Reference SummaryTurusov VS, Int J Cancer 1992 Jan 2;50(1):131-5
Title |
Occurrence of tumours in the descendants of CBA male mice prenatally treated with diethylstilbestrol. |
Authors |
Turusov VS; Trukhanova LS; Parfenov YuD; Tomatis L |
Journal |
Int J Cancer |
Volume |
50 |
Issue |
1 |
Year |
1992 |
Pages |
131-5 |
Abstract |
There is well documented evidence both in humans and in experimental animals that exposure to diethylstilbestrol (DES) during pregnancy results in an increased incidence of tumours in the progeny. The increased cancer risk has been reported to persist in the second generation descendants of DES-exposed pregnant mice. In the present experiment, female mice of the CBA strain were treated at day 17 of pregnancy with 1 microgram/g body weight of DES. The descendants of DES-treated mothers, described as F1DES, were mated among each other or with untreated animals. The F1DES females were found to be sterile when mated with either F1DES or untreated males. F1DES males were successfully mated with untreated females. In the female offspring so obtained, but not in the male, a statistically significant increased incidence of tumours was observed, in particular of uterine sarcomas, and also of benign ovarian tumours and of lymphomas. |
Links |
J:2844 – MGI References 1728603 – National Library of Medicine/PubMed |
| Strain | Model Name | Treatment Agent(s) | Organ Affected | Frequency | Model Details |
|---|---|---|---|---|---|
| CBA | Adrenal gland - Cortex adenoma |
|
Adrenal gland - Cortex |
1.2 |
|
| CBA | Kidney adenoma |
|
Kidney |
2.5 |
|
| CBA | Kidney adenoma | Kidney |
1.9 - 2.4 |
||
| CBA | Kidney carcinoma |
|
Kidney |
1.0 |
|
| CBA | Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma |
|
Uterus |
10.9 - 16.7 |
|
| CBA | Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma | Uterus |
4.9 - 6.0 |
||
| CBA | Leukocyte - Monocyte - Macrophage - Histiocyte histiocytoma - malignant |
|
Skin |
1.2 - 2.5 |
|
| CBA | Leukocyte lymphoma |
|
Leukocyte |
2.2 - 20.2 |
|
| CBA | Leukocyte lymphoma | Leukocyte |
0 - 12.2 |
||
| CBA | Liver tumor |
|
Liver |
0 - 46.1 |
|
| CBA | Liver tumor | Liver |
5.0 - 51.9 |
||
| CBA | Lung tumor |
|
Lung |
2.2 - 20.0 |
|
| CBA | Lung tumor | Lung |
5.0 - 25.6 |
||
| CBA | Mammary gland carcinoma |
|
Mammary gland |
0 - 50 |
|
| CBA | Mammary gland carcinoma | Mammary gland |
0 - 13.4 |
||
| CBA | Mesodermal cell/mesoblast sarcoma |
|
Uterus |
10.9 - 25 |
|
| CBA | Mesodermal cell/mesoblast sarcoma |
|
Mesodermal cell/mesoblast |
2.5 |
|
| CBA | Mesodermal cell/mesoblast sarcoma | Uterus |
0 - 6.0 |
||
| CBA | Mesodermal cell/mesoblast sarcoma | Mesodermal cell/mesoblast |
1.9 - 4.9 |
||
| CBA | Ovary - Granulosa cell tumor - malignant |
|
Ovary - Granulosa cell |
1.2 |
|
| CBA | Ovary adenoma - tubular |
|
Ovary |
observed |
|
| CBA | Ovary adenoma - tubular | Ovary |
observed |
||
| CBA | Ovary tumor |
|
Ovary |
0 - 19.0 |
|
| CBA | Ovary tumor | Ovary |
5.0 - 9.0 |
||
| CBA | Ovary tumor - granulosa-theca cell - benign |
|
Ovary |
observed |
|
| CBA | Ovary tumor - granulosa-theca cell - benign | Ovary |
observed |
||
| CBA | Seminal vesicle adenoma |
|
Seminal vesicle |
2.5 |
|
| CBA | Skin carcinoma |
|
Skin |
1.2 |
|
| CBA | Testis tumor - malignant |
|
Testis |
1.0 |
|
| CBA | Uterus adenocarcinoma |
|
Uterus |
2.4 |
|
| CBA | Uterus carcinoma |
|
Uterus |
0 - 2.4 |
|
| CBA | Uterus carcinoma | Uterus |
0 |
||
| CBA | Uterus polyp - fibrous |
|
Uterus |
6.25 |
|
| CBA | (Unspecified organ) angiosarcoma |
|
Vagina |
1.2 |
|
| CBA | (Unspecified organ) angiosarcoma |
|
Prostate gland |
1.0 |
|
| CBA | (Unspecified organ) tumor |
|
(Unspecified organ) |
2.2 - 12.5 |
|
| CBA | (Unspecified organ) tumor | (Unspecified organ) |
8.5 - 23.1 |