Reference SummaryAnisimov VN, Int J Cancer 2004 Sep 10;111(4):475-9

Title

 Effect of exposure to light-at-night on life span and spontaneous carcinogenesis in female CBA mice.

Authors

 Anisimov VN; Baturin DA; Popovich IG; Zabezhinski MA; Manton KG; Semenchenko AV; Yashin AI

Journal

 Int J Cancer

Volume

 111

Issue

 4

Year

 2004

Pages

 475-9

Abstract

 The effect of constant illumination on the development of spontaneous tumors in female CBA mice was investigated. Fifty female CBA mice starting from the age of 2 months were kept under standard light/dark regimen (12 hr light:12hr dark; LD) and 50 CBA mice of similar age were kept under constant illumination (24 hr a day, 2,500 Lux, LL). Exposure to the LL regimen decreased food consumption but did not influence body weight, significantly accelerated age-related disturbances in estrous function, and was followed by a significant increase in spontaneous tumor incidence in female CBA mice. Tumor incidence as well as the number of total or malignant tumors was significantly increased in the LL group compared to the LD group (p < 0.001). The incidence of lung adenocarcinomas, leukemias and hepatocarcinomas was 7/50; 6/50 and 4/50 in the LL group and 1/50; 0/50 and 0/50 in the LD group. Mice from the LL groups had shorter life spans then those from the LD group. The data demonstrate, for the first time, that exposure to constant illumination was followed by increases in the incidence of spontaneous lung carcinoma, leukemias and hepatocarcinoma in female CBA mice.

Links

 J:91123 – MGI References
15239122 – National Library of Medicine/PubMed

Strain Notes

Strain Note
CBA/Rap Mice reported in this reference were "purchased from the 'Rappolovo' Animal Farm of the Russian Academy of Medical Sciences."

Models
Strain Model Name Treatment Agent(s) Organ Affected Frequency Model Details
CBA/Rap Blood vessel hemangioma Liver

0
CBA/Rap Blood vessel hemangioma
  • constant light
 Liver

2.0
CBA/Rap Forestomach papilloma Forestomach

0
CBA/Rap Forestomach papilloma
  • constant light
 Forestomach

2.0
CBA/Rap Leukocyte leukemia Leukocyte

0
CBA/Rap Leukocyte leukemia
  • constant light
 Leukocyte

12
CBA/Rap Liver hepatocellular carcinoma Liver

0
CBA/Rap Liver hepatocellular carcinoma
  • constant light
 Liver

8.0
CBA/Rap Lung adenocarcinoma Lung

2.0
CBA/Rap Lung adenocarcinoma
  • constant light
 Lung

14
CBA/Rap Lung adenoma Lung

2.0
CBA/Rap Lung adenoma
  • constant light
 Lung

2.0
CBA/Rap Mammary gland adenocarcinoma Mammary gland

2.0
CBA/Rap Mammary gland adenocarcinoma
  • constant light
 Mammary gland

4.0
CBA/Rap Mesodermal cell/mesoblast sarcoma - histiocytic fibrous Mesodermal cell/mesoblast

2.0
CBA/Rap Mesodermal cell/mesoblast sarcoma - histiocytic fibrous
  • constant light
 Mesodermal cell/mesoblast

0
CBA/Rap Skin - Epidermis - Basal cell carcinoma Skin - Epidermis - Basal cell

2.0
CBA/Rap Skin - Epidermis - Basal cell carcinoma
  • constant light
 Skin - Epidermis - Basal cell

0
CBA/Rap (Unspecified organ) tumor (Unspecified organ)

8.0
CBA/Rap (Unspecified organ) tumor
  • constant light
 (Unspecified organ)

30