Reference SummaryDixon D, Exp Lung Res 1991 Mar-Apr;17(2):131-55
Title |
Histomorphology and ultrastructure of spontaneous pulmonary neoplasms in strain A mice. |
Authors |
Dixon D; Horton J; Haseman JK; Talley F; Greenwell A; Nettesheim P; Hook GE; Maronpot RR |
Journal |
Exp Lung Res |
Volume |
17 |
Issue |
2 |
Year |
1991 |
Pages |
131-55 |
Abstract |
The microscopic and ultrastructural characteristics of spontaneous pulmonary neoplasms in strain A (strA) mice are described. Fifty-one spontaneous lung tumors were identified in 34 out of 57, 11-23-month-old male strA/Hen mice. Grossly, all tumors appeared as yellow-white, discrete nodules ranging in size from 1.0-10 mm. Tumor types were randomly distributed throughout the lung; however, the right lung lobes were most frequently involved. Histologically, tumors were classified as adenoma (34/51) or carcinoma (17/51) as defined by standard histopathologic criteria. Adenomas were usually less than 4 mm in diameter and had solid (16/34), papillary (10/34), or mixed (8/34) histologic growth patterns. Carcinomas were usually greater than 4 mm in diameter and had papillary (13/17) or mixed (4/17) histologic growth patterns. Ultrastructurally, benign tumors consisted of solid or papillary areas of neoplastic type II-like cells. Cells comprising malignant tumors had varying ultrastructural characteristics ranging from well-differentiated alveolar cell types to undifferentiated cells having intracytoplasmic osmiophilic dense bodies, vacuoles, or few specialized organelles commonly observed in mature nonneoplastic pulmonary epithelial cells. |
Links |
J:27691 – MGI References 1646706 – National Library of Medicine/PubMed |
| Strain | Model Name | Treatment Agent(s) | Organ Affected | Frequency | Model Details |
|---|---|---|---|---|---|
| A/HeN | Lung - Club cell hyperplasia | Lung - Club cell |
observed |
||
| A/HeN | Lung adenoma - mixed | Lung |
observed |
||
| A/HeN | Lung adenoma - papillary | Lung |
observed |
||
| A/HeN | Lung adenoma - solid | Lung |
observed |
||
| A/HeN | Lung carcinoma - mixed | Lung |
observed |
||
| A/HeN | Lung carcinoma - papillary | Lung |
observed |
||
| A/HeN | Lung carcinoma - solid | Lung |
0 |
||
| A/HeN | Lung tumor | Lung |
33 - 86 |