Reference SummaryBeamer WG, Cancer Res 1998 Aug 15;58(16):3694-9
Title |
Multigenic and imprinting control of ovarian granulosa cell tumorigenesis in mice. | ||||||||||
Authors |
Beamer WG; Shultz KL; Tennent BJ; Nadeau JH; Churchill GA; Eicher EM | ||||||||||
Journal |
Cancer Res | ||||||||||
Volume |
58 | ||||||||||
Issue |
16 | ||||||||||
Year |
1998 | ||||||||||
Pages |
3694-9 | ||||||||||
Abstract |
Spontaneous juvenile ovarian granulosa cell (GC) tumors that occur in young girls are similar to GC carcinomas that develop in SWR-derived inbred mice. We analyzed female offspring from a series of matings among SWR and SJL inbred mice for chromosomal loci underlying tumor susceptibility. Intercross F-2 female mice were produced by reciprocal matings of (SWR x SJL)F-1 and (SJL x SWR)F-1 parents. Tumorigenesis in these: F-2 mice as well as in SWXJ recombinant inbred and congenic strains of mice derived from SWR and SJL showed significant (P < 0.001) association with Gct1, a dominant susceptibility locus on chromosome (CHR)4 and with Gct2 on CHR 12. Suggestive (P < 0.01) association was found with Gct3 on CHR 15. A fourth susceptibility locus, Gct4 on CHR X, was demonstrated with a strong parent-of-origin effect associated with the paternal genotype. Imprinting and complex interactions among these four loci combine to establish the probability for GC tumorigenesis in this mouse model. | ||||||||||
Links |
J:49710 – MGI References 9721880 – National Library of Medicine/PubMed |
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Strain Notes
|
Strain | Model Name | Treatment Agent(s) | Organ Affected | Frequency | Model Details |
---|---|---|---|---|---|
(SJL/Bm x SWR/Bm)F2 | Ovary - Granulosa cell tumor | Ovary - Granulosa cell |
0.9 |
||
(SJL/Bm x SWR/Bm)F1 x (SWR/Bm x SJL/Bm)F1 | Ovary - Granulosa cell tumor | Ovary - Granulosa cell |
0 |
||
(SWR/Bm x SJL/Bm)F1 x (SJL/Bm x SWR/Bm)F1 | Ovary - Granulosa cell tumor | Ovary - Granulosa cell |
1.2 |
||
(SWR/Bm x SJL/Bm)F2 | Ovary - Granulosa cell tumor | Ovary - Granulosa cell |
0 |
||
SWR/Bm-Chr X.1SJL/Bm | Ovary - Granulosa cell tumor | Ovary - Granulosa cell |
4.5 |
||
SWR/Bm-Chr X.2SJL/Bm | Ovary - Granulosa cell tumor | Ovary - Granulosa cell |
23 |
||
SWR/Bm-Chr X.3SJL/Bm | Ovary - Granulosa cell tumor | Ovary - Granulosa cell |
27 |
||
SWR/Bm-Chr X.4SJL/Bm | Ovary - Granulosa cell tumor | Ovary - Granulosa cell |
0 |
||
(SWR/Bm x SJL/Bm)F1 | Ovary - Granulosa cell tumor | Ovary - Granulosa cell |
2.7 |
||
SWR/Bm-Chr XSJL/Bm (N2) | Ovary - Granulosa cell tumor | Ovary - Granulosa cell |
0 |
||
SWR/Bm-Chr XSJL/Bm (N3) | Ovary - Granulosa cell tumor | Ovary - Granulosa cell |
19 |
||
SWR/Bm-Chr XSJL/Bm (N4) | Ovary - Granulosa cell tumor | Ovary - Granulosa cell |
1.2 |
||
SWR/Bm-Chr XSJL/Bm (N5) | Ovary - Granulosa cell tumor | Ovary - Granulosa cell |
34 |
||
SWR/Bm-Chr XSJL/Bm (N6) | Ovary - Granulosa cell tumor | Ovary - Granulosa cell |
5.1 |
||
SWR/Bm-Chr XSJL/Bm (N7) | Ovary - Granulosa cell tumor | Ovary - Granulosa cell |
13 |
||
(SWR/Bm x SWXJ1/Bm)F1 | Ovary - Granulosa cell tumor | Ovary - Granulosa cell |
11 |
||
(SWXJ1/Bm x SWR/Bm)F1 | Ovary - Granulosa cell tumor | Ovary - Granulosa cell |
1.0 |
||
(SWR/Bm x SWXJ9/Bm)F1 | Ovary - Granulosa cell tumor | Ovary - Granulosa cell |
24 |
||
(SWXJ9/Bm x SWR/Bm)F1 | Ovary - Granulosa cell tumor | Ovary - Granulosa cell |
7.0 |
||
(SWR/Bm x SWXJ13/Bm)F1 | Ovary - Granulosa cell tumor | Ovary - Granulosa cell |
7.4 |
||
(SWXJ13/Bm x SWR/Bm)F1 | Ovary - Granulosa cell tumor | Ovary - Granulosa cell |
0 |
||
(SWR/Bm x SWXJ6/Bm)F1 | Ovary - Granulosa cell tumor | Ovary - Granulosa cell |
0.6 |
||
(SWXJ6/Bm x SWR/Bm)F1 | Ovary - Granulosa cell tumor | Ovary - Granulosa cell |
2.8 |
||
(SWR/Bm x SWXJ14/Bm)F1 | Ovary - Granulosa cell tumor | Ovary - Granulosa cell |
0 |
||
(SWXJ14/Bm x SWR/Bm)F1 | Ovary - Granulosa cell tumor | Ovary - Granulosa cell |
0 |
||
SWR/Bm | Ovary - Granulosa cell tumor | Ovary - Granulosa cell |
observed |