Reference SummaryBeamer WG, Cancer Res 1998 Aug 15;58(16):3694-9

Title

 Multigenic and imprinting control of ovarian granulosa cell tumorigenesis in mice.

Authors

 Beamer WG; Shultz KL; Tennent BJ; Nadeau JH; Churchill GA; Eicher EM

Journal

 Cancer Res

Volume

 58

Issue

 16

Year

 1998

Pages

 3694-9

Abstract

 Spontaneous juvenile ovarian granulosa cell (GC) tumors that occur in young girls are similar to GC carcinomas that develop in SWR-derived inbred mice. We analyzed female offspring from a series of matings among SWR and SJL inbred mice for chromosomal loci underlying tumor susceptibility. Intercross F-2 female mice were produced by reciprocal matings of (SWR x SJL)F-1 and (SJL x SWR)F-1 parents. Tumorigenesis in these: F-2 mice as well as in SWXJ recombinant inbred and congenic strains of mice derived from SWR and SJL showed significant (P < 0.001) association with Gct1, a dominant susceptibility locus on chromosome (CHR)4 and with Gct2 on CHR 12. Suggestive (P < 0.01) association was found with Gct3 on CHR 15. A fourth susceptibility locus, Gct4 on CHR X, was demonstrated with a strong parent-of-origin effect associated with the paternal genotype. Imprinting and complex interactions among these four loci combine to establish the probability for GC tumorigenesis in this mouse model.

Links

 J:49710 – MGI References
9721880 – National Library of Medicine/PubMed

Strain Notes

Strain Note
SWR/Bm-Chr X.1SJL/Bm DXMit55 and DXMit46 were of SJL origin while DXMit16, DXMit38, and DXMit182 were of SWR origin.
SWR/Bm-Chr X.2SJL/Bm DXMit46 and DXMit16 were of SJL origin while DXMit55, DXMit38, and DXMit182 were of SWR origin.
SWR/Bm-Chr X.3SJL/Bm DXMit16 and DXMit38 were of SJL origin while DXMit55, DXMit46, and DXMit182 were of SWR origin.
SWR/Bm-Chr X.4SJL/Bm DXMit38 and DXMit182 were of SJL origin while DXMit55, DXMit46, and DXMit16 were of SWR origin.

Models
Strain Model Name Treatment Agent(s) Organ Affected Frequency Model Details
(SJL/Bm x SWR/Bm)F2 Ovary - Granulosa cell tumor Ovary - Granulosa cell

0.9
(SJL/Bm x SWR/Bm)F1 x (SWR/Bm x SJL/Bm)F1 Ovary - Granulosa cell tumor Ovary - Granulosa cell

0
(SWR/Bm x SJL/Bm)F1 x (SJL/Bm x SWR/Bm)F1 Ovary - Granulosa cell tumor Ovary - Granulosa cell

1.2
(SWR/Bm x SJL/Bm)F2 Ovary - Granulosa cell tumor Ovary - Granulosa cell

0
SWR/Bm-Chr X.1SJL/Bm Ovary - Granulosa cell tumor Ovary - Granulosa cell

4.5
SWR/Bm-Chr X.2SJL/Bm Ovary - Granulosa cell tumor Ovary - Granulosa cell

23
SWR/Bm-Chr X.3SJL/Bm Ovary - Granulosa cell tumor Ovary - Granulosa cell

27
SWR/Bm-Chr X.4SJL/Bm Ovary - Granulosa cell tumor Ovary - Granulosa cell

0
(SWR/Bm x SJL/Bm)F1 Ovary - Granulosa cell tumor Ovary - Granulosa cell

2.7
SWR/Bm-Chr XSJL/Bm (N2) Ovary - Granulosa cell tumor Ovary - Granulosa cell

0
SWR/Bm-Chr XSJL/Bm (N3) Ovary - Granulosa cell tumor Ovary - Granulosa cell

19
SWR/Bm-Chr XSJL/Bm (N4) Ovary - Granulosa cell tumor Ovary - Granulosa cell

1.2
SWR/Bm-Chr XSJL/Bm (N5) Ovary - Granulosa cell tumor Ovary - Granulosa cell

34
SWR/Bm-Chr XSJL/Bm (N6) Ovary - Granulosa cell tumor Ovary - Granulosa cell

5.1
SWR/Bm-Chr XSJL/Bm (N7) Ovary - Granulosa cell tumor Ovary - Granulosa cell

13
(SWR/Bm x SWXJ1/Bm)F1 Ovary - Granulosa cell tumor Ovary - Granulosa cell

11
(SWXJ1/Bm x SWR/Bm)F1 Ovary - Granulosa cell tumor Ovary - Granulosa cell

1.0
(SWR/Bm x SWXJ9/Bm)F1 Ovary - Granulosa cell tumor Ovary - Granulosa cell

24
(SWXJ9/Bm x SWR/Bm)F1 Ovary - Granulosa cell tumor Ovary - Granulosa cell

7.0
(SWR/Bm x SWXJ13/Bm)F1 Ovary - Granulosa cell tumor Ovary - Granulosa cell

7.4
(SWXJ13/Bm x SWR/Bm)F1 Ovary - Granulosa cell tumor Ovary - Granulosa cell

0
(SWR/Bm x SWXJ6/Bm)F1 Ovary - Granulosa cell tumor Ovary - Granulosa cell

0.6
(SWXJ6/Bm x SWR/Bm)F1 Ovary - Granulosa cell tumor Ovary - Granulosa cell

2.8
(SWR/Bm x SWXJ14/Bm)F1 Ovary - Granulosa cell tumor Ovary - Granulosa cell

0
(SWXJ14/Bm x SWR/Bm)F1 Ovary - Granulosa cell tumor Ovary - Granulosa cell

0
SWR/Bm Ovary - Granulosa cell tumor Ovary - Granulosa cell

observed