Reference SummaryWard JM, J Natl Cancer Inst 1979 Sep;63(3):849-54

Title

 Neoplastic and nonneoplastic lesions in aging (C57BL/6N x C3H/HeN)F1 (B6C3F1) mice.

Authors

 Ward JM; Goodman DG; Squire RA; Chu KC; Linhart MS

Journal

 J Natl Cancer Inst

Volume

 63

Issue

 3

Year

 1979

Pages

 849-54

Abstract

 Neoplastic and nonneoplastic lesions in untreated (C57BL/6N x C3H/HeN)F1 (B6C3F1) mice used as controls in carcinogenesis tests were tabulated and evaluated. The most common neoplasms in 2,543 male mice were hepatocellular adenomas and carcinomas. In 2,522 female mice, common tumors were lymphomas, leukemias, pulmonary adenomas and carcinomas, hepatocellular adenomas and carcinomas, and pituitary adenomas. The risk of developing most neoplasms increased with the age of the mouse. Hepatocellular carcinomas metastasized in 12% of the animals with these tumors. Other than lymphomas and leukemias, few other tumors metastasized. Nonneoplastic lesions included cystic hyperplasia of the uterus, nephritis, ovarian and uterine cysts, inflammatory lesions of the lung, mineralization in the brain, and focal hyperplasias in several tissues. The focal hyperplasias in lung and pituitary, adrenal, and thyroid glands were suggestive of the early stages of neoplasia. Comparative aspects of lesions in aging mice and their interpretation in carcinogenesis tests are discussed.

Links

 J:27160 – MGI References
288939 – National Library of Medicine/PubMed

Models
Strain Model Name Treatment Agent(s) Organ Affected Frequency Model Details
(C57BL/6N x C3H/HeN)F1 Adipose tissue lipoma Skin

0.12 - 0.16
(C57BL/6N x C3H/HeN)F1 Adipose tissue lipoma Urinary bladder

0 - 0.04
(C57BL/6N x C3H/HeN)F1 Adipose tissue lipoma Ovary

0.04
(C57BL/6N x C3H/HeN)F1 Adipose tissue liposarcoma Skin

0 - 0.04
(C57BL/6N x C3H/HeN)F1 Adrenal gland - Cortex adenoma Adrenal gland - Cortex

0.36 - 0.55
(C57BL/6N x C3H/HeN)F1 Adrenal gland - Cortex carcinoma Adrenal gland - Cortex

0 - 0.12
(C57BL/6N x C3H/HeN)F1 Adrenal gland - Medulla pheochromocytoma Adrenal gland - Medulla

0.28 - 0.31
(C57BL/6N x C3H/HeN)F1 Adrenal gland hyperplasia Adrenal gland

observed
(C57BL/6N x C3H/HeN)F1 Adrenal gland hyperplasia - focal Adrenal gland

3.85 - 5.15
(C57BL/6N x C3H/HeN)F1 Adrenal gland preneoplastic lesion Adrenal gland

observed
(C57BL/6N x C3H/HeN)F1 Blood vessel hemangioma Spleen

observed
(C57BL/6N x C3H/HeN)F1 Blood vessel hemangioma Liver

observed
(C57BL/6N x C3H/HeN)F1 Blood vessel hemangioma Skin

observed
(C57BL/6N x C3H/HeN)F1 Blood vessel hemangioma Lymph node

observed
(C57BL/6N x C3H/HeN)F1 Blood vessel hemangioma (Unspecified organ)

observed
(C57BL/6N x C3H/HeN)F1 Blood vessel hemangioma Blood vessel

0.79 - 1.3
(C57BL/6N x C3H/HeN)F1 Blood vessel hemangiosarcoma Spleen

observed
(C57BL/6N x C3H/HeN)F1 Blood vessel hemangiosarcoma Liver

observed
(C57BL/6N x C3H/HeN)F1 Blood vessel hemangiosarcoma Skin

observed
(C57BL/6N x C3H/HeN)F1 Blood vessel hemangiosarcoma Lymph node

observed
(C57BL/6N x C3H/HeN)F1 Blood vessel hemangiosarcoma (Unspecified organ)

observed
(C57BL/6N x C3H/HeN)F1 Blood vessel hemangiosarcoma Blood vessel

1.11 - 1.61
(C57BL/6N x C3H/HeN)F1 Bone osteochondroma Bone

0 - 0.04
(C57BL/6N x C3H/HeN)F1 Bone osteoma Lung

0 - 0.04
(C57BL/6N x C3H/HeN)F1 Bone osteosarcoma Skin

0.04
(C57BL/6N x C3H/HeN)F1 Bone osteosarcoma Lung

0 - 0.04
(C57BL/6N x C3H/HeN)F1 Bone osteosarcoma Bone

0.04 - 0.16
(C57BL/6N x C3H/HeN)F1 CNS - Brain - Oligodendroglial cell oligodendroglioma CNS - Brain - Oligodendroglial cell

0 - 0.04
(C57BL/6N x C3H/HeN)F1 CNS - Brain glioma CNS - Brain

0 - 0.04
(C57BL/6N x C3H/HeN)F1 CNS - Meninges meningioma CNS - Meninges

0 - 0.08
(C57BL/6N x C3H/HeN)F1 Connective tissue - Fibroblast fibroadenoma Mammary gland

0 - 0.12
(C57BL/6N x C3H/HeN)F1 Connective tissue - Fibroblast fibroma Skin

0.04 - 0.31
(C57BL/6N x C3H/HeN)F1 Connective tissue - Fibroblast fibroma Pancreas

0 - 0.04
(C57BL/6N x C3H/HeN)F1 Connective tissue - Fibroblast fibrosarcoma Skin

0.56 - 0.87
(C57BL/6N x C3H/HeN)F1 Connective tissue - Fibroblast fibrosarcoma Kidney

0 - 0.04
(C57BL/6N x C3H/HeN)F1 Esophagus papilloma Esophagus

0 - 0.04
(C57BL/6N x C3H/HeN)F1 Esophagus squamous cell carcinoma Esophagus

0.04
(C57BL/6N x C3H/HeN)F1 Eye - Harderian gland adenoma Eye - Harderian gland

0.44 - 0.75
(C57BL/6N x C3H/HeN)F1 Eye - Lacrimal gland adenoma Eye - Lacrimal gland

0.08 - 0.16
(C57BL/6N x C3H/HeN)F1 Eye melanoma - malignant Eye

0 - 0.04
(C57BL/6N x C3H/HeN)F1 Intestine - Small Intestine adenocarcinoma Intestine - Small Intestine

0.04 - 0.28
(C57BL/6N x C3H/HeN)F1 Intestine - Small Intestine adenoma Intestine - Small Intestine

0.04 - 0.16
(C57BL/6N x C3H/HeN)F1 Kidney - Renal tubule adenocarcinoma - tubular Kidney - Renal tubule

0.04 - 0.08
(C57BL/6N x C3H/HeN)F1 Kidney - Renal tubule adenoma - tubular Kidney - Renal tubule

0 - 0.08
(C57BL/6N x C3H/HeN)F1 Leukocyte - Lymphocyte lymphoma Leukocyte - Lymphocyte

observed
(C57BL/6N x C3H/HeN)F1 Leukocyte - Lymphocyte lymphoma Lymph node

observed
(C57BL/6N x C3H/HeN)F1 Leukocyte - Lymphocyte lymphoma Spleen

observed
(C57BL/6N x C3H/HeN)F1 Leukocyte - Lymphocyte lymphoma Liver

observed
(C57BL/6N x C3H/HeN)F1 Leukocyte - Lymphocyte lymphoma Peyer's patch

observed
(C57BL/6N x C3H/HeN)F1 Leukocyte - Lymphocyte lymphoma - lymphocytic Leukocyte - Lymphocyte

observed
(C57BL/6N x C3H/HeN)F1 Leukocyte - Lymphocyte lymphoma - mixed Leukocyte - Lymphocyte

observed
(C57BL/6N x C3H/HeN)F1 Leukocyte - Myelocyte (Granulocyte) - Basophil - Mast cell tumor (Unspecified organ)

0 - 0.04
(C57BL/6N x C3H/HeN)F1 Leukocyte - Myelocyte (Granulocyte) leukemia - myelocytic Leukocyte - Myelocyte (Granulocyte)

0.24
(C57BL/6N x C3H/HeN)F1 Leukocyte leukemia Lymph node

observed
(C57BL/6N x C3H/HeN)F1 Leukocyte leukemia Spleen

observed
(C57BL/6N x C3H/HeN)F1 Leukocyte leukemia Liver

observed
(C57BL/6N x C3H/HeN)F1 Leukocyte leukemia (Unspecified organ)

8.3 - 16.77
(C57BL/6N x C3H/HeN)F1 Leukocyte lymphoma (Unspecified organ)

8.3 - 16.77
(C57BL/6N x C3H/HeN)F1 Leukocyte lymphoma - histiocytic Leukocyte

observed
(C57BL/6N x C3H/HeN)F1 Liver carcinoma - undifferentiated Liver

0 - 0.04
(C57BL/6N x C3H/HeN)F1 Liver hepatocellular adenoma Liver

1.59 - 7.9
(C57BL/6N x C3H/HeN)F1 Liver hepatocellular carcinoma Liver

2.3 - 13.72
(C57BL/6N x C3H/HeN)F1 Liver hepatocellular neoplasm Liver

3.9 - 21.6
(C57BL/6N x C3H/HeN)F1 Liver hepatoma Liver

observed
(C57BL/6N x C3H/HeN)F1 Liver hyperplasia - adenomatous Liver

observed
(C57BL/6N x C3H/HeN)F1 Liver lesion Liver

observed
(C57BL/6N x C3H/HeN)F1 Liver tumor Liver

observed
(C57BL/6N x C3H/HeN)F1 Lung - Alveolus hyperplasia - epithelial Lung - Alveolus

0.56 - 0.83
(C57BL/6N x C3H/HeN)F1 Lung adenoma Lung

observed - 7.79
(C57BL/6N x C3H/HeN)F1 Lung carcinoma Lung

observed - 5.03
(C57BL/6N x C3H/HeN)F1 Lung hyperplasia Lung

observed
(C57BL/6N x C3H/HeN)F1 Lung neoplasm Lung

4.4 - 12.7
(C57BL/6N x C3H/HeN)F1 Lung preneoplastic lesion Lung

observed
(C57BL/6N x C3H/HeN)F1 Lymph node hyperplasia Lymph node

4.12 - 4.25
(C57BL/6N x C3H/HeN)F1 Lymphoid tissue hyperplasia - lymphoid Lung

7.43 - 10.86
(C57BL/6N x C3H/HeN)F1 Mammary gland adenoma Mammary gland

0 - 0.12
(C57BL/6N x C3H/HeN)F1 Mammary gland carcinoma Mammary gland

0 - 0.59
(C57BL/6N x C3H/HeN)F1 Mesodermal cell/mesoblast sarcoma Skin

0.12 - 0.16
(C57BL/6N x C3H/HeN)F1 Mesodermal cell/mesoblast sarcoma Lung

0 - 0.04
(C57BL/6N x C3H/HeN)F1 Mesodermal cell/mesoblast sarcoma Intestine - Small Intestine

0.04 - 0.08
(C57BL/6N x C3H/HeN)F1 Mesodermal cell/mesoblast sarcoma Uterus

0.08
(C57BL/6N x C3H/HeN)F1 Mesodermal cell/mesoblast sarcoma Vagina

0.04
(C57BL/6N x C3H/HeN)F1 Mesodermal cell/mesoblast sarcoma Abdominal cavity

0 - 0.12
(C57BL/6N x C3H/HeN)F1 Mesodermal cell/mesoblast sarcoma Thoracic cavity

0 - 0.12
(C57BL/6N x C3H/HeN)F1 Mesothelium mesothelioma Abdominal cavity

0 - 0.08
(C57BL/6N x C3H/HeN)F1 Mesothelium mesothelioma Thoracic cavity

0 - 0.08
(C57BL/6N x C3H/HeN)F1 Muscle - Smooth leiomyoma Uterus

0.04
(C57BL/6N x C3H/HeN)F1 Muscle - Smooth leiomyosarcoma Skin

0.08 - 0.12
(C57BL/6N x C3H/HeN)F1 Muscle - Smooth leiomyosarcoma Intestine - Large Intestine

0 - 0.08
(C57BL/6N x C3H/HeN)F1 Muscle - Smooth leiomyosarcoma Uterus

0.2
(C57BL/6N x C3H/HeN)F1 Muscle - Striated - Skeletal rhabdomyosarcoma Muscle - Striated - Skeletal

0 - 0.08
(C57BL/6N x C3H/HeN)F1 Myoepithelial cell myoepithelioma Mammary gland

0 - 0.04
(C57BL/6N x C3H/HeN)F1 Ovary - Granulosa cell tumor Ovary - Granulosa cell

0.12
(C57BL/6N x C3H/HeN)F1 Ovary - Hilus cell tumor Ovary - Hilus cell

0.04
(C57BL/6N x C3H/HeN)F1 Ovary adenocarcinoma Ovary

0.12
(C57BL/6N x C3H/HeN)F1 Ovary adenoma - papillary Ovary

0.28
(C57BL/6N x C3H/HeN)F1 Ovary adenoma - tubular Ovary

0.08
(C57BL/6N x C3H/HeN)F1 Ovary cyst Ovary

11.38
(C57BL/6N x C3H/HeN)F1 Ovary lesion Ovary

observed
(C57BL/6N x C3H/HeN)F1 Ovary luteoma Ovary

0.08
(C57BL/6N x C3H/HeN)F1 Oviduct lesion Oviduct

observed
(C57BL/6N x C3H/HeN)F1 PNS - Schwann cell neurofibrosarcoma Skin

0.04 - 0.08
(C57BL/6N x C3H/HeN)F1 PNS - Schwann cell neurofibrosarcoma Intestine - Large Intestine

0 - 0.04
(C57BL/6N x C3H/HeN)F1 PNS - Schwann cell schwannoma Skin

0.04 - 0.08
(C57BL/6N x C3H/HeN)F1 PNS - Schwann cell schwannoma PNS - Schwann cell

0.04
(C57BL/6N x C3H/HeN)F1 Pancreas - Duct cyst Pancreas - Duct

0.2 - 0.75
(C57BL/6N x C3H/HeN)F1 Pancreas - Islet of Langerhans adenoma Pancreas - Islet of Langerhans

0.08 - 0.28
(C57BL/6N x C3H/HeN)F1 Pancreas - Islet of Langerhans carcinoma Pancreas - Islet of Langerhans

0 - 0.08
(C57BL/6N x C3H/HeN)F1 Pancreas - Islet of Langerhans hyperplasia Pancreas - Islet of Langerhans

0.2 - 1.57
(C57BL/6N x C3H/HeN)F1 Pancreas adenoma Pancreas

0 - 0.04
(C57BL/6N x C3H/HeN)F1 Parathyroid gland adenoma Parathyroid gland

0 - 0.04
(C57BL/6N x C3H/HeN)F1 Pituitary gland adenoma Pituitary gland

0.12 - 3.01
(C57BL/6N x C3H/HeN)F1 Pituitary gland carcinoma Pituitary gland

0.08 - 0.16
(C57BL/6N x C3H/HeN)F1 Pituitary gland hyperplasia Pituitary gland

observed - 0.36
(C57BL/6N x C3H/HeN)F1 Pituitary gland preneoplastic lesion Pituitary gland

observed
(C57BL/6N x C3H/HeN)F1 Prostate gland adenocarcinoma Prostate gland

0.04
(C57BL/6N x C3H/HeN)F1 Renal pelvis - Transitional cell papilloma Renal pelvis - Transitional cell

0 - 0.04
(C57BL/6N x C3H/HeN)F1 Seminal vesicle adenoma - papillary Seminal vesicle

0.04
(C57BL/6N x C3H/HeN)F1 Skin - Epidermis - Basal cell carcinoma - basal Skin - Epidermis - Basal cell

0 - 0.04
(C57BL/6N x C3H/HeN)F1 Skin - Hair follicle - Basal cell trichoepithelioma Skin - Hair follicle - Basal cell

0
(C57BL/6N x C3H/HeN)F1 Skin - Melanocyte melanoma - malignant Skin - Melanocyte

0.04
(C57BL/6N x C3H/HeN)F1 Skin adenocarcinoma Skin

0 - 0.04
(C57BL/6N x C3H/HeN)F1 Skin adenoma - sebaceous Skin

0 - 0.08
(C57BL/6N x C3H/HeN)F1 Skin keratoacanthoma Skin

0.04
(C57BL/6N x C3H/HeN)F1 Skin lesion Skin

observed
(C57BL/6N x C3H/HeN)F1 Skin papilloma Skin

0.04 - 0.12
(C57BL/6N x C3H/HeN)F1 Skin squamous cell carcinoma Skin

0.04 - 0.12
(C57BL/6N x C3H/HeN)F1 Stomach carcinoma Stomach

0.04
(C57BL/6N x C3H/HeN)F1 Stomach hyperplasia Stomach

0.75 - 0.87
(C57BL/6N x C3H/HeN)F1 Stomach papilloma Stomach

0.28 - 0.31
(C57BL/6N x C3H/HeN)F1 Stomach polyp - adenomatous Stomach

0.04 - 0.08
(C57BL/6N x C3H/HeN)F1 Stomach squamous cell carcinoma Stomach

0 - 0.04
(C57BL/6N x C3H/HeN)F1 Testis - Germ cell carcinoma - embryonal Testis - Germ cell

0.08
(C57BL/6N x C3H/HeN)F1 Testis - Germ cell seminoma Testis - Germ cell

0.04
(C57BL/6N x C3H/HeN)F1 Testis - Leydig cell (Interstitial cell) tumor Testis - Leydig cell (Interstitial cell)

0.28
(C57BL/6N x C3H/HeN)F1 Thyroid gland - Follicular cell adenoma Thyroid gland - Follicular cell

0.63 - 1.19
(C57BL/6N x C3H/HeN)F1 Thyroid gland - Follicular cell carcinoma Thyroid gland - Follicular cell

0.24 - 0.28
(C57BL/6N x C3H/HeN)F1 Thyroid gland - Follicular cell hyperplasia - cystic Thyroid gland - Follicular cell

0.9 - 1.23
(C57BL/6N x C3H/HeN)F1 Thyroid gland - Follicular cell hyperplasia - follicular Thyroid gland - Follicular cell

0.59 - 1.55
(C57BL/6N x C3H/HeN)F1 Thyroid gland - Medulla - C cell adenoma Thyroid gland - Medulla - C cell

0 - 0.04
(C57BL/6N x C3H/HeN)F1 Thyroid gland - Medulla - C cell carcinoma Thyroid gland - Medulla - C cell

0 - 0.04
(C57BL/6N x C3H/HeN)F1 Thyroid gland hyperplasia Thyroid gland

observed
(C57BL/6N x C3H/HeN)F1 Thyroid gland preneoplastic lesion Thyroid gland

observed
(C57BL/6N x C3H/HeN)F1 Urethra adenoma Urethra

0 - 0.04
(C57BL/6N x C3H/HeN)F1 Urinary bladder adenoma - papillary Urinary bladder

0 - 0.04
(C57BL/6N x C3H/HeN)F1 Urinary bladder hyperplasia - epithelial Urinary bladder

1.15 - 1.26
(C57BL/6N x C3H/HeN)F1 Urinary bladder papilloma Urinary bladder

0 - 0.08
(C57BL/6N x C3H/HeN)F1 Uterus - Endometrium - Stroma polyp Uterus - Endometrium - Stroma

0.52
(C57BL/6N x C3H/HeN)F1 Uterus adenocarcinoma Uterus

0.08
(C57BL/6N x C3H/HeN)F1 Uterus adenoma Uterus

0.24
(C57BL/6N x C3H/HeN)F1 Uterus cyst Uterus

5.79
(C57BL/6N x C3H/HeN)F1 Uterus hyperplasia Uterus

observed
(C57BL/6N x C3H/HeN)F1 Uterus hyperplasia - cystic Uterus

35.01
(C57BL/6N x C3H/HeN)F1 Uterus lesion Uterus

observed
(C57BL/6N x C3H/HeN)F1 Vagina squamous cell carcinoma Vagina

0.04
(C57BL/6N x C3H/HeN)F1 (Unspecified organ) neoplasm (Unspecified organ)

observed