Strain Summary(C3H/HeJ x B6.129S2)F1-Nf1^tm1Tyj Trp53^tm1Tyj/+ +

Strain Name	(C3H/HeJ x B6.129S2)F1-Nf1^tm1Tyj Trp53^tm1Tyj/+ +
Strain Type(s)	hybrid • targeted mutation (knockout)
Strain Synonym(s)	(C3H/HeJ x B6.129S2)F1-Nf1^tm1Tyj/+ Trp53^tm1Tyj/+ • C3H/HeJxB6 Nf1;Trp53 cis • C3H/HeJxB6 Npcis • HxB6 Nf1;Trp53 cis • HxB6 NPcis
Description	Mice heterozygous for Nf1^tm1Tyj and Trp53^tm1Tyj on the same copy of chromosome 11 ("cis"). The background of these mice was 50% C3H/HeJ.
Strain Genetics	List all models in MMHCdb carrying the Nf1^tm1Tyj allele Nf1^tm1Tyj / Nf1⁺
	List all models in MMHCdb carrying the Trp53^tm1Tyj allele Trp53^tm1Tyj / Trp53⁺

Models
4 unique models displayed. *A model is a set of tumors that share the same tumor name, organ(s) affected, and treatment type for a specific strain.*
			Frequency
Model Name	Organ Affected	Tumor Inducing Agent(s)	Female	Male	Mixed Pop.	Unspecified	Additional Information	Model Details
CNS - Brain - Astrocyte astrocytoma	CNS - Brain - Astrocyte				75 - 100		References: Reilly KM, Nat Genet 2000 Sep;26(1):109-13
CNS - Brain glioblastoma	CNS - Brain				4.2		References: Reilly KM, Nat Genet 2000 Sep;26(1):109-13
Mesodermal cell/mesoblast sarcoma	Mesodermal cell/mesoblast				50		References: Reilly KM, Nat Genet 2000 Sep;26(1):109-13
(Unspecified organ) tumor	(Unspecified organ)				100		References: Reilly KM, Nat Genet 2000 Sep;26(1):109-13

Models