Strain SummaryB6.129S1-Cdkn2c^tm1Bbd

Strain Name	B6.129S1-Cdkn2c^tm1Bbd
Strain Type(s)	congenic • targeted mutation (knockout)
Strain Synonym(s)	C57BL/6J p18^INK4c null • p18^INK4c-deficient • p18^INK4c KO
Description	Mice homozygous for a targeted mutation of Cdkn2c (p18INK4c). This strain was backcrossed to C57BL/6J.
Strain Genetics	List all models in MMHCdb carrying the Cdkn2c^tm1Bbd allele Cdkn2c^tm1Bbd / Cdkn2c^tm1Bbd

Models
5 unique models displayed. *A model is a set of tumors that share the same tumor name, organ(s) affected, and treatment type for a specific strain.*
			Frequency
Model Name	Organ Affected	Tumor Inducing Agent(s)	Female	Male	Mixed Pop.	Unspecified	Additional Information	Model Details
Leukocyte lymphoma	Leukocyte	12-O-tetradecanoylphorbol-13-acetate (TPA) ⋅ 7,12-dimethylbenz[a]anthracene (DMBA)				70	References: Sotillo R, Proc Natl Acad Sci U S A 2001 Nov 6;98(23):13312-7
Mesodermal cell/mesoblast sarcoma	Mesodermal cell/mesoblast	12-O-tetradecanoylphorbol-13-acetate (TPA) ⋅ 7,12-dimethylbenz[a]anthracene (DMBA)				17	References: Sotillo R, Proc Natl Acad Sci U S A 2001 Nov 6;98(23):13312-7
Skin - Melanocyte melanoma	Skin - Melanocyte	12-O-tetradecanoylphorbol-13-acetate (TPA) ⋅ 7,12-dimethylbenz[a]anthracene (DMBA)				observed	References: Sotillo R, Proc Natl Acad Sci U S A 2001 Nov 6;98(23):13312-7
Skin lesion	Skin	12-O-tetradecanoylphorbol-13-acetate (TPA) ⋅ 7,12-dimethylbenz[a]anthracene (DMBA)				very high	References: Sotillo R, Proc Natl Acad Sci U S A 2001 Nov 6;98(23):13312-7
Skin papilloma	Skin	12-O-tetradecanoylphorbol-13-acetate (TPA) ⋅ 7,12-dimethylbenz[a]anthracene (DMBA)				very high	References: Sotillo R, Proc Natl Acad Sci U S A 2001 Nov 6;98(23):13312-7

Models