 |
|
| BT/Os | Mammary gland tumor |
|
Mammary gland |
0 |
|
| C57BL/6Os | Mammary gland tumor |
|
Mammary gland |
0 |
|
| C3H/HeOs | Mammary gland tumor | Mammary gland |
0 |
||
| C3H/HeOs | Mammary gland tumor |
|
Mammary gland |
0 |
|
| C3H/HeOs | Mammary gland tumor |
|
Mammary gland |
0 |
|
| BT/Os | Mesodermal cell/mesoblast sarcoma |
|
Skin |
0 - 5.6 |
|
| BT/Os | Mesodermal cell/mesoblast sarcoma |
|
Skin |
0 |
|
| C57BL/6Os | Mesodermal cell/mesoblast sarcoma |
|
Skin |
0 |
|
| C57BL/6Os | Mesodermal cell/mesoblast sarcoma |
|
Skin |
0 - 12.5 |
|
| C3H/HeOs | Mesodermal cell/mesoblast sarcoma |
|
Skin |
5.1 |
|
| C3H/HeOs | Mesodermal cell/mesoblast sarcoma |
|
Skin |
0 |
|
| BALB/cOs | Mesodermal cell/mesoblast sarcoma |
|
Skin |
3.2 |
|
| BALB/cOs | Mesodermal cell/mesoblast sarcoma |
|
Skin |
5.9 |
|
| BT/Os | Ovary tumor | Ovary |
0 |
||
| BT/Os | Ovary tumor |
|
Ovary |
6.3 |
|
| BT/Os | Ovary tumor |
|
Ovary |
4.5 |
|
| C57BL/6Os | Ovary tumor | Ovary |
1.6 |
||
| C57BL/6Os | Ovary tumor |
|
Ovary |
11 |
|
| C57BL/6Os | Ovary tumor |
|
Ovary |
3.0 |
|
| C3H/HeOs | Ovary tumor | Ovary |
8.6 |
||
| C3H/HeOs | Ovary tumor |
|
Ovary |
0 |
|
| C3H/HeOs | Ovary tumor |
|
Ovary |
0 |
|
| BALB/cOs | Ovary tumor | Ovary |
1.6 |
||
| BALB/cOs | Ovary tumor |
|
Ovary |
13 |
|
| BALB/cOs | Ovary tumor |
|
Ovary |
12 |
|
| BT/Os | Skin keratoacanthoma |
|
Skin |
5.6 - 6.3 |
|
| BT/Os | Skin keratoacanthoma |
|
Skin |
13 |
|
| BT/Os | Skin keratoacanthoma |
|
Skin |
9.1 |
|
| C57BL/6Os | Skin keratoacanthoma |
|
Skin |
13 - 30 |
|
| C57BL/6Os | Skin keratoacanthoma |
|
Skin |
33 - 37.5 |
|
| C3H/HeOs | Skin keratoacanthoma |
|
Skin |
0 |
|
| C3H/HeOs | Skin keratoacanthoma |
|
Skin |
3.8 |
|
| BALB/cOs | Skin keratoacanthoma |
|
Skin |
13 |
|
| BALB/cOs | Skin keratoacanthoma |
|
Skin |
0 |
|
| BT/Os | Skin squamous cell carcinoma |
|
Skin |
0 - 17 |
|
| BT/Os | Skin squamous cell carcinoma |
|
Skin |
0 - 13 |
|
| C57BL/6Os | Skin squamous cell carcinoma |
|
Skin |
0 - 3.7 |
|
| C57BL/6Os | Skin squamous cell carcinoma |
|
Skin |
3.0 - 12.5 |
|
| C3H/HeOs | Skin squamous cell carcinoma |
|
Skin |
10 |
|
| C3H/HeOs | Skin squamous cell carcinoma |
|
Skin |
12 |
|
| BALB/cOs | Skin squamous cell carcinoma |
|
Skin |
3.2 |
|
| BALB/cOs | Skin squamous cell carcinoma |
|
Skin |
0 |
|
| BT/Os | Skin squamous cell papilloma |
|
Skin |
5.6 - 12.5 |
|
| BT/Os | Skin squamous cell papilloma |
|
Skin |
0 - 4.3 |
|
| C57BL/6Os | Skin squamous cell papilloma |
|
Skin |
0 - 16 |
|
| C57BL/6Os | Skin squamous cell papilloma |
|
Skin |
12.5 - 18 |
|
| C3H/HeOs | Skin squamous cell papilloma |
|
Skin |
21 |
|
| C3H/HeOs | Skin squamous cell papilloma |
|
Skin |
23 |
|
| BALB/cOs | Skin squamous cell papilloma |
|
Skin |
16 |
|
| BALB/cOs | Skin squamous cell papilloma |
|
Skin |
5.9 |
|
| BT/Os | Skin tumor | Skin |
0 |
||
| C57BL/6Os | Skin tumor | Skin |
0 |
||
| C3H/HeOs | Skin tumor | Skin |
0 |
||
| C3H/HeOs | Skin tumor |
|
Skin |
0 |
|
| C3H/HeOs | Skin tumor |
|
Skin |
0 |
|
| BALB/cOs | Skin tumor | Skin |
0 |