Strain SummaryCD-1;129-Cdk4tm1.1Bbd

Strain Name

 CD-1;129-Cdk4tm1.1Bbd

Strain Type(s)

 targeted mutation (knock-in)

Strain Synonym(s)

 Cdk4R24C/R24C  •  mixed 129/SvJ X CD-1 Cdk4R24C/R24C

Description

 Homozygous mice. The genetic background of these mice was a mixture of 129X1/SvJ, 129S1/Sv, and outbred CD-1.

Strain Genetics

 Cdk4tm1.1Bbd / Cdk4tm1.1Bbd

Models

52 unique models displayed. A model is a set of tumors that share the same tumor name, organ(s) affected, and treatment type for a specific strain.
Frequency
Model Name Organ Affected Tumor Inducing Agent(s) Female Male Mixed Pop. Unspecified Additional Information Model Details
Adipose tissue lipoma Adipose tissue

observed

References: Sotillo R, EMBO J 2001 Dec 3;20(23):6637-47

Adipose tissue liposarcoma Adipose tissue

observed

References: Sotillo R, EMBO J 2001 Dec 3;20(23):6637-47

Adrenal gland - Subcapsular cell lesion Adrenal gland - Subcapsular cell

very low

References: Sotillo R, EMBO J 2001 Dec 3;20(23):6637-47

Blood vessel hemangiosarcoma Blood vessel

22 - 56

References: Sotillo R, EMBO J 2001 Dec 3;20(23):6637-47

Sites of Metastasis: (Unspecified organ) , Intestine
Bone osteoma Bone

observed

References: Sotillo R, EMBO J 2001 Dec 3;20(23):6637-47

Bone osteosarcoma Bone

observed

References: Sotillo R, EMBO J 2001 Dec 3;20(23):6637-47

Connective tissue - Fibroblast fibrosarcoma Connective tissue - Fibroblast

observed

References: Sotillo R, EMBO J 2001 Dec 3;20(23):6637-47

Intestine tumor Intestine

observed

References: Sotillo R, EMBO J 2001 Dec 3;20(23):6637-47

Kidney tumor Kidney

observed

References: Sotillo R, EMBO J 2001 Dec 3;20(23):6637-47

Leukocyte - Lymphocyte hyperplasia Spleen

6.0

References: Sotillo R, EMBO J 2001 Dec 3;20(23):6637-47

Leukocyte - Lymphocyte hyperplasia Lymph node

13

References: Sotillo R, EMBO J 2001 Dec 3;20(23):6637-47

Leukocyte - Myelocyte (Granulocyte) - Basophil - Mast cell tumor Leukocyte - Myelocyte (Granulocyte) - Basophil - Mast cell

1.0 - 2.0

References: Sotillo R, EMBO J 2001 Dec 3;20(23):6637-47

Leukocyte - Myelocyte (Granulocyte) metaplasia Leukocyte - Myelocyte (Granulocyte)

13

References: Sotillo R, EMBO J 2001 Dec 3;20(23):6637-47

Leukocyte lymphoma Leukocyte

0 - 1.9

References: Sotillo R, EMBO J 2001 Dec 3;20(23):6637-47

Leukocyte lymphoma Leukocyte 12-O-tetradecanoylphorbol-13-acetate (TPA)   ⋅   7,12-dimethylbenz[a]anthracene (DMBA)

20

References: Sotillo R, Proc Natl Acad Sci U S A 2001 Nov 6;98(23):13312-7

Liver - Hepatocyte lesion Liver - Hepatocyte

very low

References: Sotillo R, EMBO J 2001 Dec 3;20(23):6637-47

Liver hepatocellular adenoma Liver

observed

References: Sotillo R, EMBO J 2001 Dec 3;20(23):6637-47

Liver hepatocellular tumor Liver

0

9.8 - 20

References: Sotillo R, EMBO J 2001 Dec 3;20(23):6637-47

Lung adenocarcinoma Lung

observed

References: Sotillo R, EMBO J 2001 Dec 3;20(23):6637-47

Lung adenoma Lung

observed

References: Sotillo R, EMBO J 2001 Dec 3;20(23):6637-47

Lung tumor Lung

18 - 32

References: Sotillo R, EMBO J 2001 Dec 3;20(23):6637-47

Mammary gland lesion Mammary gland

very low

References: Sotillo R, EMBO J 2001 Dec 3;20(23):6637-47

Mesodermal cell/mesoblast sarcoma Mesodermal cell/mesoblast

26 - 62

References: Sotillo R, EMBO J 2001 Dec 3;20(23):6637-47

Mesodermal cell/mesoblast sarcoma Mesodermal cell/mesoblast 12-O-tetradecanoylphorbol-13-acetate (TPA)   ⋅   7,12-dimethylbenz[a]anthracene (DMBA)

observed

References: Sotillo R, Proc Natl Acad Sci U S A 2001 Nov 6;98(23):13312-7

Mesodermal cell/mesoblast sarcoma - undifferentiated Mesodermal cell/mesoblast

observed

References: Sotillo R, EMBO J 2001 Dec 3;20(23):6637-47

Mesodermal cell/mesoblast tumor Mesodermal cell/mesoblast

32 - 68

References: Sotillo R, EMBO J 2001 Dec 3;20(23):6637-47

Mesodermal cell/mesoblast tumor - benign Mesodermal cell/mesoblast

6.0 - 7.6

References: Sotillo R, EMBO J 2001 Dec 3;20(23):6637-47

Ovary - Granulosa cell tumor Ovary - Granulosa cell

observed

References: Sotillo R, EMBO J 2001 Dec 3;20(23):6637-47

Pancreas - Islet of Langerhans - Beta cell tumor Pancreas - Islet of Langerhans - Beta cell

30 - 42

References: Sotillo R, EMBO J 2001 Dec 3;20(23):6637-47

Pancreas - Islet of Langerhans adenoma Pancreas - Islet of Langerhans

observed

References: Sotillo R, EMBO J 2001 Dec 3;20(23):6637-47

Pancreas - Islet of Langerhans hyperplasia Pancreas - Islet of Langerhans

observed

References: Sotillo R, EMBO J 2001 Dec 3;20(23):6637-47

Pituitary gland adenocarcinoma Pituitary gland

observed

References: Sotillo R, EMBO J 2001 Dec 3;20(23):6637-47

Pituitary gland adenoma Pituitary gland

observed

References: Sotillo R, EMBO J 2001 Dec 3;20(23):6637-47

Pituitary gland tumor Pituitary gland

6.0 - 22

References: Sotillo R, EMBO J 2001 Dec 3;20(23):6637-47

Prostate gland lesion Prostate gland

very low

References: Sotillo R, EMBO J 2001 Dec 3;20(23):6637-47

Salivary gland lesion Salivary gland

very low

References: Sotillo R, EMBO J 2001 Dec 3;20(23):6637-47

Skin - Melanocyte melanoma Skin - Melanocyte

0

0

References: Sotillo R, EMBO J 2001 Dec 3;20(23):6637-47   ⋅   Sotillo R, Proc Natl Acad Sci U S A 2001 Nov 6;98(23):13312-7

Skin - Melanocyte melanoma Skin - Melanocyte 12-O-tetradecanoylphorbol-13-acetate (TPA)   ⋅   7,12-dimethylbenz[a]anthracene (DMBA)

70

References: Sotillo R, Proc Natl Acad Sci U S A 2001 Nov 6;98(23):13312-7

7 pathology image(s)
Skin - Melanocyte melanoma Skin - Melanocyte ultraviolet-B radiation (UVB)   ⋅   7,12-dimethylbenz[a]anthracene (DMBA)

observed

References: Sotillo R, Proc Natl Acad Sci U S A 2001 Nov 6;98(23):13312-7

Skin - Melanocyte melanoma Skin - Melanocyte ultraviolet-B radiation (UVB)

0

References: Sotillo R, Proc Natl Acad Sci U S A 2001 Nov 6;98(23):13312-7

Skin lesion Skin 12-O-tetradecanoylphorbol-13-acetate (TPA)   ⋅   7,12-dimethylbenz[a]anthracene (DMBA)

very high

References: Sotillo R, Proc Natl Acad Sci U S A 2001 Nov 6;98(23):13312-7

1 pathology image(s)
Skin lesion Skin 7,12-dimethylbenz[a]anthracene (DMBA)

observed

References: Sotillo R, Proc Natl Acad Sci U S A 2001 Nov 6;98(23):13312-7

Skin papilloma Skin 12-O-tetradecanoylphorbol-13-acetate (TPA)   ⋅   7,12-dimethylbenz[a]anthracene (DMBA)

very high

References: Sotillo R, Proc Natl Acad Sci U S A 2001 Nov 6;98(23):13312-7

Skin squamous cell carcinoma Skin 12-O-tetradecanoylphorbol-13-acetate (TPA)   ⋅   7,12-dimethylbenz[a]anthracene (DMBA)

15

References: Sotillo R, Proc Natl Acad Sci U S A 2001 Nov 6;98(23):13312-7

Testis - Leydig cell (Interstitial cell) hyperplasia Testis - Leydig cell (Interstitial cell)

observed

References: Sotillo R, EMBO J 2001 Dec 3;20(23):6637-47

Testis - Leydig cell (Interstitial cell) tumor Testis - Leydig cell (Interstitial cell)

62 - 70

References: Sotillo R, EMBO J 2001 Dec 3;20(23):6637-47

Sites of Metastasis: (Unspecified organ)
Thyroid gland tumor Thyroid gland

observed

References: Sotillo R, EMBO J 2001 Dec 3;20(23):6637-47

Uterus - Endometrium lesion Uterus - Endometrium

very low

References: Sotillo R, EMBO J 2001 Dec 3;20(23):6637-47

(Unspecified organ) carcinoma (Unspecified organ) 12-O-tetradecanoylphorbol-13-acetate (TPA)   ⋅   7,12-dimethylbenz[a]anthracene (DMBA)

observed

References: Sotillo R, Proc Natl Acad Sci U S A 2001 Nov 6;98(23):13312-7

(Unspecified organ) histiocytoma - fibrous - malignant (Unspecified organ)

observed

References: Sotillo R, EMBO J 2001 Dec 3;20(23):6637-47

(Unspecified organ) lymphohematopoietic neoplasm (Unspecified organ)

2.0 - 2.9

References: Sotillo R, EMBO J 2001 Dec 3;20(23):6637-47

(Unspecified organ) tumor (Unspecified organ)

100

95

References: Sotillo R, EMBO J 2001 Dec 3;20(23):6637-47