Reference SummaryImai S, J Natl Cancer Inst 1984 Oct;73(4):935-41

Title

 Urethan-induced mammary tumorigenesis in a murine mammary tumor virus (MuMTV)-positive mouse strain: evidence for a keratinized nodule as an MuMTV-negative precursor lesion for squamous cell tumors.

Authors

 Imai S; Tsubura Y; Hilgers J

Journal

 J Natl Cancer Inst

Volume

 73

Issue

 4

Year

 1984

Pages

 935-41

Abstract

 Administration of urethan (CAS: 51-79-6; carbamic acid, ethyl ester) in the drinking water of breeding female mice of the murine mammary tumor virus (MuMTV)-positive DD/Tbr strain and the MuMTV-negative DDf strain induced so-called keratinized nodules, which were demonstrable in wholemount preparations of mammary glands. It also induced squamous cell tumors (also called adenoacanthoma) at an extremely early age. The keratinized lesions appearing in the lobular areas of the mammary glands showed heavy infiltration with lymphocytes and as such were very different from hyperplastic alveolar nodules, the preneoplastic lesions for adenocarcinomas. Immunoperoxidase tests with antibodies against the MuMTV revealed that positivity of normal mammary gland epithelium in the DD/Tbr strain was not found in the keratinized nodules, which was further evidence that in squamous cell tumorigenesis of the mammary gland the MuMTV is not expressed overtly even at an early stage in tumorigenesis, in contrast to the case with adenocarcinoma tumorigenesis. These findings substantiate previous conclusions that the MuMTV is not involved in chemical carcinogenesis of the mouse mammary gland.

Links

 J:24723 – MGI References
6090751 – National Library of Medicine/PubMed

Strain Notes

Strain Note
DD/Tbr Mice were carriers of infectious MMTV.
DD/TbrfC57BL Mice were NOT carriers of infectious MMTV.

Models
Strain Model Name Treatment Agent(s) Organ Affected Frequency Model Details
DD/TbrfC57BL Mammary gland adenoacanthoma
  • urethane (ethyl carbamate)
 Mammary gland

45
DD/Tbr Mammary gland adenocarcinoma
  • MMTV - mouse mammary tumor virus
 Mammary gland

53
DD/Tbr Mammary gland adenocarcinoma
  • urethane (ethyl carbamate)
  • MMTV - mouse mammary tumor virus
 Mammary gland

45
DD/Tbr Mammary gland hyperplasia - alveolar
  • MMTV - mouse mammary tumor virus
 Mammary gland

5.6
DD/Tbr Mammary gland hyperplasia - alveolar
  • urethane (ethyl carbamate)
  • MMTV - mouse mammary tumor virus
 Mammary gland

11
DD/TbrfC57BL Mammary gland hyperplasia - alveolar Mammary gland

0
DD/TbrfC57BL Mammary gland hyperplasia - alveolar
  • urethane (ethyl carbamate)
 Mammary gland

7.1
DD/TbrfC57BL Mammary gland tumor Mammary gland

0