Reference SummaryVerschoyle RD, Toxicol Pathol 2004 Jan-Feb;32(1):22-5
Title |
Articular Chondromatosis and Chrondroid Metaplasia in Transgenic TAg Mice. | ||||
Authors |
Verschoyle RD; Edwards R; Nolan B; Greaves P | ||||
Journal |
Toxicol Pathol | ||||
Volume |
32 | ||||
Issue |
1 | ||||
Year |
2004 | ||||
Pages |
22-5 | ||||
Abstract |
The C3(1)/SV40 T antigen transgenic mouse model for which rapid mammary and prostate tumor development has been documented uses the FVB/N mouse as a background strain. In this study, where the background strain used was the C57BL/6J mouse, neither mammary nor prostate tumors developed over periods of up to 40 weeks. However, a disturbance of hyaline cartilage in joints was observed similar to that found in synovial chondromatosis in humans. In addition, cartilage thickening in the external ears and cartilaginous metaplasia of the ascending aorta also occurred. This suggests that rearrangement of the transgene occurred in breeding on the C57BL background, thus modifying its expression. It raises the possibility that the genetic changes induced by the SV40 T antigen transforming sequence are important in cartilage homeostasis. | ||||
Links |
J:88112 – MGI References 14713544 – National Library of Medicine/PubMed |
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Strain Notes
|
Strain | Model Name | Treatment Agent(s) | Organ Affected | Frequency | Model Details |
---|---|---|---|---|---|
C57BL/6J | Blood vessel - Aorta metaplasia - cartilaginous | Blood vessel - Aorta |
0 |
||
B6.FVB-Tg(C3-1-TAg)cJeg/J | Blood vessel - Aorta metaplasia - cartilaginous | Blood vessel - Aorta |
25 |
||
C57BL/6J | Connective tissue - Cartilage - Articular hyperplasia | Limb - Hindlimb |
0 |
||
B6.FVB-Tg(C3-1-TAg)cJeg/J | Connective tissue - Cartilage - Articular hyperplasia | Limb - Hindlimb |
very high |
||
C57BL/6J | Connective tissue - Cartilage hyperplasia | Bone - Sternum |
0 |
||
C57BL/6J | Connective tissue - Cartilage hyperplasia | Ear - Outer ear |
0 |
||
B6.FVB-Tg(C3-1-TAg)cJeg/J | Connective tissue - Cartilage hyperplasia | Bone - Sternum |
very high |
||
B6.FVB-Tg(C3-1-TAg)cJeg/J | Connective tissue - Cartilage hyperplasia | Ear - Outer ear |
very high |
||
B6.FVB-Tg(C3-1-TAg)cJeg/J | Connective tissue - Synovium hyperplasia | Connective tissue - Synovium |
very low |
||
B6.FVB-Tg(C3-1-TAg)cJeg/J | Connective tissue metaplasia | Limb - Hindlimb |
observed |
||
B6.FVB-Tg(C3-1-TAg)cJeg/J | Epididymis hyperplasia | Epididymis |
0 |
||
B6.FVB-Tg(C3-1-TAg)cJeg/J | Epididymis tumor | Epididymis |
0 |
||
B6.FVB-Tg(C3-1-TAg)cJeg/J | Heart - Heart valve metaplasia - cartilaginous | Heart - Heart valve |
0 |
||
B6.FVB-Tg(C3-1-TAg)cJeg/J | Intestine lesion | Intestine |
0 |
||
B6.FVB-Tg(C3-1-TAg)cJeg/J | Kidney lesion | Kidney |
0 |
||
B6.FVB-Tg(C3-1-TAg)cJeg/J | Liver lesion | Liver |
0 |
||
B6.FVB-Tg(C3-1-TAg)cJeg/J | Mammary gland hyperplasia | Mammary gland |
0 |
||
B6.FVB-Tg(C3-1-TAg)cJeg/J | Mammary gland tumor | Mammary gland |
0 |
||
B6.FVB-Tg(C3-1-TAg)cJeg/J | Muscle - Striated - Cardiac lesion | Muscle - Striated - Cardiac |
0 |
||
B6.FVB-Tg(C3-1-TAg)cJeg/J | Pancreas lesion | Pancreas |
0 |
||
B6.FVB-Tg(C3-1-TAg)cJeg/J | Prostate gland hyperplasia | Prostate gland |
0 |
||
B6.FVB-Tg(C3-1-TAg)cJeg/J | Prostate gland tumor | Prostate gland |
0 |
||
B6.FVB-Tg(C3-1-TAg)cJeg/J | Salivary gland lesion | Salivary gland |
0 |
||
B6.FVB-Tg(C3-1-TAg)cJeg/J | Seminal vesicle hyperplasia | Seminal vesicle |
0 |
||
B6.FVB-Tg(C3-1-TAg)cJeg/J | Seminal vesicle tumor | Seminal vesicle |
0 |
||
B6.FVB-Tg(C3-1-TAg)cJeg/J | Spleen lesion | Spleen |
0 |
||
B6.FVB-Tg(C3-1-TAg)cJeg/J | Testis hyperplasia | Testis |
0 |
||
B6.FVB-Tg(C3-1-TAg)cJeg/J | Testis tumor | Testis |
0 |
||
B6.FVB-Tg(C3-1-TAg)cJeg/J | Thymus lesion | Thymus |
0 |