Strain SummaryFVB/N-Mmp2tm1Ito Tg(KRT14-HPV16)wt1Dh
Strain Name |
FVB/N-Mmp2tm1Ito Tg(KRT14-HPV16)wt1Dh |
Strain Type(s) |
targeted mutation (knockout) • transgenic |
Strain Synonym(s) |
FVB.Cg-Mmp2tm1Ito Tg(KRT14-HPV16)wt1Dh • HPV/E2-MMP-2?null • HPV/E2-MMP-2-/- • K14-HPV16 MMP-2?/? |
Description |
Compound mutant mice. These mice are the product of an intercross between strains on a predominantly FVB/N background. |
Strain Genetics |
Tg(KRT14-HPV16)wt1Dh |
Mmp2tm1Ito / Mmp2tm1Ito |
Frequency | ||||||||
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Model Name | Organ Affected | Tumor Inducing Agent(s) | Female | Male | Mixed Pop. | Unspecified | Additional Information | Model Details |
Uterus - Cervix cervical intraepithelial neoplasia (CIN) | Uterus - Cervix | 17beta-estradiol (E2) |
observed |
References: Giraudo E, J Clin Invest 2004 Sep;114(5):623-33 |
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Uterus - Cervix squamous cell carcinoma | Uterus - Cervix | 17beta-estradiol (E2) |
very high |
References: Giraudo E, J Clin Invest 2004 Sep;114(5):623-33 |