Strain SummaryC57BL/6-Tg(TRAMP)8247Ng

Strain Name

 C57BL/6-Tg(TRAMP)8247Ng

Strain Type(s)

 transgenic

Strain Synonym(s)

 C57BL/6-TgN(TRAMP)8247Ng  •  C57BL/6 TRAMP  •  rPB-SV40 Tag  •  rPB-Tag  •  TRAMP  •  TRansgenic Adenocarcinoma Mouse Prostate  •  transgenic adenocarcinoma mouse prostate

Description

 Transgenic mice expressing the SV40 early genes (TAg) under control of the prostate epithelium-specific rat probasin promoter. The founder line (#8247) was generated on a C57BL/6 background.

Strain Genetics

 Tg(TRAMP)8247Ng

Models

5 unique models displayed. A model is a set of tumors that share the same tumor name, organ(s) affected, and treatment type for a specific strain.
Frequency
Model Name Organ Affected Tumor Inducing Agent(s) Female Male Mixed Pop. Unspecified Additional Information Model Details
Prostate gland adenocarcinoma Prostate gland

observed - very high

References: Foster BA, Cancer Res 1997 Aug 15;57(16):3325-30   ⋅   Greenberg NM, Proc Natl Acad Sci U S A 1995 Apr 11;92(8):3439-43

Sites of Metastasis: Adrenal gland , Bone , Kidney , Lung , Lymph node
Prostate gland carcinoma Prostate gland

16 - 100

References: Bruckheimer EM, Oncogene 2000 Nov 2;19(46):5251-8

Sites of Metastasis: Lymph node
Prostate gland hyperplasia Prostate gland

observed - 100

References: Greenberg NM, Proc Natl Acad Sci U S A 1995 Apr 11;92(8):3439-43

Prostate gland prostatic intraepithelial neoplasia (PIN) Prostate gland

very high

References: Foster BA, Cancer Res 1997 Aug 15;57(16):3325-30

Prostate gland tumor Prostate gland castration

36

References: Bruckheimer EM, Oncogene 2000 Nov 2;19(46):5251-8