Reference SummaryTillmann T, Exp Toxicol Pathol 2000 Jun;52(3):221-5
Title |
Incidence and spectrum of spontaneous neoplasms in male and female CBA/J mice |
Authors |
Tillmann T; Kamino K; Mohr U |
Journal |
Exp Toxicol Pathol |
Volume |
52 |
Issue |
3 |
Year |
2000 |
Pages |
221-5 |
Abstract |
Although CBA mice are occasionally used in biomedical research, little is known about their life-data and diseases ('background pathology'). Therefore, it was the aim of this study to determine the life expectancy, spectrum and incidence of spontaneous neoplasms of the inbred CBA/J mouse strain. A total of 631 untreated mice (293 females; 338 males) were kept from birth to death under standard laboratory conditions. A complete histological examination was performed on all organs/tissues. In female CBA mice, the average lifespan was 94 weeks, while the mean age in males was 85 weeks. Neoplastic lesions were observed in 70% (238/338) of the males and 51% (150/293) of the female CBA/J mice. Tumours of the liver, lung and haematopoietic tissue were common in males, while tumours of the lung, ovary and haematopoietic tissue were the most frequent neoplasms in female CBA/J mice. |
Links |
J:64648 – MGI References 10930122 – National Library of Medicine/PubMed |
| Strain | Model Name | Treatment Agent(s) | Organ Affected | Frequency | Model Details |
|---|---|---|---|---|---|
| CBA/J | Adrenal gland - Cortex adenoma | Adrenal gland - Cortex |
2.4 - 5.3 |
||
| CBA/J | Adrenal gland - Medulla pheochromocytoma | Adrenal gland - Medulla |
0.6 - 0.7 |
||
| CBA/J | Blood vessel hemangiosarcoma | Spleen |
0.3 |
||
| CBA/J | Connective tissue - Fibroblast fibrosarcoma | Connective tissue - Fibroblast |
0.3 |
||
| CBA/J | Eye - Harderian gland adenoma | Eye - Harderian gland |
2.7 - 3.8 |
||
| CBA/J | Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma | Leukocyte - Monocyte - Macrophage - Histiocyte |
3.4 - 4.7 |
||
| CBA/J | Leukocyte lymphoma | Leukocyte |
5.0 - 8.2 |
||
| CBA/J | Liver hepatocellular adenoma | Liver |
3.8 - 34 |
||
| CBA/J | Liver hepatocellular carcinoma | Liver |
2.0 - 24 |
||
| CBA/J | Lung adenoma | Lung |
15 - 16 |
||
| CBA/J | Lung carcinoma | Lung |
2.4 - 3.6 |
||
| CBA/J | Mammary gland adenoacanthoma | Mammary gland |
0.3 |
||
| CBA/J | Mammary gland adenocarcinoma | Mammary gland |
2.7 |
||
| CBA/J | Mesodermal cell/mesoblast sarcoma - stromal | Uterus |
0.3 |
||
| CBA/J | Muscle - Smooth leiomyosarcoma | Uterus |
0.3 |
||
| CBA/J | Ovary - Granulosa cell tumor | Ovary - Granulosa cell |
3.4 |
||
| CBA/J | Ovary - Sex cord stromal cell tumor - benign | Ovary - Sex cord stromal cell |
0.3 |
||
| CBA/J | Ovary adenocarcinoma - tubulostromal | Ovary |
0.3 |
||
| CBA/J | Ovary adenoma - tubulostromal | Ovary |
12 |
||
| CBA/J | Pancreas - Acinar cell adenocarcinoma | Pancreas - Acinar cell |
0.3 |
||
| CBA/J | Pancreas - Islet of Langerhans adenoma | Pancreas - Islet of Langerhans |
0.7 |
||
| CBA/J | Pituitary gland adenoma | Pituitary gland |
0.3 |
||
| CBA/J | Skin keratoacanthoma | Skin |
0.3 |
||
| CBA/J | Thymus thymoma | Thymus |
0.3 |
||
| CBA/J | Thyroid gland - Follicular cell adenoma | Thyroid gland - Follicular cell |
1.0 |
||
| CBA/J | Uterus adenocarcinoma | Uterus |
0.7 |
||
| CBA/J | (Unspecified organ) tumor | (Unspecified organ) |
8.3 - 79 |