Reference Summaryvan Kreijl CF, Toxicol Pathol 2001;29 Suppl():117-27

Title

 Xpa and Xpa/p53+/- knockout mice: overview of available data.

Authors

 van Kreijl CF; McAnulty PA; Beems RB; Vynckier A; van Steeg H; Fransson-Steen R; Alden CL; Forster R; van der Laan JW; Vandenberghe J

Journal

 Toxicol Pathol

Volume

 29 Suppl

Issue

Year

 2001

Pages

 117-27

Abstract

 DNA repair deficient Xpa-/- and Xpa-/-/p53+/- knock-out mice in a C57BL/6 genetic background, referred to as respectively the XPA and XPA/p53 model, were investigated in the international collaborative research program coordinated by International Life Sciences Institute (ILSI)/Health and Environmental Science Institute. From the selected list of 21 ILSI compounds, 13 were tested in the XPA model, and 10 in the XPA/p53 model. With one exception, all studies had a duration of 9 months (39 weeks). The observed spontaneous tumor incidence for the XPA model after 9 months was comparable to that of wild-type mice (total 6%). For the XPA/p53 model, this was somewhat higher (9%/13% for males/females). The 3 positive control compounds used, B[a]P, p-cresidine, and 2-AAF, gave positive and consistent tumor responses in both the XPA and XPA/p53 model, but no or lower responses in wild-type mice. From the 13 ILSI compounds tested, the single genotoxic carcinogen (phenacetin) was negative in both the XPA and XPA/p53 model. Positive tumor responses were observed for 4 compounds, the immunosuppressant cyclosporin A, the hormone carcinogens DES and estradiol, and the peroxisome proliferator WY-14,643. Negative results were obtained with 5 other nongenotoxic rodent carcinogens, and 2 noncarcinogens tested. As expected, both DNA repair deficient models respond to genotoxic carcinogens. Combined with previous results, 6 out of 7 (86%) of the genotoxic human and/or rodent carcinogens tested are positive in the XPA model. The positive results obtained with the 4 mentioned nongenotoxic ILSI compounds may point to other carcinogenic mechanisms involved, or may raise some doubts about their true nongenotoxic nature. In general. the XPA/p53 model appears to be more sensitive to carcinogens than the XPA model.

Links

 J:73024 – MGI References
11695547 – National Library of Medicine/PubMed

Strain Notes

Strain Note
B6.129P2-Xpatm1Hvs "The Xpa-/- mice used in the ILSI studies were an 8th generation".
These mice were described as being on a C57BL/6J genetic background.
These mice were "generated, bred, and supplied by the RIVM."
"The 'XPA model' Xpa-/- mice (C57Bl/6J-TgH(XPAIm)55Cmg), containing 2 identical null alleles with a deletion spanning exons 3 and 4".
C57BL/6JIco "Wild-type C57BL/6J mice were obtained from IFFA CREDO (France)."
C57BL/6J-Trp53tm1Tyj/+ Xpatm1Hvs The "Xpa-/-/p53+/- mice" were "an 8th/5th generation backcross into C57Bl/6J from ola129 X C57Bl/6J chimera."
"The 'XPA/p53 model' mice were Xpa-/-/p53+/- mice, generated by crossing the Xpa-/- mice with the p53+/- mice." [Editorial note: The progeny of that cross must have been crossed to generate the desired genotype.]

Models
Strain Model Name Treatment Agent(s) Organ Affected Frequency Model Details
C57BL/6JIco Adipose tissue lipoma Abdominal cavity

0
B6.129P2-Xpatm1Hvs Adipose tissue lipoma Abdominal cavity

0
C57BL/6J-Trp53tm1Tyj/+ Xpatm1Hvs Adipose tissue lipoma Abdominal cavity

0 - 0.8
C57BL/6JIco Adipose tissue lipoma CNS - Brain

0
C57BL/6JIco Adipose tissue lipoma
  • estradiol (E2)
 CNS - Brain

0
B6.129P2-Xpatm1Hvs Adipose tissue lipoma CNS - Brain

0
B6.129P2-Xpatm1Hvs Adipose tissue lipoma
  • estradiol (E2)
 CNS - Brain

0
C57BL/6J-Trp53tm1Tyj/+ Xpatm1Hvs Adipose tissue lipoma CNS - Brain

0 - 6.7
C57BL/6J-Trp53tm1Tyj/+ Xpatm1Hvs Adipose tissue lipoma
  • estradiol (E2)
 CNS - Brain

0
C57BL/6JIco Adrenal gland - Cortex adenoma Adrenal gland - Cortex

0 - 0.8
B6.129P2-Xpatm1Hvs Adrenal gland - Cortex adenoma Adrenal gland - Cortex

0 - 2.2
C57BL/6J-Trp53tm1Tyj/+ Xpatm1Hvs Adrenal gland - Cortex adenoma Adrenal gland - Cortex

0 - 2.2
C57BL/6JIco Adrenal gland - Medulla pheochromocytoma Adrenal gland - Medulla

0
B6.129P2-Xpatm1Hvs Adrenal gland - Medulla pheochromocytoma Adrenal gland - Medulla

0 - 1.1
C57BL/6J-Trp53tm1Tyj/+ Xpatm1Hvs Adrenal gland - Medulla pheochromocytoma Adrenal gland - Medulla

0
C57BL/6JIco Adrenal gland - Medulla pheochromocytoma
  • diethylstilbestrol (DES)
 Adrenal gland - Medulla

0
B6.129P2-Xpatm1Hvs Adrenal gland - Medulla pheochromocytoma
  • diethylstilbestrol (DES)
 Adrenal gland - Medulla

0
C57BL/6J-Trp53tm1Tyj/+ Xpatm1Hvs Adrenal gland - Medulla pheochromocytoma
  • diethylstilbestrol (DES)
 Adrenal gland - Medulla

0 - 6.7
C57BL/6JIco Blood vessel hemangiosarcoma Blood vessel

0
B6.129P2-Xpatm1Hvs Blood vessel hemangiosarcoma Blood vessel

0 - 0.6
C57BL/6J-Trp53tm1Tyj/+ Xpatm1Hvs Blood vessel hemangiosarcoma Blood vessel

0 - 1.5
C57BL/6JIco Bone lesion - fibro-osseous Bone

0
C57BL/6JIco Bone lesion - fibro-osseous
  • estradiol (E2)
 Bone

66.7 - 93.3
B6.129P2-Xpatm1Hvs Bone lesion - fibro-osseous Bone

0
B6.129P2-Xpatm1Hvs Bone lesion - fibro-osseous
  • estradiol (E2)
 Bone

46.7 - 100
C57BL/6J-Trp53tm1Tyj/+ Xpatm1Hvs Bone lesion - fibro-osseous Bone

0 - 6.7
C57BL/6J-Trp53tm1Tyj/+ Xpatm1Hvs Bone lesion - fibro-osseous
  • estradiol (E2)
 Bone

33.3 - 66.7
C57BL/6JIco Bone osteosarcoma Bone

0
B6.129P2-Xpatm1Hvs Bone osteosarcoma Bone

0 - 0.6
C57BL/6J-Trp53tm1Tyj/+ Xpatm1Hvs Bone osteosarcoma Bone

0 - 0.8
C57BL/6JIco Bone osteosarcoma
  • diethylstilbestrol (DES)
 Bone

0
B6.129P2-Xpatm1Hvs Bone osteosarcoma
  • diethylstilbestrol (DES)
 Bone

0 - 6.7
C57BL/6J-Trp53tm1Tyj/+ Xpatm1Hvs Bone osteosarcoma
  • diethylstilbestrol (DES)
 Bone

13.3 - 33.3
C57BL/6JIco Bone osteosarcoma
  • estradiol (E2)
 Bone

0
B6.129P2-Xpatm1Hvs Bone osteosarcoma
  • estradiol (E2)
 Bone

0
C57BL/6J-Trp53tm1Tyj/+ Xpatm1Hvs Bone osteosarcoma
  • estradiol (E2)
 Bone

0 - 20
C57BL/6JIco CNS - Brain glioma CNS - Brain

0
C57BL/6JIco CNS - Brain glioma
  • diethylstilbestrol (DES)
 CNS - Brain

0
B6.129P2-Xpatm1Hvs CNS - Brain glioma CNS - Brain

0
B6.129P2-Xpatm1Hvs CNS - Brain glioma
  • diethylstilbestrol (DES)
 CNS - Brain

0
C57BL/6J-Trp53tm1Tyj/+ Xpatm1Hvs CNS - Brain glioma CNS - Brain

0
C57BL/6J-Trp53tm1Tyj/+ Xpatm1Hvs CNS - Brain glioma
  • diethylstilbestrol (DES)
 CNS - Brain

0 - 6.7
C57BL/6JIco Connective tissue - Fibroblast fibrosarcoma Skin

0 - 0.8
B6.129P2-Xpatm1Hvs Connective tissue - Fibroblast fibrosarcoma Skin

0 - 0.6
C57BL/6J-Trp53tm1Tyj/+ Xpatm1Hvs Connective tissue - Fibroblast fibrosarcoma Skin

0 - 0.8
C57BL/6JIco Connective tissue - Fibroblast fibrosarcoma Uterus - Cervix

0
C57BL/6JIco Connective tissue - Fibroblast fibrosarcoma
  • diethylstilbestrol (DES)
 Uterus - Cervix

0
B6.129P2-Xpatm1Hvs Connective tissue - Fibroblast fibrosarcoma Uterus - Cervix

0
B6.129P2-Xpatm1Hvs Connective tissue - Fibroblast fibrosarcoma
  • diethylstilbestrol (DES)
 Uterus - Cervix

0
C57BL/6J-Trp53tm1Tyj/+ Xpatm1Hvs Connective tissue - Fibroblast fibrosarcoma Uterus - Cervix

0
C57BL/6J-Trp53tm1Tyj/+ Xpatm1Hvs Connective tissue - Fibroblast fibrosarcoma
  • diethylstilbestrol (DES)
 Uterus - Cervix

6.7
C57BL/6JIco Forestomach tumor
  • benzo[a]pyrene (BP) (BaP) (B[a]P)
 Forestomach

6.7
B6.129P2-Xpatm1Hvs Forestomach tumor
  • benzo[a]pyrene (BP) (BaP) (B[a]P)
 Forestomach

0 - 40
C57BL/6JIco Gallbladder papilloma
  • 2-acetamidofluorene (2-AAF)
 Gallbladder

0
B6.129P2-Xpatm1Hvs Gallbladder papilloma
  • 2-acetamidofluorene (2-AAF)
 Gallbladder

0 - 26.7
C57BL/6J-Trp53tm1Tyj/+ Xpatm1Hvs Gallbladder papilloma
  • 2-acetamidofluorene (2-AAF)
 Gallbladder

0 - 13.3
C57BL/6JIco Intestine - Small Intestine adenocarcinoma Intestine - Small Intestine

0 - 6.7
C57BL/6JIco Intestine - Small Intestine adenocarcinoma
  • WY-14,643
 Intestine - Small Intestine

0
B6.129P2-Xpatm1Hvs Intestine - Small Intestine adenocarcinoma Intestine - Small Intestine

0
B6.129P2-Xpatm1Hvs Intestine - Small Intestine adenocarcinoma
  • WY-14,643
 Intestine - Small Intestine

0
C57BL/6JIco Intestine - Small Intestine tumor Intestine - Small Intestine

0 - 1.7
B6.129P2-Xpatm1Hvs Intestine - Small Intestine tumor Intestine - Small Intestine

0
C57BL/6J-Trp53tm1Tyj/+ Xpatm1Hvs Intestine - Small Intestine tumor Intestine - Small Intestine

0 - 1.5
C57BL/6JIco Intestine tumor
  • benzo[a]pyrene (BP) (BaP) (B[a]P)
 Intestine

0 - 40
B6.129P2-Xpatm1Hvs Intestine tumor
  • benzo[a]pyrene (BP) (BaP) (B[a]P)
 Intestine

0 - 46.7
C57BL/6J-Trp53tm1Tyj/+ Xpatm1Hvs Kidney adenoma
  • phenacetin
 Kidney

observed
C57BL/6JIco Kidney hyperplasia
  • phenacetin
 Kidney

0
B6.129P2-Xpatm1Hvs Kidney hyperplasia
  • phenacetin
 Kidney

observed
C57BL/6J-Trp53tm1Tyj/+ Xpatm1Hvs Kidney hyperplasia
  • phenacetin
 Kidney

observed
C57BL/6JIco Kidney transitional cell carcinoma
  • p-cresidine
 Kidney

0
B6.129P2-Xpatm1Hvs Kidney transitional cell carcinoma
  • p-cresidine
 Kidney

0 - 6.7
C57BL/6J-Trp53tm1Tyj/+ Xpatm1Hvs Kidney transitional cell carcinoma
  • p-cresidine
 Kidney

6.7 - 20
C57BL/6JIco Kidney tumor
  • phenacetin
 Kidney

0
B6.129P2-Xpatm1Hvs Kidney tumor
  • phenacetin
 Kidney

0
C57BL/6J-Trp53tm1Tyj/+ Xpatm1Hvs Kidney tumor
  • phenacetin
 Kidney

0 - observed
C57BL/6JIco Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma Leukocyte - Monocyte - Macrophage - Histiocyte

0 - 0.8
B6.129P2-Xpatm1Hvs Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma Leukocyte - Monocyte - Macrophage - Histiocyte

0 - 0.6
C57BL/6J-Trp53tm1Tyj/+ Xpatm1Hvs Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma Leukocyte - Monocyte - Macrophage - Histiocyte

0 - 0.8
C57BL/6JIco Leukocyte - Myelocyte (Granulocyte) leukemia - myelocytic Leukocyte - Myelocyte (Granulocyte)

0
C57BL/6JIco Leukocyte - Myelocyte (Granulocyte) leukemia - myelocytic
  • estradiol (E2)
 Leukocyte - Myelocyte (Granulocyte)

0 - 6.7
B6.129P2-Xpatm1Hvs Leukocyte - Myelocyte (Granulocyte) leukemia - myelocytic Leukocyte - Myelocyte (Granulocyte)

0
B6.129P2-Xpatm1Hvs Leukocyte - Myelocyte (Granulocyte) leukemia - myelocytic
  • estradiol (E2)
 Leukocyte - Myelocyte (Granulocyte)

0
C57BL/6J-Trp53tm1Tyj/+ Xpatm1Hvs Leukocyte - Myelocyte (Granulocyte) leukemia - myelocytic Leukocyte - Myelocyte (Granulocyte)

0
C57BL/6J-Trp53tm1Tyj/+ Xpatm1Hvs Leukocyte - Myelocyte (Granulocyte) leukemia - myelocytic
  • estradiol (E2)
 Leukocyte - Myelocyte (Granulocyte)

0
C57BL/6JIco Leukocyte - Myelocyte (Granulocyte) sarcoma - myeloid Leukocyte - Myelocyte (Granulocyte)

0 - 0.8
B6.129P2-Xpatm1Hvs Leukocyte - Myelocyte (Granulocyte) sarcoma - myeloid Leukocyte - Myelocyte (Granulocyte)

0
C57BL/6J-Trp53tm1Tyj/+ Xpatm1Hvs Leukocyte - Myelocyte (Granulocyte) sarcoma - myeloid Leukocyte - Myelocyte (Granulocyte)

0
C57BL/6JIco Leukocyte lymphoma Leukocyte

0 - 2.5
B6.129P2-Xpatm1Hvs Leukocyte lymphoma Leukocyte

0 - 1.1
C57BL/6J-Trp53tm1Tyj/+ Xpatm1Hvs Leukocyte lymphoma Leukocyte

0 - 13.3
C57BL/6JIco Leukocyte lymphoma
  • benzo[a]pyrene (BP) (BaP) (B[a]P)
 Leukocyte

0 - 13.3
B6.129P2-Xpatm1Hvs Leukocyte lymphoma
  • benzo[a]pyrene (BP) (BaP) (B[a]P)
 Leukocyte

13.3 - 66.7
C57BL/6JIco Leukocyte lymphoma
  • Cyclosporin A
 Leukocyte

0 - 21.4
B6.129P2-Xpatm1Hvs Leukocyte lymphoma
  • Cyclosporin A
 Leukocyte

0 - 30.8
C57BL/6J-Trp53tm1Tyj/+ Xpatm1Hvs Leukocyte lymphoma
  • Cyclosporin A
 Leukocyte

13.3 - 72.7
C57BL/6JIco Leukocyte lymphoma
  • diethylstilbestrol (DES)
 Leukocyte

0 - 6.7
B6.129P2-Xpatm1Hvs Leukocyte lymphoma
  • diethylstilbestrol (DES)
 Leukocyte

0 - 6.7
C57BL/6J-Trp53tm1Tyj/+ Xpatm1Hvs Leukocyte lymphoma
  • diethylstilbestrol (DES)
 Leukocyte

0 - 13.3
C57BL/6JIco Leukocyte lymphoma
  • estradiol (E2)
 Leukocyte

0
B6.129P2-Xpatm1Hvs Leukocyte lymphoma
  • estradiol (E2)
 Leukocyte

0
C57BL/6J-Trp53tm1Tyj/+ Xpatm1Hvs Leukocyte lymphoma
  • estradiol (E2)
 Leukocyte

6.7 - 13.3
C57BL/6JIco Leukocyte lymphoma
  • WY-14,643
 Leukocyte

0 - 6.7
B6.129P2-Xpatm1Hvs Leukocyte lymphoma
  • WY-14,643
 Leukocyte

0
C57BL/6JIco Liver adenoma Liver

0 - observed
B6.129P2-Xpatm1Hvs Liver adenoma Liver

0 - 0.6
C57BL/6J-Trp53tm1Tyj/+ Xpatm1Hvs Liver adenoma Liver

0
C57BL/6JIco Liver hepatocellular adenoma Liver

0
C57BL/6JIco Liver hepatocellular adenoma
  • WY-14,643
 Liver

6.7 - 13.3
B6.129P2-Xpatm1Hvs Liver hepatocellular adenoma Liver

0
B6.129P2-Xpatm1Hvs Liver hepatocellular adenoma
  • WY-14,643
 Liver

0 - 40
C57BL/6JIco Liver hepatocellular carcinoma Liver

0
C57BL/6JIco Liver hepatocellular carcinoma
  • estradiol (E2)
 Liver

0
B6.129P2-Xpatm1Hvs Liver hepatocellular carcinoma Liver

0
B6.129P2-Xpatm1Hvs Liver hepatocellular carcinoma
  • estradiol (E2)
 Liver

0
C57BL/6J-Trp53tm1Tyj/+ Xpatm1Hvs Liver hepatocellular carcinoma Liver

0
C57BL/6J-Trp53tm1Tyj/+ Xpatm1Hvs Liver hepatocellular carcinoma
  • estradiol (E2)
 Liver

0 - 6.7
C57BL/6JIco Liver hepatocellular carcinoma
  • WY-14,643
 Liver

0 - 6.7
B6.129P2-Xpatm1Hvs Liver hepatocellular carcinoma
  • WY-14,643
 Liver

0 - 6.7
C57BL/6JIco Liver hyperplasia - oval cell Liver

0
C57BL/6JIco Liver hyperplasia - oval cell
  • WY-14,643
 Liver

40 - 46.7
B6.129P2-Xpatm1Hvs Liver hyperplasia - oval cell Liver

0
B6.129P2-Xpatm1Hvs Liver hyperplasia - oval cell
  • WY-14,643
 Liver

0 - 26.7
C57BL/6JIco Liver tumor
  • p-cresidine
 Liver

0 - 33.3
B6.129P2-Xpatm1Hvs Liver tumor
  • p-cresidine
 Liver

0 - 53.3
C57BL/6J-Trp53tm1Tyj/+ Xpatm1Hvs Liver tumor
  • p-cresidine
 Liver

13.3 - 93.3
C57BL/6JIco Liver tumor
  • 2-acetamidofluorene (2-AAF)
 Liver

0 - 10
B6.129P2-Xpatm1Hvs Liver tumor
  • 2-acetamidofluorene (2-AAF)
 Liver

13.3 - 46.7
C57BL/6J-Trp53tm1Tyj/+ Xpatm1Hvs Liver tumor
  • 2-acetamidofluorene (2-AAF)
 Liver

6.7 - 26.7
C57BL/6JIco Lung adenoma Lung

0 - 6.7
B6.129P2-Xpatm1Hvs Lung adenoma Lung

0 - 6.7
C57BL/6J-Trp53tm1Tyj/+ Xpatm1Hvs Lung adenoma Lung

0 - 6.7
C57BL/6JIco Lung adenoma
  • estradiol (E2)
 Lung

0
B6.129P2-Xpatm1Hvs Lung adenoma
  • estradiol (E2)
 Lung

0 - 6.7
C57BL/6J-Trp53tm1Tyj/+ Xpatm1Hvs Lung adenoma
  • estradiol (E2)
 Lung

0
C57BL/6JIco Mammary gland adenocarcinoma Mammary gland

0
B6.129P2-Xpatm1Hvs Mammary gland adenocarcinoma Mammary gland

0
C57BL/6J-Trp53tm1Tyj/+ Xpatm1Hvs Mammary gland adenocarcinoma Mammary gland

0 - 6.7
C57BL/6JIco Mammary gland adenocarcinoma
  • diethylstilbestrol (DES)
 Mammary gland

0
B6.129P2-Xpatm1Hvs Mammary gland adenocarcinoma
  • diethylstilbestrol (DES)
 Mammary gland

0
C57BL/6J-Trp53tm1Tyj/+ Xpatm1Hvs Mammary gland adenocarcinoma
  • diethylstilbestrol (DES)
 Mammary gland

0
C57BL/6JIco Mesodermal cell/mesoblast sarcoma CNS - Brain

0
C57BL/6JIco Mesodermal cell/mesoblast sarcoma Abdominal cavity

0
B6.129P2-Xpatm1Hvs Mesodermal cell/mesoblast sarcoma CNS - Brain

0
B6.129P2-Xpatm1Hvs Mesodermal cell/mesoblast sarcoma Abdominal cavity

0
C57BL/6J-Trp53tm1Tyj/+ Xpatm1Hvs Mesodermal cell/mesoblast sarcoma CNS - Brain

0 - 6.7
C57BL/6J-Trp53tm1Tyj/+ Xpatm1Hvs Mesodermal cell/mesoblast sarcoma Abdominal cavity

0 - 6.7
C57BL/6JIco Mesodermal cell/mesoblast sarcoma Skin

0
C57BL/6JIco Mesodermal cell/mesoblast sarcoma
  • estradiol (E2)
 Skin

0
C57BL/6JIco Mesodermal cell/mesoblast sarcoma
  • estradiol (E2)
 CNS - Brain

0
C57BL/6JIco Mesodermal cell/mesoblast sarcoma
  • estradiol (E2)
 Abdominal cavity

0
B6.129P2-Xpatm1Hvs Mesodermal cell/mesoblast sarcoma Skin

0
B6.129P2-Xpatm1Hvs Mesodermal cell/mesoblast sarcoma
  • estradiol (E2)
 Skin

0
B6.129P2-Xpatm1Hvs Mesodermal cell/mesoblast sarcoma
  • estradiol (E2)
 CNS - Brain

0
B6.129P2-Xpatm1Hvs Mesodermal cell/mesoblast sarcoma
  • estradiol (E2)
 Abdominal cavity

0
C57BL/6J-Trp53tm1Tyj/+ Xpatm1Hvs Mesodermal cell/mesoblast sarcoma Skin

40 - 46.7
C57BL/6J-Trp53tm1Tyj/+ Xpatm1Hvs Mesodermal cell/mesoblast sarcoma
  • estradiol (E2)
 Skin

20 - 33.3
C57BL/6J-Trp53tm1Tyj/+ Xpatm1Hvs Mesodermal cell/mesoblast sarcoma
  • estradiol (E2)
 CNS - Brain

0
C57BL/6J-Trp53tm1Tyj/+ Xpatm1Hvs Mesodermal cell/mesoblast sarcoma
  • estradiol (E2)
 Abdominal cavity

0
C57BL/6JIco Muscle - Smooth leiomyosarcoma Muscle - Smooth

0
B6.129P2-Xpatm1Hvs Muscle - Smooth leiomyosarcoma Muscle - Smooth

0
C57BL/6J-Trp53tm1Tyj/+ Xpatm1Hvs Muscle - Smooth leiomyosarcoma Muscle - Smooth

0 - 0.8
C57BL/6JIco Ovary - Germ cell teratoma CNS - Brain

0
C57BL/6JIco Ovary - Germ cell teratoma
  • estradiol (E2)
 CNS - Brain

0
B6.129P2-Xpatm1Hvs Ovary - Germ cell teratoma CNS - Brain

0
B6.129P2-Xpatm1Hvs Ovary - Germ cell teratoma
  • estradiol (E2)
 CNS - Brain

0
C57BL/6J-Trp53tm1Tyj/+ Xpatm1Hvs Ovary - Germ cell teratoma CNS - Brain

0
C57BL/6J-Trp53tm1Tyj/+ Xpatm1Hvs Ovary - Germ cell teratoma
  • estradiol (E2)
 CNS - Brain

0
C57BL/6JIco Ovary - Granulosa cell tumor Ovary - Granulosa cell

0
B6.129P2-Xpatm1Hvs Ovary - Granulosa cell tumor Ovary - Granulosa cell

0
C57BL/6J-Trp53tm1Tyj/+ Xpatm1Hvs Ovary - Granulosa cell tumor Ovary - Granulosa cell

0.8
C57BL/6JIco Ovary adenoma - tubulostromal Ovary

0.8
B6.129P2-Xpatm1Hvs Ovary adenoma - tubulostromal Ovary

0.6
C57BL/6J-Trp53tm1Tyj/+ Xpatm1Hvs Ovary adenoma - tubulostromal Ovary

0
C57BL/6JIco Pituitary gland adenoma Pituitary gland

0
C57BL/6JIco Pituitary gland adenoma
  • diethylstilbestrol (DES)
 Pituitary gland

13.3
B6.129P2-Xpatm1Hvs Pituitary gland adenoma Pituitary gland

0
B6.129P2-Xpatm1Hvs Pituitary gland adenoma
  • diethylstilbestrol (DES)
 Pituitary gland

0 - 33.3
C57BL/6J-Trp53tm1Tyj/+ Xpatm1Hvs Pituitary gland adenoma Pituitary gland

0
C57BL/6J-Trp53tm1Tyj/+ Xpatm1Hvs Pituitary gland adenoma
  • diethylstilbestrol (DES)
 Pituitary gland

13.3
C57BL/6JIco Placenta - Decidua deciduoma Placenta - Decidua

0
B6.129P2-Xpatm1Hvs Placenta - Decidua deciduoma Placenta - Decidua

0.6
C57BL/6J-Trp53tm1Tyj/+ Xpatm1Hvs Placenta - Decidua deciduoma Placenta - Decidua

0
C57BL/6JIco Testis - Germ cell teratoma CNS - Brain

0
C57BL/6JIco Testis - Germ cell teratoma
  • estradiol (E2)
 CNS - Brain

0
B6.129P2-Xpatm1Hvs Testis - Germ cell teratoma CNS - Brain

0
B6.129P2-Xpatm1Hvs Testis - Germ cell teratoma
  • estradiol (E2)
 CNS - Brain

0
C57BL/6J-Trp53tm1Tyj/+ Xpatm1Hvs Testis - Germ cell teratoma CNS - Brain

0
C57BL/6J-Trp53tm1Tyj/+ Xpatm1Hvs Testis - Germ cell teratoma
  • estradiol (E2)
 CNS - Brain

6.7
C57BL/6JIco Testis - Leydig cell (Interstitial cell) adenoma Testis - Leydig cell (Interstitial cell)

0
C57BL/6JIco Testis - Leydig cell (Interstitial cell) adenoma
  • diethylstilbestrol (DES)
 Testis - Leydig cell (Interstitial cell)

6.7
B6.129P2-Xpatm1Hvs Testis - Leydig cell (Interstitial cell) adenoma Testis - Leydig cell (Interstitial cell)

0
B6.129P2-Xpatm1Hvs Testis - Leydig cell (Interstitial cell) adenoma
  • diethylstilbestrol (DES)
 Testis - Leydig cell (Interstitial cell)

0 - 26.7
C57BL/6J-Trp53tm1Tyj/+ Xpatm1Hvs Testis - Leydig cell (Interstitial cell) adenoma Testis - Leydig cell (Interstitial cell)

0
C57BL/6J-Trp53tm1Tyj/+ Xpatm1Hvs Testis - Leydig cell (Interstitial cell) adenoma
  • diethylstilbestrol (DES)
 Testis - Leydig cell (Interstitial cell)

33.3
C57BL/6JIco Thymus thymoma Thymus

0
B6.129P2-Xpatm1Hvs Thymus thymoma Thymus

0
C57BL/6J-Trp53tm1Tyj/+ Xpatm1Hvs Thymus thymoma Thymus

0 - 0.8
C57BL/6JIco Thyroid gland - Follicular cell adenoma Thyroid gland - Follicular cell

0 - 0.8
B6.129P2-Xpatm1Hvs Thyroid gland - Follicular cell adenoma Thyroid gland - Follicular cell

0
C57BL/6J-Trp53tm1Tyj/+ Xpatm1Hvs Thyroid gland - Follicular cell adenoma Thyroid gland - Follicular cell

0
B6.129P2-Xpatm1Hvs Urinary bladder preneoplastic lesion
  • p-cresidine
 Urinary bladder

observed
C57BL/6JIco Urinary bladder tumor
  • p-cresidine
 Urinary bladder

0 - 13.3
B6.129P2-Xpatm1Hvs Urinary bladder tumor
  • p-cresidine
 Urinary bladder

0 - 13.3
C57BL/6J-Trp53tm1Tyj/+ Xpatm1Hvs Urinary bladder tumor
  • p-cresidine
 Urinary bladder

13.3 - 46.7
C57BL/6JIco Urinary bladder tumor
  • 2-acetamidofluorene (2-AAF)
 Urinary bladder

0 - 20
B6.129P2-Xpatm1Hvs Urinary bladder tumor
  • 2-acetamidofluorene (2-AAF)
 Urinary bladder

6.7 - 20
C57BL/6J-Trp53tm1Tyj/+ Xpatm1Hvs Urinary bladder tumor
  • 2-acetamidofluorene (2-AAF)
 Urinary bladder

53.3 - 60
C57BL/6JIco (Unspecified organ) tumor (Unspecified organ)

0 - 5.9
B6.129P2-Xpatm1Hvs (Unspecified organ) tumor (Unspecified organ)

0 - 7.2
C57BL/6J-Trp53tm1Tyj/+ Xpatm1Hvs (Unspecified organ) tumor (Unspecified organ)

0 - 12.9
C57BL/6JIco (Unspecified organ) tumor
  • benzo[a]pyrene (BP) (BaP) (B[a]P)
 (Unspecified organ)

20 - 46.7
B6.129P2-Xpatm1Hvs (Unspecified organ) tumor
  • benzo[a]pyrene (BP) (BaP) (B[a]P)
 (Unspecified organ)

26.7 - 93.3
C57BL/6JIco (Unspecified organ) tumor
  • p-cresidine
 (Unspecified organ)

0 - 46.7
B6.129P2-Xpatm1Hvs (Unspecified organ) tumor
  • p-cresidine
 (Unspecified organ)

0 - 60
C57BL/6J-Trp53tm1Tyj/+ Xpatm1Hvs (Unspecified organ) tumor
  • p-cresidine
 (Unspecified organ)

26.7 - 93.3
C57BL/6JIco (Unspecified organ) tumor
  • 2-acetamidofluorene (2-AAF)
 (Unspecified organ)

10 - 20
B6.129P2-Xpatm1Hvs (Unspecified organ) tumor
  • 2-acetamidofluorene (2-AAF)
 (Unspecified organ)

26.7 - 46.7
C57BL/6J-Trp53tm1Tyj/+ Xpatm1Hvs (Unspecified organ) tumor
  • 2-acetamidofluorene (2-AAF)
 (Unspecified organ)

53.3 - 60
C57BL/6JIco (Unspecified organ) tumor
  • diethylstilbestrol (DES)
 (Unspecified organ)

13.3 - 26.7
B6.129P2-Xpatm1Hvs (Unspecified organ) tumor
  • diethylstilbestrol (DES)
 (Unspecified organ)

0 - 53.3
C57BL/6J-Trp53tm1Tyj/+ Xpatm1Hvs (Unspecified organ) tumor
  • diethylstilbestrol (DES)
 (Unspecified organ)

46.7 - 86.7