Strain SummaryB6.129S7-Trp53tm1Brd/+
Strain Name |
B6.129S7-Trp53tm1Brd/+ |
Strain Type(s) |
congenic • targeted mutation (knockout) |
Strain Synonym(s) |
C57BL/6-Trp53tm1Bay/+ • heterozygote p53 knockout • p53(+/-) • p53+/- • Trp53+/- • p53+/- • p53-deficient • p53 heterozygous • TGS-p53tm • TSG-p53(+/-) |
Description |
Heterozygous mice. These mice had been backcrossed to C57BL/6. The targeted mutation was generated in 129S7/SvEvBrd-Hprt+-derived ES cells. |
Strain Genetics |
Trp53tm1Brd / Trp53+ |
Frequency | ||||||||
---|---|---|---|---|---|---|---|---|
Model Name | Organ Affected | Tumor Inducing Agent(s) | Female | Male | Mixed Pop. | Unspecified | Additional Information | Model Details |
Blood vessel hemangioma | Urinary bladder | N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN) |
23 - 42 |
References: Ozaki K, Cancer Res 1998 Sep 1;58(17):3806-11 |
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Blood vessel hemangiosarcoma | Urinary bladder | N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN) |
7.7 - 17 |
References: Ozaki K, Cancer Res 1998 Sep 1;58(17):3806-11 |
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Bone osteosarcoma | Bone |
8.8 |
References: Nister M, Oncogene 2005 May 19;24(22):3563-73 |
|||||
Connective tissue - Fibroblast fibrosarcoma | Connective tissue - Fibroblast |
6.1 |
References: Nister M, Oncogene 2005 May 19;24(22):3563-73 |
|||||
Germ cell (sex not specified) teratocarcinoma | Germ cell (sex not specified) |
0.7 |
References: Nister M, Oncogene 2005 May 19;24(22):3563-73 |
|||||
Leukocyte lymphoma | Leukocyte |
8.2 - 10 |
References: Nister M, Oncogene 2005 May 19;24(22):3563-73 |
|||||
Leukocyte lymphoma | Thymus |
2.0 |
References: Nister M, Oncogene 2005 May 19;24(22):3563-73 |
|||||
Liver carcinoma | Liver |
0.7 |
References: Nister M, Oncogene 2005 May 19;24(22):3563-73 |
|||||
Mesodermal cell/mesoblast sarcoma | Mesodermal cell/mesoblast |
16 |
References: Nister M, Oncogene 2005 May 19;24(22):3563-73 |
|||||
Salivary gland carcinoma | Salivary gland |
0.7 |
References: Nister M, Oncogene 2005 May 19;24(22):3563-73 |
|||||
Skin carcinoma | Skin |
0.7 |
References: Nister M, Oncogene 2005 May 19;24(22):3563-73 |
|||||
Skin papilloma | Skin |
0.7 |
References: Nister M, Oncogene 2005 May 19;24(22):3563-73 |
|||||
Testis tumor - cystic | Testis |
0.7 |
References: Nister M, Oncogene 2005 May 19;24(22):3563-73 |
|||||
Urinary bladder dysplasia | Urinary bladder | p-cresidine |
high |
References: Dunn SE, Cancer Res 1997 Nov 1;57(21):4667-72 |
||||
Urinary bladder dysplasia | Urinary bladder | N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN) |
46 - 100 |
100 |
References: Ozaki K, Cancer Res 1998 Sep 1;58(17):3806-11 |
|||
Urinary bladder hyperplasia | Urinary bladder | p-cresidine |
high |
References: Dunn SE, Cancer Res 1997 Nov 1;57(21):4667-72 |
||||
Urinary bladder hyperplasia | Urinary bladder | N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN) |
observed |
References: Ozaki K, Cancer Res 1998 Sep 1;58(17):3806-11 |
||||
Urinary bladder squamous cell carcinoma | Urinary bladder | N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN) |
0 - 50 |
20 |
References: Ozaki K, Cancer Res 1998 Sep 1;58(17):3806-11 |
|||
Urinary bladder transitional cell carcinoma | Urinary bladder | p-cresidine |
40 - 100.0 |
References: Dunn SE, Cancer Res 1997 Nov 1;57(21):4667-72 |
||||
Urinary bladder transitional cell carcinoma | Urinary bladder | calorie restricted ⋅ p-cresidine |
0 |
References: Dunn SE, Cancer Res 1997 Nov 1;57(21):4667-72 |
||||
Urinary bladder transitional cell carcinoma | Urinary bladder | calorie restricted ⋅ insulin-like growth factor 1 - human recombinant (IGF-1) ⋅ p-cresidine |
60 |
References: Dunn SE, Cancer Res 1997 Nov 1;57(21):4667-72 |
||||
Urinary bladder transitional cell carcinoma | Urinary bladder | N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN) |
0 - 100 |
60 |
References: Ozaki K, Cancer Res 1998 Sep 1;58(17):3806-11 |
|||
Urinary bladder transitional cell carcinoma in situ | Urinary bladder | p-cresidine |
0 |
References: Dunn SE, Cancer Res 1997 Nov 1;57(21):4667-72 |
||||
Urinary bladder transitional cell carcinoma in situ | Urinary bladder | calorie restricted ⋅ p-cresidine |
20 |
References: Dunn SE, Cancer Res 1997 Nov 1;57(21):4667-72 |
||||
Urinary bladder transitional cell carcinoma in situ | Urinary bladder | calorie restricted ⋅ insulin-like growth factor 1 - human recombinant (IGF-1) ⋅ p-cresidine |
0 |
References: Dunn SE, Cancer Res 1997 Nov 1;57(21):4667-72 |
||||
Urinary bladder tumor | Urinary bladder |
0 |
References: Dunn SE, Cancer Res 1997 Nov 1;57(21):4667-72 ⋅ Ozaki K, Cancer Res 1998 Sep 1;58(17):3806-11 |
|||||
(Unspecified organ) adenocarcinoma | (Unspecified organ) |
0.7 |
References: Nister M, Oncogene 2005 May 19;24(22):3563-73 |
|||||
(Unspecified organ) angiosarcoma | (Unspecified organ) |
0.7 |
References: Nister M, Oncogene 2005 May 19;24(22):3563-73 |
|||||
(Unspecified organ) tumor | (Unspecified organ) |
31 - 72 |
References: Nister M, Oncogene 2005 May 19;24(22):3563-73 |