Reference SummaryGuy CT, Mol Cell Biol 1992 Mar;12(3):954-61

Title

 Induction of mammary tumors by expression of polyomavirus middle T oncogene: a transgenic mouse model for metastatic disease.

Authors

 Guy CT; Cardiff RD; Muller WJ

Journal

 Mol Cell Biol

Volume

 12

Issue

 3

Year

 1992

Pages

 954-61

Abstract

 The effect of mammary gland-specific expression of the polyomavirus middle T antigen was examined by establishing lines of transgenic mice that carry the middle T oncogene under the transcriptional control of the mouse mammary tumor virus promoter/enhancer. By contrast to most transgenic strains carrying activated oncogenes, expression of polyomavirus middle T antigen resulted in the widespread transformation of the mammary epithelium and the rapid production of multifocal mammary adenocarcinomas. Interestingly, the majority of the tumor-bearing transgenic mice developed secondary metastatic tumors in the lung. Taken together, these results suggest that middle T antigen acts as a potent oncogene in the mammary epithelium and that cells that express it possess an enhanced metastatic potential.

Links

 J:46460 – MGI References
1312220 – National Library of Medicine/PubMed

Strain Notes

Strain Note
FVB/N-Tg(MMTV-PyVT)121Mul Expression of the "MMTVPyVT" transgene was reported to not be detected in the mammary glands, salivary glands, lungs, seminal vesicles, testis, and epididymus of these mice.
Expression of the "MMTVPyVT" transgene was reported to not be detected in the salivary glands of these mice.
Multiparous mice develop an inability to lactate.
The "MMTV PyVT" transgene was reported to be highly expressed in the mammary glands and slightly expressed in the lungs and ovaries of these mice.
FVB/N-Tg(MMTV-PyVT)196Mul The male founder mouse didn't transmit the transgene to its progeny.
The "MMTVPyVT" transgene was reported to be highly expressed in the mammary glands, expressed in the seminal vesicles, and slightly expressed in the salivary glands and lungs of these mice.
FVB/N-Tg(MMTV-PyVT)235Mul Expression of the "MMTVPyVT" transgene was reported to not be detected in the salivary glands and lungs of these mice.
From the time of the first pregnancy the female founder mouse showed an inability to lactate.
The female founder mouse didn't transmit the transgene to its progeny.
The "MMTVPyVT" transgene was reported to be highly expressed in the mammary glands and slightly expressed in the ovaries of these mice.
FVB/N-Tg(MMTV-PyVT)634Mul Expression of the "MMTVPyVT" transgene was reported to not be detected in the seminal vesicle and epididymis of these mice.
Female mice from the time of the first pregnancy show an inability to lactate.
The "MMTVPyVT" transgene was reported to be highly expressed in the mammary glands and slightly expressed in the salivary glands, epididymis, lungs and testis of these mice.
The "MMTVPyVT" transgene was reported to be highly expressed in the mammary glands, expressed in the lungs, and slightly expressed in the ovaries and salivary glands of these mice.
FVB/N-Tg(MMTV-PyVT)654Mul Expression of the "MMTVPyVT" transgene was reported to not be detected in the mammary glands, salivary glands, lungs, seminal vesicles, testis, and epididymus of these mice.
Expression of the "MMTVPyVT" transgene was reported to not be detected in the ovaries of these mice.
The "MMTVPyVT" transgene was reported to be highly expressed in the mammary glands and slightly expressed in the salivary glands and lungs of these mice.
FVB/N-Tg(MMTV-PyVT)668Mul Expression of the "MMTVPyVT" transgene was reported to not be detected in the ovaries of these mice.
Female mice from the time of the first pregnancy show an inability to lactate.
The "MMTVPyVT" transgene was reported to be highly expressed in the mammary glands and lungs and expressed in the salivary glands of these mice.
FVB/N-Tg(MMTV-PyVT)670Mul Expression of the "MMTVPyVT" transgene was reported to not be detected in the mammary glands, salivary glands, lungs, seminal vesicles, testis, and epididymus of these mice.
Expression of the "MMTVPyVT" transgene was reported to not be detected in the salivary glands and ovaries of these mice.
The "MMTVPyVT" transgene was reported to be highly expressed in the mammary glands and slightly expressed in the lungs of these mice.

Models
Strain Model Name Treatment Agent(s) Organ Affected Frequency Model Details
FVB/N-Tg(MMTV-PyVT)196Mul Blood vessel hemangioma Blood vessel

100
FVB/N-Tg(MMTV-PyVT)121Mul Mammary gland adenocarcinoma Mammary gland

100
FVB/N-Tg(MMTV-PyVT)196Mul Mammary gland adenocarcinoma Mammary gland

100
FVB/N-Tg(MMTV-PyVT)235Mul Mammary gland adenocarcinoma Mammary gland

100
FVB/N-Tg(MMTV-PyVT)634Mul Mammary gland adenocarcinoma Mammary gland

100
FVB/N-Tg(MMTV-PyVT)654Mul Mammary gland adenocarcinoma Mammary gland

100
FVB/N-Tg(MMTV-PyVT)668Mul Mammary gland adenocarcinoma Mammary gland

100
FVB/N-Tg(MMTV-PyVT)670Mul Mammary gland adenocarcinoma Mammary gland

100
FVB/N-Tg(MMTV-PyVT)196Mul Seminal vesicle adenocarcinoma Seminal vesicle

100
FVB/N-Tg(MMTV-PyVT)121Mul (Unspecified organ) tumor (Unspecified organ)

0
FVB/N-Tg(MMTV-PyVT)654Mul (Unspecified organ) tumor (Unspecified organ)

0
FVB/N-Tg(MMTV-PyVT)670Mul (Unspecified organ) tumor (Unspecified organ)

0